Allergy (and clinical immunology)
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Allergy (and clinical immunology)
Ressources et Actualités pour la spécialité Allergie
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Scooped by Gilbert C FAURE
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A topic dedicated to allergy

... dans le contexte du DESC d'Immunologie clinique et allergologie en France

 

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Immunology: http://www.scoop.it/t/immunology

Mucosal immunity: http://www.scoop.it/t/mucosal-immunity

Autoimmunity: http://www.scoop.it/t/autoimmunity

Rheumatology: http://www.scoop.it/t/rheumatology-rhumatologie

Immunology and Biotherapies: http://www.scoop.it/t/immunology-and-biotherapies

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SYFAL Syndicat français des allergologues

SYFAL Syndicat français des allergologues | Allergy (and clinical immunology) | Scoop.it
SYFAL Syndicat français des allergologues
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Allergy amplifier implicated in asthma also intensifies food allergy

Allergy amplifier implicated in asthma also intensifies food allergy | Allergy (and clinical immunology) | Scoop.it
Almost eight percent of children under three years old and four percent of adults suffer food allergies, which trigger not only discomfiting symptoms like dermatitis and diarrhea but can cause deadly anaphylactic shock. Allergi
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Infant Allergenic Food Introduction and Risk of Allergic/Autoimmune Disease

This meta-analysis summarizes evidence about associations between timing of allergenic food introduction during infancy and risk of allergic or autoimmune disea
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Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins | Allergy (and clinical immunology) | Scoop.it
The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization. However, these events have not been organized in a sequence of related events that is plausible to result in sensitization, and useful to challenge current hypotheses. The aim of this manuscript was to collect and structure the current mechanistic understanding of sensitization induction to food proteins by applying the concept of adverse outcome pathway (AOP). The proposed AOP for food sensitization is based on information on molecular and cellular mechanisms and pathways evidenced to be involved in sensitization by food and food proteins and uses the AOPs for chemical skin sensitization and respiratory sensitization induction as templates. Available mechanistic data on protein respiratory sensitization were included to fill out gaps in the understanding of how proteins may affect cells, cell–cell interactions and tissue homeostasis. Analysis revealed several key events (KE) and biomarkers that may have potential use in testing and assessment of proteins for their sensitizing potential. The application of the AOP concept to structure mechanistic in vivo and in vitro knowledge has made it possible to identify a number of methods, each addressing a specific KE, that provide information about the food allergenic potential of new proteins. When applied in the context of an integrated strategy these methods may reduce, if not replace, current animal testing approaches. The proposed AOP will be shared at the
www.aopwiki.org

platform to expand the mechanistic data, improve the confidence in each of the proposed KE and key event relations (KERs), and allow for the identification of new, or refinement of established KE and KERs.
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Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the same individuals1, partly because of a shared genetic origin2,3,4. To identify shared risk variants, we performed a genome-wide association study (GWAS; n = 360,838) of a broad allergic disease phenotype that considers the presence of any one of these three diseases. We identified 136 independent risk variants (P < 3 × 10−8), including 73 not previously reported, which implicate 132 nearby genes in allergic disease pathophysiology. Disease-specific effects were detected for only six variants, confirming that most represent shared risk factors. Tissue-specific heritability and biological process enrichment analyses suggest that shared risk variants influence lymphocyte-mediated immunity. Six target genes provide an opportunity for drug repositioning, while for 36 genes CpG methylation was found to influence transcription independently of genetic effects. Asthma, hay fever and eczema partly coexist because they share many genetic risk variants that dysregulate the expression of immune-related genes.

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Access : MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens : Mucosal Immunology

Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues. The journal reflects the interests of scientists studying gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, and genitourinary immunology through the publication of original research articles, scholarly reviews, and timely commentaries, editorials and letters.
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Food Allergy Lab Fits on Your Keychain

Food Allergy Lab Fits on Your Keychain | Allergy (and clinical immunology) | Scoop.it
Individuals with allergies can test their meal at the restaurant table.
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Cross-reactivity in β-Lactam Allergy

