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Lifestyle Changes Can Impact Gene Structure Tied to Aging - Psych Central News

Lifestyle Changes Can Impact Gene Structure Tied to Aging - Psych Central News | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
A test developed by Foundation Medicine Inc. analyzes tumor DNA to help find targeted treatment options for patients with cancer (credit: Foundation
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Safety and Tolerability of Essential Oil from Cinnamomum zeylanicum Blume Leaves with Action on Oral Candidosis and Its Effect on the Physical Properties of the Acrylic Resin

Safety and Tolerability of Essential Oil from Cinnamomum zeylanicum Blume Leaves with Action on Oral Candidosis and Its Effect on the Physical Properties of the Acrylic Resin | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

The anti-Candida activity of essential oil from Cinnamomum zeylanicum Blume, as well as its effect on the roughness and hardness of the acrylic resin used in dental prostheses, was assessed. The safety and tolerability of the test product were assessed through a phase I clinical trial involving users of removable dentures. Minimum inhibitory concentration (MIC) and minimum fungicidal concentrations (MFC) were determined against twelve Candida strains. Acrylic resin specimens were exposed to artificial saliva (GI), C. zeylanicum (GII), and nystatin (GIII) for 15 days. Data were submitted to ANOVA and Tukey posttest (%). For the phase I clinical trial, 15 healthy patients used solution of C. zeylanicum at MIC (15 days, 3 times a day) and were submitted to clinical and mycological examinations. C. zeylanicum showed anti-Candida activity, with MIC = 625.0 µg/mL being equivalent to MFC. Nystatin caused greater increase in roughness and decreased the hardness of the material (), with no significant differences between GI and GII. As regards the clinical trial, no adverse clinical signs were observed after intervention. The substance tested had a satisfactory level of safety and tolerability, supporting new advances involving the clinical use of essential oil from C. zeylanicum

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Potential nephroprotective effects of the Chinese herb Angelica sinensis against cisplatin tubulotoxicity. - PubMed - NCBI

Potential nephroprotective effects of the Chinese herb Angelica sinensis against cisplatin tubulotoxicity. - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

Abstract Context: Acute kidney injury (AKI) is often encountered in patients receiving cisplatin (CisPt), a chemotherapeutic drug that induces numerous toxic side effects. Techniques used to limit nephrotoxicity during CisPt treatment are not fully effective; about a third of patients experience AKI. New nephroprotective strategies, including pharmacological approaches, must be developed. Objective: The present study investigated the nephroprotective potential of Angelica sinensis (Oliv.) Diels (Apiaceae) root towards CisPt tubulotoxicity. Materials and methods: HK-2 cells were incubated with CisPt (10 µM) and/or with a methanolic extract of A. sinensis (AS). Nephroprotective capacity was evaluated by means of cellular viability (resazurin assay) and apoptosis (annexin-V/PI staining), oxidative stress generation (H2DCF-DA oxidation), Ki-67 index (immunofluorescence), cell cycle analysis (DNA staining), cell migration rate (scratch assay), extracellular matrix deposition (collagen determination), and β-catenin relocalization. Results: CisPt decreased cell viability [76% versus Ctrl], which was associated with an increased apoptosis. Simultaneous treatment with 50 µg/ml AS enhanced cell survival [84% versus Ctrl] and decreased the apoptosis rate. AS could not alleviate CisPt-induced oxidative stress; but doses of 5 and 50 µg/ml raised the Ki-67 index [135 and 244% versus Ctrl] and cell migration rates [1.2 and 1.3-fold versus Ctrl]. Finally, both doses of AS limited the amount of collagen deposition [121.6 and 119.6% for 5 and 50 µg/ml, respectively, versus 131.0% for CisPt-treated cells] and prevented the relocalization of β-catenin from the membrane to the nucleus. Conclusion: These results confirm the nephroprotective potential of A. sinensis and require further investigations aiming at identifying its active compounds.

