Virology News
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Virology News
Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
Curated by Ed Rybicki
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Natural History of Human Papilloma Virus Infection of the Cervix

Natural History of Human Papilloma Virus Infection of the Cervix | Virology News | Scoop.it

Persistent HPV infection with an oncogenic strain of high-risk HPV is a necessary risk factor for the development of invasive cervical cancer. The improved understanding of the cytopathic effects of HPV led to the development of novel diagnostic and preventative tools. HPV manages to evade the immune response of the host. Oncogenic HPV infection does not progress to cancer in all infected individuals and certain variables make individuals more susceptible to the development of pre-malignant and malignant disease. The alpha HPV types are divided into high- and low-risk types according to their ability to cause malignant disease. HPV is mostly transmitted by mucosal contact and infects basal keratinocytes, most likely at a site of micro-trauma that exposes the basal layer to virus. The ability of low-risk HPV to disrupt cell proliferation is limited. In high-risk HPV infections, E6 and E7 are expressed early and strongly leading to accumulation of genetic changes that progress to cancer. The specific HPV type is the strongest factor associated with persistence and oncogenic potential. The concept of latency and reactivation may explain the re-emergence of HPV DNA detection many years after exposure. After a period of latency, reactivation of detectable HPV may follow immune suppression or hormonal changes.

 
 
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Edited by our own Lyn Denny!

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Deadly bornavirus discovered in Scandinavian geese

Deadly bornavirus discovered in Scandinavian geese | Virology News | Scoop.it
A virus that plagues wild geese in North America has now been detected in Scandinavia.
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We’re zeroing in on the poliovirus

We’re zeroing in on the poliovirus | Virology News | Scoop.it
More proof we’re closer than ever to ending polio – we’ve likely eliminated 2 of 3 strains of the virus. https://t.co/APDGRZot1R
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Elizabeth Taylor Ran a Secret Network to Get Drugs to HIV Patients

Elizabeth Taylor Ran a Secret Network to Get Drugs to HIV Patients | Virology News | Scoop.it
Out of her home in Bel-Air.
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Brazil Links Fast-Spreading Zika Virus to Birth Defects

Brazil has linked the fast-spreading, dengue-like Zika virus to a birth defect called microcephaly, where babies are born with small heads, according to the ...
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Unprotected sex more common among young gay, bi men with detectable HIV

Unprotected sex more common among young gay, bi men with detectable HIV | Virology News | Scoop.it
New strategies to reduce risky sexual behaviors among young gay and bisexual men with human immunodeficiency virus may be needed to reduce new infections, according to a new study.
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World’s fastest DNA motor doesn’t walk. It rolls

World’s fastest DNA motor doesn’t walk. It rolls | Virology News | Scoop.it
A new rolling DNA-based motor is 1,000 times faster than its competitors, which typically use legs to walk. “Unlike other Read More…
The post World’s fastest DNA motor doesn’t walk. It rolls appeared first on Futurity.
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Progress, challenges in tackling pediatric HIV/AIDS

December 7, 2015 — Since the first World AIDS Day in 1988, the first day in December has been a day to remember those who have died in the epidemic and to acknowledge progress made in treatme…
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Production of H5N1 M2e Protein Bodies as a Candidate Universal Influenza Vaccine

The spread of influenza A viruses is partially controlled and prevented by vaccination. The matrix protein 2 ectodomain (M2e) is the most conserved sequence in influenza A viruses, and is therefore a good potential target for a vaccine to protect against multiple virus subtypes. We explored the feasibility of a M2e-based universal influenza A vaccine candidate based on the highly pathogenic avian influenza A virus, H5N1. A synthetic M2e gene was human and plant codon optimised and fused in-frame with a sequence encoding the N-terminal proline-rich domain (Zera®) of the γ-zein protein of maize. Zera®M2e was expressed transiently in Nicotiana benthamiana and Sf21 baculovirus / insect cell expression systems, and Zera®M2e protein bodies (PBs) were successfully produced in both expression systems. The plant-produced Zera®M2e PBs were purified and injected into Balb/c mice. Western blot analysis using insect cell-produced Zera®M2e PBs and multiple tandem M2e sequences (5xM2e) fused with the avian influenza H5N1 transmembrane and cytosolic tail (5xM2e_tHA) confirmed the presence of M2e-specific antibodies in immunised mice sera. The immunogenicity of the Zera®M2e indicates that our plant-produced protein has potential as an inexpensive universal influenza A vaccine.
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Final version B-)

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HIV myths debunked by the experts

HIV myths debunked by the experts | Virology News | Scoop.it
HIV has killed around 39 million people to date, but making it more dangerous are the myths, misunderstandings and stigmas that surround it.
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Cuba to expand clinical trial of its lung cancer vaccine across the country

