Mass spectrometry
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Rescooped by Joseval Estigaribia from Mass Spectrometry at Bruker
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Ultra Mass Resolution MALDI Imaging of Proteins and Metabolites in a Mouse Model of Glioblastoma #solariX 15T #Bruker

Ultra Mass Resolution MALDI Imaging of Proteins and Metabolites in a Mouse Model of Glioblastoma #solariX 15T #Bruker | Mass spectrometry | Scoop.it
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Webinar: metabolomics research to discover developmental disorders in children related to environmental contaminants @VUAmsterdam Pim Leonards


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How does salt lower the freezing point of water? - World Of Chemicals

How does salt lower the freezing point of water? - World Of Chemicals | Mass spectrometry | Scoop.it
Salt mixed with ice creates a brine that has a temperature lower than 32 F; When salt is added to ice water, it lowers melting temperature of ice down to 0 F or so; Brine is so cold that it easily freezes the ice cream mixture

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Bruker Leiderdorp (NL) Controller (m/f) - job opening #career $BRKR The #Netherlands #finance administration Leiden Bioscience Life Sciences

As one of the world’s leading analytical instrumentation companies, Bruker covers a broad spectrum of advanced solutions in all fields of research and development. All our systems and instruments are designed to improve safety of products, accelerate time-to-market and support industries in successfully enhancing quality of life. We’ve been driving innovation in analytical instrumentation for 50 years now. Today, worldwide more than 6,000 employees are working on this permanent challenge, at over 70 locations on all continents.

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Production of ethyl acetate by esterification - World Of Chemicals

Production of ethyl acetate by esterification - World Of Chemicals | Mass spectrometry | Scoop.it
Ethyl acetate is synthesised via the Fischer esterification reaction from ethanol and acetic acid, typically in the presence of an acid catalyst such as concentrated sulfuric acid; check here for more

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An Integrated Mass Spectrometry‐Based Approach to Probe the Structure of the Full‐Length Wild‐Type Tetrameric p53 Tumor Suppressor

An Integrated Mass Spectrometry‐Based Approach to Probe the Structure of the Full‐Length Wild‐Type Tetrameric p53 Tumor Suppressor | Mass spectrometry | Scoop.it
We present an integrated approach for investigating the topology of proteins through native mass spectrometry (MS) and cross‐linking/MS, which we applied to the full‐length wild‐type p53 tetramer
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Rescooped by Joseval Estigaribia from Natural Products Chemistry Breaking News
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Recent Advances in NMR-Based Metabolomics 

Recent Advances in NMR-Based Metabolomics  | Mass spectrometry | Scoop.it
G. A. Nagana Gowda† and Daniel Raftery*†‡§
†Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine and ‡Department of Chemistry, University of Washington, Seattle, Washington 98109, United States,
§ Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, United States
Anal. Chem., Article ASAP
DOI: 10.1021/acs.analchem.6b04420

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NatProdChem's curator insight, December 3, 2016 7:11 AM

What's new in NMR metabolomics.

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Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes 

Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes  | Mass spectrometry | Scoop.it

Click hFew secondary metabolites have been reported from mammalian microbiome bacteria despite the large numbers of diverse taxa that inhabit warm-blooded higher vertebrates. As a means to investigate natural products from these microorganisms, an opportunistic sampling protocol was developed, which focused on exploring bacteria isolated from roadkill mammals. This initiative was made possible through the establishment of a newly created discovery pipeline, which couples laser ablation electrospray ionization mass spectrometry (LAESIMS) with bioassay testing, to target biologically active metabolites from microbiome-associated bacteria. To illustrate this process, this report focuses on samples obtained from the ear of a roadkill opossum (Dideiphis virginiana) as the source of two bacterial isolates (Pseudomonas sp. and Serratia sp.) that produced several new and known cyclic lipodepsipeptides (viscosin and serrawettins, respectively). These natural products inhibited biofilm formation by the human pathogenic yeast Candida albicans at concentrations well below those required to inhibit yeast viability. Phylogenetic analysis of 16S rRNA gene sequence libraries revealed the presence of diverse microbial communities associated with different sites throughout the opossum carcass. A putative biosynthetic pathway responsible for the production of the new serrawettin analogues was identified by sequencing the genome of the Serratia sp. isolate. This study provides a functional roadmap to carrying out the systematic investigation of the genomic, microbiological, and chemical parameters related to the production of natural products made by bacteria associated with non-anthropoidal mammalian microbiomes. Discoveries emerging from these studies are anticipated to provide a working framework for efforts aimed at augmenting microbiomes to deliver beneficial natural products to a host.ere to edit the content


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NatProdChem's curator insight, November 27, 2016 10:15 AM

Weirdest sampling pipeline !

