Vitae Herbae (her...
Follow
Find
2.5K views | +1 today
Vitae Herbae (herbal, natural, integrative medicine  & health)
web-based scientific information on natural medicine
Your new post is loading...
Scooped by Pasquale Valente
Scoop.it!

High-fiber foods - MayoClinic.com

High-fiber foods - MayoClinic.com | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Eating enough high-fiber foods? Find out the dietary fiber content of some common foods.
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Toxicity and Carcinogenicity Studies of Ginkgo biloba Extract in Rat and Mouse: Liver, Thyroid, and Nose Are Targets.

Abstract

Ginkgo biloba extract (GBE) is a popular herbal supplement that is used to improve circulation and brain function. In spite of widespread human exposure to relatively high doses over potentially long periods of time, there is a paucity of data from animal studies regarding the toxicity and carcinogenicity associated with GBE. In order to fill this knowledge gap, 3-month and 2-year toxicity and carcinogenicity studies with GBE administered by oral gavage to B6C3F1/N mice and F344/N rats were performed as part of the National Toxicology Program's Dietary Supplements and Herbal Medicines Initiative. The targets of GBE treatment were the liver, thyroid, and nose. These targets were consistent across exposure period, sex, and species, albeit with varying degrees of effect observed among studies. Key findings included a notably high incidence of hepatoblastomas in male and female mice and evidence of carcinogenic potential in the thyroid gland of both mice and rats. Various nonneoplastic lesions were observed beyond control levels in the liver, thyroid gland, and nose of rats and mice administered GBE. Although these results cannot be directly extrapolated to humans, the findings fill an important data gap in assessing risk associated with GBE use.

KEYWORDS:

hepatocarcinogenicity, herbal, nasal lesions., natural medicine, thyroid tumors

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Comparative study on in vitro activities of citral, limonene and essential oils from Lippia citriodora and L. alba on yellow fever virus.

Abstract

The aim of this study was to compare the antiviral activities in vitro of citral, limonene and essential oils (EOs) from Lippia citriodora and L. alba on the replication of yellow fever virus (YFV). Citral and EOs were active before and after virus adsorption on cells; IC50 values were between 4.3 and 25 microg/mL and SI ranged from 1.1 to 10.8. Results indicate that citral could contribute to the antiviral activity of the L. citriodora EO. Limonene was not active and seemed to play an insignificant role in the antiviral activity of the examined EOs.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

[Study on in vitro anti-inflammatory activity of total flavonoids from Glycyrrhizae Radix et Rhizoma and its ingredients].

[Study on in vitro anti-inflammatory activity of total flavonoids from Glycyrrhizae Radix et Rhizoma and its ingredients]. | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

OBJECTIVE:To examine the anti-inflammatory mechanism of total flavonoids of Glycyrrhizae Radix et Rhizoma (TFGR) and its ingredient on IFN-gamma and LPS-induced macrophage RAW264.7.METHOD:

Solvent extraction and macroporous resin enrichment were adopted for preparing ethanol extracts of Glycyrrhizae Radix et Rhizoma, components and total flavonoids. Ultraviolet spectroscopy was used to determine the content of total flavonoids. An IFN-gamma and LPS-induced cell inflammatory model was established. Griess reaction was used for detecting the effect of extracts at all levels and flavonoid monomers on nitrite content in cell culture supernatant. FRAP was used for measuring anti-oxidation capacity. RT-PCR was used for determining the effect of TFGR and isoliquiritigenins on intracellular inducible nitric oxide synthase iNOS, COX-2, IL-6 and PPAR-gamma. Western blot was used for detecting the effect of TFGR and isoliquiritigenins on iNOS, COX-2 and MAPK signal transduction pathways.

RESULT:

Compared with other extracts, ethyl acetate fractions from Glycyrrhizae Radix et Rhizoma showed the highest inhibition ratio on nitrite content at the same concentration. After being enriched with macroporous resin, TFGR (60. 08% of liquiritin) of ethyl acetate extracts from Glycyrrhizae Radix et Rhizoma showed dose-dependence, and inhibited the nitrite content in cell culture supernatant, which was superior to ethyl acetate extracts, and had the protective effect on post-stimulated cell activity, with a stronger total anti-oxidation than other extracts. TFGR inhibited iNOS, IL-6 mRNA, protein expressions of iNOS, COX-2 and IL-6. Isoliquiritigenin, a flavonoid monomer, could inhibited iNOS, COX-2 gene and protein expression and gene expressions of IL-1beta and IL-6, and upside-regulated gene expression of PPAR-gamma.