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Salvianolic acid B promotes bone formation by increasing activity of alkaline phosphatase in a rat tibia fracture model: a pilot study. - PubMed - NCBI

Abstract
BACKGROUND:

Radix Salviae miltiorrhizae is a herb frequently used within traditional Chinese medicine for the treatment of cardiovascular- and trauma-related diseases. Danshen is the dried root of Salviae miltiorrhizae, from which the polyphenolic compound Salvianolic acid B (Sal B) can be obtained. Sal B is a key component of Danshen. The aim of this study was to determine the effect of Sal B on the healing of long bones following trauma in a rat tibia fracture model.

METHODS:

Tibia fractures were created in 20 male Sprague Dawley rats. The animals were divided into two groups: (1) experimental group (n = 10); and (2) control group (n = 10). Rats in the experimental group were intraperitoneally administered with Sal B (40 mg/kg/d) for 3 weeks, while rats in the control group received an identical volume of physiological saline solution, administered in the same way. X-ray photographs were taken of all animals at the time points. Rats were euthanized at weeks 1, 3, 8 and 12 post-fracture. Fracture calluses were measured and callus sections were obtained and stained using hematoxylin and eosin (HE) and the calcium cobalt method. HE stained sections were observed and evaluated according to different grades of bone remodeling. Sections stained using the calcium cobalt method were analyzed with an imagine analysis system.

RESULTS:

Data showed that callus growth was significantly greater in the experimental group compared with the control group (P < 0.05). Furthermore, histological scores in the Sal B-treated group were statistically higher than in the saline treated group at weeks 1, 3 and 8 post-fracture (P < 0.05). Alkaline phosphatase (ALP) activity was enhanced in the experimental group at weeks 1 and 3 post-fracture (P < 0.05).

CONCLUSIONS:

Our results suggest that Sal B may accelerate early-stage fracture healing. Increased activity of ALP may be one factor which promotes the healing process. This pilot study provides brief insight into the effect of Sal B in fracture healing. These findings will contribute to the development of more and enhanced treatment options for trauma fracture patients.

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Mistletoe extract doubles survival time of pancreatic cancer patients

Mistletoe extract doubles survival time of pancreatic cancer patients | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

This new Phase III clinical trial was randomized, open-label and carried out in Serbia on 220 patients. All patients received Best Supportive Care. Patients in the treatment group also received subcutaneous injections of mistletoe extract three times weekly with dosages escalating from 0.01 mg up to a constant 10 mg after the twenty-second dose. Patients who started the study with a ‘good prognosis’ saw their survival times more than double from 3.2 months (if untreated) to 6.6 months if treated with mistletoe. Likewise, patients with a ‘poor prognosis’ averaged 2.0 months survival if untreated, but 3.4 months if treated with mistletoe. Remarkably, the group treated with mistletoe experienced only 16 adverse events compared to 53 adverse events in the untreated group. Rather than carrying negative side effects as chemo drugs do, the mistletoe treatment actually decreased the likelihood of painful or undesirable effects (adverse events) by 75 percent. And none of the adverse events in the mistletoe group were caused by the mistletoe itself.


Via Jonathan Middleton
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VaL therapy showed a significant and clinically relevant prolongation of OS. The study findings suggest VaL to be a non-toxic and effective second-line therapy that offers a prolongation of OS as well as less disease-related symptoms for patients with locally advanced or metastatic pancreatic cancer. http://www.ncbi.nlm.nih.gov/pubmed/23890767

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Salvianolic acid B inhibits platelets-mediated inflammatory response in vascular endothelial cells. PubMed - NCBI

Salvianolic acid B inhibits platelets-mediated inflammatory response in vascular endothelial cells. PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Abstract

