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Molecular Details of How Bacteria Propagate Antibiotic Resistance ...

Molecular Details of How Bacteria Propagate Antibiotic Resistance ... | Viruses and drug resistance | Scoop.it
Before the plasmid gene for drug resistance can be passed, it must be processed for the transfer. This occurs when a protein called the Nicking Enzyme of Staphylococci, or NES, binds with its active area, known as the ...
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Viruses and drug resistance
news on the management of different viral diseases and host pathogen interactions
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Gilead (GILD) | AbbVie (ABBV) | Breaking Down The HCV Pricing Battle | CNA Finance

Gilead (GILD) | AbbVie (ABBV) | Breaking Down The HCV Pricing Battle | CNA Finance | Viruses and drug resistance | Scoop.it
Gilead Sciences, Inc. (NASDAQ: GILD) AbbVie Inc (NYSE: ABBV) Before I get into the details, this article was written as a request from Ward Agular
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Learning From Ebola - Intellectual Property Watch

Learning From Ebola - Intellectual Property Watch | Viruses and drug resistance | Scoop.it
In 1976, Yambuku village school headmaster Mabalo Lokela felt sick when he returned from a trip to northern Zaire near the Central African Republic border. He had a high fever, diarrhea, and bleed...
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HIV Drug Resistance Testing Technology has Critical Global Implications

HIV Drug Resistance Testing Technology has Critical Global Implications | Viruses and drug resistance | Scoop.it
Boston-based Startup and Winner of Verizon’s Powerful Answers Award is Taking the Disease Head-on
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HIV Strains Traced to Gorillas, Newsday - BBC World Service

HIV Strains Traced to Gorillas, Newsday - BBC World Service | Viruses and drug resistance | Scoop.it
Half of HIV strains are now thought to have originated in gorillas
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Fake Cures For AIDS Have A Long And Dreadful History - NPR (blog)

Fake Cures For AIDS Have A Long And Dreadful History - NPR (blog) | Viruses and drug resistance | Scoop.it
Fake Cures For AIDS Have A Long And Dreadful History NPR (blog) "The biggest disaster imposed on us was Duesberg with his statements that HIV did not cause AIDS," says Max Essex, chairman of the Harvard School of Public Health AIDS Initiative.
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Five promising steps forward in HIV science - The Conversation

Five promising steps forward in HIV science - The Conversation | Viruses and drug resistance | Scoop.it
Five promising steps forward in HIV science
The Conversation
The field of HIV treatment and prevention has been freshly energised by the findings from several recent clinical trials.
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HIV relapses in Miss. girl who was medical first - Jackson Clarion Ledger

HIV relapses in Miss. girl who was medical first - Jackson Clarion Ledger | Viruses and drug resistance | Scoop.it
HIV relapses in Miss. girl who was medical first Jackson Clarion Ledger The Mississippi child hailed last year as the world's first person cured of HIV saw the immunodeficiency virus return this month, shattering researchers' hopes for a cure and...
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Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction: Cell

Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction: Cell | Viruses and drug resistance | Scoop.it

A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic insights into virus-host interaction. We developed a proteomic technique called “quantitative temporal viromics” (QTV), which employs multiplexed tandem-mass-tag-based mass spectrometry. Human cytomegalovirus (HCMV) is not only an important pathogen but a paradigm of viral immune evasion. QTV detailed how HCMV orchestrates the expression of >8,000 cellular proteins, including 1,200 cell-surface proteins to manipulate signaling pathways and counterintrinsic, innate, and adaptive immune defenses. QTV predicted natural killer and T cell ligands, as well as 29 viral proteins present at the cell surface, potential therapeutic targets. Temporal profiles of >80% of HCMV canonical genes and 14 noncanonical HCMV open reading frames were defined. QTV is a powerful method that can yield important insights into viral infection and is applicable to any virus with a robust in vitro model.


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Rakesh Yashroy's curator insight, July 3, 2014 4:38 PM

As such, host-pathogen signaling is fast becoming the field of immense interest @ https://en.wikipedia.org/wiki/Membrane_vesicle_trafficking

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SimFlu: A simulation tool for predicting the variation pattern of influenza A virus.

