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New Hope for HIV Vaccine - New York Times

New Hope for HIV Vaccine - New York Times | Virology News | Scoop.it

“Kafkaesque” is not a word normally used to describe immune responses, but it’s how Dr. Louis J. Picker described what his experimental vaccine did to his rhesus monkeys: “It’s like their T-cells were turned into the East German secret police, hunting down infected cells until there were none left.”

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Cytomegalovirus as a HIV vaccine vector: smart idea; take something that operates by stealth and use it to vector something else that does too - and get what looks like a unique sort of immune response that MAY just result in clearance.

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Virology News
Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
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WATCH: Egg shortage looms as bird flu spreads 

WATCH: Egg shortage looms as bird flu spreads  | Virology News | Scoop.it
As poultry farms deal with the crippling consequences of the avian influenza outbreak, consumers are warned to prepare themselves for higher prices and … source
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Chris Upton + helpers's comment, October 11, 5:52 PM
Oh... and what do they grow the flu vaccine in? Eggs!
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Retrospective study of porcine circovirus type 2 infection reveals a novel genotype PCV2f

Transbound Emerg Dis. 2017 Sep 30. doi: 10.1111/tbed.12721. [Epub ahead of print]
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HPV-related Multiphenotypic Sinonasal Carcinoma

Am J Surg Pathol. 2017 Sep 4. doi: 10.1097/PAS.0000000000000944. [Epub ahead of print]
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A novel mechanism of antibody-mediated enhancement of flavivirus infection

A novel mechanism of antibody-mediated enhancement of flavivirus infection | Virology News | Scoop.it
Author summary Antibodies are an important component of antiviral host responses and their binding to the surface of virus particles usually leads to neutralization of viral infectivity. In some instances, however, antibodies at sub-neutralizing concentrations can enhance infection of certain cells, because they facilitate the uptake of infectious virus-antibody complexes through interactions with antibody-specific cellular receptors (Fcγ receptors). This mechanism is designated antibody-dependent enhancement of infection and implicated in the pathogenesis of dengue and possibly Zika virus infections, both mosquito-transmitted flaviviruses. Here we describe a novel mechanism of infection enhancement by antibodies that is independent of interactions with Fcγ receptors, using another important human-pathogenic flavivirus, tick-borne encephalitis virus. We demonstrate that binding of a specific antibody to the envelope protein E at the viral surface promotes the exposure of a structural element that interacts with the lipids of the cellular plasma membrane, thus increasing infection. Our study provides new insights into mechanisms that potentially modulate the antiviral effects of antibody populations present in post-infection sera.
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Indian Scientists Testing Dendritic Therapy Against Cervix Cancer

Indian Scientists Testing Dendritic Therapy Against Cervix Cancer | Virology News | Scoop.it
Immunotherapy is a new approach that exploits body’s inner capability to put up a fight against cancer. Under the approach, either immune system is given a boost or the T cells are “trained’’ to identify recalcitrant cancer cells and kill them.
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Human infection with avian influenza A(H7N9) virus – China

Human infection with avian influenza A(H7N9) virus – China | Virology News | Scoop.it
On 18, 25 August and 4 September 2017, the National Health and Family Planning Commission of China (NHFPC) notified WHO of four additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus in China.Details of the case-p
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5 African countries approach control of their HIV epidemics

Data released today from the US President’s Emergency Plan for AIDS Relief (PEPFAR) show that the HIV epidemic is coming under control in Lesotho. These results add to prior PEPFAR-supported …
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HPV test beats pap smears for detecting cervical cancer, trial shows

HPV test beats pap smears for detecting cervical cancer, trial shows | Virology News | Scoop.it
HPV screening is more effective at detecting precancerous lesions than pap tests, backing a new national cervical cancer screening program.
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HIV Risk Associated With Community Level Educational Status

HIV Risk Associated With Community Level Educational Status | Virology News | Scoop.it
Link found between HIV risk and individual and community level educational status. The study were more opt to engage in transactional sex, the exchange of sex for drugs.
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There’s no vaccine yet for stupidity: anti-HPV vaccine campaigning in Ireland

There’s no vaccine yet for stupidity: anti-HPV vaccine campaigning in Ireland | Virology News | Scoop.it
The recent comments by Finian McGrath on the HPV vaccine made Dr Amy Morgan despair
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Melbourne girl, eight, dies as Australia's 'horror' flu season continues

Melbourne girl, eight, dies as Australia's 'horror' flu season continues | Virology News | Scoop.it
Victoria’s health minister urges people to get vaccinated as eastern seaboard sees slight decline in cases
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MIT creates microscopic cups to deliver vaccine doses to kids in one injection

MIT creates microscopic cups to deliver vaccine doses to kids in one injection | Virology News | Scoop.it
WASHINGTON, Sept. 18 (Xinhua) -- One single injection carrying several doses of vaccines has become true thanks to the research of the Massachusetts Institute of Technology (MIT). The MIT reported the technical breakthrough on its website of MIT news last week, telling the world their method of...
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Researchers make breakthrough in search for African Swine Fever vaccine