Salvianolic acid B (SAB) is a hydrophilic component isolated from the Chinese herb Salviae miltiorrhizae, which has been used clinically for the treatment of ischemic cardiovascular and cerebrovascular diseases. Platelets-mediated vascular inflammatory response contributes to the initiation and progression of atherosclerosis. In this paper, we focus on the modulating effects of SAB on the inflammatory reaction of endothelial cells triggered by activated platelets. Human umbilical vein endothelial cells (EA.hy926) were pretreated with SAB followed by co-culture with ADP-activated platelets. Adhesion of platelets to endothelial cells was observed by amorphological method. The activation of nuclear factor-kappa B was evaluated by NF-κB p65 nuclear translocation and the protein phosphorylation. A determination of the pro-inflammatory mediators (ICAM-1, IL-1β, IL-6, IL-8, MCP-1) mRNA and protein were also conducted. In addition, the inhibitory effects of SAB on platelets activation were also evaluated using a platelet aggregation assay and assessing the release level of soluble P-selectin. The results showed that SAB dose-dependently inhibited ADP- or α-thrombin-induced human platelets aggregation in platelet rich plasma (PRP) samples, and significantly decreased soluble P-selectin release from both agonists stimulated washed platelets. It was also found that pre-treatment with SAB reduced adhesion of ADP-activated platelets to EA.hy926 cells and inhibited NF-κB activation. In addition, SAB significantly suppressed pro-inflammatory mediators mRNA and protein in EA.hy926 cells in a dose-dependent manner. These results indicated that, in addition to its inhibitory effects on platelets activation, SAB was able to attenuate platelets-mediated inflammatory responses in endothelial cells even if the platelets had already been activated. This anti-inflammatory effect was related to the inhibition of NF-κB activation. Our findings suggest that SAB may be a potential candidate for the treatment of various atherosclerotic diseases.

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Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes.


Via Jonathan Middleton
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If You Do Ecstasy (MDMA) Consider Ginger

If You Do Ecstasy (MDMA) Consider Ginger | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Ginger May Salvage the Brains of Those Ectasy (MDMA)


Via Tonya Scholz
Pasquale Valente's insight:

The new study published in the journal Basic Clinical Neuroscience titled "Ecstasy-induced caspase expression alters following ginger treatment," used an animal model administering to the body cavities (intraperitoneally) of 15 male rats 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, for 7 days.  When their brains were analyzed for markers of neurological injury and inflammation (caspases 3,8 and 9), the ginger + MDMA group was found to have significantly reduced  MDMA-induced cell death (apoptosis) in the hippocampus (an important brain structure substantially involved in learning and memory) of the male rats, leading the researchers to conclude: "Therefore, ginger appears to be a useful medicinal herb as a potential treatment for the MDMA- associated adverse effects."

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Study of curcumin immunomodulatory effects on reactive astrocyte cell function.- PubMed - NCBI

Abstract

Multiple sclerosis (MS) is considered an inflammatory and neurodegenerative disease of the central nervous system (CNS) which most often presents as relapsing-remitting episodes. Recent evidence suggests that activated astrocytes play a dual functional role in CNS inflammatory disorders such as MS. In this study, we tried to induce anti-inflammatory functions of astrocytes by curcumin. The effects of curcumin were examined on human a astrocyte cell line (U373-MG) induced by lipopolysaccharide (LPS) in vitro. Matrix metalloproteinase (MMP)-9 activity was assessed by gelatin zymography. Cytokine levels were evaluated by quantitative ELISA method and mRNA expression was measured by real-time PCR. We found thatcurcumin decreased the release of IL-6 and reduced MMP-9 enzyme activity. It down-regulated MCP-1 mRNA expression too. However, curcumin did not have significant effects on the expression of neurotrophin (NT)-3 and insulin-like growth factor (IGF)-1 mRNAs. Results suggest that curcuminmight beneficially affect astrocyte population in CNS neuroinflammatory environment lean to anti-inflammatory response and help to components in respects of CNS repair. Our findings offer curcumin as a new therapeutic agent with the potential of regulating astrocyte-mediated inflammatory diseases in the CNS.

