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NORSE: 5 Important Facts | Neurology Times

NORSE: 5 Important Facts | Neurology Times | AntiNMDA | Scoop.it
Although rare, new onset refractory status epilepticus can be life threatening if not identified quickly. 1
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A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis

A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis | AntiNMDA | Scoop.it
Objective To construct a grading score that predicts neurologic function 1 year after diagnosis of anti-NMDA receptor (NMDAR) encephalitis.

Methods Three hundred eighty-two patients with detailed information and functional status at 1 year were studied. Factors associated with poor status (defined as modified Rankin Scale score ≥3) were identified and incorporated into a multivariate logistic regression model. This model was used to develop a 5-point prediction score, termed the anti-NMDAR Encephalitis One-Year Functional Status (NEOS) score.

Results Intensive care unit admission ( p < 0.001), treatment delay >4 weeks ( p = 0.012), lack of clinical improvement within 4 weeks ( p < 0.001), movement disorder ( p = 0.001), central hypoventilation ( p < 0.001), elevated CSF white blood cell count ( p < 0.001), elevated CSF protein level ( p = 0.027), and abnormal MRI ( p = 0.002) were associated with 1-year functional status in univariate analysis. Intensive care unit admission, treatment delay >4 weeks, lack of clinical improvement within 4 weeks, abnormal MRI, and CSF white blood cell count >20 cells/μL were independent predictors for outcome in multivariate regression modeling. These 5 variables were assigned 1 point each to create the NEOS score. NEOS score strongly associated with the probability of poor functional status at 1 year (3% for 0 or 1 point to 69% for 4 or 5 points, p < 0.001).

Conclusions The NEOS score accurately predicts 1-year functional status in patients with anti-NMDAR encephalitis. This score could help estimate the clinical course following diagnosis and may aid in identifying patients who could benefit from novel therapies.
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A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis

A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis | AntiNMDA | Scoop.it
Objective To construct a grading score that predicts neurologic function 1 year after diagnosis of anti-NMDA receptor (NMDAR) encephalitis.

Methods Three hundred eighty-two patients with detailed information and functional status at 1 year were studied.
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Clinical Reasoning: A middle-aged man with new onset seizures and myoclonic jerks

Clinical Reasoning: A middle-aged man with new onset seizures and myoclonic jerks | AntiNMDA | Scoop.it
A 53-year-old man with a history of hypertension presented with new-onset seizures. On the day of admission, he was witnessed by his son to have right-sided jerking that lasted for 1 minute, after which he fell forward and lost consciousness.
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HLA class II allele DRB1*16:02 is associated with anti-NMDAR encephalitis

Background and objective Aetiology and pathogenesis of anti- N -methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the most common autoimmune encephalitis, is largely unknown. Since an association of the disease with the human leucocyte antigen (HLA) has not been shown so far, we here...
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Where the Amazing Story Began…

Where the Amazing Story Began… | AntiNMDA | Scoop.it
The movie, Brain on Fire (2016), based on the memoir by Susannah Cahalan entitled Brain on Fire: My Month of Madness (2012) ended abruptly.In the movie’s final scenes, Susannah, played by Chloe Moretz, recovers from her ordeal—her “month of madness”—and several months of rehabilitation, and returns...
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Frontiers | Characteristics of Seizure and Antiepileptic Drug Utilization in Outpatients With Autoimmune Encephalitis | Neurology

Frontiers | Characteristics of Seizure and Antiepileptic Drug Utilization in Outpatients With Autoimmune Encephalitis | Neurology | AntiNMDA | Scoop.it
Autoimmune encephalitis (AE) is a kind of encephalitis which associates with specific neuronal antigens. Most patients with AE likely suffer from seizure, but data on the characteristics of seizure and antiepileptic drugs (AEDs) utilization in this patient group remains limited.
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The Anti-NMDA Receptor Encephalitis Foundation Newsletter

The Anti-NMDA Receptor Encephalitis Foundation Newsletter | AntiNMDA | Scoop.it
A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis From...
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Japanese Encephalitis Virus-Induced Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature. - PubMed - NCBI

Japanese Encephalitis Virus-Induced Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature. - PubMed - NCBI | AntiNMDA | Scoop.it
Neuropediatrics. 2019 Jan 8. doi: 10.1055/s-0038-1675607.[Epub ahead of print]...
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A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis

A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis | AntiNMDA | Scoop.it
Objective To construct a grading score that predicts neurologic function 1 year after diagnosis of anti-NMDA receptor (NMDAR) encephalitis.

Methods Three hundred eighty-two patients with detailed information and functional status at 1 year were studied.
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Management and prognostic markers in patients with autoimmune encephalitis requiring ICU treatment

Management and prognostic markers in patients with autoimmune encephalitis requiring ICU treatment | AntiNMDA | Scoop.it
Objective To assess intensive care unit (ICU) complications, their management, and prognostic factors associated with outcomes in a cohort of patients with autoimmune encephalitis (AE).

Methods This study was an observational multicenter registry of consecutively included patients diagnosed with AE requiring Neuro-ICU treatment between 2004 and 2016 from 18 tertiary hospitals. Logistic regression models explored the influence of complications, their management, and diagnostic findings on the dichotomized (0–3 vs 4–6) modified Rankin Scale score at hospital discharge.

