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Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger. [Indian J Physiol Pharmacol. 2013 Jan-Mar] - PubMed - NCBI

Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger.  [Indian J Physiol Pharmacol. 2013 Jan-Mar] - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

Chemical compositions of ginger oil as well as its antioxidant, anti-inflammatory and antinociceptive potential were evaluated in the present study. The main constituents as detected by GC/MS analysis was alpha-zingiberene which constituted 31% of the total area, ar-curcumene (15.4%) and a -sesquiphellandrene (14.02%). Ginger oil scavenged superoxide, DPPH, hydroxyl radicals and inhibited tissue lipid peroxidation in vitro. Intraperitoneal administration of ginger oil was found to inhibit phorbol-12-myristate-13-acetate induced superoxide radicals elicited by macrophages. Oral administration of ginger oil for one month, significantly increased superoxide dismutase, glutathione and glutathione reductase enzymes level (P < 0.001) in blood of mice and glutathione-S-transferase, glutathione peroxidase and superoxide dismutase enzymes in liver. Ginger oil produced significant reduction in acute inflammation produced by carrageenan and dextran and formalin induced chronic inflammation (P < 0.001). It also exhibited significant reduction in acetic acid induced writhing movements (P < 0.001). The present report revealed that ginger oil possesses antioxidant activity as well as significant anti-inflammatory and antinociceptive property.

Pasquale Valente's insight:

"The present report revealed that ginger oil possesses antioxidant activity as well as significant anti-inflammatory and antinociceptive property."

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Vitae Herbae | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Vitae Herbae , by pasquale valente: herbal, natural, integrative medicine and disease prevention
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Hepatoprotective Effects of Silybum marianum (Silymarin) and Glycyrrhiza glabra (Glycyrrhizin) in Combination: A Possible Synergy

Hepatoprotective Effects of Silybum marianum (Silymarin) and Glycyrrhiza glabra (Glycyrrhizin) in Combination: A Possible Synergy | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

"Treatment with various doses of SLN and GLN significantly reduced ALT, AST, ALP, and TBARS levels and increased GSH, SOD, and CAT levels. Our findings indicated that SLN and GLN have hepatoprotective effects against oxidative stress of the liver."

Pasquale Valente's insight:

"findings strongly suggest that the combination of drugs at higher doses, that is, SLN (200 mg/kg) and GLN (50 mg/kg), may have synergistic activity and confer the best hepatoprotective effects. "

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Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death

Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Traumatic brain injury (TBI) is often caused by accidents that damage the brain. TBI can induce glutamate excitotoxicity and lead to neuronal and glial cell death. In this study, we investigated the mechanism of cell death during the secondary damage caused by TBI in vivo and in vitro, as well as the protective effect of resveratrol (RV). 


Pasquale Valente's insight:

the results indicated that resveratrol may serve as a potential therapeutic agent in the treatment of Traumatic brain injury (TBI).

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CoQ10 Proven Benefits In Heart Failure Patients - Life Extension

CoQ10 Proven Benefits In Heart Failure Patients - Life Extension | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

The European Journal of Heart Failure has published data from one of the most robust studies to date on coenzyme Q10.

This ten year study conclusively showed that CoQ10 supplementation significantly improves survival for even the most severe heart failure patients while radically reducing incidences of hospitalization.1

This new study shows that CoQ10 supplementation can restore deficient CoQ10 levels in patients with moderate-to-severe heart failure, extend lifespan, and improve quality of life.1

The compelling results from this 10-year-long study found that patients who took 100 mg of CoQ10 three times daily were…

Significantly less likely to die from heart failure,Less than half as likely to die from any cause at all, andHalf as likely to have a major adverse cardiac event during the study period, compared with control subjects.1

After only three months of supplementation, the researchers detected a trend towards reduced levels of a blood marker of heart failure severity that is released from over-worked heart muscle cells.1,2 At two years, significantly more treated patients had improved measurements of heart function than did placebo recipients.1

This impressive study demonstrates how CoQ10 offers important heart health benefits and how essential it is to cardiac patients. Ideally, the practice of cardiology will soon include CoQ10 as part of their protocol to improve the lives of those living with heart failure.