Cross-reactivity in β-Lactam Allergy | Allergy (and clinical immunology) | Scoop.it
β-Lactam drugs (penicillins, amoxicillin, and cephalosporins) account for 42.6% of
all severe drug-induced anaphylaxis. In this review, we focus on clinically significant
immunologic cross-reactivity in patients with confirmed penicillin allergy to cephalosporins,
and the structural involvement of the R1 and R2 chemical side chains of the cephalosporins
causing IgE-mediated cross-reactivity with penicillin and other cephalosporins. Skin
tests predict IgE-mediated reactions and showed cross-reactivity between penicillins
and early generation cephalosporins that shared side chains, but confirmatory challenge
data are lacking.
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Vancomycin and DRESS: A retrospective chart review of 32 cases in Los Angeles, California

Vancomycin and DRESS: A retrospective chart review of 32 cases in Los Angeles, California | Allergy (and clinical immunology) | Scoop.it
To the Editor: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe cutaneous hypersensitivity reaction that typically occurs 2 to 8 weeks after continuous exposure to an offending agent (medication). The diagnosis can be challenging and is largely clinical, with manifestations that can include fever, rash, lymphadenopathy, eosinophilia, and internal organ involvement.1 Current understanding of the pathogenesis, triggers, and predisposing factors for DRESS is incomplete.
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Risk Factors of Allergic Disease: A Study with a Large Data Set

Risk Factors of Allergic Disease: A Study with a Large Data Set | Allergy (and clinical immunology) | Scoop.it
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject-specific sections.
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Bioavailability of House Dust Mite Allergens in Sublingual Allergy Tablets Is Highly Dependent on the Formulation

Bioavailability of House Dust Mite Allergens in Sublingual Allergy Tablets Is Highly Dependent on the Formulation | Allergy (and clinical immunology) | Scoop.it
<b><i>Background:</i></b> In sublingual immunotherapy (SLIT), the immune system is addressed by solubilized allergen that interacts with immunocompetent cells of the oral mucos
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Differences in the Anaphylactic Response between C3H/HeOuJ and BALB/c Mice

Differences in the Anaphylactic Response between C3H/HeOuJ and BALB/c Mice | Allergy (and clinical immunology) | Scoop.it
<b><i>Background:</i></b> Anaphylaxis is a severe and potentially lethal allergic reaction whose incidence is increasing. Murine models can elucidate the underlying mechanisms
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Investigating Immune Gene Signatures in Peripheral Blood from Subjects with Allergic Rhinitis Undergoing Nasal Allergen Challenge

Investigating Immune Gene Signatures in Peripheral Blood from Subjects with Allergic Rhinitis Undergoing Nasal Allergen Challenge | Allergy (and clinical immunology) | Scoop.it
Nasal allergen challenge (NAC) is a human model of allergic rhinitis (AR) that delivers standardized allergens locally to the nasal mucosa allowing clinical symptoms and biospecimens such as peripheral blood to be collected. Although many studies have focused on local inflammatory sites, peripheral blood, an important mediator and a component of the systemic immune response, has not been well studied in the setting of AR. We sought to investigate immune gene signatures in peripheral blood collected after NAC under the setting of AR. Clinical symptoms and peripheral blood samples from AR subjects were collected during NAC. Fuzzy c-means clustering method was used to identify immune gene expression patterns in blood over time points (before NAC and 1, 2, and 6 h after NAC). We identified and validated seven clusters of differentially expressed immune genes after NAC onset. Clusters 2, 3, and 4 were associated with neutrophil and lymphocyte frequencies and neutrophil/lymphocyte ratio after the allergen challenge. The patterns of the clusters and immune cell frequencies were associated with the clinical symptoms of the AR subjects and were significantly different from healthy nonallergic subjects who had also undergone NAC. Our approach identified dynamic signatures of immune gene expression in blood as a systemic immune response associated with clinical symptoms after NAC. The immune gene signatures may allow cross-sectional investigation of the pathophysiology of AR and may also be useful as a potential objective measurement for diagnosis and treatment of AR combined with the NAC model.
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Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation

Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation | Allergy (and clinical immunology) | Scoop.it
Article
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Low-Dose Allergen-Specific Immunotherapy Induces Tolerance in a Murine Model of Shrimp Allergy

Low-Dose Allergen-Specific Immunotherapy Induces Tolerance in a Murine Model of Shrimp Allergy | Allergy (and clinical immunology) | Scoop.it
<b><i>Background:</i></b> The efficacy and safety of allergen-specific immunotherapy (AIT) are highly dose-dependent. <b><i>Methods:</i></b> We investig
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Non‐allergic rhinitis: Position paper of the European Academy of Allergy and Clinical Immunology

Non‐allergic rhinitis: Position paper of the European Academy of Allergy and Clinical Immunology | Allergy (and clinical immunology) | Scoop.it
This EAACI position paper aims at providing a state‐of‐the‐art overview on nonallergic rhinitis (NAR). A significant number of patients suffering from persistent rhinitis are defined as nonallergi
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Do Food Preparation Methods Affect Allergies?

