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Use of Pharmacologic Interventions for Breast Cancer Risk Reduction: American Society of Clinical Oncology Clinical Practice Guideline | ASCO.org

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The purpose of the guideline is to provide recommendations on pharmacologic interventions for breast cancer (BCa) risk reduction. Recommendations are available for postmenopausal and premenopausal women.

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Advanced Prostate Cancer Patients May Live Longer with New Drug

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Men with advanced prostate cancer that has spread to the bone were less likely to die from their disease if they took a new drug called radium-223.

Via Graham Player Ph.D.
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Graham Player Ph.D.'s curator insight, July 18, 2013 5:56 AM

Men with advanced prostate cancer may live longer after receiving a new type of targeted radiation treatment, a new study suggests.

The study of 921 men, of average age 71 with advanced prostate cancer, given a new type of targeted radioactive drug treatment found that life expectancy was extended to 14.9 months on average after their diagnosis. While those who received a placebo lived 11.3 months. Meaning the drug extended life by about 3.5 months.

The new drug is called radium-223 dichloride (marketed as Xofigo). The study was funded by Bayer HealthCare, which makes Xofigo. The treatment consisting of six injections costs $69,000.

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CiteULike: A phase II trial of neoadjuvant docetaxel and capecitabine for locally advanced breast cancer.

CiteULike: A phase II trial of neoadjuvant docetaxel and capecitabine for locally advanced breast cancer. | Anti Cancer Medication | Scoop.it

"This study evaluated the toxicity and efficacy of docetaxel/capecitabine as neoadjuvant treatment for stage 2/3 breast cancer. Subjects with newly diagnosed invasive stage 2 and 3 breast cancer were eligible. The first cohort of patients was treated at dose A with neoadjuvant docetaxel (75 mg/m(2) i.v. day 1) and capecitabine (1000 mg/m(2) orally twice daily days 2-15) for four cycles. A second cohort of subjects was treated with a reduced dose, dose B, of docetaxel (60 mg/m(2) i.v. day 1) and capecitabine (937.5 mg/m(2) orally twice daily days 2-15). Thirty patients were enrolled."


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The Poor State of Health of Americans

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A new study highlights some of the reasons the United States is falling so far behind other developed countries by most measures of public health.

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Graham Player Ph.D.'s curator insight, July 11, 2013 12:33 AM

Researchers at the University of Washington and the US Burden of Disease Project have analyzed two decades’ worth of health records from 34 developed countries and determined “which diseases, injuries and risk factors are related to the greatest losses of health, and how these risk factors and health outcomes are changing over time.”

They found that 27 out of 33 peer countries now out-rank the USA on mortality statistics such as life expectancy and premature death. They also show the leading causes of disability and death in the USA and compare their change from the previous decade. Here is a partial list of diseases showing their percentage increase over that period:

Alzheimer disease - 159%
Chronic kidney disease - 69%
Diabetes - 58%
Osteoarthritis - 56%
Major depressive disorder - 43%
Cirrhosis - 38%
Chronic obstructive pulmonary disease (COPD) - 34%
Schizophrenia - 29%
Non-ischemic cardiovascular diseases - 27%
Asthma - 14%
Lung cancer - 4%
Colorectal cancer - 3%

The researchers point out that the average American has seen “an increase in the number of years lived with disability” since 1990, and “chronic disability now accounts for nearly half of the health burden in the United States.”

The high rates of death and disability in the USA are driven by social, economic and environmental factors, rather than biological factors. Medicine is not the remedy for that situation. The primary root causes of these problems are related to lifestyle, physical inactivity, diet, and environmental pollution.

RISE4WAR 's curator insight, July 11, 2013 10:01 AM

VERY Sad. #Rise4War: http://on.fb.me/16FKXNW

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