 


Via Tonya Scholz
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Chemists discover secret to dark chocolate's health benefits

Chemists discover secret to dark chocolate's health benefits | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
For years, chocolate lovers have remained blissfully unaware of the precise reason bittersweet dark chocolate seems to improve cardiovascular health. At least until, now that is.
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Yoga May Help Overcome Fatigue After Breast Cancer

Yoga May Help Overcome Fatigue After Breast Cancer | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Yoga is increasingly incorporated into breast cancer treatment and recovery programs.
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Nigella sativa Oil Enhances the Spatial Working Memory Performance of Rats on a Radial Arm Maze. [Evid Based Complement Alternat Med. 2013] - PubMed - NCBI

Abstract

Nigella sativa, an established historical and religion-based remedy for a wide range of health problems, is a herbal medicine known to have antioxidant and neuroprotective effects. This present study investigated the effect of Nigella sativa oil (NSO) administration on the spatial memory performance (SMP) of male adult rats using eight-arm radial arm maze (RAM). Twelve Sprague Dawley rats (7-9 weeks old) were force-fed daily with 6.0  μ L/100 g body weight of Nigella sativa oil (NSO group; n = 6) or 0.1 mL/100 g body weight of corn oil (control) (CO group; n = 6) for a period of 20 consecutive weeks. For each weekly evaluation of SMP, one day food-deprived rats were tested by allowing each of them 3 minutes to explore the RAM for food as their rewards. Similar to the control group, the SMP of the treated group was not hindered, as indicated by the establishment of the reference and working memory components of the spatial memory. The results demonstrated that lesser mean numbers of error were observed for the NSO-treated group in both parameters as compared to the CO-treated group. NSO could therefore enhance the learning and memory abilities of the rats; there was a significant decrease in the overall mean number of working memory error (WME) in the NSO-treated group.

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Curcumin Halts Pancreatic Cancer Cell Growth - Natural News Blogs

Curcumin Halts Pancreatic Cancer Cell Growth - Natural News Blogs | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Study Finds Curcumin Halts the Spread of Pancreatic Cancer Cells and Suppresses Tumor Growth

Via Troy Mccomas (troy48)
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Alison D. Gilbert's curator insight, January 12, 5:23 AM

This magnificent orange powder is from a root called curcumin, the active medicinal component of turmeric root, not only stops pancreatic cells from metastasizing, or spreading, but inhibits pancreatic tumor growth as well.

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Anti-inflammatory effects of anethole in lipopolysa... [Life Sci. 2013] - PubMed - NCBI

Anti-inflammatory effects of anethole in lipopolysa... [Life Sci. 2013] - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

AIMS:

Anethole, the major component of the essential oil of star anise, has been reported to have antioxidant, antibacterial, antifungal, anti-inflammatory, and anesthetic properties. In this study, we investigated the anti-inflammatory effects of anethole in a mouse model of acute lung injury induced by lipopolysaccharide (LPS).

MAIN METHODS:

BALB/C mice were intraperitoneally administered anethole (62.5, 125, 250, or 500 mg/kg) 1 h before intratracheal treatment with LPS (1.5 mg/kg) and sacrificed after 4 h. The anti-inflammatory effects of anethole were assessed by measuring total protein and cell levels and inflammatory mediator production and by histological evaluation and Western blot analysis.

KEY FINDINGS:

LPS significantly increased total protein levels; numbers of total cells, including macrophages and neutrophils; and the production of inflammatory mediators such as matrix metalloproteinase 9 (MMP-9), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and nitric oxide (NO) in bronchoalveolar lavage fluid. Anethole (250 mg/kg) decreased total protein concentrations; numbers of inflammatory cells, including neutrophils and macrophages; and the inflammatory mediators MMP-9, TNF-α and NO. In addition, pretreatment with anethole decreased LPS-induced histopathological changes. The anti-inflammatory mechanism of anethole in LPS-induced acute lung injury was assessed by investigating the effects of anethole on NF-κB activation. Anethole suppressed the activation of NF-κB by blocking IκB-α degradation.

SIGNIFICANCE:

These results, showing that anethole prevents LPS-induced acute lung inflammation in mice, suggest that anethole may be therapeutically effective in inflammatory conditions in humans.

Pasquale Valente's insight:

Anethole (250 mg/kg) decreased total protein concentrations; numbers of inflammatory cells, including neutrophils and macrophages; and the inflammatory mediators MMP-9, TNF-α and NO.

