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The Proximal Tubule in Progressive Diabetic Nephropathy: Are Tubular Polyamines a New Paradigm for Developing Therapies?

The Proximal Tubule in Progressive Diabetic Nephropathy: Are Tubular Polyamines a New Paradigm for Developing Therapies? | Autacoids | Scoop.it
Autacoids's insight:

The World Health Organization estimates that by 2030, 350 million people will have diabetes. Type 1 Diabetes (T1D) usually strikes children and young adults, but disease onset can occur at any age.

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Are we able to Manage Effectively Opioid-Induced Bowel Dysfunction?

Are we able to Manage Effectively Opioid-Induced Bowel Dysfunction? | Autacoids | Scoop.it
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Opioid–Induced Bowel Dysfunction (OIBD) is commonly associated with the chronic use of opioid analgesics and affects 80-90% of treated patients. OIBD comprises constipation, anorexia, nausea and vomiting, gastro-oesophageal reflux, delayed digestion, abdominal pain, flatulence, bloating, hard stool, straining during bowel movement and incomplete evacuation

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Recent Research Perspectives on in vivo Auto-activation Surfaces of Factor XII

Recent Research Perspectives on in vivo Auto-activation Surfaces of Factor XII | Autacoids | Scoop.it
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The identification of a convincing in vivo surface that supports constitutive auto-activation of Factor (F)XII has proven to be a formidable task. Nonetheless, extracellular RNA, platelet-released polyphosphates and misfolded and aggregated proteins have recently been described as FXII binding surfaces, which induce auto-activation of the zymogen.

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OMICS Group - Open Access Journals, Scientific Conferences & Events Organizer

OMICS Group - Open Access Journals, Scientific Conferences & Events Organizer | Autacoids | Scoop.it

OMICS Publishing Group is an Open Access publication model that enables the dissemination of research articles to the global community.
OMICS Publishing Group strongly supports the Open Access initiative. Abstracts and full texts (HTML, XML and PDF format) of all articles published by OMICS Publishing Group are freely accessible to everyone immediately after publication.
200 Open Access Journals
20,000 Editorial Members

21 day rapid review process with international peer-review standards.

Timeline of processing from Submission to Publication is 45 days.

Manuscript will be published within 7days of acceptance.
Better discount for your subsequent articles

 

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'Criteria of speaker selection is important to convey the quality level' - Express Pharma Online

'Criteria of speaker selection is important to convey the quality level' - Express Pharma Online | Autacoids | Scoop.it
Find latest pharma market on the detailed improvement in pharmaceutical industry including news influencing from pharmaceutical events, biotech market, pharma industry associations, trade association for pharma market experts from...
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Testosterone role in Fetal Development

Testosterone role in Fetal Development | Autacoids | Scoop.it
Testosterone is a steroid hormone present in all mammals. It is mainly secreted in the testicles of males and ovaries of females and also by adrenal ...
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The role of a1B-ARs in regulating renal hemodynamic and renal functions in hypertensive rats; impact of high dietary sodium intake

The role of a1B-ARs in regulating renal hemodynamic and renal functions in hypertensive rats; impact of high dietary sodium intake | Autacoids | Scoop.it

Renal α1B-adrenoreceptors (α1-ARs) contributes to the pathogenesis of hypertension in spontaneously hypertensive rats (SHR). The present study examined the role of α1B-ARs in renal hemodynamic and tubular functions in SHR subjected to high-salt diet (SHRHNa) for 6 weeks.

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Intracellular Angiotensin II AT1 Receptor-an Important Component of the Cardiac Intracrine Action of the Peptide

Intracellular Angiotensin II AT1 Receptor-an Important Component of the Cardiac Intracrine Action of the Peptide | Autacoids | Scoop.it

The systemic Renin Angiotensin System (RAS) depends on the release of renin and the action of the enzyme on angiotensinogen to generate the decapeptide angiotensin I which in turn is converted to angiotensin I by the Angiotensin Converting Enzyme (ACE) in the pulmonary circulation.