Researchers make breakthrough in search for African Swine Fever vaccine | Virology News | Scoop.it
Researchers in Australia and the US have uncovered genetic data they believe may contain the key to developing a vaccine for African Swine Fever
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Experiences of operational costs of HPV vaccine delivery strategies in Gavi-supported demonstration projects

Experiences of operational costs of HPV vaccine delivery strategies in Gavi-supported demonstration projects | Virology News | Scoop.it
From 2012 to 2016, Gavi, the Vaccine Alliance, provided support for countries to conduct small-scale demonstration projects for the introduction of the human papillomavirus vaccine, with the aim of determining which human papillomavirus vaccine delivery strategies might be effective and sustainable upon national scale-up. This study reports on the operational costs and cost determinants of different vaccination delivery strategies within these projects across twelve countries using a standardized micro-costing tool. The World Health Organization Cervical Cancer Prevention and Control Costing Tool was used to collect costing data, which were then aggregated and analyzed to assess the costs and cost determinants of vaccination. Across the one-year demonstration projects, the average economic and financial costs per dose amounted to US$19.98 (standard deviation ±12.5) and US$8.74 (standard deviation ±5.8), respectively. The greatest activities representing the greatest share of financial costs were social mobilization at approximately 30% (range, 6–67%) and service delivery at about 25% (range, 3–46%). Districts implemented varying combinations of school-based, facility-based, or outreach delivery strategies and experienced wide variation in vaccine coverage, drop-out rates, and service delivery costs, including transportation costs and per diems. Size of target population, number of students per school, and average length of time to reach an outreach post influenced cost per dose. Although the operational costs from demonstration projects are much higher than those of other routine vaccine immunization programs, findings from our analysis suggest that HPV vaccination operational costs will decrease substantially for national introduction. Vaccination costs may be decreased further by annual vaccination, high initial investment in social mobilization, or introducing/strengthening school health programs. Our analysis shows that drivers of cost are dependent on country and district characteristics. We therefore recommend that countries carry out detailed planning at the national and district levels to define a sustainable strategy for national HPV vaccine roll-out, in order to achieve the optimal balance between coverage and cost.
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Detection and genome sequencing of porcine circovirus 3 in neonatal pigs with congenital tremors in South China

Transbound Emerg Dis. 2017 Oct 3. doi: 10.1111/tbed.12702. [Epub ahead of print]
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Sanofi teams with researchers to develop trispecific antibodies for HIV

Sanofi teams with researchers to develop trispecific antibodies for HIV
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Exclusive: Africa to get state-of-art HIV drugs for $75 a year

Exclusive: Africa to get state-of-art HIV drugs for $75 a year | Virology News | Scoop.it
Makers of generic AIDS drugs will start churning out millions of pills for Africa containing a state-of-the-art medicine widely used in rich countries, after securing a multi-million dollar guarantee that caps prices at just $75 per patient a year.
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Leading Physician Organizations Call for Shingles Vaccine for People Over 50

Leading Physician Organizations Call for Shingles Vaccine for People Over 50 | Virology News | Scoop.it
SAN FRANCISCO, Sept. 18, 2017 /PRNewswire-USNewswire/ -- The American Academy of Ophthalmology and the American Dermatological Association recommend people age 50 and older get the shingles vaccine – 10 years younger than a previous recommendation. It is now estimated that one in three people will develop
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Damn, I really should get vaccinated...!
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Smokers with HIV far more likely to die of lung cancer

Smokers with HIV far more likely to die of lung cancer | Virology News | Scoop.it
MIAMI, United States (AFP) — People who are infected with human immunodeficiency virus an
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HPV vaccine can improve chances of conception in some women

HPV vaccine can improve chances of conception in some women | Virology News | Scoop.it
More than 40 percent of American teens are now getting vaccinated against human papillomavirus (HPV). But, despite HPV infection being associated with reduced semen quality and lower pregnancy rates, there is still public concern about whether the HPV vaccine itself could affect future fertility.
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Hep B vaccine should be given sooner: pediatricians group

Hep b vaccine should be given sooner: pediatricians group MONDAY, Aug. 28, 2017 HealthDay News The first dose of the hepatitis B vaccine should be given t
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Gavi CEO blames anti-vaccine mums for return of diseases

Mothers refusing to vaccinate children are helping to bring deadly diseases back to the West as hostility to science puts the developed world at risk
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Marijuana Exposure Associated With Improved Immunity in HIV Patients

Marijuana Exposure Associated With Improved Immunity in HIV Patients | NORML PETERSBURG, VA — Patients with HIV who test positive for pas
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Who knows? But it sounded good B-)
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Crack down on vaccine disinformation to prevent next Minnesota measles outbreak

Crack down on vaccine disinformation to prevent next Minnesota measles outbreak | Virology News | Scoop.it
Hearing needed this fall on the vaccine misinformation campaign that fueled measles outbreak.
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