Cuba to expand clinical trial of its lung cancer vaccine across the country | Virology News | Scoop.it
Cuba will expand the use of its therapeutic vaccine for lung cancer to municipal clinics across the country as part of a new clinical trial that is already under way in some areas, official media reported Wednesday.
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HIV Rate Second Highest In The Greater Accra Region

HIV Rate Second Highest In The Greater Accra Region | Virology News | Scoop.it
For those who thought it was over, think again. HIV is very much alive and Accra comes second in the prevalence rate in Ghana. The Greater Accra region acc
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HPV vaccination not linked with risky sexual behavior among teenage girls

HPV vaccination not linked with risky sexual behavior among teenage girls | Virology News | Scoop.it
Opposing concerns over increased promiscuity following HPV vaccination, a new large study published in CMAJ finds that the introduction of the routine HPV vaccination has not affected the sexual behavior of teenage girls.
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Canine Circovirus Warning

In this short presentation, Dr. Cynda Crawford, DVM, PhD and Clinical Assistant Professor for the Maddie's® Shelter Medicine Program at the University of . C...
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Health Minister suspends Ebola vaccine trial [in Ghana]

Health Minister suspends Ebola vaccine trial [in Ghana] | Virology News | Scoop.it
The Minister of Health, Alex Segbefia, has directed that the Ebola vaccination trial to be held in the Volta Region be suspended.
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HIV-Positive Moms And HIV-Free Kids Show What AIDS-Free Generation Looks Like

HIV-Positive Moms And HIV-Free Kids Show What AIDS-Free Generation Looks Like | Virology News | Scoop.it
17 countries may have eliminated mother-to-child transmission.
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HPV Changing the Face of Cancer

Call it the changing face of cancer, HPV now drives upwards of 70% of cancers of the throat, tongue and tonsils. For years the top instigator was tobacco.
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Biotech Foods are Safe. You have a problem with that??

Biotech Foods are Safe. You have a problem with that?? | Virology News | Scoop.it
Biotech foods ('GMOs') are safe. Period. That may seem like a bold statement, but it comes with the weight of a huge body of research and global consensus among preeminent health organizations.
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A new approach to predict evolution of influenza viruses can enhance vaccine efficacy

A new approach to predict evolution of influenza viruses can enhance vaccine efficacy | Virology News | Scoop.it
New results from a study performed at the University of Helsinki suggest that genomic information from circulating influenza viruses can help in producing more efficient seasonal vaccines.
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This FDA-approved drug might prevent Ebola

This FDA-approved drug might prevent Ebola | Virology News | Scoop.it
The recent Ebola outbreak in West Africa has claimed more than 11,300 lives—a stark reminder of the lack of effective Read More…
The post This FDA-approved drug might prevent Ebola appeared first on Futurity.
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Formation of Potato Virus A-Induced RNA Granules and Viral Translation Are Interrelated Processes Required for Optimal Virus Accumulation

Formation of Potato Virus A-Induced RNA Granules and Viral Translation Are Interrelated Processes Required for Optimal Virus Accumulation | Virology News | Scoop.it
Author Summary Cytoplasmic RNA granules play a central role in mRNA metabolism both in animal and plant cells.
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Scientists Grow Norovirus In A Dish

Scientists Grow Norovirus In A Dish | Virology News | Scoop.it

Scientists have long known that noroviruses need a particular kind of carbohydrate to infect cells.

“What we’ve shown is that noroviruses attach to that carbohydrate expressed on commensal bacteria, and that this interaction stimulates viral infection of the B cell,” Karst says.

“This is a really exciting, emerging theme. A variety of intestinal viruses seem to exploit the bacteria that are present in our intestines all the time. These viral infections are enhanced by the presence of bacteria in the gut.

Ultimately, this system should open up new avenues for norovirus vaccine and antiviral drug development.”

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PrEP: Can it end the AIDS epidemic?

PrEP: Can it end the AIDS epidemic? | Virology News | Scoop.it
Truvada, known as PrEP, has proven effective in preventing HIV infection if taken as prescribed by a doctor. But some say it will erode "condom culture."
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China has vaccine against HFMD virus

China has vaccine against HFMD virus | Virology News | Scoop.it
China's food and drug watchdog approved the production of a vaccine Thursday that can effectively curb the hand-foot-and-mouth disease (HFMD).
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Japan bans French foie gras imports over bird flu virus

Japan bans French foie gras imports over bird flu virus | Virology News | Scoop.it
Japan, the largest importer of French foie gras, bans poultry imports after bird flu outbreak
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Just ban it because it's nasty, rather!

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