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Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway. [PLoS One. 2013] - PubMed - NCBI

Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway. [PLoS One. 2013] - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ) and loss of neurons. Recently, a growing body of evidences have indicated that as a herbal compound naturally derived from grapes, resveratrol modulates the pathophysiology of AD, however, with a largely unclear mechanism. Therefore, we aimed to investigate the protection of resveratrol against the neurotoxicity of β-amyloid peptide 25-35 (Aβ(25-35)) and further explore its underlying mechanism in the present study. PC12 cells were injuried by Aβ(25-35), and resveratrol at different concentrations was added into the culture medium. We observed that resveratrol increased cell viability through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) colorimetric assays. Flow cytometry indicated the reduction of cell apoptosis by resveratrol. Moreover, resveratrol also stabilized the intercellular Ca(2+) homeostasis and attenuated Aβ(25-35) neurotoxicity. Additionally, Aβ(25-35)-suppressed silent information regulator 1 (SIRT1) activity was significantly reversed by resveratrol, resulting in the downregulation of Rho-associated kinase 1 (ROCK1). Our results clearly revealed that resveratrol significantly protected PC12 cells and inhibited the β-amyloid-induced cell apoptosis through the upregulation of SIRT1. Moreover, as a downstream signal molecule, ROCK1 was negatively regulated by SIRT1. Taken together, our study demonstrated that SIRT1-ROCK1 pathway played a critical role in the pathomechanism of AD.

Pasquale Valente's insight:

"results clearly revealed that resveratrol significantly protected PC12 cells and inhibited the β-amyloid-induced cell apoptosis through the upregulation of SIRT1. "

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Chinese herbal compound relieves inflammatory and neuropathic pain

Chinese herbal compound relieves inflammatory and neuropathic pain | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
A compound derived from a traditional Chinese herbal medicine has been found effective at alleviating pain, pointing the way to a new nonaddictive analgesic for acute inflammatory and nerve pain, according to UC Irvine pharmacology researchers.
Pasquale Valente's insight:

"Corydalis is a flowering herbal plant that grows in Siberia, Northern China and Japan. People utilize its root extract to alleviate menstrual cramps, chest pain and abdominal pain. It’s been previously studied for its analgesic properties, but this is the first time DHCB has been identified, extracted and tested."


http://www.sciencedirect.com/science/article/pii/S0960982213014942

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A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets

A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

For thousands of years, tonic herbs have been successfully used all around the world to improve health, energy, and vitality. However, their underlying mechanisms of action in molecular/systems levels are still a mystery. In this work, two sets of tonic herbs, so called Qi-enriching herbs (QEH) and Blood-tonifying herbs (BTH) in TCM, were selected to elucidate why they can restore proper balance and harmony inside body, organ and energy system. Firstly, a pattern recognition model based on artificial neural network and discriminant analysis for assessing the molecular difference between QEH and BTH was developed. It is indicated that QEH compounds have high lipophilicity while BTH compounds possess high chemical reactivity. Secondly, a systematic investigation integrating ADME (absorption, distribution, metabolism, and excretion) prediction, target fishing and network analysis was performed and validated on these herbs to obtain the compound-target associations for reconstructing the biologically-meaningful networks. The results suggest QEH enhance physical strength, immune system and normal well-being, acting as adjuvant therapy for chronic disorders while BTH stimulate hematopoiesis function in body. As an emerging approach, the systems pharmacology model might facilitate to understand the mechanisms of action of the tonic herbs, which brings about new development for complementary and alternative medicine.

Pasquale Valente's insight:

"The proposed model integrates the oral bioavailability screening, pattern recognition, discrimination analysis, drug targeting and network pharmacology analysis. The mechanisms of action of tonic herbs with a holistic way to improve health condition as well as treating disease were deeply uncovered."

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Ginsenoside Rg3 improves cardiac mitochondrial population quality: Mimetic exercise training [Biochem Biophys Res Commun. 2013] - PubMed - NCBI

Abstract

Emerging evidence indicates exercise training could mediate mitochondrial quality control through the improvement of mitochondrial dynamics. Ginsenoside Rg3 (Rg3), one of the active ingredients in Panax ginseng, is well known in herbal medicine as a tonic and restorative agent. However, the molecular mechanism underlying the beneficial effects of Rg3 has been elusive. In the present study, we compared the effects of Rg3 administration with aerobic exercise on mitochondrial adaptation in cardiac muscle tissue of Sprague-Dawley (SD) rats. Three groups of SD rats were studied: (1) sedentary control, (2) Rg3-treated and (3) aerobic exercise trained. Both aerobic exercise training and Rg3 supplementation enhanced peroxisome proliferator-activated receptor coactivator 1 alpha (PGC-1α) and nuclear factor-E2-related factor 2 (Nrf2) protein levels in cardiac muscle. The activation of PGC-1α led to increased mRNA levels of mitochondrial transcription factor A (Tfam) and nuclear related factor 1(Nrf1), these changes were accompanied by increases in mitochondrial DNA copy number and complex protein levels, while activation of Nrf2 increased levels of phase II detoxifying enzymes, including nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1(NQO1), superoxide dismutase (MnSOD) and catalase. Aerobic exercise also enhanced mitochondrial autophagy pathway activity, including increased conversion of LC3-I to LC3-II and greater expression of beclin1 and autophagy-related protein 7 (ATG7), these effects of aerobic exercise are comparable to that of Rg3. These results demonstrate that Rg3 mimics improved cardiac adaptations to exercise by regulating mitochondria dynamic remodeling and enhancing the quantity and quality of mitochondria.

