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Sea cucumber extract kills 95 percent of breast cancer cells and shrinks lung tumors in vitro

Sea cucumber extract kills 95 percent of breast cancer cells and shrinks lung tumors in vitro | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Sea cucumber extract kills 95 percent of breast cancer cells and shrinks lung tumors

Via Ingrid Long, Pasquale Valente
Pasquale Valente's insight:

Frondoside A enhanced the inhibition of lung tumor growth induced by the chemotherapeutic agent cisplatin.

http://www.ncbi.nlm.nih.gov/pubmed/23308143

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Pasquale Valente's curator insight, December 3, 2013 11:38 AM

"Frondoside A enhanced the inhibition of lung tumor growth induced by the chemotherapeutic agent cisplatin. "

Page Administrator's curator insight, December 19, 2013 6:06 PM

Excellent!

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Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells

Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Total Astragalus saponins inhibited human gastric cancer cell growth, decreased the invasion ability and induced the apoptosis. This suggested the possibility of further developing Astragalus as an alternative treatment option, or perhaps using it as adjuvant chemotherapeutic agent in gastric cancer therapy

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Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer. [Mol Med Rep. 2013] - PubMed - NCBI

Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer. [Mol Med Rep. 2013] - PubMed - NCBI | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

Abstract

Cinnamaldehyde is an active monomer isolated from the stem bark of Cinnamomum cassia, a traditional oriental medicinal herb, which is known to possess marked antitumor effects in vitro and in vivo. The aim of the present study was to examine the potential advantages of using cinnamaldehyde in combination with chemotherapeutic agents commonly used in colorectal carcinoma (CRC) therapy, as well as to investigate the effect of cinnamaldehyde on chemotherapeutic-associated gene expression. The synergistic interaction of cinnamaldehyde and chemotherapeutic agents on human CRC HT-29 and LoVo cells was evaluated using the combination index (CI) method. The double staining with Annexin V conjugated to fluorescein-isothiocyanate and phosphatidylserine was employed for apoptosis detection. The expression of drug-metabolizing genes, including excision repair cross‑complementing 1 (ERCC1), orotate phosphoribosyltransferase (OPRT), thymidylate synthase (TS), breast cancer susceptibility gene 1 (BRCA1) and topoisomerase 1 (TOPO1), all in HT-29 and LoVo cells, with or without the addition of cinnamaldehyde, was examined by quantitative polymerase chain reaction (PCR). Cinnamaldehyde had a synergistic effect on the chemotherapeutic agents cytotoxicity in HT-29 and LoVo cells. In addition, cinnamaldehyde suppressed BRCA1, TOPO1, ERCC1 and TS mRNA expression, except for OPRT expression, which was markedly upregulated. Our findings indicate that cinnamaldehyde appears to be a promising candidate as an adjuvant in combination therapy with 5-fluorouracil (5-FU) and oxaliplatin (OXA), two chemotherapeutic agents used in CRC treatment. The possible mechanisms of its action may involve the regulation of drug‑metabolizing genes.

Pasquale Valente's insight:

"Cinnamaldehyde had a synergistic effect on the chemotherapeutic agents cytotoxicity in HT-29 and LoVo cells. In addition, cinnamaldehyde suppressed BRCA1, TOPO1, ERCC1 and TS mRNA expression, except for OPRT expression, which was markedly upregulated. "

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