CONCLUSION:

Activity-oriented extraction suggests that ethyl acetate fractions from Glycyrrhizae Radix et Rhizoma is one of components with anti-inflammatory activity. TFGR obtained by enriching the active component showed dose-dependence, and inhibited the nitrite content in cell culture supernatant. The anti-inflammatory effect is partially achieved by regulating ERK signal pathway and inhibiting iNOS and COX-2 gene and protein expressions through extracellular signals of mitogen activated protein kinases (MAPKs). Specifically, isoliquiritigenin may be a component with TFGR anti-inflammatory activity.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer

Pasquale Valente's insight:

Elevated levels of proinflammatory mediators cause both local and systemic effects. Of particular relevance with regard to breast cancer is increased transcription of the CYP19 gene encoding aromatase, the rate-limiting enzyme for estrogen synthesis. Notably, this obesity-inflammation-aromatase axis provides a plausible explanation for increased rates of post-menopausal, hormone receptor-positive breast cancer associated with obesity and hence may offer targets for interventions to attenuate risk or improve prognosis. Potential approaches include weight reduction, exercise, and suppression of obesity-driven signaling pathways using pharmaceutical or dietary agents. 

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Novel Chinese herbal medicine JSK improves spinal cord injury outcomes in rats

Novel Chinese herbal medicine JSK improves spinal cord injury outcomes in rats | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
A new study demonstrates that Chinese herbal medicine Ji-Sui-Kang (JSK), given systemically for three weeks after injury in rats, improved locomotor function, reduced tissue damage, and preserved the structure of neural cells compared to control...
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Herbal medicinal products target defined biochemical and molecular mediators of inflammatory autoimmune arthritis.

Abstract

Rheumatoid arthritis (RA) is a chronic debilitating disease characterized by synovial inflammation, damage to cartilage and bone, and deformities of the joints. Several drugs possessing anti-inflammatory and immunomodulatory properties are being used in the conventional (allopathic) system of medicine to treat RA. However, the long-term use of these drugs is associated with harmful side effects. Therefore, newer drugs with low or no toxicity for the treatment of RA are actively being sought. Interestingly, several herbs demonstrate anti-inflammatory and anti-arthritic activity. In this review, we describe the role of the major biochemical and molecular mediators in the pathogenesis of RA, and highlight the sites of action of herbal medicinal products that have anti-arthritic activity. With the rapidly increasing use of CAM products by patients with RA and other inflammation-related disorders, our review presents timely information validating the scientific rationale for the use of natural therapeutic products.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular en...

Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular en... | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
The Biochemical Journal publishes important new findings and reviews across all areas of the molecular biosciences by authors in the international scientific community
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Direct link between aristolochic acid and upper urinary tract cancers.

Direct link between aristolochic acid and upper urinary tract cancers. | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Geneticists confirm herbal remedy carcinogen
Medical News Today
... (IARC) has classified herbal compounds derived from birthwort as Group 1 carcinogens, meaning there is evidence they cause cancer in humans.
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

How Happiness Keeps You Healthy

How Happiness Keeps You Healthy | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Research shows the genes of people with a deep sense of purpose in life are better equipped to fight disease and infection.
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Cinnamon regulates your blood sugar: Research-proven

Cinnamon regulates your blood sugar: Research-proven | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Cinnamon regulates your blood sugar: Research-proven
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways.

Abstract The development of colorectal cancer (CRC) is strongly correlated with the aberrant activation of multiple intracellular signaling transduction cascades including STAT3, ERK, JNK and p38 pathways which usually function redundantly. In addition, crosstalk between these pathways forms a complicated signaling network that is regulated by compensatory mechanisms. Therefore, most of the currently used and single-target-based antitumor agents might not always be therapeutically effective. Moreover, long-term use of these agents often generates drug resistance. These problems highlight the urgent need for the development of novel anticancer chemotherapies. Ursolic acid (UA) is a major active compound present in many medicinal herbs that have long been used for the clinical treatment of CRC. Although previous studies have demonstrated an antitumor effect for UA, the precise mechanisms of its tumoricidal activity are not well understood. In the present study, using CRC mouse xenograft model and the HT-29 human colon carcinoma cell line, we evaluated the efficacy of UA against tumor growth in vivo and in vitro and investigated the underlying molecular mechanisms. We found that UA inhibits cancer growth without apparent toxicity. Furthermore, UA significantly suppresses the activation of several CRC-related signaling pathways and alters the expression of critical target genes. These molecular effects lead to the induction of apoptosis and inhibition of cellular proliferation. These data demonstrate that UA possesses a broad range of anticancer activities due to its ability to affect multiple intracellular targets, suggesting that UA could be a novel multipotent therapeutic agent for cancer treatment.
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

CIMER - Home Page | MD Anderson Cancer Center

CIMER - Home Page | MD Anderson Cancer Center | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
MD Anderson Cancer Center’s Complementary/Integrative Medicine Education Resources (CIMER) Web site is offered to help patients and physicians decide how best to integrate complementary and integrative therapies into their care.
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Unexpected Benefits of Olive Leaf Extract - Life Extension

Unexpected Benefits of Olive Leaf Extract - Life Extension | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Scientists have isolated a unique molecule in olive oil that provides its cardio-protective benefits.
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice.