Copyright © 2014 Elsevier B.V. All rights reserved.

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Study on effect of astragali radix polysaccharides in improving learning and memory functions in aged rats and its mechanism

Zhongguo Zhong Yao Za Zhi. 2014 Jun;39(11):2071-5. English Abstract; Research Support, Non-U.S. Gov't
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Pasquale Valente's curator insight, October 29, 8:14 AM
Abstract

To observe the effect of Astragali Radix polysaccharides (APS) on the learning and memory functions of aged rats, in order to explore its mechanism for improving the learning and memory functions. Natural aging female SD rats were selected in the animal model and randomly divided into the control group, the APS low-dose group (50 mg x kg(-1)), the APS high-dose group (150 mg x kg(-1)) and the piracetam-treated group (560 mg x kg(-1)). They were orally administered with the corresponding drugs for consecutively 60 days. Besides, a young control group was set. The learning and memory functions of the rats were tested by the open-field test and the Morris water maze task. The Western-blot method was used to observe the levels of relevant neural plasticity protein N-methyl-D-aspartate receptor (NMDA receptor) in hippocampus, calcium/calmodulin dependent protein kinase II (CaMK II), protein kinase (PKA), the phosphorylation level of CAMP response element binding protein (CREB) and the protein expression of brain derived neurotrophic factor(BDNF). In this study, the authors found that the learning and memory functions and the hippocampus neural plasticity protein expression of the aged rat group were much lower than that of the young control group (P < 0.01). Compared with the aged rat group, the APS group showed the significant improvement in the impaired learning and memory functions of aged rats and the up-regulation in the hippocampus neural plasticity protein expression. The results showed that APS may improve the learning and memory functions of aged rats by increasing the expressions of relevant neural plasticity proteins.

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A Phase II trial of a combination herbal supplement for men with biochemically recurrent prostate cancer.

Abstract

BACKGROUND:Men with biochemical recurrence (BCR) of prostate cancer are typically observed or treated with androgen-deprivation therapy. Non-hormonal, non-toxic treatments to slow the rise of PSA are desirable. We studied a combination herbal supplement, Prostate Health Cocktail (PHC), in prostate cancer cell lines and in a population of men with BCR.METHODS:PC3, LAPC3 and LNCaP cells were incubated with increasing concentrations of PHC suspension. Men previously treated for prostate cancer with surgery, radiation or both with rising PSA but no radiographic metastases were treated with three capsules of PHC daily; the primary end point was 50% PSA decline. Circulating tumor cells (CTCs) were identified using parylene membrane filters.RESULTS:PHC showed a strong dose-dependent anti-proliferative effect in androgen-sensitive and independent cell lines in vitro and suppression of androgen receptor expression. Forty eligible patients were enrolled in the clinical trial. Median baseline PSA was 2.8 ng ml-1 (1.1-84.1) and 15 men (38%) had a PSA decline on study (1-55% reduction); 25 (62%) had rising PSA on study. The median duration of PSA stability was 6.4 months. Two patients had grade 2/3 transaminitis; the only other grade 2 toxicities were hyperglycemia, hypercalcemia and flatulence. There were no significant changes in testosterone or dihydrotestosterone. CTCs were identified in 19 men (47%).CONCLUSIONS:Although the primary end point was not met, PHC was well tolerated and was associated with PSA declines and stabilization in a significant number of patients. We believe this is the first report of detecting CTCs in men with BCR prostate cancer. Randomized studies are needed to better define the effect of PHC in men with BCR.Prostate Cancer and Prostatic Disease advance online publication, 23 September 2014; doi:10.1038/pcan.2014.37.

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"PHC was well tolerated and was associated with PSA declines and stabilization in a significant number of patients."

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New Defense Mechanism Against Viruses Discovered

New Defense Mechanism Against Viruses Discovered | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Researchers have discovered that a known quality control mechanism in human, animal and plant cells is active against viruses. They think it might represent one of the oldest defense mechanisms against viruses in evolutionary history.

