After 10 years virus hunting, Ge et al. are now able to fill in important missing links associated with SARS origin and epidemic (Fig. 1). Firstly, they identified two novel SL-CoV stains RsSHC014 and RS3367 in Chinese horseshoe bats, which show higher sequence similarity (~95% identity) with human SARS-CoV than observed previously (Lau S K, et al, 2005; Li F, 2013; Ren W, et al, 2006; Tong S, et al, 2009). Particularly, their RBDs are more closely related to (85% aa identity for RsSHC014 and 96% for RS3367)SARS-CoV RBD, with perfect sequence alignment and absence of any deletion or insertion. Secondly, theyreported the first isolation of a live bat SL-CoV strain (SL-CoV-WIV1) with Vero E6 cells. This isolate is almost identical to its parental virus Rs3367, with 99% nt identity and 100% aa identity even in the highly variable S1 region. Thirdly, by using this valuable isolate WIV1, Ge et al. demonstrated for the first time that a bat SL-CoV strain can exploit human-, civet- and bat-derived ACE2 as its cellular entry receptors and replicated efficiently in HeLa cells which express these receptors. They further assessed the host ranges of WIV1 with a variety of cell lines and found that cells from different species (human, pig, and bat) are able to support the virus replication at different levels. In addition, WIV1 can be neutralized by different SARS- patient sera collected in 2003. These findings suggested a much closer relationship between bat WIV1 strain and SARS-CoV.