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Immune disorder's symptoms mimic two mental illnesses

Immune disorder's symptoms mimic two mental illnesses | AntiNMDA | Scoop.it
When singer/songwriter/actor Demi Lovato was diagnosed with bipolar disorder at age 22, it came as a relief, and allowed her to deal with her condition. "When I focus on my treatment plan with my team and my support system, I'm able to not only maintain a healthy mind, but ... to maintain my sobriety."
Imagine, however, if you were diagnosed with that mental illness - for which there is no cure - when in fact you had a treatable immune disorder!
Back in 2007, researchers discovered that there was a form of immune encephalitis that affects specific brain receptor functions and triggers symptoms, such as paranoia and hearing voices, that are associated with bipolar disorder and with schizophrenia as well.
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Mycophenolate mofetil, azathioprine and methotrexate usage in paediatric anti-NMDAR encephalitis: A systematic literature review | Read by QxMD

Mycophenolate mofetil, azathioprine and methotrexate usage in paediatric anti-NMDAR encephalitis: A systematic literature review | Read by QxMD | AntiNMDA | Scoop.it
BACKGROUND: Available data on mycophenolate mofetil (MMF), azathioprine (AZA) and methotrexate (MTX) for paediatric-onset anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is limited. METHODS: Systematic literature review on patients treated with MMF/AZA/MTX for paediatric-onset anti-NMDARE, with focus on modes of use, efficacy and safety. RESULTS: 87 patients were included (age at onset median 11 years, range 0.8-18 years; 69% females). 46% had a relapsing course. 52% received MMF, 27% AZA, 15% MTX, and 6% a combination of MMF/AZA/MTX (7 patients received intrathecal MTX). Before MMF/AZA/MTX, 100% patients received steroids, 83% intravenous immunoglobulin and 45% plasma exchange, and 50% received second-line treatments (rituximab/cyclophosphamide). MMF/AZA/MTX were administered >6 months from onset in 51%, and only after relapse in 40%. Worst mRS before MMF/AZA/MTX was median 4.5 (range 3-5). At last follow-up (median 2 years, range 0.2-8.6), median mRS was 1 (range 0-6). Median annualised relapse rate was 0.4 (range 0-6.7) pre-MMF/AZA/MTX (excluding first events), and 0 on MMF/AZA/MTX (mean 0.03, range 0-0.8). 7% patients relapsed on MMF/AZA/MTX. These relapsing patients had low rate of second-line treatments before MMF/AZA/MTX (25%), long median time between onset and MMF/AZA/MTX usage (18 months), and frequently they were started on MMF/AZA/MTX only after relapse (75%). Relapse rate was lower among patients who received first immune therapy ≤30 days (25%) than later (64%), who received second-line treatments at first event (14%) rather than not (64%), who were started on MMF/AZA/MTX after the first (12%) rather than subsequent events (17%), and who were started on MMF/AZA/MTX ≤3 months from onset (33%) rather than later (53%). Adverse reactions to MMF/AZA/MTX occurred in 2 cases (cytomegalovirus colitis and respiratory infection), of grade 3 Common Terminology Criteria for Adverse Events v4.0. DISCUSSION: Our literature review disclosed heterogeneity in the use of MMF/AZA/MTX in paediatric-onset anti-NMDARE. MMF/AZA/MTX usage is mostly restricted to retrospective cohort descriptions. These agents may reduce risk of relapse, and have a reasonable safety profile, however data on larger cohorts are required to definitively determine effect.
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The Anti-NMDA Receptor Encephalitis Foundation Newsletter

The Anti-NMDA Receptor Encephalitis Foundation Newsletter | AntiNMDA | Scoop.it
Ketogenic diet treatment for pediatric super-refractory status epilepticus. – PubMed – NCBI

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Frontiers | Detection Methods for Autoantibodies in Suspected Autoimmune Encephalitis | Neurology

Frontiers | Detection Methods for Autoantibodies in Suspected Autoimmune Encephalitis | Neurology | AntiNMDA | Scoop.it
This review provides an overview on different antibody test methods that can be applied in cases of suspected paraneoplastic neurological syndromes (PNS) and anti-neuronal autoimmune encephalitis (AIE) in order to explain their diagnostic value, describe potential pitfalls and limitations, and...
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Anti-NMDA receptor encephalitis presenting as isolated aphasia in an adult. - PubMed - NCBI