Via Gilbert Faure au nom de l'ASSIM
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Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer? - Applied Physiology, Nutrition, and Metabolism

Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer? - Applied Physiology, Nutrition, and Metabolism | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
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Flaxseeds & Breast Cancer Survival: Clinical Evidence | NutritionFacts.org

Flaxseeds & Breast Cancer Survival: Clinical Evidence | NutritionFacts.org | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
A randomized double-blind placebo-controlled clinical trial of flaxseeds in breast cancer patients finds flax appears to have the potential to reduce tumor growth in just a matter of weeks.

Via Ingrid Long
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Chemical Composition and Biological Activity of Four Salvia Essential Oils and Individual Compounds against Two Species of Mosquitoes- PubMed - NCBI

Chemical Composition and Biological Activity of Four Salvia Essential Oils and Individual Compounds against Two Species of Mosquitoes- PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Abstract

Chemical composition of essential oils obtained from four species of genus Salvia were analyzed by gas chromatography (GC) and gas chromatography mass spectrometry (GC-MS). Main compounds identified from Salvia species essential oils were as follows: 1,8-cineole (71.7%), -pinene (5.1%), camphor (4.4%) and -pinene (3.8%) in S. apiana; borneol (17.4%), -eudesmol (10.4%), bornyl acetate (5%) and guaiol (4.8%) in S. elegans; bornyl acetate (11.4%), -caryophyllene (6.5%), caryophyllene oxide (13.5%) and spathulenol (7.0%) in S. leucantha; -thujene (25.8%), viridiflorol (20.4%), -thujene (5.7%) and camphor (6.4%) in S. officinalis. In biting deterrent bioassays, essential oil of S. leucantha and S. elegans at 10 µg/cm2 showed activity similar to DEET (97%, N, N-diethyl-meta-toluamide) in both the species of mosquitoes whereas activity of S. officinalis and S. apiana was lower than the other oils or DEET. Pure compounds β-eudesmol and guaiol showed biting deterrent activity similar to DEET at 25 nmol/cm2 whereas activity of 13-epi-manool, caryophyllene oxide, borneol, bornyl acetate and β-caryophyllene was significantly lower than β-eudesmol, guaiol or DEET. All essential oils showed larvicidal activity except S. apiana which was inactive at the highest dose of 125 ppm against both mosquito species. Based on 95% CIs, all the essential oils showed higher toxicity in Anopheles quadrimaculatus than Aedes aegypti. Essential oil of S. leucantha with LC50 value of 6.2 ppm showed highest toxicity in An. quadrimaculatus

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Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves

Abstract

Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250μg/mL and above showed a significant (*P < 0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells. A dose-dependent downregulation of MMP-9 expression was observed with the treatment of OSEO compared to the control. Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, advocating further investigation for clinical applications in the treatment of inflammation associated cancer.

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Systematic Review of Complementary and Alternative Medicine Treatments in Inflammatory Bowel Diseases - PubMed - NCBI

Abstract
OBJECTIVE:

We performed a systematic review for Complementary and Alternative Medicine [CAM] as defined by the National Institute of Health in Inflammatory Bowel Disease [IBD], ie Crohn's disease [CD] and ulcerative colitis [UC], with the exception of dietary and nutritional supplements, and manipulative therapies.

METHODS:

A computerized search of databases [Cochrane Library, Pubmed/Medline, PsychINFO, and Scopus] through March 2014 was performed. We screened the reference sections of original studies and systematic reviews in English language for CAM in IBD, CD and UC. Randomized controlled trials [RCT] and controlled trials [CT] were referred and assessed using the Cochrane risk of bias tool.

