Historically, this blog has focused on “news you can use,” but in the spirit of two-way communication, for this post I thought I would try something that might generate more discussion. I’m sharing my thoughts on an issue I’ve been contemplating a lot: the hazards of overly hypothesis-driven science.
When I was a member of one study section, I often saw grant applications that began, “The overarching hypothesis of this application is….” Frequently, these applications were from junior investigators who, I suspect, had been counseled that what study sections want is hypothesis-driven science. In fact, one can even find this advice in articles about grantsmanship .
Despite these beliefs about “what study sections want,” such applications often received unfavorable reviews because the panel felt that if the “overarching hypothesis” turned out to be wrong, the only thing that would be learned is that the hypothesis was wrong. Knowing how a biological system doesn’t work is certainly useful, but most basic research study sections expect that a grant will tell us more about how biological systems do work, regardless of the outcomes of the proposed experiments. Rather than praising these applications for being hypothesis-driven, the study section often criticized them for being overly hypothesis-driven.