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Herbal, natural, integrative medicine  & health. Scuola Viterbese di Fitoterapia - Italia
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Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death

Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death | Vitae Herbae | Scoop.it

Traumatic brain injury (TBI) is often caused by accidents that damage the brain. TBI can induce glutamate excitotoxicity and lead to neuronal and glial cell death. In this study, we investigated the mechanism of cell death during the secondary damage caused by TBI in vivo and in vitro, as well as the protective effect of resveratrol (RV). 


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the results indicated that resveratrol may serve as a potential therapeutic agent in the treatment of Traumatic brain injury (TBI).

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Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases

Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases | Vitae Herbae | Scoop.it

Abstract

Substantial evidence from both genetic and toxin induced animal and cellular models and postmortem human brain tissue indicates that mitochondrial dysfunction plays a central role in pathophysiology of the neurodegenerative disorders including Parkinson's disease (PD), and Huntington's disease (HD). This review discusses the emerging understanding of the role of mitochondrial dysfunction including bioenergetics defects, mitochondrial DNA mutations, familial nuclear DNA mutations, altered mitochondrial fusion/fission and morphology, mitochondrial transport/trafficking, altered transcription and increased interaction of pathogenic proteins with mitochondria in the pathogenesis of PD and HD. This review recapitulates some of the key therapeutic strategies applied to surmount mitochondrial dysfunction in these debilitating disorders. We discuss the therapeutic role of mitochondrial bioenergetic agents such as creatine, Coenzyme-Q10, mitochondrial targeted antioxidants and peptides, the SIRT1 activator resveratrol, and the pan-PPAR agonist bezafibrate in toxin and genetic cellular and animal models of PD and HD. We also summarize the phase II-III clinical trials conducted using some of these agents. Lastly, we discuss PGC-1α, TORC and Sirtuins as potential therapeutic targets for mitochondrial dysfunction in neurodegenerative disorders. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'

Pasquale Valente's insight:

"the therapeutic role of mitochondrial bioenergetic agents such as creatine, Coenzyme-Q10, mitochondrial targeted antioxidants and peptides, the SIRT1 activator resveratrol in the neurodegenerative disorders"

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Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53

Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53 | Vitae Herbae | Scoop.it

Resveratrol and clofarabine enhances a strong cytotoxicity with increased p53 activity.

Combination treatment of resveratrol and clofarabine enhances p53 transactivation.

The combined effect of resveratrol and clofarabine on apoptosis is synergistic.

Resveratrol could be useful to increase the efficacy of existing chemotherapy in the treatment of MM.

Pasquale Valente's insight:

"results demonstrate that resveratrol and clofarabine synergistically elicit apoptotic signal via a p53-dependent pathway, and provide a scientific rationale for clinical evaluation of resveratrol as a promising chemopotentiator in MM."

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Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway. [PLoS One. 2013] - PubMed - NCBI

Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway. [PLoS One. 2013] - PubMed - NCBI | Vitae Herbae | Scoop.it

Abstract

Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ) and loss of neurons. Recently, a growing body of evidences have indicated that as a herbal compound naturally derived from grapes, resveratrol modulates the pathophysiology of AD, however, with a largely unclear mechanism. Therefore, we aimed to investigate the protection of resveratrol against the neurotoxicity of β-amyloid peptide 25-35 (Aβ(25-35)) and further explore its underlying mechanism in the present study. PC12 cells were injuried by Aβ(25-35), and resveratrol at different concentrations was added into the culture medium. We observed that resveratrol increased cell viability through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) colorimetric assays. Flow cytometry indicated the reduction of cell apoptosis by resveratrol. Moreover, resveratrol also stabilized the intercellular Ca(2+) homeostasis and attenuated Aβ(25-35) neurotoxicity. Additionally, Aβ(25-35)-suppressed silent information regulator 1 (SIRT1) activity was significantly reversed by resveratrol, resulting in the downregulation of Rho-associated kinase 1 (ROCK1). Our results clearly revealed that resveratrol significantly protected PC12 cells and inhibited the β-amyloid-induced cell apoptosis through the upregulation of SIRT1. Moreover, as a downstream signal molecule, ROCK1 was negatively regulated by SIRT1. Taken together, our study demonstrated that SIRT1-ROCK1 pathway played a critical role in the pathomechanism of AD.

Pasquale Valente's insight:

"results clearly revealed that resveratrol significantly protected PC12 cells and inhibited the β-amyloid-induced cell apoptosis through the upregulation of SIRT1. "

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Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway

Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway | Vitae Herbae | Scoop.it

Resveratrol, extracted from Chinese herbal medicine Polygonum cuspidatum, is known to inhibit invasion and metastasis of human colorectal cancer (CRC), in which long non-coding Metastasis Associated Lung Adenocarcinoma Transcript 1 (RNA-MALAT1) also plays an important role. Using MALAT1 lentiviral shRNA and over-expression constructs in CRC derived cell lines, LoVo and HCT116, we demonstrated that the anti-tumor effects of resveratrol on CRC are through inhibiting Wnt/β-catenin signaling, thus the expression of its target genes such as c-Myc, MMP-7, as well as the expression of MALAT1. In detail, resveratrol down-regulates MALAT1, resulting in decreased nuclear localization of β-catenin thus attenuated Wnt/β-catenin signaling, which leads to the inhibition of CRC invasion and metastasis.This finding of ours surely provides important pre-clinical evidence supporting future use of resveratrol in prevention and treatment of CRC.

Pasquale Valente's insight:

 "results uncovered the mechanisms by which resveratrol regulates MALAT1, in turn alters the nuclear localization of β-catenin, resulting in lowered Wnt/β-catenin signaling and eventual inhibition of invasion and metastasis. This discovery will surely provide vital pre-clinical evidence supporting future use of resveratrol in prevention and treatment of CRC."

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Resveratrol From Grapes Found to Benefit Cancer Treatment

Resveratrol From Grapes Found to Benefit Cancer Treatment | Vitae Herbae | Scoop.it
A recent study by a University of Missouri researcher shows that resveratrol, a compound found in grape skins and red wine, can make certain tumor cells more susceptible to radiation treatment.

Via Graham Player Ph.D.
Pasquale Valente's insight:

Nicholl said  "If we can develop a successful way to deliver the compound to tumor sites, resveratrol could potentially be used to treat many types of cancers."

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Graham Player Ph.D.'s curator insight, October 13, 2013 8:48 AM

A study by a University of Missouri researcher shows that resveratrol, a compound found in grape skins and red wine, can make certain tumor cells more susceptible to radiation treatment.

It was found that when the cancer was treated with resveratrol alone, 44% of the tumor cells were killed. When the cancer cells were treated with a combination of both resveratrol and radiation, 65% of the tumor cells died.