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Mexican Authorities: More Than 1 Million Chickens Exposed to Bird Flu - Fox News Latino

Mexican Authorities: More Than 1 Million Chickens Exposed to Bird Flu - Fox News Latino | Virology News | Scoop.it
Latinos Post Mexican Authorities: More Than 1 Million Chickens Exposed to Bird Flu Fox News Latino The outbreak of bird flu detected in the central Mexican state of Guanajuato is confined to 12 farms that have more than 1 million chickens, the...
Ed Rybicki's insight:

Again??  Vaccines, people!!

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Virology News
Topical news snippets about viruses that affect people. And other things.
Curated by Ed Rybicki
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Is the trade in bush meat and apes responsible for spread of Ebola virus?

Is the trade in bush meat and apes responsible for spread of Ebola virus? | Virology News | Scoop.it
The vicious Ebola virus outbreak that has already killed more than 800 people this year, in addition to sowing panic, fear and confusion throughout West Africa, was not a strain endemic to the region as initially believed.
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REALLY nice article, with horrific images from bush meat markets - which illustrate just how likely the scenario is.

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Novel Vaccine for Chikungunya Virus?

Novel Vaccine for Chikungunya Virus? | Virology News | Scoop.it

While there is currently no FDA-approved vaccine to prevent the spread of the chikungunya virus, the head of viral immunity research at the Vaccine & Gene Therapy Institute of Florida (VGTI Florida®), a leading non-profit biomedical research institute, has developed a new platform vaccine technology that is expected to provide complete protection against chikungunya virus infection.

“We have developed a novel virus-like particle (VLP) vaccine that is a next-generation cell-culture technology, unique from traditional vaccines which are predominantly produced in chicken eggs,” stated Ted Ross, Ph.D., VGTI Florida’s Program Director of Vaccines & Viral Immunity. “Our VLP platform uses specific, proprietary proteins from the chikungunya virus capable of eliciting a potent, robust and enduring immune response, enabling the immune system to prevent replication of virus, and thus, prevent infection.”

 
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What Would Happen if You Got Ebola?

What Would Happen if You Got Ebola? | Virology News | Scoop.it
A secondary infection in the U.S. is highly unlikely. But here's how the healthcare system would respond if there was one.
Ed Rybicki's insight:

Goes without saying that this would happen in a lot of other places, too.  Including our very own South Africa - where it HAS happened, with Marburg, Ebola and Lujo viruses.  Written about right here on ViroBlogy.

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How can geminiviral Rep capture the cell cycle of differentiated plant cells?

How can geminiviral Rep capture the cell cycle of differentiated plant cells? | Virology News | Scoop.it

African cassava mosaic virus (ACMV) in the geminivirus family has being affected 500 million people worldwide by devastating cassava crops during the past decades. It has caused severe symptoms and reduced yield up to the complete loss of roots, the main starchy food source especially for subsistence farmers in Africa. How can a tiny virus with a small genome evoke such dramatic effects? The viral key component, the replication-initiator protein (Rep), forces differentiated plant cells in the phloem to reactivate DNA synthesis. Even more, it does the same in model cells of fission yeast. We have identified, now, a potential cyclin interaction motif, RXL, in the sequence of ACMV Rep, which may be important for cell cycle control. This motif is essential to induce rereplication in yeast and necessary for viral infection of plants.

 
Ed Rybicki's insight:

I am a sucker for geminiviruses and their replication - as can be seen in the pages published here and elsewhere over the years.  It is fascinating to me that a small protein like Rep - only ~30 kDa - can do so many things, and especially interfere in such a fundamental way with organised, differentiated cells.

What is even more interesting is that it can do it in such a wide variety of systems: it's been shown that ACMV can replicate in maize protoplasts as well as in the dicotyledonous cassava; it can evidently function well in yeast as well - and via a pathway that no-one suspected before now.

Truly, a protein of many parts!  Congratulations to Katharina Hipp and to my old friends Bruno and Holger.

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Tracing Ebola’s Breakout to an African 2-Year-Old

Tracing Ebola’s Breakout to an African 2-Year-Old | Virology News | Scoop.it
The current Ebola outbreak, the largest ever, seems likely to surpass all previous known Ebola outbreaks combined, and epidemiologists predict it will take months to control.
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ViralZone: Ebolavirus

ViralZone: Ebolavirus | Virology News | Scoop.it
A knowledge resource to understand virus diversity
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I am very remiss in not scooping this previously: a nice little "instant expert" site for just about ANY virus family.

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Ebola: an opportunity for a clinical trial?

Ebola: an opportunity for a clinical trial? | Virology News | Scoop.it

As the largest outbreak of Ebola virus has forced hitherto neglected tropical diseases on to the public agenda, debate is growing over whether affected patients should have the chance to try experimental drugs. Sophie Arie reports

 

Ebola virus graphic from Russell Kightley Media

 
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The Ebola Outbreak in West Africa: Facts, Figures and Vaccine Prospects

The Ebola Outbreak in West Africa: Facts, Figures and Vaccine Prospects | Virology News | Scoop.it
The Ebola Outbreak in West Africa: Facts, Figures and Vaccine Prospects
Ed Rybicki's insight:

Nice infographic - although ZMApp is a therapy / treatment, not a vaccine.

