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Curcumin Together With Cancer Inhibiting Peptides Shown to Reduce Cancer Severity in Mesothelioma

Curcumin Together With Cancer Inhibiting Peptides Shown to Reduce Cancer Severity in Mesothelioma | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

PIAS3 levels, which brought down STAT3 activity and caused mesothelioma cells to die. Their study served as proof of principle about the effectiveness of these two compounds in treating malignant mesothelioma, a first step in moving a treatment toward clinical trials.


Via Graham Player Ph.D.
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Graham Player Ph.D.'s curator insight, September 19, 2014 1:42 PM

The culprit in sparking many cancers, particularly mesothelioma, is the intracellular protein and transcription factor STAT3 (signal transducer and activator of transcription 3). A signal transducer and activator is a pathway for instructing the growth and survival of cells, and a transcription factor is a protein that controls genetic information directing cells how to perform. STAT3 is notorious for sending signals to trigger the onset of human cancers and to fuel their continued growth.

The great neutralizer of STAT3 is PIAS3 (protein inhibitor of activated STAT3). PIAS3 possesses the strength to inhibit and block STAT3's ability to cause cancer. Scientists from Case Western Reserve University and the Georg-Speyer-Haus in Frankfurt, Germany, demonstrated that application of curcumin, a derivative of the spice turmeric, and cancer-inhibiting peptides increase PIAS3 levels, which brought down STAT3 activity and caused mesothelioma cells to die.

Their study served as proof of principle about the effectiveness of these two compounds in treating malignant mesothelioma, a first step in moving a treatment toward clinical trials.

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Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53

Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53 | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Resveratrol and clofarabine enhances a strong cytotoxicity with increased p53 activity.

Combination treatment of resveratrol and clofarabine enhances p53 transactivation.

The combined effect of resveratrol and clofarabine on apoptosis is synergistic.

Resveratrol could be useful to increase the efficacy of existing chemotherapy in the treatment of MM.

Pasquale Valente's insight:

"results demonstrate that resveratrol and clofarabine synergistically elicit apoptotic signal via a p53-dependent pathway, and provide a scientific rationale for clinical evaluation of resveratrol as a promising chemopotentiator in MM."

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