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Astragaloside IV prevents damage to human mesangial cells ... [Int J Mol Med. 2014] - PubMed - NCBI

Glomerular hypertrophy and hyperfiltration are the two major pathological characteristics of the early stages of diabetic nephropathy (DN), which are respectively related to mesangial cell (MC) proliferation and a decrease in calcium influx conducted by canonical transient receptor potential cation channel 6 (TRPC6). The marked increase in the production of reactive oxygen species (ROS) induced by hyperglycemia is the main sponsor of multiple pathological pathways in DN. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is an important source of ROS production in MCs. Astragaloside IV (AS‑IV) is an active ingredient of Radix Astragali which has a potent antioxidative effect. In this study, we aimed to investigate whether high glucose (HG)‑induced NADPH oxidase activation and ROS production contribute to MC proliferation and the downregulation of TRPC6 expression; we also wished to determine the effects of AS‑IV on MCs under HG conditions.

Pasquale Valente's insight:

 "Results suggest that AS‑IV inhibits HG‑induced mesangial cell proliferation and glomerular contractile dysfunction through the NADPH oxidase/ROS/Akt/nuclear factor‑κB (NF‑κB) pathway, providing a new perspective for the clinical treatment of DN."

  
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Effect of ginger root on cyclooxygenase-1 ... [Eur J Cancer Prev. 2013] - PubMed - NCBI

Effect of ginger root on cyclooxygenase-1 ... [Eur J Cancer Prev. 2013] - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Elevated tissue levels of prostaglandin E2, produced by cyclooxygenase (COX), are an early event in colorectal cancer (CRC). Data suggest the efficacy of nonsteroidal anti-inflammatory drugs, such as cancer preventives, in the inhibition of COX activity; however, side effects of nonsteroidal anti-inflammatory pose unacceptable limitations. Ginger has been reported to have anti-inflammatory activities with significant CRC preventive potential. We investigated whether consumption of 2.0 g ginger daily regulated the level of two key enzymes that control prostaglandin E2 production, COX-1 and NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Thirty participants at normal and 20 participants at increased risk for CRC were randomized and given 2.0 g/day ginger or placebo for 28 days. Flexible sigmoidoscopy was used to obtain colon biopsies at baseline and the end of the study. Tissue levels of COX-1 and 15-PGDH were assessed using western blotting

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Pasquale Valente's curator insight, April 2, 12:23 AM

"After ginger consumption, participants at increased risk for CRC had a significantly reduced colonic COX-1 protein level (23.8±41%) compared with the placebo group (18.9±52%; P=0.03)"

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Hepatoprotective effect of silymarin

Hepatoprotective effect of silymarin | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such asSilybum marianum, Phyllanthus niruri, and Panus giganteus (Berk.) have been shown to ameliorate hepatic lesions. Silymarin is a natural compound derived from the species Silybum marianum, which is commonly known as Milk thistle. This plant contains at least seven flavoligands and the flavonoid taxifolin. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol, acetaminophen, and carbon tetrachloride. The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation. Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver. It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity. A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls.

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Bioavailability and Potential Uses of Vegetarian Sources of Omega-3 Fatty Acids: A Review of the Literature

Bioavailability and Potential Uses of Vegetarian Sources of Omega-3 Fatty Acids: A Review of the Literature | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Presently alpha-linolenic acid (ALA) is the most widely used vegetarian LC3PUFA, but only marginal amounts are converted into eicosapentaenoic (EPA) and docosahexaenoic acid (DHA); both of which are strongly related to human health. Currently, fish oils represent the most prominent dietary sources of EPA and DHA; however, these are unsuitable for vegetarians. Alternative sources include flaxseed, echium, walnut, and algal oil but their conversion to EPA and DHA must be considered. The present systematic review sets out to collate information from intervention studies examining the bioavailability of alternative vegetarian long chain omega-3 (n-3) polyunsaturated fatty acids (LC3PUFA) sources. Ten key papers published over the last 10 years were identified with seven intervention studies reporting that ALA from nut and seed oils was not converted to DHA at all. Three studies showed that ingestion of micro-algae oil led to significant increases in blood erythrocyte and plasma DHA. Further work is now needed to identify optimal doses of alternative vegetarian LC3PUFAs and how these can be integrated within daily diets. The potential role of algal oils appears to be particularly promising and an area in which further research is warranted