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Inflammatory Breast Cancer is Associated with Hyperactivated Mitogen Activated Kinase

Inflammatory Breast Cancer is Associated with Hyperactivated Mitogen Activated Kinase | Autacoids | Scoop.it
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Inflammatory Breast Cancer (IBC) is a distinct clinical subtype of locally advanced breast cancer, with a particularly aggressive behavior and poor prognosis. Clinically, IBC typically presents with rapidly progressive breast warmth, erythema and edema.

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A Decade Later

A Decade Later | Autacoids | Scoop.it
Autacoids's insight:

It has been over a decade since the first draft of the human genome was published. At that time, the expectations regarding short and long-term impacts were high. In line with all new revolutionary undertakings, one needs to wonder whether projected outcomes were overly ambitious.

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Need to Redefine Population-Specific Reference Values of Vitamin-D

Need to Redefine Population-Specific Reference Values of Vitamin-D | Autacoids | Scoop.it
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Recently, epidemiology of Vitamin D deficiency has gained much attention among the scientific community. Based on the reference ranges obtained in one country scientists from everywhere especially from those countries of South Asia and Middle East are reporting a mass level Vitamin D deficiency in people who are apparently healthy. (Read more Interesting)

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Journal of Autacoids| OMICS Group

Journal of Autacoids| OMICS Group | Autacoids | Scoop.it

Autacoids are biological factors that behave like local self relieving hormones, and act near the site of synthesis. The journal gives clear information regarding types and pharmacology of autacoids. It is an online manuscript submission, review and tracking system for quality and quick reviewing processing. Review processing is performed by the editorial board members or outside experts; at least two independent reviewers approval followed by editorial approval is required for acceptance of any citable manuscript.

 

Submit your manuscript at

http://omicsgroup.org/editorialtracking/autacoids/SubmitManuscript.php

 

Submit Manuscripts as e-mail attachment to the Editorial Office at :

editor.autacoids@omicsonline.org

 

 

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The Therapeutic Potential of Gaseous Autacoids

The Therapeutic Potential of Gaseous Autacoids | Autacoids | Scoop.it

Carbon Monoxide (CO) and Hydrogen Sulfide (H2S) are small, lipid-soluble gaseous autacoids that modulate numerous physiological processes. Historically, both gases were considered highly noxious environmental hazard shaving well-defined modes of toxicity: CO binds avidly to hemoglobin reducing the oxygen-carrying capacity of the protein leading to tissue hypoxia while H2S is a potent mitochondrial poison that blocks cellular respiration. Surprisingly, research conducted in the past couple of decades discovered that CO and H2S are produced endogenously by mammalian cells and serve as important signaling molecules in the nervous, inflammatory, and cardiovascular systems.

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Is Salivary Alpha Amylase Useful as a Biomarker of Stress in Oral Diseases?

Is Salivary Alpha Amylase Useful as a Biomarker of Stress in Oral Diseases? | Autacoids | Scoop.it

Although salivary alpha amylase (SAA) has been investigated during past thirty years as a biomarker of stress, still remains certain doubt regarding its utility. Additionally, there has been a lot of debate whether SAA reflects sympathetic activity solely, however, recent data suggested that this is unlikely due to the parasympathetic activity which innervates salivary glands whose product is Salivary Alpha Amylase.

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Renin -Angiotensin and Sympathetic Nervous System Interactions in the Control of Blood Pressure in Fructose-Induced Metabolic Syndrome

Renin -Angiotensin and Sympathetic Nervous System Interactions in the Control of Blood Pressure in Fructose-Induced Metabolic Syndrome | Autacoids | Scoop.it

Activation of the sympathetic nervous system (SNS) stimulates renin release from the juxtraglomerular cells of the kidneys that leads to the generation of angiotensin I, which is then converted to angiotensin II (Ang II), the major effector peptide of the renin-angiotensin system (RAS).

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