Abstract
ETHNOPHARMACOLOGICAL RELEVANCE:

Perilla frutescens (Perilla leaf), a traditional Chinese medicinal herb, has been used for centuries to treat various conditions including depression. A previous study of the authors demonstrated that essential oil of Perilla frutescens (EOPF) attenuated the depressive-like behavior in mice.

AIM OF THE STUDY:

This study was undertaken to explore the dynamic change of behaviors and brain-derived neurotrophic factor (BDNF) expression induced by chronic unpredictable mild stress (CUMS), and improved by EOPF.

MATERIALS AND METHODS:

Four separate CUMS experimental groups (1-week, 2-week, 3-week and 4-week treatment) were treated with EOPF (3 mg/kg and 6 mg/kg, p.o.) or fluoxetine (20 mg/kg, p.o.), followed by sucrose preference, locomotor activity, immobility and hippocampal BDNF measurement.

RESULTS:

EOPF, as well as fluoxetine, restored the CUMS-induced decreased sucrose preference and increased immobility time, without affecting body weight gain and locomotor activity. Furthermore, CUMS (3 or 4-week) produced a reduction in both BDNF mRNA and protein expression in the hippocampus, which were ameliorated by EOPF (4-week) and fluoxetine (3 or 4-week) treatment.

CONCLUSION:

These results presented here show that BDNF is expressed depending on length of CUMS procedure and EOPF administration. And this study might contribute to the underlying reason for the slow onset of antidepressant activity in clinic.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Anti-inflammatory effects of essential oil in Echinacea purpurea L.

Anti-inflammatory effects of essential oil in Echinacea purpurea L. | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

Echinacea purpurea L. is a medicinal plant originally from North America. It has become a commonly used herbal medicine worldwide because it contains various biologically active compounds. This study was designed to investigate the anti-inflammatory effects of essential oils from E. purpurea in both mice and rats. The extract was obtained from flower of E. purpurea by steam distillation. The anti-inflammatory potential was evaluated in vivo by using different animal models such as xylene-induced mouse ear edema, egg-white-induced rat paw edema, and cotton-induced granuloma tissue proliferating inflammation in mice. The serial dosages were used in vivo: the low dosage, the medium dosage and the high dosage. The low, medium and high dosages of extracts produced inhibitions of 39.24%, 47.22% and 44.79% respectively in the ear edema induced by xylene when compare with the control group. Only the high dosage group showed statistically significant inhibition (48.51%) of paw edema formation induced three hours by egg white compared with the control group (P<0.01). Moreover, the granulation formation was also significantly reduced the most by 28.52% in the high dose groups compared with the control group (P <0.05). The pro-inflammatory cytokines such as IL-2, IL-6 and TNF-α in the blood were reduced in the treated groups. The essential oils from extracts of E. purpurea have anti-inflammatory effects.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice.

Abstract

Licorice, the roots and rhizomes of several Glycyrrhiza species (Leguminosae), is an important natural sweetening agent and a widely used herbalmedicine. In this work, six flavonoids, 5-(1,1-dimethylallyl)-3,4,4'-trihydroxy-2-methoxychalcone (1), licochalcone B (2), licochalcone A (3), echinatin (4), glycycoumarin (5) and glyurallin B (6), were isolated from the extracts of licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis). Their structures were elucidated using various spectroscopic methods. To our knowledge, compound 1 was isolated from natural plants for the first time. All the isolates were tested by antioxidant and anti-inflammatory assays. Compounds 2, 4 and 5 showed strong scavenging activity toward the ABTS(+) radical, and compounds 1, 2, 3, 5 and 6 exhibited potent inhibition of lipid peroxidation in rat liver microsomes compared with the reference controls. Compounds 1-4 dose-dependently inhibited LPS induced reactive oxygen species (ROS) production in RAW 264.7 cells. Furthermore, compounds 1-5 were demonstrated to inhibit the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells. Moreover, the contents of the six compounds, in different Glycyrrhiza species, were quantified by HPLC-MS.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Pronounced transcriptional regulation of apoptotic and TNF-NF-kappa-B signaling genes during the course of thymoquinone mediated apoptosis in HeLa cells.

Pasquale Valente's insight:

This study implicates the role of TQ in the inhibition of cancer cell proliferation and migration. At the same time, the results strongly suggest that TQ intervenes with TNF and NF-kappa-B signaling during TQ-mediated induction of apoptosis in cancer cells.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling.