Do Food Preparation Methods Affect Allergies? | Allergy (and clinical immunology) | Scoop.it
Allergist Dr Gary Stadtmauer looks at the relationship between food preparation and food allergy severity.
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Targeting of Immune Cells by Dual TLR2/7 Ligands Suppresses Features of Allergic Th2 Immune Responses in Mice

Targeting of Immune Cells by Dual TLR2/7 Ligands Suppresses Features of Allergic Th2 Immune Responses in Mice | Allergy (and clinical immunology) | Scoop.it
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
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Detection of the Peanut Allergens Ara h 2 and Ara h 6 in Human Breast Milk: Development of 2 Sensitive and Specific Sandwich ELISA Assays

Detection of the Peanut Allergens Ara h 2 and Ara h 6 in Human Breast Milk: Development of 2 Sensitive and Specific Sandwich ELISA Assays | Allergy (and clinical immunology) | Scoop.it
<b><i>Background:</i></b> Little is known about breast milk as a vehicle for tolerance development or sensitization to peanuts very early in life. Thus, well-characterized and
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Sensing and responding to allergic response cytokines through a genetically encoded circuit

Sensing and responding to allergic response cytokines through a genetically encoded circuit | Allergy (and clinical immunology) | Scoop.it
Article
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Life-threatening Chlorhexidine Anaphylaxis: A Case Report. - PubMed - NCBI

Malays Orthop J. 2017 Jul;11(2):72-74. doi: 10.5704/MOJ.1707.008.
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Quality indicators for the acute and long-term management of anaphylaxis: a systematic review

Quality indicators for the acute and long-term management of anaphylaxis: a systematic review | Allergy (and clinical immunology) | Scoop.it
The quality of acute and long-term anaphylaxis management is variable and this contributes to the poor outcomes experienced by many patients. Clinical practice guidelines have the potential to improve outcomes, but implementing guideline recommendations in routine practice is challenging. Quality indicators have the potential to support guideline implementation efforts. To identify quality indicators to support the acute and long-term management of anaphylaxis. We conducted a systematic review of the literature that involved searching Medline, EMBASE and CINAHL databases for peer-reviewed published literature for the period 1 January 2005–31 December 2015. Additionally we searched Google for grey and unpublished literature. The identified indicators were descriptively summarized against the most recent international anaphylaxis guidelines (i.e. those produced by the European Academy of Allergy and Clinical Immunology) and critically evaluated using the Agency for Healthcare Research and Quality’s criteria for indicator development. Our searches revealed 830 publications, from which we identified five sources for 54 indicators addressing both acute (n = 27) and long-term (n = 27) management of anaphylaxis. The majority of indicators were developed through expert consensus with relatively few of these having been formally piloted or tested to demonstrate that they could discriminate between variations in practice and/or that they were sensitive to change. There is a need for a comprehensive set of quality indicators for anaphylaxis management. We have however identified some indicators for the acute and long-term management of anaphylaxis that could with relatively little additional work support efforts to translate guideline recommendations into clinical care.
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Diagnostic tools in ocular allergy

Diagnostic tools in ocular allergy | Allergy (and clinical immunology) | Scoop.it
Ocular allergy (OA) includes a group of common and less frequent hypersensitivity disorders frequently misdiagnosed and not properly managed. The diagnosis of OA is usually based on clinical histor
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Early-life home environment and risk of asthma among inner-city children - ScienceDirect

Early-life home environment and risk of asthma among inner-city children - ScienceDirect | Allergy (and clinical immunology) | Scoop.it
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Food Allergy

Food Allergy | Allergy (and clinical immunology) | Scoop.it
Food allergies affect 4 to 6 percent of children and 4 percent of adults. Learn about the types of food allergies, symptoms, diagnosis and treatment here.

Via Jana Pearce
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