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Clinical trial: Acupuncture for migraine - brain functional activity and mechanism

Clinical trial: Acupuncture for migraine - brain functional activity and mechanism | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

The central analgesic mechanism ofacupuncture for migraine remains poorly understood.

Acupuncture has been shown to become a recommended treatment for migraine sufferers.

However, a single acupuncture stimulus cannot be indicative of the cumulative effects of acupuncture treatment.

Prof. Fanrong Liang and colleagues from Chengdu University of Traditional Chinese Medicine recruited migraine sufferers receiving 1 month of acupuncture treatment and explored the central analgesic mechanism of the cumulative effects of acupuncture for migraine.

The aim of their study was to examine changes in brain functional activity and central networks in subjects with migraine undergoing acupuncture at Shaoyang uncommon acupoints.

This trial has been registered on http://www.clinicaltrial.gov/ and provides a further explanation of the central analgesic mechanism by which acupuncture at Shaoyang acupoints treats migraine.

These findings are published in Neural Regeneration Research (Vol. 8, No. 28, 2013)


Via Bedford Acupuncture, Shaftesbury Clinic
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Citronellol reduces orofacial nociceptive behaviour in mice [Basic Clin Pharmacol Toxicol. 2013] - PubMed - NCBI

Citronellol reduces orofacial nociceptive behaviour in mice [Basic Clin Pharmacol Toxicol. 2013] - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

Citronellol (CT) is a monoterpenoid alcohol present in the essential oil of many medicinal plants, such as Cymbopogon citratus. We evaluated the antinociceptive effects of CT on orofacial nociception in mice and investigated the central pathway involved in the effect. Male Swiss mice were pretreated with CT (25, 50 and 100 mg/kg, i.p.), morphine (5 mg/kg, i.p.) or vehicle (saline + tween 80 0.2%). Thirty minutes after the treatment, we injected formalin (20 μl, 2%), capsaicin (20 μl, 2.5 μg) or glutamate (40 μl, 25 μM) into the right limb. For the action in the CNS, ninety minutes after the treatment, the animals were perfused, the brains collected, crioprotected, cut in a criostate and submitted in an immunofluorescence protocol for Fos protein. CT produced significant (p < 0.01) antinociceptive effect, in all doses, in the formalin, capsaicin and glutamate tests. The immunofluorescence showed that the CT activated significantly (p < 0.05) the olfactory bulb, the piriform cortex, the retrosplenial cortex and the periaqueductal grey of the CNS. Together, our results provide first-time evidence that this monoterpene attenuates orofacial pain at least, in part, through an activation of CNS areas, mainly retrosplenial cortex and periaqueductal grey

Pasquale Valente's insight:

"results provide first-time evidence that this monoterpene attenuates orofacial pain at least, in part, through an activation of CNS areas, mainly retrosplenial cortex and periaqueductal grey"

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Can medical herbs stimulate regeneration or neuroprotection and treat neuropathic pain in chemotherapy-induced peripheral neuropathy ? [Evid Based Complement Alternat Med. 2013] - PubMed - NCBI

Can medical herbs stimulate regeneration or neuroprotection and treat neuropathic pain in chemotherapy-induced peripheral neuropathy ? [Evid Based Complement Alternat Med. 2013] - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

Chemotherapy-induced neuropathy (CIPN) has a relevant impact on the quality of life of cancer patients. There are no curative conventional treatments, so further options have to be investigated. We conducted a systematic review in English and Chinese language databases to illuminate the role of medical herbs. 26 relevant studies on 5 single herbs, one extract, one receptor-agonist, and 8 combinations of herbs were identified focusing on the single herbs Acorus calamus rhizoma, Cannabis sativa fructus, Chamomilla matricaria, Ginkgo biloba, Salvia officinalis, Sweet bee venom, Fritillaria cirrhosae bulbus, and the herbal combinations Bu Yang Huan Wu, modified Bu Yang Huan Wu plus Liuwei Di Huang, modified Chai Hu Long Gu Mu Li Wan, Geranii herba plus Aconiti lateralis praeparata radix , Niu Che Sen Qi Wan (Goshajinkigan), Gui Zhi Jia Shu Fu Tang (Keishikajutsubuto), Huang Qi Wu Wu Tang (Ogikeishigomotsuto), and Shao Yao Gan Cao Tang (Shakuyakukanzoto). The knowledge of mechanism of action is still limited, the quality of clinical trials needs further improvement, and studies have not yielded enough evidence to establish a standard practice, but a lot of promising substances have been identified. While CIPN has multiple mechanisms of neuronal degeneration, a combination of herbs or substances might deal with multiple targets for the aim of neuroprotection or neuroregeneration in CIPN

Pasquale Valente's insight:

"Experimental and clinical studies have not yielded enough evidence to establish a standard practice for the treatment of CIPN, but from this literature review, a lot of promising substances, mainly Chinese medical herbs with possible effect in CIPN or a putative influence on mechanisms of CIPN, have been identified in the last years."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747437/ 

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Chinese herbal compound relieves inflammatory and neuropathic pain

Chinese herbal compound relieves inflammatory and neuropathic pain | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
A compound derived from a traditional Chinese herbal medicine has been found effective at alleviating pain, pointing the way to a new nonaddictive analgesic for acute inflammatory and nerve pain, according to UC Irvine pharmacology researchers.
Pasquale Valente's insight:

"Corydalis is a flowering herbal plant that grows in Siberia, Northern China and Japan. People utilize its root extract to alleviate menstrual cramps, chest pain and abdominal pain. It’s been previously studied for its analgesic properties, but this is the first time DHCB has been identified, extracted and tested."


http://www.sciencedirect.com/science/article/pii/S0960982213014942

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Painkiller in brain buffers social snubs - Futurity

Painkiller in brain buffers social snubs - Futurity | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Research shows the brain releases natural painkillers during rejection to ease emotional pain. The discovery may help our understanding of depression and social anxieties.

What’s more, people who score high on a personality trait called resilience—the ability to adjust to environmental change—had the highest amount of natural painkiller activation.

The research team, based at the University of Michigan’s Molecular and Behavioral Neuroscience Institute, combined advanced brain-scanning that can track chemical release in the brain with a model of social rejection based on online dating.

They focused on the mu-opioid receptor system in the brain—the same system that the team has studied for years in relation to response to physical pain. Over more than a decade, their work has shown that when a person feels physical pain, their brains release chemicals called opioids into the space between neurons, dampening pain signals.

David T. Hsu, the lead author of the new paper that appears in the journal Nature, says the research on social rejection grew out of recent studies by others, which suggest that the brain pathways that are activated during physical pain and social pain are similar.

This is the first study to peer into the human brain to show that the opioid system is activated during social rejection,” says Hsu, a research assistant professor of psychiatry. “In general, opioids have been known to be released during social distress and isolation in animals, but where this occurs in the human brain has not been shown until now.”


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Network Analysis of Acupuncture Points Used in the Treatment of Low Back Pain

Network Analysis of Acupuncture Points Used in the Treatment of Low Back Pain | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
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