Via Jonathan Middleton
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Clinical trial: Acupuncture for migraine - brain functional activity and mechanism

Clinical trial: Acupuncture for migraine - brain functional activity and mechanism | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

The central analgesic mechanism ofacupuncture for migraine remains poorly understood.

Acupuncture has been shown to become a recommended treatment for migraine sufferers.

However, a single acupuncture stimulus cannot be indicative of the cumulative effects of acupuncture treatment.

Prof. Fanrong Liang and colleagues from Chengdu University of Traditional Chinese Medicine recruited migraine sufferers receiving 1 month of acupuncture treatment and explored the central analgesic mechanism of the cumulative effects of acupuncture for migraine.

The aim of their study was to examine changes in brain functional activity and central networks in subjects with migraine undergoing acupuncture at Shaoyang uncommon acupoints.

This trial has been registered on http://www.clinicaltrial.gov/ and provides a further explanation of the central analgesic mechanism by which acupuncture at Shaoyang acupoints treats migraine.

These findings are published in Neural Regeneration Research (Vol. 8, No. 28, 2013)


Via Bedford Acupuncture, Shaftesbury Clinic
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Natural plant compound prevents Alzheimer’s disease in mice | KurzweilAI

Natural plant compound prevents Alzheimer’s disease in mice | KurzweilAI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

A daily dose of fisetin, an  antioxidant chemical that’s found in fruits and vegetables from strawberries to cucumbers, appears to stop memory loss that accompanies Alzheimer’s disease in mice, scientists at the Salk Institute for Biological Studies have discovered.


In experiments on mice that normally develop Alzheimer’s symptoms less than a year after birth, a daily dose of the compound prevented the progressive memory and learning impairments.


The drug, however, did not alter the formation of amyloid plaques in the brain, accumulations of proteins that are commonly blamed for Alzheimer’s disease. The new finding suggests a way to treat Alzheimer’s symptoms independently of targeting amyloid plaques.




Via Ray and Terry's
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Tai Chi May Benefit Older Adults With Knee Osteoarthritis | NCCAM

Tai Chi May Benefit Older Adults With Knee Osteoarthritis | NCCAM | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Researchers conducted a long-term, randomized, controlled trial comparing tai chi and conventional exercise in a group of 40 adults (mean age 65) with symptomatic knee osteoarthritis.
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Herbal medicine (Gan Mai Da Zao decoction) for depression: a systematic review protocol. [BMJ Open. 2014] - PubMed - NCBI

Herbal medicine (Gan Mai Da Zao decoction) for depression: a systematic review protocol. [BMJ Open. 2014] - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

INTRODUCTION:

The aim of this systematic review is to analyse trial data on the effectiveness of a herbal medicine (Gan Mai Da Zao (GMDZ) decoction) in treating depression.

METHODS AND ANALYSIS:

12 databases will be searched from their inception: PubMed, EMBASE, AMED, the Cochrane Library, five Korean medical databases (KoreaMed, DBpia, OASIS, the Research Information Service System (RISS) and the Korean Studies Information Service System (KISS)) and three Chinese medical databases (China National Knowledge Infrastructure (CNKI), the Wanfang Database and the Chinese Scientific Journals Database (VIP)). Randomised clinical trials (RCTs) or quasi-RCTs using a GMDZ decoction for any type of depression will be considered. The selection of the studies, data abstraction and validations will be performed independently by two researchers.

DISSEMINATION:

The findings will be disseminated to appropriate audiences via peer-reviewed publication and conference presentations.

TRIAL REGISTRATION NUMBER: PROSPERO 2013:CRD42013005100.
Pasquale Valente's insight:

 http://bmjopen.bmj.com/content/4/1/e003690.full.pdf+html 

GMDZ/100 g is generally 16.1 g Glycyrrhiza, 64.5 g Triticum and 19.4g   Zizyphi Fructus and the dosage is 2.00–3.25 g/day for adults 

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American Herbal Pharmacopoeia releases cannabis monograph ...

