Alertes de seguretat de fàrmacs
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Alertes de seguretat de fàrmacs
Monitorització d'alertes de seguretat de fàrmacs. Seguretat clínica a recepta electrònica. Centre d'Informació de Medicaments de Catalunya (CedimCat) http://www.cedimcat.info
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Dolutegravir y riesgo de defectos del tubo neural

Dolutegravir (▼Tivicay®, ▼Triumeq®) y riesgo de defectos del tubo neural: como medida de precaución, se recomienda evitar el embarazo en mujeres en tratamiento
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Second-generation antipsychotic medications and risk of chronic kidney disease in schizophrenia

Objectives The study aims to compare the risk of chronic kidney diseases (CKDs) between patients with schizophrenia using first and second-generation antipsychotics.

Setting Datasets of 2000–2013 National Health Insurance in Taiwan were used.
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Concomitant administration of candesartan cilexetil in patients on paclitaxel and carboplatin combination therapy increases risk of severe neutropenia

Int J Clin Pharmacol Ther. 2018 May 24. doi: 10.5414/CP203180.[Epub ahead of print]...
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Long-term opioids for musculoskeletal pain and increased risk of reproductive dysfunction in women

Eur J Pain. 2018 Jun 6. doi: 10.1002/ejp.1256.[Epub ahead of print]...
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Statin Coadministration Increases the Risk of Daptomycin-Associated Myopathy

Daptomycin-associated myopathy has been identified in 2-14% of patients, and rhabdomyolysis is a known adverse effect.

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Selective Serotonin Reuptake Inhibitors during pregnancy and associations between brain structure and connectivity in infants

This cohort study examines the association between prenatal exposure to selective serotonin reuptake inhibitors and fetal brain development.
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Recent opioid use and increased risk of fall and an increased likelihood of death in older adults

A total of 67 929 patients were retained for analysis. Mean age was 80.9 (± 8.0) years and 69% were women. The percentage of patients who had filled an opioid prescription in the 2 weeks preceding an injury was 4.9% (95% confidence interval [CI] 4.7%–5.1%) for patients who had had a fall, compared with 1.5% (95% CI 1.2%–1.8%) for those who had had an injury through another mechanism. After we controlled for confounding variables, patients who had filled an opioid prescription within 2 weeks before injury were 2.4 times more likely to have a fall rather than any other type of injury. For patients who had a fall-related injury, those who used opioids were at increased risk of in-hospital death (odds ratio 1.58; 95% CI 1.34–1.86).

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Retinoides (acitretina, alitretinoína, isotretinoína): actualización medidas para evitar exposición durante el embarazo y advertencias sobre efectos neuropsiquiátricos

Retinoides (acitretina, alitretinoína, isotretinoína): actualización de las medidas para evitar la exposición durante el embarazo y de las advertencias sobre efectos neuropsiquiátricos
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Valproate during pregnancy and high risk of malformations and developmental problems

The CMDh has endorsed new measures to avoid exposure of babies to valproate medicines in the womb, because exposed babies are at high risk of malformations and developmental problems.

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Anticolinérgicos y riesgo de demencia en personas de edad avanzada

Según el editorial acompañante, en general se recomienda evitar los fármacos anticolinérgicos en personas de edad avanzada, y considerar medidas no farmacológicas o alternativas farmacológicas a los fármacos con más carga anticolinérgica (BMJ 2018;361:k1722).

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Oral over-the-counter benzocaine and risk of serious and potentially fatal blood disorder

Oral over-the-counter benzocaine, a local anesthetic for the temporary relief of pain due to minor irritation, soreness, or injury of the mouth or throat, should not be used to treat infants and children younger than 2 years and should only be used in adults and children 2 years and older if they contain certain warnings on the drug label.

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Mannitol and increased risk for in-hospital mortality in patients with acute ischemic stroke and cerebral edema

Am J Cardiovasc Drugs. 2018 May 30. doi: 10.1007/s40256-018-0285-0.[Epub ahead of print]...
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Physician Prescribing of Opioids to Patients at Increased Risk of Overdose From Benzodiazepine Use

JAMA Psychiatry. 2018 Apr 12. doi: 10.1001/jamapsychiatry.2018.0544.[Epub ahead of print]...
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Vitamin D, Calcium, or combined supplementation, and increased incidence of kidney stones

Vitamin D supplementation alone or with calcium was not associated with reduced fracture incidence among community-dwelling adults without known vitamin D deficiency, osteoporosis, or prior fracture. Vitamin D with calcium was associated with an increase in the incidence of kidney stones

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Lamictal (lamotrigine) and serious immune system reaction

The FDA is warning that the medicine lamotrigine (Lamictal) for seizures and bipolar disorder can cause a rare but very serious reaction that excessively activates the body’s infection-fighting immune system. This can cause severe inflammation throughout the body and lead to hospitalization and death, especially if the reaction is not diagnosed and treated quickly.

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Cardiovascular drugs, psychotropics and other drugs and fall risk

Use of certain medications is recognized as a major and modifiable risk factor for falls. Although the literature on psychotropic drugs is compelling, the literature on cardiovascular drugs as potential fall-risk-increasing drugs is conflicting. The aim of this systematic review and meta-analysis is to provide a comprehensive overview of the associations between cardiovascular medications and fall risk in older adults.

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Antiepileptic drugs and major congenital malformations (EURAP registry)

These findings facilitate rational selection of these drugs, taking into account comparative risks associated with treatment alternatives.

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Obeticholic acid (Ocaliva▼) and risk of serious liver injury in patients with pre-existing moderate or severe hepatic impairment

Follow dose reduction and monitoring advice in these patients to reduce the risk of serious liver injury.

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Se contraindica la administración concomitante de ▼Xofigo (dicloruro de radio 223) con acetato de abiraterona y prednisona/prednisolona

Se contraindica la administración concomitante de ▼Xofigo (dicloruro de radio 223) con acetato de abiraterona y prednisona/prednisolona
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Towards better patient care: drugs to avoid in 2018. Prescrire in English

Changes 2018

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