Anti-NMDA receptor encephalitis presenting as isolated aphasia in an adult. - PubMed - NCBI | AntiNMDA | Scoop.it
Neurocase. 2018 Oct 6:1-7. doi: 10.1080/13554794.2018.1524915.[Epub ahead of print]...
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Prevalence of Autoimmune Encephalitis in Herpes Simplex Encephalitis Explored

Prevalence of Autoimmune Encephalitis in Herpes Simplex Encephalitis Explored | AntiNMDA | Scoop.it
A significant risk factor for autoimmune encephalitis was antibody detection within a 3-week period of herpes simplex encephalitis.
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NMDA-receptor antibodies alter cortical microcircuit dynamics - UCL Discovery

NMDA-receptor antibodies alter cortical microcircuit dynamics - UCL Discovery | AntiNMDA | Scoop.it
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
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Suicidality is a common and serious feature of anti-N-methyl-D-aspartate receptor encephalitis - UCL Discovery

Suicidality is a common and serious feature of anti-N-methyl-D-aspartate receptor encephalitis - UCL Discovery | AntiNMDA | Scoop.it
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
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LGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis | Journal of Neuroinflammation | Full Text

LGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis | Journal of Neuroinflammation | Full Text | AntiNMDA | Scoop.it
While brain asymmetry has been a fascinating issue in neuroscience, the critical mechanism remains to be elucidated. Based on some index cases with asymmetric 18F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) uptake in leucine-rich glioma-inactivated 1 (LGI1)-antibody...
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Transient extreme spindles in a young child with anti-NMDAR encephalitis: A case report. - PubMed - NCBI

Transient extreme spindles in a young child with anti-NMDAR encephalitis: A case report. - PubMed - NCBI | AntiNMDA | Scoop.it
Brain Dev. 2018 Sep 29. pii: S0387-7604(18)30093-7. doi: 10.1016/j.braindev.2018.09.001.[Epub ahead of print]...
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Neuropsychological assessment as an objective tool to monitor treatment response in anti-N-methyl-D-aspartate receptor encephalitis. - PubMed - NCBI

Neuropsychological assessment as an objective tool to monitor treatment response in anti-N-methyl-D-aspartate receptor encephalitis. - PubMed - NCBI | AntiNMDA | Scoop.it
BMJ Case Rep. 2018 Jun 8;2018. pii: bcr-2018-224169. doi: 10.1136/bcr-2018-224169.
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5.12. Anti-NMDA-Receptor Encephalitis - Myoclonus [Spring Video Atlas]

View the entire playlist here: https://www.youtube.com/playlist?list=PLwlvPe1bGTl9GqPMhEG5_zRVd3NVSSQ46 This video series contains a visual demonstration of ...
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Autoimmune encephalitis with elevated N-type calcium channel antibodies as a multiple sclerosis mimic. – Newsemia

Autoimmune encephalitis with elevated N-type calcium channel antibodies as a multiple sclerosis mimic. – Newsemia | AntiNMDA | Scoop.it
Latest Medical News & Articles...
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Opinion | He Got Schizophrenia. He Got Cancer. And Then He Got Cured. - The New York Times

Opinion | He Got Schizophrenia. He Got Cancer. And Then He Got Cured. - The New York Times | AntiNMDA | Scoop.it
A bone-marrow transplant treated a patient’s leukemia — and his delusions, too. Some doctors think they know why....
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Monitoring treatment response with neuropsychological testing in AE

Monitoring treatment response with neuropsychological testing in AE | AntiNMDA | Scoop.it
Although a majority of patients with anti-NMDA receptor encephalitis make a good recovery, it can take time for patients to recover. Physicians are often looking for objective means to assess a patient’s recovery and ways to monitor for relapses.
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Ketogenic diet treatment for pediatric super-refractory status epilepticus. - PubMed - NCBI

Ketogenic diet treatment for pediatric super-refractory status epilepticus. - PubMed - NCBI | AntiNMDA | Scoop.it
Seizure. 2016 Oct;41:62-5. doi: 10.1016/j.seizure.2016.07.006. Epub 2016 Jul 21.
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[Anti-NMDA receptor antibody-positive meningoencephalitis with SIADH and CNS demyelination: A case report]. - PubMed - NCBI