Results Of 120 patients with AE (median age 43 years [interquartile range 24–62]; 70 females), 101 developed disorders of consciousness, 54 autonomic disturbances, 42 status epilepticus, and 39 severe sepsis. Sixty-eight patients were mechanically ventilated, 85 patients had detectable neuronal autoantibodies, and 35 patients were seronegative. Worse neurologic outcome at hospital discharge was associated with necessity of mechanical ventilation (sex- and age-adjusted OR 6.28; 95% CI, 2.71–15.61) tracheostomy (adjusted OR 6.26; 95% CI, 2.68–15.73), tumor (adjusted OR 3.73; 95% CI, 1.35–11.57), sepsis (adjusted OR 4.54; 95% CI, 1.99–10.43), or autonomic dysfunction (adjusted OR 2.91; 95% CI, 1.24–7.3). No significant association was observed with autoantibody type, inflammatory changes in CSF, or pathologic MRI.

Conclusion In patients with AE, mechanical ventilation, sepsis, and autonomic dysregulation appear to indicate longer or incomplete convalescence. Classic ICU complications better serve as prognostic markers than the individual subtype of AE. Increased awareness and effective management of these AE-related complications are warranted, and further prospective studies are needed to confirm our findings and to develop specific strategies for outcome improvement.

AE=
: autoimmune encephalitis;
AED=
: antiepileptic drug;
DWI=
: diffusion-weighted imaging;
eCRF=
: electronic case report form;
FDG-PET=
: fluorodeoxyglucose PET;
FLAIR=
: fluid-attenuated inversion recovery;
GENERATE=
: German Network for Research in Autoimmune Encephalitis;
ICU=
: intensive care unit;
IGNITE=
: Initiative of German Neurointensive Trial Engagement;
IQR=
: interquartile range;
mRS=
: modified Rankin Scale;
RE=
: receptor encephalitis;
SE=
: status epilepticus
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BBC - Future - Can an auto-immune illness explain the Salem witch trials?

BBC - Future - Can an auto-immune illness explain the Salem witch trials? | AntiNMDA | Scoop.it
There are now compelling reasons to think that at least one of the girls may have suffered from a much-misunderstood neurological condition...
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EEG findings in NMDA encephalitis - A systematic review. - PubMed - NCBI

EEG findings in NMDA encephalitis - A systematic review. - PubMed - NCBI | AntiNMDA | Scoop.it
Seizure. 2018 Dec 19;65:20-24. doi: 10.1016/j.seizure.2018.12.015.[Epub ahead of print] Review...
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Nailing the Suspect: The Prevalence of Autoimmune Encephalitis Compared with Infectious Encephalitis

Nailing the Suspect: The Prevalence of Autoimmune Encephalitis Compared with Infectious Encephalitis | AntiNMDA | Scoop.it
For people with encephalitis, rapid treatment of their acute brain inflammation is critical for avoiding devastating physical and cognitive deficits. But appropriate treatment requires identifying the culprit causing the symptoms.
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Scientists publish new findings on autoantibodies targeting synaptic proteins

Scientists publish new findings on autoantibodies targeting synaptic proteins | AntiNMDA | Scoop.it
New findings on autoantibodies targeting synaptic proteins have been recently published in Neuron and BRAIN journals by researchers from the Institute of...
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Forecasting outcomes in anti-NMDAR encephalitis

Forecasting outcomes in anti-NMDAR encephalitis | AntiNMDA | Scoop.it
“It's dangerous to make forecasts, especially about the future.” Mark Twain's words hold true in many situations in medicine, particularly in critical illnesses that carry both risk of death and the chance of full recovery, exemplified by autoimmune encephalitis.
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Mum 'possessed by evil spirits' is unable to walk or talk and suffers six seizures a day

Mum 'possessed by evil spirits' is unable to walk or talk and suffers six seizures a day | AntiNMDA | Scoop.it
Lorina Gutierrez was found to be suffering a rare illness causing her immune system to attack her brain...
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'Ask the Expert podcast series' on Autoimmune Encephalitis

'Ask the Expert podcast series' on Autoimmune Encephalitis | AntiNMDA | Scoop.it
Every month the Transverse Myelitis Association holds a podcast on a topic that affects those with rare neuro-immune disorders. Experts in the field share the latest knowledge and answer questions from their community.
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Where the Amazing Story Began…

Where the Amazing Story Began… | AntiNMDA | Scoop.it
Dear Subscriber,
It has been nearly twelve years since the discovery of anti-NMDA receptor encephalitis and I never dreamed that I would become so fascinated with ...Read More...
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Diagnostic tools for immune causes of encephalitis. - PubMed - NCBI

Diagnostic tools for immune causes of encephalitis. - PubMed - NCBI | AntiNMDA | Scoop.it
Clin Microbiol Infect. 2018 Dec 21. pii: S1198-743X(18)30800-0. doi: 10.1016/j.cmi.2018.12.012.[Epub ahead of print] Review...
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Characteristics of Seizure and Antiepileptic Drug Utilization in Outpatients With Autoimmune Encephalitis | MyNeuroNews

