Allergy (and clinical immunology)
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Sickweather: using social media to track illness

Sickweather: using social media to track illness | Allergy (and clinical immunology) | Scoop.it

Sickweather.com uses social media updates to follow outbreaks of the flu, allergies and other illnesses around the country. Sickweather scans Facebook and Twitter for posts about sickness and gathers the data to form an interactive map showing the areas with the most statuses about infections.


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Allergy (and clinical immunology)
Ressources et Actualités pour la spécialité Allergie
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A topic dedicated to allergy

... dans le contexte du DESC d'Immunologie clinique et allergologie en France

 

opened for 4 years, 

2000 Highly selected scoops in an evolving and controversial field

 

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Il peut être complèté par les topics, couvrant des domaines fondamentaux et/ou appliqués

Immunology: http://www.scoop.it/t/immunology

Mucosal immunity: http://www.scoop.it/t/mucosal-immunity

Autoimmunity: http://www.scoop.it/t/autoimmunity

Rheumatology: http://www.scoop.it/t/rheumatology-rhumatologie

Immunology and Biotherapies: http://www.scoop.it/t/immunology-and-biotherapies

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Samantha Walker: Asthma diagnosis—harnessing the power of new technologies – The BMJ

Samantha Walker: Asthma diagnosis—harnessing the power of new technologies – The BMJ | Allergy (and clinical immunology) | Scoop.it
In the UK, deaths due to asthma attacks are at their highest level for a decade, but with better diagnostics and tailoring of treatment to asthma sub-type, these could be [...]More...
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Low-Dose Oral Immunotherapy Using Low-Egg-Allergen Cookies for Severe Egg-Allergic Children Reduces Allergy Severity and Affects Allergen-Specific Antibodies in Serum

Low-Dose Oral Immunotherapy Using Low-Egg-Allergen Cookies for Severe Egg-Allergic Children Reduces Allergy Severity and Affects Allergen-Specific Antibodies in Serum | Allergy (and clinical immunology) | Scoop.it
<b><i>Background:</i></b> We evaluated the safety and efficacy of low-egg-allergen cookies (LAC) as low-dose oral immunotherapy (OIT) in children with severe egg allergy. We al
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Targeting Neutrophils in Severe Asthma via Siglec-9

Targeting Neutrophils in Severe Asthma via Siglec-9 | Allergy (and clinical immunology) | Scoop.it
Severe asthma comprises only 5% of patients with asthma, but the burden it brings to the social health system accounts for more than half of all asthmatics. Clinical evidence shows that severe asthma
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#1 Allergy Tests - Find out if you suffer from food intolerance with a simple test

#1 Allergy Tests - Find out if you suffer from food intolerance with a simple test | Allergy (and clinical immunology) | Scoop.it
Test Your Intolerance are the UK's market leaders in food intolerance testing and the world. Our allergy tests require no blood, but just a sample of hair
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Emerging Treatment Options in Atopic Dermatitis: Topical Therapies

Emerging Treatment Options in Atopic Dermatitis: Topical Therapies | Allergy (and clinical immunology) | Scoop.it
Atopic dermatitis is a chronic inflammatory skin disorder affecting children and adults, with the majority presenting mild to moderate disease severity. The use of topical corticosteroids (TCSs) in co
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Education Is Key! Call for Action! - European Medical Journal

Education Is Key! Call for Action! - European Medical Journal | Allergy (and clinical immunology) | Scoop.it
I have been asked to share my opinion about the diagnostics of anaphylaxis and how to treat it. As you probably know, anaphylaxis is the extreme outing of an allergic reaction and is likely if any one of three criteria is fulfilled
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Immunotherapeutic efficacy of liposome-encapsulated refined allergen vaccines against Dermatophagoides pteronyssinus allergy. - PubMed - NCBI

Immunotherapeutic efficacy of liposome-encapsulated refined allergen vaccines against Dermatophagoides pteronyssinus allergy. - PubMed - NCBI | Allergy (and clinical immunology) | Scoop.it
PLoS One. 2017 Nov 28;12(11):e0188627. doi: 10.1371/journal.pone.0188627. eCollection 2017.
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Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy

Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy | Allergy (and clinical immunology) | Scoop.it
<b><i>Background:</i></b> Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at i
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IL-21 Is Increased in Nasal Polyposis and after Stimulation with Staphylococcus aureus Enterotoxin B