RESULTS:

A total of: 26 RCT and 3 CT for herbal medicine, eg aloe-vera gel, andrographis paniculata, artemisia absinthium, barley foodstuff, boswellia serrata, cannabis, curcumin, evening primrose oil, Myrrhinil intest®, plantago ovata, silymarin, sophora, tormentil, wheatgrass-juice and wormwood; 1 RCT for trichuris suis ovata; 7 RCT for mind/body interventions such as lifestyle modification, hypnotherapy, relaxation training and mindfulness; and 2 RCT in acupuncture; were found. Risk of bias was quite heterogeneous. Best evidence was found for herbal therapy, ie plantago ovata and curcumin in UC maintenance therapy, wormwood in CD, mind/body therapy and self-intervention in UC, and acupuncture in UC and CD.

CONCLUSIONS:

Complementary and alternative therapies might be effective for the treatment of inflammatory bowel diseases; however, given the low number of trials and the heterogeneous methodological quality of trials, further in-depth research is necessary.

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Ginsenoside 20(S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells- PubMed - NCBI

Ginsenoside 20(S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells- PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Abstract

Cancer cells prefer to metabolize glucose through aerobic glycolysis, known as the Warburg effect. It plays a crucial role in proliferation and progression of cancer cells. However, the complete mechanism remains elusive. In recent studies, the signal transducer and activator of transcription 3 (STAT3) signaling has been discovered to have roles in cancer‑associated changes in metabolism. In this study, we find that the ginsenoside 20(S)‑Rg3, a pharmacologically active component of the traditional Chinese herb Panax ginseng, inhibits glycolysis in ovarian cancer cells by regulating hexokinase 2 (HK2) and pyruvate kinase M2 (PKM2). We also show that 20(S)‑Rg3 regulates HK2 through downregulation of p‑STAT3 (Tyr705). Furthermore, overexpression of STAT3 in ovarian cancer cells weakened the suppression of Warburg effect induced by 20(S)‑Rg3. Importantly, 20(S)‑Rg3 treatment represses HK2 expression in nude mouse xenograft models of ovarian cancer. Taken together, our results show that 20(S)‑Rg3 inhibits the Warburg effect by targeting STAT3/HK2 pathway in ovarian cancer cells, highlighting the potentiality of 20(S)‑Rg3 to be used as a therapeutic agent for ovarian cancer.

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The effect of most important medicinal plants on two importnt psychiatric disorders (anxiety and depression)-a review

Pasquale Valente's insight:
Abstract

Anxiety and depression are highly comorbid psychiatric conditions that the prevalence will be increased to the second greatest risk of morbidity, causing a significant socioeconomic burden. Due to side effects and destructive effects of some chemical drugs, many patients prefer herbal medicines to treat diseases. Although there are key review papers in the area of medicinal plants and psychiatry disorders, they have either covered the area in a relatively cursory manner or focused on a specific plant medicine. In the present study, we tried to present the effect of most important medicinal plants on two important highly comorbid psychiatric conditions-anxiety and depression.

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Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modula... - PubMed - NCBI

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Review of the regulations for clinical research in herbal medicines... - PubMed - NCBI

Chin J Integr Med. 2014 Dec;20(12):883-93. doi: 10.1007/s11655-014-2024-y. Epub 2014 Nov 27.
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Olea europaea leaf extract improves the treatment response of GBM stem cells by modulating miRNA expression

Olea europaea leaf extract improves the treatment response of GBM stem cells by modulating miRNA expression | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

