Novartis and Novavax have simultaneously announced some shining results from early-stage trials with their respective H7N9 vaccines.
The Novartis vaccine is a cell-culture vaccine which, when given in conjunction with MF59 adjuvant, conferred immunological protection on 85% of subjects after two doses in a 400-strong Phase I clinical trial. The cell-culture technology can significantly ramp up speed of production compared to egg-based manufacturing methods.
Novavax announced that their VLP vaccine candidate induced protective HAI levels in 81% of recipients given 5ug of the ISCOMATRIX adjuvanted-vaccine. 91% of recipients had anti-neuraminidase antibody responses. Like Novartis’ vaccine, the VLP vaccine can be rapidly manufactured, with the VLP technique reportedly able to produce 50 million doses within four months and hundreds of millions within six months.