IL-21 Is Increased in Nasal Polyposis and after Stimulation with Staphylococcus aureus Enterotoxin B | Allergy (and clinical immunology) | Scoop.it
<b><i>Background:</i></b> Chronic rhinosinusitis with nasal polyposis (CRSwNP) is an inflammatory disease associated with lymphoid aggregates and local IgE production related t
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Maternal IgG immune complexes induce food allergen–specific tolerance in offspring

Maternal IgG immune complexes induce food allergen–specific tolerance in offspring | Allergy (and clinical immunology) | Scoop.it
The role of maternal immune responses in tolerance induction is poorly understood. To study whether maternal allergen sensitization affects offspring susceptibility to food allergy, we epicutaneously sensitized female mice with ovalbumin (OVA) followed by epicutaneous sensitization and oral challenge of their offspring with OVA. Maternal OVA sensitization prevented food anaphylaxis, OVA-specific IgE production, and intestinal mast cell expansion in offspring. This protection was mediated by neonatal crystallizable fragment receptor (FcRn)–dependent transfer of maternal IgG and OVA immune complexes (IgG-IC) via breast milk and induction of allergen-specific regulatory T (T reg) cells in offspring. Breastfeeding by OVA-sensitized mothers or maternal supplementation with IgG-IC was sufficient to induce neonatal tolerance. FcRn-dependent antigen presentation by CD11c+ dendritic cells (DCs) in offspring was required for oral tolerance. Human breast milk containing OVA-IgG-IC induced tolerance in humanized FcRn mice. Collectively, we demonstrate that interactions of maternal IgG-IC and offspring FcRn are critical for induction of T reg cell responses and control of food-specific tolerance in neonates.
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Local allergic rhinitis: evolution of concepts

Local allergic rhinitis: evolution of concepts | Allergy (and clinical immunology) | Scoop.it
The discovery of an exclusive local production of IgE antibodies dates back to the 1970s, but only recently the pathophysiology of such phenomenon was deeply investigated, leading to the concept of local allergic rhinitis (LAR). Currently, LAR is defined by the occurrence, in patients with symptoms clearly suggesting allergic rhinitis but with negative results to common allergy testing, of allergen specific IgE in the nasal mucosa. Most studies investigating LAR were based on the development of rhinitis symptoms following nasal provocation test (NPT) with the suspected allergens, but such test may be performed by a number of options, none of them being as yet acknowledged and recommended in consensus document. On the other hand, also the mere detection of IgE in the nasal mucosa indicates, as for IgE measurement in blood or other tissues, allergic sensitization but cannot give the certainty of clinical allergy. Therefore, the combination of IgE detection in nasal mucosa and a positive result of NPT should be used to diagnose LAR. Recent data on the use for in vitro testing of molecular allergy diagnostics in place of whole allergen extracts suggest that this method could improve the sensitivity and specificity of laboratory tests, and an appraisal of the basophil activation test as a third level technique, to be implemented when the results of local IgE testing and NPT are uncertain, is currently ongoing.
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Oral challenge without skin tests in children with non‐severe beta‐lactam hypersensitivity: Time to change the paradigm?

Oral challenge without skin tests in children with non‐severe beta‐lactam hypersensitivity: Time to change the paradigm? | Allergy (and clinical immunology) | Scoop.it
Suspected allergy to penicillins and cephalosporins is very common in childhood. After a proper evaluation, allergy will be confirmed only in a small portion of them. Intradermal tests are usuall
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AbbVie’s Upadacitinib gets FDA breakthrough designation for atopic dermatitis - Pharmaceutical Business Review

AbbVie’s Upadacitinib gets FDA breakthrough designation for atopic dermatitis - Pharmaceutical Business Review | Allergy (and clinical immunology) | Scoop.it
AbbVie’s investigational, once-daily oral JAK1-selective inhibitor upadacitinib (ABT-494) has secured breakthrough therapy designation from the US Food and Drug Administration (FDA) for the treatment of adult patients with moderate to severe atopic dermatitis who are candidates for systemic therapy.
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Food Allergy & Anaphylaxis Connection Team - education

Food Allergy & Anaphylaxis Connection Team - education | Allergy (and clinical immunology) | Scoop.it
Food Allergies and Schools Food allergies continue to rise – especially among children – and are a safety and public health concern across the United States. School staff continue to face challenges each school year due to the increasing number of students with food allergies entering school.
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Exclusive & Affordable Food Allergy Testing Now Available!