SimFlu: A simulation tool for predicting the variation pattern of influenza A virus. | Viruses and drug resistance | Scoop.it

Since the first pandemic outbreak of avian influenza A virus (H5N1 subtype) in 1997, the National Center for Biotechnology Information (NCBI) has provided a large number of influenza virus sequences with well-organized annotations. Using the time-series sequences of influenza A viruses, we developed a simulation tool for influenza virus, named SimFlu, to predict possible future variants of influenza viruses. SimFlu can create variants from a seed nucleotide sequence of influenza A virus using the codon variation parameters included in the SimFlu package. The SimFlu library provides pre-calculated codon variation parameters for the H1N1, H3N2, and H5N1 subtypes of influenza A virus isolated from 2000 to 2011, allowing the users to simulate their own nucleotide sequences by selecting their preferred parameter options. SimFlu supports three operating systems - Windows, Linux, and Mac OS X. SimFlu is publicly available at http://lcbb.snu.ac.kr/simflu.


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Ask Dr. K: Antibiotic resistance big problem - The Spokesman Review

Ask Dr. K: Antibiotic resistance big problem - The Spokesman Review | Viruses and drug resistance | Scoop.it
Ask Dr. K: Antibiotic resistance big problem
The Spokesman Review
DEAR DOCTOR K: I've been hearing a lot about “antibiotic resistance.” What does it mean?
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Bioafrica.net - News Section, printed & online media on HIV & TB drug resistance, treatment, community engagement and bioinformatics in Africa - SATuRN and BioAfrica

Bioafrica.net - News Section, printed & online media on HIV & TB drug resistance, treatment, community engagement and bioinformatics in Africa - SATuRN and BioAfrica | Viruses and drug resistance | Scoop.it
Here we provide you with news articles, blogs and tweets on the key aspects of our bioinformatics and drug resistance work
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Standards for Sequencing Viral Genomes in the Era of High-Throughput Sequencing

Standards for Sequencing Viral Genomes in the Era of High-Throughput Sequencing | Viruses and drug resistance | Scoop.it

Thanks to high-throughput sequencing technologies, genome sequencing has become a common component in nearly all aspects of viral research; thus, we are experiencing an explosion in both the number of available genome sequences and the number of institutions producing such data. However, there are currently no common standards used to convey the quality, and therefore utility, of these various genome sequences. Here, we propose five “standard” categories that encompass all stages of viral genome finishing, and we define them using simple criteria that are agnostic to the technology used for sequencing.


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Self-Assembling Nanoparticles Sneak Antisense RNA Into Cells - The Biological SCENE

Self-Assembling Nanoparticles Sneak Antisense RNA Into Cells - The Biological SCENE | Viruses and drug resistance | Scoop.it
Self-Assembling Nanoparticles Sneak Antisense RNA Into Cells The Biological SCENE A transmission electron microscope image (TEM) shows spherical nanoparticles that deliver antisense RNA into cells.
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The 25 U.S. Cities With the Highest Rates of HIV Infection

The 25 U.S. Cities With the Highest Rates of HIV Infection | Viruses and drug resistance | Scoop.it
In its 2013 HIV Surveillance Report, the Centers for Disease Control released a collection of data from state and local health departments that tracked the rate of new HIV infections across the countr...
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CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba - EBioMedicine

Health Ministry issues warning on new #HIV strain #CRF19. Read full OA article @EBioMedicine http://t.co/kAbwnR2Fez http://t.co/TqMMdneNb1
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Genome Editing Keeps HIV at Bay Long Term - Medscape

Genome Editing Keeps HIV at Bay Long Term
Medscape
LA JOLLA, California — Geneticists have been able to modify the immune system to confer resistance to HIV infection.
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Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction: Cell

Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction: Cell | Viruses and drug resistance | Scoop.it

