Munich, January 31, 2014 - Icon Genetics GmbH (ICON) successfully completed a Phase I clinical study on the safety and immunogenicity of personalized vaccines to treat patients with follicular non-Hodgkin's lymphoma. The vaccines, which consist of monoclonal antibodies derived from each patient's own tumor and serve as disease-specific markers, were administered to induce a tumor-specific immune reaction. The vaccines were manufactured in tobacco plants using magnICON® technology in the facility owned and operated by ICON in Halle, Germany. Results of the 27-patient study demonstrated the safety, tolerability and tumor-specific immunogenicity of the plant-made vaccines. Cancer patients receiving ICON's vaccines did not exhibit the types of side effects that are typically associated with more traditional approaches for cancer treatment. Thus, these vaccines have the potential of offering patients improved quality of life throughout their therapeutic regimen. While not designed to assess efficacy, the study evaluated immune responses to vaccination. Of the patients evaluated at study completion, 73% were found to have mounted a tumor-specific immune response. The Phase I trial was sponsored by Bayer Innovation GmbH and conducted under US FDA IND at 3 clinical centers in the United States, with primary treatment at the University of Texas Southwestern Medical Center and Baylor Medical Center, both in Dallas, Texas, with local coordination and oversight provided by DAVA Oncology, LP.