[Anti-NMDA receptor antibody-positive meningoencephalitis with SIADH and CNS demyelination: A case report]. - PubMed - NCBI | AntiNMDA | Scoop.it
Rinsho Shinkeigaku. 2018 Sep 28;58(9):560-564. doi: 10.5692/clinicalneurol.cn-001178. Epub 2018 Aug 31.Case Reports...
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Voltage-gated Potassium Channel Antibody Autoimmune Encephalopathy Presenting With Isolated Psychosis in an Adolescent - Buy PDF

Voltage-gated Potassium Channel Antibody Autoimmune Encephalopathy Presenting With Isolated Psychosis in an Adolescent - Buy PDF | AntiNMDA | Scoop.it
Pon, N.C.; Houck, K.M.; Muscal, E.; Idicula, S.A., 2018: Voltage-gated Potassium Channel Antibody Autoimmune Encephalopathy Presenting With Isolated Psychosis in an Adolescent...
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The Anti-NMDA Receptor Encephalitis Foundation Newsletter

The Anti-NMDA Receptor Encephalitis Foundation Newsletter | AntiNMDA | Scoop.it
Frontiers | Features and Prognostic Value of Quantitative Electroencephalogram Changes in Critically Ill and Non-critically Ill Anti-NMDAR Encephalitis Patients: A ...Read More...
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Beyond the limbic system: disruption and functional compensation of large-scale brain networks in patients with anti-LGI1 encephalitis

Beyond the limbic system: disruption and functional compensation of large-scale brain networks in patients with anti-LGI1 encephalitis | AntiNMDA | Scoop.it
Objective Hippocampal inflammation in anti-LGI1 encephalitis causes memory deficits, seizures and behavioural abnormalities. Recent findings suggest that extralimbic brain areas are additionally affected and that patients also suffer from non-limbic cognitive symptoms.
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Frontiers | Features and Prognostic Value of Quantitative Electroencephalogram Changes in Critically Ill and Non-critically Ill Anti-NMDAR Encephalitis Patients: A Pilot Study | Neurology

Frontiers | Features and Prognostic Value of Quantitative Electroencephalogram Changes in Critically Ill and Non-critically Ill Anti-NMDAR Encephalitis Patients: A Pilot Study | Neurology | AntiNMDA | Scoop.it
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a common cause of encephalitis in intensive care units. Until now, no reliable method has existed for predicting the outcome of anti-NMDAR encephalitis.
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Antineuronal antibody testing in patients with first episode psychosis

Antineuronal antibody testing in patients with first episode psychosis | AntiNMDA | Scoop.it
Up to 80 percent of patients with anti-NMDA receptor encephalitis (ANMDARE) are first seen by psychiatrists, as a result of the psychiatric symptoms seen in ...Read More...
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The Anti-NMDA Receptor Encephalitis Foundation Newsletter

The Anti-NMDA Receptor Encephalitis Foundation Newsletter | AntiNMDA | Scoop.it
NMDA-receptor antibodies alter cortical microcircuit dynamics

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Analysis of Relation Between Electroclinical Features and Cerebrospinal Fluid Antibody Titers in Patients With anti-NMDAR Encephalitis. - PubMed - NCBI

Analysis of Relation Between Electroclinical Features and Cerebrospinal Fluid Antibody Titers in Patients With anti-NMDAR Encephalitis. - PubMed - NCBI | AntiNMDA | Scoop.it
Clin EEG Neurosci. 2018 Sep 24:1550059418800867. doi: 10.1177/1550059418800867.[Epub ahead of print]...
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He Got Schizophrenia. He Got Cancer. And Then He Got Cured. | The Trending Press News

He Got Schizophrenia. He Got Cancer. And Then He Got Cured. | The Trending Press News | AntiNMDA | Scoop.it
Modern doctors have also observed that people who suffer from certain autoimmune diseases, like lupus, can develop what looks like psychiatric illness.These...
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NMDA-receptor antibodies alter cortical microcircuit dynamics

NMDA-receptor antibodies alter cortical microcircuit dynamics | AntiNMDA | Scoop.it
Recently, autoantibodies against NMDA receptors (NMDARs) were identified as a major cause of autoimmune encephalitis. They cause abnormalities in brain function often associated with significant changes in patients’ brain dynamics.
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