“Open access” is entering the mainstream. What began as the vision of a few enthusiasts over a decade ago—to make research literature freely available—is now becoming achievable. Many large research funders now have policies promoting open access, many research universities and many subject communities now have open-access repositories to house papers, and many large journal publishers now allow authors to make their work openly accessible in some way (either by self-archiving in repositories or by open publication in journals). Open-access publishers, such as Public Library of Science (PLoS) and BioMed Central (BMC), are respected in their fields and publish journals with high impact factors. The business model they operate is recognized to be viable, with perhaps the greatest demonstration of this coming when the mainstream publisher Springer bought out BMC in 2008 in order to get an “in” to open-access publishing.