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Role of Oxalic Acid in Human Body | List of Oxalic Acid Foods

Role of Oxalic Acid in Human Body |  List of Oxalic Acid Foods | Mass spectrometry | Scoop.it
Oxalic Acid belonging to the family of carboxylic acids and this chemical also termed as Ethanedioic Acid. Oxalic acid is widely used as an acid rinse in laundries, where it can able to remove rust and ink stains because of its capability of converting insoluble iron compounds into a soluble complex ion.For the same reason, it is the chief ingredient of many commercial preparations used for removing scale from automobile radiators. It occurs naturally in high levels in many common foods, including several vegetables like Potatoes, Beets, Broccoli, Carrots and other foods like fruits, nuts&seeds, legumes&grains, Chocolate, Beer etc. In some of these food items, it tastes pleasantly sour, and in others it’s essentially tasteless. Because it binds with some nutrients making them unavailable, for this reason the oxalic acid is often described as an anti-nutrient. We don’t believe oxalic acid poses a health threat if you’re reasonable about your consumption. More than 90 per cent of the oxalic acid you consume is normally excreted in your urine. Organic form of oxalic acid, in low concentration, is essential to maintain peristaltic motion in our body. However, when it is processed or cooked, it becomes inorganic form, and may have certain negative effects on the body. Foods high in both calcium and oxalic acid are less of a concern than those merely high in oxalic acid, since the calcium bonds with the oxalic acid in the stomach. In lower doses, oxalic acid can limiting the absorption of some nutrients, particularly calcium and iron. When oxalic acid combines with calcium and some of these other minerals it creates oxalate crystals, which can contribute to kidney stones, gout etc. Oxalic acid can also interfere with the absorption of minerals in our diet such as calcium, potassium, and magnesium. Hence, it is advisable for people with certain health conditions to limit its intake through the diet. One thing to be kept in mind is that, oxalic acid is harmless if consumed in organic form and moderate amounts. However, too much of it can have several adverse effects on your body.

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Chemical Analysis, Mass Spectrometry, Helps Identify Substances

Chemical Analysis, Mass Spectrometry, Helps Identify Substances | Mass spectrometry | Scoop.it
Name that chemical! Scientists use chemical analysis - Mass Spectrometry, Raman Spectroscopy, and more - to determine the identity of chemical residues.
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Ion Mobility-Mass Spectrometry as a Tool for the Structural Characterization of Peptides Bearing Intramolecular Disulfide Bond(s)

Ion Mobility-Mass Spectrometry as a Tool for the Structural Characterization of Peptides Bearing Intramolecular Disulfide Bond(s) | Mass spectrometry | Scoop.it
Disulfide bonds are post-translationnal modifications that can be crucial for the stability and the biological activities of natural peptides. Considering the importance of these disulfide bond-contai

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Characterization of Indium Phosphide Quantum Dot Growth Intermediates Using MALDI-TOF Mass Spectrometry - Journal of the American Chemical Society (ACS Publications)

Characterization of Indium Phosphide Quantum Dot Growth Intermediates Using MALDI-TOF Mass Spectrometry - Journal of the American Chemical Society (ACS Publications) | Mass spectrometry | Scoop.it

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The Art of Destruction: Optimizing Collision Energies in Quadrupole-Time of Flight (Q-TOF) Instruments for Glycopeptide-Based Glycoproteomics - Online First - Springer

The Art of Destruction: Optimizing Collision Energies in Quadrupole-Time of Flight (Q-TOF) Instruments for Glycopeptide-Based Glycoproteomics - Online First - Springer | Mass spectrometry | Scoop.it

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The Art of Destruction: Optimizing Collision Energies in Quadrupole-Time of Flight (Q-TOF) Instruments for Glycopeptide-Based Glycoproteomics - Online First - Springer

The Art of Destruction: Optimizing Collision Energies in Quadrupole-Time of Flight (Q-TOF) Instruments for Glycopeptide-Based Glycoproteomics - Online First - Springer | Mass spectrometry | Scoop.it

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How is Polyvinyl Chloride Made? - World Of Chemicals