Qi Huang, Meigang Ma, Xing Wei, Yuhan Liao, Hengchang Qi, Yuejuan Wu, Yuan Wu...
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Fundraiser by Cheryl Carew Martin : Hannah’s fight Against BRAIN ON FIRE

Fundraiser by Cheryl Carew Martin : Hannah’s fight Against BRAIN ON FIRE | AntiNMDA | Scoop.it
Cheryl Carew Martin needs your help today! Hannah’s fight Against BRAIN ON FIRE - This is our niece, sister,cousin ,friend and most importantly , daughter... sweet Hannah. 5 weeks ago Hannah experienced some simple memory loss.
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Predictive value of electroencephalography in anti-NMDA receptor encephalitis

Predictive value of electroencephalography in anti-NMDA receptor encephalitis | AntiNMDA | Scoop.it
Objectives Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a severe, but treatable disease. This study aims to give a detailed description of electroencephalogram (EEG) results in paediatric and adult patients to improve disease recognition, and analyses the predictive value of the first EEG for the final clinical outcome.

Methods This nationwide cohort study includes patients with N-methyl-D-aspartate receptor antibodies confirmed with cell-based assay and immunohistochemistry in serum and cerebrospinal fluid. EEG recordings were re-evaluated by two experienced neurophysiologists, mixed with control EEGs for blinding. Initial EEG as well as follow-up registrations were analysed.

Results 35 adults and 18 children were included. Only two patients (4%) had a normal EEG. During the first recording, the majority of the patients had normal posterior rhythm (71%), which was associated with better modified Rankin Scale at final outcome (OR 4.74; 95% CI 1.56 to 14.47; p=0.006). In addition, EEGs showed focal (73%) or diffuse (67%) slowing. The first EEG was severely abnormal in 26%. However, 8 of 14 patients with a severely abnormal first EEG still had a favourable outcome. During the course of the disease, extreme delta brushes (EDBs) were present in 6 of 53(11%)patients.

Conclusions The first EEG commonly shows normal posterior rhythm with focal or diffuse slowing. Although the sensitivity of an abnormal EEG is high (96%), normal EEG does not exclude anti-NMDARE. EDBs are only present in severely affected patients. The first EEG recording is predictive of the final clinical outcome.
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CNS Society Prizes

CNS Society Prizes | AntiNMDA | Scoop.it
The Francis McNaughton Memorial Prize for Clinical Research and The André Barbeau Memorial Prize for Basic Research The Canadian Neurological Society invites expanded abstract submissions for its two prizes: the Francis McNaughton Memorial Prize for Clinical Research and the André Barbeau Memorial Prize for Basic Research. These prizes were designed to encourage neurology trainees to undertake research projects. Prizes are awarded for the best submitted expanded, structured abstract, based on work done during neurology residency or in post-residency training. Contestants must be a member in good standing with any one of the five Societies of the CNSF (a Junior member or an Active member within two years of receiving their certificate). Contestants must submit a letter from their program chair indicating that the work was done by the resident and was principally the work of that resident. The Francis McNaughton and André Barbeau prizes will each consist of: Presentation of your work during the Grand Plenary session at the Congress A Prize Certificate $1,000 cash Full registration to the Congress Travel to the Congress (economy fare) 3 nights’ accommodation Additional $500 prize awards may be presented. New for 2019 – the Anti-NMDA Receptor Encephalitis Foundation in association with the CNS is offering an additional $1500 prize for the best paper submitted on Autoimmune Encephalitis The prize will consist of: Presentation of your work at the Congress, highlighted as a prize-winning abstract A Prize Certificate $1500 cash intended to defray costs related to attending the Congress General Requirements for all CNS Prizes Contestants need not be the sole authors, but should have been primarily responsible for the work being presented. Contestants must submit a structured abstract, expanded up to, but not exceeding 3 pages, which is to include any figures, tables, and necessary references. Submissions longer than 3 pages of single spaced typing will not be considered. The format followed should consist of Background, Materials and Methods, Results, and Conclusions. The authors should bear in mind, in the background section, that not all judges will be experts in the subject of the research paper. Contestants must submit a small biography which indicates where the candidate is in their residency or in a diploma program (if applicable), and listing other work that he/she has done. Contestants must also submit their basic abstract to the CNSF Annual Congress, on the official online abstract submission site. Submission Details All Society Prize submissions must be received by January 31, 2019. Clearly indicate which Society prize you are submitting for. Submissions should be sent as three separate PDF files: Letter from their program chair (for McNaughton and Barbeau prizes) Biography Expanded Abstract Applicants for these prizes should send their submissions to: Canadian Neurological Society c/o marika-fitzgerald@cnsfederation.org
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The Anti-NMDA Receptor Encephalitis Foundation Newsletter

The Anti-NMDA Receptor Encephalitis Foundation Newsletter | AntiNMDA | Scoop.it
New Prize offered by The Anti-NMDA Receptor Encephalitis Foundation at the 54th annual Congress of the Canadian Neurological Sciences Federation...
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