Vitae Herbae (her...
Follow
Find tag "glutathione"
2.7K views | +2 today
Vitae Herbae (herbal, natural, integrative medicine  & health)
web-based scientific information on natural medicine
Your new post is loading...
Your new post is loading...
Rescooped by Pasquale Valente from Salus (Health)
Scoop.it!

Hepatoprotective effect of silymarin

Hepatoprotective effect of silymarin | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such asSilybum marianum, Phyllanthus niruri, and Panus giganteus (Berk.) have been shown to ameliorate hepatic lesions. Silymarin is a natural compound derived from the species Silybum marianum, which is commonly known as Milk thistle. This plant contains at least seven flavoligands and the flavonoid taxifolin. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol, acetaminophen, and carbon tetrachloride. The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation. Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver. It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity. A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls.

more...
No comment yet.
Scooped by Pasquale Valente
Scoop.it!

Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome. [Nutr Res. 2013] - PubMed - NCBI

Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome. [Nutr Res. 2013] - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

Green tea, a popular polyphenol-containing beverage, has been shown to alleviate clinical features of the metabolic syndrome. However, its effects in endogenous antioxidant biomarkers are not clearly understood. Thus, we tested the hypothesis that green tea supplementation will upregulate antioxidant parameters (enzymatic and nonenzymatic) in adults with the metabolic syndrome. Thirty-five obese participants with the metabolic syndrome were randomly assigned to receive one of the following for 8 weeks: green tea (4 cups per day), control (4 cups water per day), or green tea extract (2 capsules and 4 cups water per day). Blood samples and dietary information were collected at baseline (0 week) and 8 weeks of the study. Circulating carotenoids (α-carotene, β-carotene, lycopene) and tocopherols (α-tocopherol, γ-tocopherol) and trace elements were measured using high-performance liquid chromatography and inductively coupled plasma mass spectroscopy, respectively. Serum antioxidant enzymes (glutathione peroxidase, glutathione, catalase) and plasma antioxidant capacity were measured spectrophotometrically. Green tea beverage and green tea extract significantly increased plasma antioxidant capacity (1.5 to 2.3 μmol/L and 1.2 to 2.5 μmol/L, respectively; P < .05) and whole blood glutathione (1783 to 2395 μg/g hemoglobin and 1905 to 2751 μg/g hemoglobin, respectively; P < .05) vs controls at 8 weeks. No effects were noted in serum levels of carotenoids and tocopherols and glutathione peroxidase and catalase activities. Green tea extract significantly reduced plasma iron vs baseline (128 to 92 μg/dL, P < .02), whereas copper, zinc, and selenium were not affected. These results support the hypothesis that green tea may provide antioxidant protection in the metabolic syndrome.

Copyright © 2013 Elsevier Inc. All rights reserved.

Pasquale Valente's insight:

Green tea beverage and green tea extract significantly increased plasma antioxidant capacity and whole blood glutathione. Green tea extract significantly reduced plasma iron vs baseline.

more...
No comment yet.