A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic insights into virus-host interaction. We developed a proteomic technique called “quantitative temporal viromics” (QTV), which employs multiplexed tandem-mass-tag-based mass spectrometry. Human cytomegalovirus (HCMV) is not only an important pathogen but a paradigm of viral immune evasion. QTV detailed how HCMV orchestrates the expression of >8,000 cellular proteins, including 1,200 cell-surface proteins to manipulate signaling pathways and counterintrinsic, innate, and adaptive immune defenses. QTV predicted natural killer and T cell ligands, as well as 29 viral proteins present at the cell surface, potential therapeutic targets. Temporal profiles of >80% of HCMV canonical genes and 14 noncanonical HCMV open reading frames were defined. QTV is a powerful method that can yield important insights into viral infection and is applicable to any virus with a robust in vitro model.


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ComplexInsight's curator insight, June 10, 2014 2:41 AM

Understanding protein change during virus-host interaction offers opportunities for new diagnostics, treatments and clear understanding of how specific viruses interact and manipulate signalling pathways and immune defenses. QTV offers a lot of promise for researchers and practitioners.

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From HIV to Ebola: How to protect health workers in West Africa - Devex

From HIV to Ebola: How to protect health workers in West Africa - Devex | Viruses and drug resistance | Scoop.it
Awoko From HIV to Ebola: How to protect health workers in West Africa Devex EDITOR'S NOTE: What can we learn from the global response to HIV and AIDS that can be applied now to aid workers dealing with the Ebola outbreak in West Africa?
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HIV infection returns in Mississippi girl thought cured - USA TODAY

HIV infection returns in Mississippi girl thought cured - USA TODAY | Viruses and drug resistance | Scoop.it
USA TODAY
HIV infection returns in Mississippi girl thought cured
USA TODAY
Disappointed federal officials Thursday announced that a nearly 4-year-old Mississippi girl, thought to have been cured of HIV, now has detectable levels of the virus.
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Five promising steps forward in HIV science - New Zealand Herald

Five promising steps forward in HIV science - New Zealand Herald | Viruses and drug resistance | Scoop.it
Five promising steps forward in HIV science New Zealand Herald Maintaining the momentum of scientific discoveries and breakthroughs is critical to preventing further HIV infections, improving care for the 35 million people living with HIV and...
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▶ Ebola virus explained in 60 seconds (video)

Here's our 60 look at why Ebola is so deadly. The World Health Organization (WHO) has called for "drastic action" to contain an Ebola outbreak in West Africa that has killed nearly 500 people. 
It is the world's largest outbreak in terms of cases, deaths and geographical spread.


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Fighting back against 'intelligent' drug-resistant bacteria - euronews

Fighting back against 'intelligent' drug-resistant bacteria - euronews | Viruses and drug resistance | Scoop.it
euronews
Fighting back against 'intelligent' drug-resistant bacteria
euronews
Of all places, hospitals are a prolific source of drug-resistant strains of bacteria.
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ATCC, CDC, Thermo Fisher Partner to Bring HIV Drug Resistance Assay to ... - GenomeWeb

ATCC, CDC, Thermo Fisher Partner to Bring HIV Drug Resistance Assay to ... - GenomeWeb | Viruses and drug resistance | Scoop.it
ATCC, CDC, Thermo Fisher Partner to Bring HIV Drug Resistance Assay to ...
GenomeWeb
In this archived webinar, recorded Feb. 19, 2014, two speakers outline applications of Rubicon Genomics' PicoPLEX DNA-seq single cell library preparation kit.
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£10m fund established to boost fight against antibiotic resistance - The Guardian

£10m fund established to boost fight against antibiotic resistance - The Guardian | Viruses and drug resistance | Scoop.it
The Guardian £10m fund established to boost fight against antibiotic resistance The Guardian The fight against antibiotic resistance will be the focus of a £10m fund, it has been announced.
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Zambia: cases and investigations

Zambia: cases and investigations | Viruses and drug resistance | Scoop.it
Unexpected infections in children. 1991-93: In 1991-93, WHO’s Global Programme on AIDS arranged for hospitals to test children aged 6-59 months (1/2 to 5 years old) admitted to pediatric care and t...
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