Exclusive & Affordable Food Allergy Testing Now Available! | Allergy (and clinical immunology) | Scoop.it
Did you know that over 30% of adults and 40% of children suffer from food allergies? Food allergies are the foundation for of symptoms related to your brain chemistry, immune system, hormones and more. Get your test and personalized analysis today!
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What Is Happening with Peanut Allergy Guidelines? Tough nut to crack for parents and pediatricians

What Is Happening with Peanut Allergy Guidelines? Tough nut to crack for parents and pediatricians | Allergy (and clinical immunology) | Scoop.it
Adopting the new peanut guidelines may be difficult for doctors and parents and will require further education.

(Results from the December 20 poll: more than 80% of responders answered "Yes" to the question, "Should patients with drug allergies be periodically re-tested?")

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FcRn is mother’s milk to allergen tolerance

FcRn is mother’s milk to allergen tolerance | Allergy (and clinical immunology) | Scoop.it
In this issue Ohsaki et al. (<https://doi.org/10.1084/jem.20171163>;) explain how breastfeeding can prevent the onset of food allergies in offspring by instructing T reg formation via neonatal Fc receptor (FcRn)–mediated transfer and uptake of allergen-containing IgG immune complexes (Ig-ICs) by gut dendritic cells (DCs).
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Luxembourg at the centre of molecular allergology: 300 allergy experts came together at ISMA 2017

Luxembourg at the centre of molecular allergology: 300 allergy experts came together at ISMA 2017 | Allergy (and clinical immunology) | Scoop.it
The 7th edition of the International Symposium on Molecular Allergology (ISMA) was held from 9th to 11th November at the European Convention Centre Luxembourg.
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EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. - PubMed - NCBI

EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. - PubMed - NCBI | Allergy (and clinical immunology) | Scoop.it
Allergy. 2017 Sep 27. doi: 10.1111/all.13319. [Epub ahead of print]
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Personalized medicine with biologics for severe type 2 asthma: current status and future prospects

Personalized medicine with biologics for severe type 2 asthma: current status and future prospects | Allergy (and clinical immunology) | Scoop.it

(2017). Personalized medicine with biologics for severe type 2 asthma: current status and future prospects. mAbs. Ahead of Print.


ABSTRACT Asthma affects more than 300 million people worldwide and poses a large socioeconomic burden, particularly in the 5% to 10% of severe asthmatics. So far, each entry of new biologics in clinical trials has led to high expectations for treating all severe asthma forms, but the outcome has only been successful if the biologic, as add-on treatment, targeted specific patient subgroups. Indeed, we now realize that asthma is a heterogeneous disease with multiple phenotypes, based on distinct pathophysiological mechanisms, called endotypes. Thus, asthma therapy is gradually moving to a personalized medicine approach, tailored to individual's asthma endotypes identified through biomarkers. Here, we review the clinical efficacy of antibody-related therapeutics undergoing clinical trials, or those already approved, for the treatment of severe type 2 asthma. Biologics targeting type 2 cytokines have shown consistent efficacy, especially in patients with evidence of type 2 inflammation, suggesting that the future of asthma biologics is promising. KEYWORDS: asthma, biologic, biomarker, cytokine, personalized medicine


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Oral Immunotherapy for Food Allergy: What Have We Achieved So Far? - European Medical Journal

Oral Immunotherapy for Food Allergy: What Have We Achieved So Far? - European Medical Journal | Allergy (and clinical immunology) | Scoop.it
The burden of food allergy is significant, multi-faceted, and well documented. In an effort to improve food-allergic patients’ quality of life, there is a continuous effort to provide novel treatment options for food allergy. Food immunotherapy is an exciting area of research that has seen tremendous progress over the last decade. This review examines the current literature and provides insights into key oral immunotherapy studies published so far. Areas requiring further study, the role of food oral immunotherapy, and its potential future applications for patient care are also discussed.
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Congresses | Eaaci.org

Congresses | Eaaci.org | Allergy (and clinical immunology) | Scoop.it
The European Academy of Allergy and Clinical Immunology, EAACI, is an association including 47 European National Societies, more than 8,000 academicians, research investigators and clinicians.
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