How is Polyvinyl Chloride Made? - World Of Chemicals | Mass spectrometry | Scoop.it
PVC contains high levels (57%) of chlorine content. Manufacturing polyvinyl chloride (PVC) involves 3 steps Ethylene dichloride production, Vinyl chloride monomer production, Polyvinyl chloride production

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Direct infusion mass spectrometry for metabolomic phenotyping of diseases. EXTREME Hi-RES MS - NO chromatography

Direct infusion mass spectrometry for metabolomic phenotyping of diseases. EXTREME Hi-RES MS - NO chromatography | Mass spectrometry | Scoop.it
Bioanalysis. 2017 Jan;9(1):131-148. Review

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How to prepare sodium acetate at home? - World Of Chemicals

How to prepare sodium acetate at home? - World Of Chemicals | Mass spectrometry | Scoop.it
Sodium acetate can be made at home using common household ingredients baking soda and vinegar. To begin the reaction, add one spoonful of baking soda to a glass container. Slowly add vinegar, being careful not to create too much foam

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TIMS-MS Discussion Board with Publications overview Trapped Ion Mobility #Bruker Mass Spectrometry - Miami Florida State Fernandez-Lima Group


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An Integrated Mass Spectrometry‐Based Approach to Probe the Structure of the Full‐Length Wild‐Type Tetrameric p53 Tumor Suppressor

An Integrated Mass Spectrometry‐Based Approach to Probe the Structure of the Full‐Length Wild‐Type Tetrameric p53 Tumor Suppressor | Mass spectrometry | Scoop.it
We present an integrated approach for investigating the topology of proteins through native mass spectrometry (MS) and cross‐linking/MS, which we applied to the full‐length wild‐type p53 tetramer
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How is bromine synthesised by laboratory process? - World Of Chemicals

How is bromine synthesised by laboratory process? - World Of Chemicals | Mass spectrometry | Scoop.it
To make bromine in the laboratory here are few steps we need to follow; we need to find a chlorine source and react it with a solution of bromide ions. After formation of the bromine, it must be separated from the solution in a suitable way

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Bruker BRKR Infrared ion spectroscopy in a modified quadrupole ion trap mass spectrometer - FELIX free electron laser laboratory

We report on modifications made to a Paul-type quadrupole ion trap
mass spectrometer and discuss its application in infrared ion spectroscopy experiments. Main modifications involve optical access to the trapped ions and hardware and software coupling to a variety of infrared laser sources at the FELIX infrared free electron laser laboratory. In comparison to previously described infrared ion spectroscopy experiments at the FELIX laboratory, we find significant improvements in efficiency and sensitivity. Effects of the trapping conditions of the ions on the IR multiple photon dissociation
spectra are explored. Enhanced photo-dissociation is found at lower pressures in the ion trap.
Spectra obtained under reduced pressure conditions are found to more closely mimic those obtained in the high-vacuum conditions of an Fourier transform ion cyclotron resonance mass spectrometer. A gas-mixing system is described enabling the controlled addition of a secondary gas into helium buffer gas flowing into the trap and allows for ion/molecule reactions in the trap. The electron transfer dissociation (ETD) option of the mass spectrometer allows for IR structure characterization of ETD-generated peptide dissociation products.

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Chemical Analysis, Mass Spectrometry, Helps Identify Substances

Chemical Analysis, Mass Spectrometry, Helps Identify Substances | Mass spectrometry | Scoop.it
Name that chemical! Scientists use chemical analysis - Mass Spectrometry, Raman Spectroscopy, and more - to determine the identity of chemical residues.
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Accurate drift time determination by traveling wave ion mobility spectrometry: The concept of the diffusion calibration - Analytical Chemistry (ACS Publications)

Accurate drift time determination by traveling wave ion mobility spectrometry: The concept of the diffusion calibration - Analytical Chemistry (ACS Publications) | Mass spectrometry | Scoop.it

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Preliminary MALDI-TOF-MS analysis of seminal plasma N-glycome of infertile men.

Glycosylation pattern within reproductive tract is now suggested to be involved in providing female immune tolerance for allograft sperm and developing embryo, but the information whether impaired glycosylation may influence male fertility...
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LUMC: automated High-Throughput Permethylation for Glycosylation Analysis of Biologics Using MALDI-TOF-MS - Analytical Chemistry (ACS Publications)

LUMC: automated High-Throughput Permethylation for Glycosylation Analysis of Biologics Using MALDI-TOF-MS - Analytical Chemistry (ACS Publications) | Mass spectrometry | Scoop.it

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