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Molecular mechanisms of curcumin action: Gene expression - Shishodia - 2012 - BioFactors - Wiley Online Library

Molecular mechanisms of curcumin action: Gene expression - Shishodia - 2012 - BioFactors - Wiley Online Library | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

The preventive and therapeutic properties of curcumin are associated with its antioxidant, anti-inflammatory, and anticancer properties...


Curcumin regulates the expression of inflammatory cytokines (e.g., TNF, IL-1), growth factors (e.g., VEGF, EGF, FGF), growth factor receptors (e.g., EGFR, HER-2, AR), enzymes (e.g., COX-2, LOX, MMP9, MAPK, mTOR, Akt), adhesion molecules (e.g., ELAM-1, ICAM-1, VCAM-1), apoptosis related proteins (e.g., Bcl-2, caspases, DR, Fas), and cell cycle proteins (e.g., cyclin D1). Curcumin modulates the activity of several transcription factors (e.g., NF-κB, AP-1, STAT) and their signaling pathways.

Pasquale Valente's insight:

"curcumin has the potential for the prevention and treatment of various diseases including cancers, arthritis, allergies, atherosclerosis, aging, neurodegenerative disease, hepatic disorders, obesity, diabetes, psoriasis, and autoimmune diseases. This review summarizes the molecular mechanisms of modulation of gene expression by curcumin."

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Rescooped by Pasquale Valente from Alternative Health Trends
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Turmeric improves skin health, protects from UVB radiation damage and aging, concludes Japanese study

Turmeric improves skin health, protects from UVB radiation damage and aging, concludes Japanese study | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
Turmeric improves skin health, protects from UVB radiation damage and aging, concludes Japanese study

Via Ingrid Long
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Antioxidants, Mitochondrial Damage, and Human Aging - Life Extension

Antioxidants, Mitochondrial Damage, and Human Aging - Life Extension | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

By Edward R. Rosick, DO, MPH, MS


"Throughout history, scientists have sought strategies for warding off the seemingly inevitable processes of aging and death.In recent decades, the free radical theory of aging has shed light on the degenerative changes that occur as people grow older.This theory holds that the body produces reactive, unstable agents known as free radicals during normal metabolism and following exposure to ultraviolet light or environmental toxins. While natural antidotes to these free radicals—internally produced antioxidants—are abundant in youth, their levels decline with age." 

Pasquale Valente's insight:

Numerous antioxidants—lipoic acid, green tea polyphenols, lycopene, and vitamins A, C, and E—have been associated with protection against many afflictions that commonly accompany aging.

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Lung Cancer Is Associated With “Aged” Immune Cells

Lung Cancer Is Associated With “Aged” Immune Cells | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it

As cells age, they eventually stop multiplying, a state known as “senescence”. Accumulation of senescent cells is thought to contribute to the symptoms of aging. A study examining T cells, a type of immune cell, found that lung cancer patients had more senescent T cells, much like healthy patients during aging. T cells from both aged individuals and lung cancer patients had increased levels of senescence-promoting proteins, and lower levels of proteins that promote continued cell multiplication. This “artificial aging” of immune cells may weaken the immune system’s ability to attack the cancer. The study’s authors suggest that treatments to ward off senescence in immune cells may in the future help avoid the weakening of the immune system seen in cancer and other aging-related diseases.


Via Cancer Commons
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Cancer Commons's curator insight, November 20, 2013 12:30 AM

Journal of Clinical Investigation | Nov 15, 2013

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Lifestyle Changes Can Impact Gene Structure Tied to Aging - Psych Central News

Lifestyle Changes Can Impact Gene Structure Tied to Aging - Psych Central News | Vitae Herbae (herbal, natural, integrative medicine  & health) | Scoop.it
A test developed by Foundation Medicine Inc. analyzes tumor DNA to help find targeted treatment options for patients with cancer (credit: Foundation
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