Abstract

Huo-luo-xiao-ling dan (HLXL) is an herbal mixture that has long been used in traditional Chinese medicine for the treatment of rheumatoid arthritis (RA) and other inflammatory disorders. Despite the availability of potent conventionally used drugs for RA, their limited efficacy in a proportion of patients coupled with their high cost and severe adverse effects has necessitated the search for novel therapeutics for this debilitating disease. Further, the control of both inflammation and bone damage is essential for effective management of arthritis. The aim of our study was to evaluate the efficacy of HLXL against arthritic bone damage in adjuvant arthritis (AA) model of RA. Our results show that HLXL treatment suppressed inflammatory arthritisand reduced bone and cartilage damage in the joints of arthritic Lewis rats. HLXL-induced protection against bone damage was mediated primarily via inhibition of mediators of osteoclastic bone remodeling (e.g., receptor activator of nuclear factor kappa-B ligand; RANKL), skewing of RANKL/osteoprotegerin (OPG) ratio in favor of antiosteoclastic activity, reduction in the number of osteoclasts in the arthrodial joint's bone, and inhibition of cytokine production and MMP activity. Our results suggest that HLXL might offer a promising alternative/adjunct treatment for both inflammation and bone damage in RA.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Mediators of inflammation-induced bone damage in arthritis and their control by herbal products.

Mediators of inflammation-induced bone damage in arthritis and their control by herbal products. | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Abstract

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints leading to bone and cartilage damage. Untreated inflammatory arthritis can result in severe deformities and disability. The use of anti-inflammatory agents and biologics has been the mainstay of treatment of RA. However, the prolonged use of such agents may lead to severe adverse reactions. In addition, many of these drugs are quite expensive. These limitations have necessitated the search for newer therapeutic agents for RA. Natural plant products offer a promising resource for potential antiarthritic agents. We describe here the cellular and soluble mediators of inflammation-induced bone damage (osteoimmunology) in arthritis. We also elaborate upon various herbal products that possess antiarthritic activity, particularly mentioning the specific target molecules. As the use of natural product supplements by RA patients is increasing, this paper presents timely and useful information about the mechanism of action of promising herbal products that can inhibit the progression of inflammation and bone damage in the course of arthritis.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

The Beer-Smell Gene and Other Ways DNA Drives Our Senses | TIME.com

The Beer-Smell Gene and Other Ways DNA Drives Our Senses | TIME.com | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Beer smells like beer and a violet smells like a violet to everyone, right? Maybe not, according to the latest study that traced the way we smell to differences in our genes.
more...
No comment yet.
Rescooped by Pasquale Valente from Glossarissimo!
Scoop.it!

(ZH)-(EN) – Herbal Glossary (Chinese Herbology) | shen-nong.com

(ZH)-(EN) – Herbal Glossary (Chinese Herbology) | shen-nong.com | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

"Chinese herb list - information about Chinese traditional herbs

 

Start your search by clicking the name or the primary function of the herb. Each section can be searched alphabetically. Once a herb or function is selected all the corresponding names will appear in the selected row. Click again on any of the corresponding names to get to the information page about your selected herb"


Via Stefano KaliFire
more...
Stefano KaliFire's curator insight, March 5, 2013 2:32 AM

Research can be made by Chinese name, Latin name, Common name (English), Scientific name

Scooped by Pasquale Valente
Scoop.it!

Sun exposure shows protective association against allergic disease | Vitamin D Council

Sun exposure shows protective association against allergic disease | Vitamin D Council | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
New research out of Australia has found that sun exposure – independent of vitamin D levels – may have a protective association against the developmen
more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

p53, aerobic metabolism, and cancer. [Antioxid Redox Signal. 2011] - PubMed - NCBI

p53, aerobic metabolism, and cancer. [Antioxid Redox Signal. 2011] - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

p53 regulates the cell cycle and deoxyribonucleic acid (DNA) repair pathways as part of its unequivocally important function to maintain genomic stability. Intriguingly, recent studies show that p53 can also transactivate genes involved in coordinating the two major pathways of energy generation to promote aerobic metabolism, but how this serves to maintain genomic stability is less clear. In an attempt to understand the biology, this review presents human epidemiologic data on the inverse relationship between aerobic capacity and cancer incidence that appears to be mirrored by the impact of p53 on aerobic capacity in mouse models. The review summarizes mechanisms by which p53 regulates mitochondrial respiration and proposes how this might contribute to maintaining genomic stability. Although disparate in nature, the data taken together suggest that the promotion of aerobic metabolism by p53 serves as an important tumor suppressor activity and may provide insights for cancer prevention strategies in the future.

  

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Curcumin: a novel Stat3 pathway inhibitor for chemopreventi... : European Journal of Cancer Prevention

Curcumin:  a novel Stat3 pathway inhibitor for chemopreventi... : European Journal of Cancer Prevention | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Multiple studies from independent groups find evidence for signal transducer and activator of transcription 3 (Stat3) activation in nearly 50% of lung cancers, suggesting a functional role for this target in subsets of lung cancer.
more...
No comment yet.