The stem-like cells of Glioblastoma multiforme (GBM) tumors (GSCs) are one of the important determinants of recurrence and drug resistance. The aims of the current study were to evaluate the anticancer effect of Olea europaea leaf extract (OLE) on GBM cell lines, the association between OLE and TMZ responses, and the effect of OLE and the OLE-TMZ combination in GSCs and to clarify the molecular mechanism of this effect on the expression of miRNAs related to cell death. The anti-proliferative activity of OLE and the effect of the OLE-TMZ combination were tested in the T98G, U-138MG and U-87MG GBM cell lines using WST-1 assay. The mechanism of cell death was analyzed with Annexin V/FITC and TUNEL assays. The effects of OLE on the expression levels of miR-181b, miR-153, miR-145 and miR-137 and potential mRNA targets were analyzed in GSCs using RT-qPCR. OLE exhibited anti-proliferative effects via apoptosis and necrosis in the GBM cell lines. In addition, OLE significantly induced the expression of miR-153, miR-145, and miR-137 and decreased the expression of the target genes of these miRNAs in GSCs (p < 0.05). OLE causes cell death in GBM cells with different TMZ responses, and this effect is synergistically increased when the cells are treated with a combination of OLE and TMZ. This is the first study to indicate that OLE may interfere with the pluripotency of GSCs by modulating miRNA expression. Further studies are required, but we suggest that OLE may have a potential for advanced therapeutic cancer drug studies in GBM.


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Could Multiple Sclerosis Begin in the Gut?

Could Multiple Sclerosis Begin in the Gut? | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
MS researchers are focusing on the content of the gut’s microbiome as a possible contributor to the body’s autoimmune attack on its nervous system
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Curcumin Together With Cancer Inhibiting Peptides Shown to Reduce Cancer Severity in Mesothelioma

Curcumin Together With Cancer Inhibiting Peptides Shown to Reduce Cancer Severity in Mesothelioma | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

PIAS3 levels, which brought down STAT3 activity and caused mesothelioma cells to die. Their study served as proof of principle about the effectiveness of these two compounds in treating malignant mesothelioma, a first step in moving a treatment toward clinical trials.


Via Graham Player Ph.D.
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Graham Player Ph.D.'s curator insight, September 19, 1:42 PM

The culprit in sparking many cancers, particularly mesothelioma, is the intracellular protein and transcription factor STAT3 (signal transducer and activator of transcription 3). A signal transducer and activator is a pathway for instructing the growth and survival of cells, and a transcription factor is a protein that controls genetic information directing cells how to perform. STAT3 is notorious for sending signals to trigger the onset of human cancers and to fuel their continued growth.

The great neutralizer of STAT3 is PIAS3 (protein inhibitor of activated STAT3). PIAS3 possesses the strength to inhibit and block STAT3's ability to cause cancer. Scientists from Case Western Reserve University and the Georg-Speyer-Haus in Frankfurt, Germany, demonstrated that application of curcumin, a derivative of the spice turmeric, and cancer-inhibiting peptides increase PIAS3 levels, which brought down STAT3 activity and caused mesothelioma cells to die.

Their study served as proof of principle about the effectiveness of these two compounds in treating malignant mesothelioma, a first step in moving a treatment toward clinical trials.

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Flavonoid and lignan intake in relation to bladder cancer [Br J Cancer. 2014] - NCBI

Flavonoid and lignan intake in relation to bladder cancer [Br J Cancer. 2014]  - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Background:

There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.


Methods:

A cohort of 477312 men and women mostly aged 35–70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.


Results:

During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HRQ5–Q1) 0.74, 95% confidence interval (CI): 0.61–0.91; P-trend=0.009) and lignans (HRQ5–Q1 0.78, 95% CI: 0.62–0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.


Conclusions:

Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.

Pasquale Valente's insight:

"inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer"

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Pasquale Valente's insight:

Researchers from UC San Francisco, Arizona State University and University of New Mexico concluded from a review of the recent scientific literature that microbes influence human eating behavior and dietary choices to favor consumption of the particular nutrients they grow best on, rather than simply passively living off whatever nutrients we choose to send their way.

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Pasquale Valente's curator insight, August 22, 4:54 AM

Researchers from UC San Francisco, Arizona State University and University of New Mexico concluded from a review of the recent scientific literature that microbes influence human eating behavior and dietary choices to favor consumption of the particular nutrients they grow best on, rather than simply passively living off whatever nutrients we choose to send their way.