American Herbal Pharmacopoeia releases cannabis monograph ... | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
American Herbal Pharmacopoeia releases cannabis monograph legitimizing herb as botanical medicine.
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Prostate Cancer Curbed by Omega-3s

Prostate Cancer Curbed by Omega-3s | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Prostate cancer is a leading cause of death among men in the United States.

 Some 230,000 American men will be diagnosed this year, and more than 29,000 will die from it. Sadly, the remarkably misleading conclusions of a prostate cancer study published last summer caused men pointless confusion and concern … and scared them away from healthful fish and fish oil. ... Overall, the evidence from cells, animals, and human studies supports the likely, plausible prospect that omega-3-rich diets help protect men’s prostates from cancer and/or slow its spread.


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Frankincense for Ovarian Cancer

Frankincense for Ovarian Cancer | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
One of the most famous Christmas gifts of all time, frankincense, may be effective for the treatment of late-stage ovarian cancer, according to a new study from UK researchers.

Via Graham Player Ph.D.
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Graham Player Ph.D.'s curator insight, December 29, 2013 10:25 PM

Research suggests that frankincense may be useful for the treatment of some cancers, including breast, colon and prostate cancer, due to a compound it contains, called acetyl-11-keto-beta-boswellic acid (AKBA).

Researchers from the University of Leicester in the UK analyzed the AKBA compound in vitro for 1 year, and tested it on a series of late-stage ovarian cancer cell lines, some of which were resistant to chemotherapy. They found that the compound effectively killed ovarian cancer cells, and were surprised to find that chemotherapy-resistant cell lines appeared to become more sensitive when the AKBA compound was applied.

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Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals

Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Cardiovascular disease and cancer are ranked as the first and second leading causes of death in the United States and in most industrialized countries. Regular consumption of fruit and vegetables is associated with reduced risks of cancer, cardiovascular disease, stroke, Alzheimer disease, cataracts, and some of the functional declines associated with aging. Prevention is a more effective strategy than is treatment of chronic diseases. Functional foods that contain significant amounts of bioactive components may provide desirable health benefits beyond basic nutrition and play important roles in the prevention of chronic diseases. The key question is whether a purified phytochemical has the same health benefit as does the whole food or mixture of foods in which the phytochemical is present. Our group found, for example, that the vitamin C in apples with skin accounts for only 0.4% of the total antioxidant activity, suggesting that most of the antioxidant activity of fruit and vegetables may come from phenolics and flavonoids in apples. We propose that the additive and synergistic effects of phytochemicals in fruit and vegetables are responsible for their potent antioxidant and anticancer activities, and that the benefit of a diet rich in fruit and vegetables is attributed to the complex mixture of phytochemicals present in whole foods.


Via Jonathan Middleton
Pasquale Valente's insight:

"The natural combination of phytochemicals in fruit and vegetables is responsible for their potent antioxidant activity"

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Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels

Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

Recent clinical data support the clinical use of oral lavender oil in patients suffering from subsyndromal anxiety. We identified the molecular mechanism of action that will alter the perception of lavender oil as a nonspecific ingredient of aromatherapy to a potent anxiolytic inhibiting voltage dependent calcium channels (VOCCs) as highly selective drug target. In contrast to previous publications where exorbitant high concentrations were used, the effects of lavender oil in behavioral, biochemical, and electrophysiological experiments were investigated in physiological concentrations in the nanomolar range, which correlate to a single dosage of 80 mg/d in humans that was used in clinical trials. We show for the first time that lavender oil bears some similarities with the established anxiolytic pregabalin. Lavender oil inhibits VOCCs in synaptosomes, primary hippocampal neurons and stably overexpressing cell lines in the same range such as pregabalin. Interestingly, Silexan does not primarily bind to P/Q type calcium channels such as pregabalin and does not interact with the binding site of pregabalin, the α2δ subunit of VOCCs. Lavender oil reduces non-selectively the calcium influx through several different types of VOCCs such as the N-type, P/Q-type and T-type VOCCs. In the hippocampus, one brain region important for anxiety disorders, we show that inhibition by lavender oil is mainly mediated via N-type and P/Q-type VOCCs. Taken together, we provide a pharmacological and molecular rationale for the clinical use of the oral application of lavender oil in patients suffering from anxiety.

Pasquale Valente's insight:

Lavender oil inhibits voltage dependent calcium channels (VOCCs) in synaptosomes, primary hippocampal neurons and stably overexpressing cell lines in the same range such as pregabalin.

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