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New York patient 'unlikely to have Ebola,' Health Department says - Washington Post

New York patient 'unlikely to have Ebola,' Health Department says - Washington Post | Virology News | Scoop.it
CBS Local
New York patient 'unlikely to have Ebola,' Health Department says
Washington Post
A man who was tested for Ebola at New York's Mount Sinai Hospital on Monday is “unlikely” to have the virus, the city's health department said.
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Ebola Drug Made From Tobacco Plant Saves U.S. Aid Workers

Ebola Drug Made From Tobacco Plant Saves U.S. Aid Workers | Virology News | Scoop.it
A tiny San Diego-based company provided an experimental Ebola treatment for two Americans infected with the deadly virus in Liberia. The biotechnology drug, produced with tobacco plants, appears to be working.
Ed Rybicki's insight:

Haven't I been saying it for years: you gotta go green...B-)

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Has the Time Come to Test Experimental Ebola Vaccines?

Has the Time Come to Test Experimental Ebola Vaccines? | Virology News | Scoop.it
The Ebola Virus is Spreading Across West Africa in The Largest Outbreak To Date

Mortality rates are currently at 60%, where normally up to 90% of affected people die. Unfortunately, there are no cures or vaccines for the disease, despite its emergence in 1976.

In March of this year, cases of Ebola were reported for the first time in Guinea, Western Africa. Notably, these outbreaks took place in Guinean districts that bordered Sierra Leone and Liberia. In the past, outbreaks have taken place in remote areas of Africa, but this outbreak has had the opportunity to cross border and spread throughout Western Africa, and it has done just that. Now fourth months since the March outbreak, 1,093 people have been infected and there have been a reported 660 deaths attributed to the deadly virus (source: CNN vital signs.)

 

Ed Rybicki's insight:

I would say - yes!  I am sure the beleaguered healthcare workers in Guinea, Liberia, Sierra Leone and now Nigeria would welcome the experimental vaccine candidates, and the experimental therapeutics, for that matter.

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Bacterial colonization prior to catching flu may protect against severe illness

Bacterial colonization prior to catching flu may protect against severe illness | Virology News | Scoop.it

Research published in the August issue of Virologysuggests that being infected with the pneumonia-causing Streptococcus pneumoniae could actually protect you from the flu.

On 10 July 2014, Science Daily reported:

“Many studies have shown that more severe illness and even death are likely to result if you develop a secondary respiratory infection after developing influenza. Now, however, a team of researchers based at The Wistar Institute has determined that if you reverse the order of infection, the bacteria Streptococcus pneumoniae (often called pneumococcus) may actually protect against a bad case of the flu.

“The researchers discovered that the bacterial protein pneumolysin, which is described as a bacterial virulence factor, might protect macrophages -- a type of immune system cell -- in the lungs. Their findings, performed in a mouse model of influenza infection, appear in the August issue of the journal Virology.

“‘Influenza remains a major killer, and there is a preponderance of evidence, both scientific and historical, to show how secondary bacterial infections can be fatal," said Jan Erikson, Ph.D., professor at The Wistar Institute. "However, pneumococci often colonize the respiratory tract asymptomatically, particularly in children, leading us to consider how pre-colonization would impact a subsequent influenza infection.’”

Ed Rybicki's insight:

Simple blocking, one assumes?  But it means that our symbiotic relationship with our bugs just got more interesting.

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Red Cross Condemns Ebola Vaccine Claims

Red Cross Condemns Ebola Vaccine Claims | Virology News | Scoop.it
Red Cross Condemns Ebola Vaccine Claims AllAfrica.com Though the Red Cross did not identify those it says are carrying on the speculation, the clarity was however made about a day after government alarmed to the public last week that unknown...
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Ill prepared for an influenza pandemic

Ill prepared for an influenza pandemic | Virology News | Scoop.it

Over the last 500 years, there have been, on average, three severe influenza pandemics in each century. The most recent pandemic was declared in 2009. Yet despite much investment in public health and many improvements in vaccine production techniques and know-how, the availability of influenza vaccines during this event was far from adequate. Six months into the pandemic, 534 million doses were available, and after one year that number had risen to 1.3 billion — enough for only 8%and 25%, respectively, of the world population. We were lucky that the pandemic declared in 2009 turned out later to be mild and that just one shot of vaccine was sufficient to protect most people. This is not usually the case during a severe influenza pandemic.

 
Ed Rybicki's insight:

"As countries continue to pre-book pandemic supply, it is more and more likely that the limited vaccines available during the first months of any pandemic during the next few years will be sold out almost completely"

And what does everyone think happened in South Africa during most of 2009 and 2010?

Well, they probably don't - because not that many of them got sick.  But THERE WAS NO VACCINE for the general population until LATE 2010 - when the chances of another round of H1N1pdm 2009 had dissipated due to summer coming on.

And the vaccine that HAD come into the the country in 2010 got used for medical personnel, and - for the 2010 World Cup staff.

Seriously, we need to do better than this - and responding QUICKLY to news of a pandemic would be the ticket.

Using plants B-)

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Nature Outlook : Vaccines. Free!

Nature Outlook : Vaccines.  Free! | Virology News | Scoop.it

Vaccination is a triumph of preventative healthcare. But the project to erect immunological shields against deadly pathogens is far from complete — some of the most lethal diseases still lack effective vaccines. Moreover, major inequities exist in the global distribution of vaccines. Despite substantial advances in vaccine production and development, global efforts to eradicate disease through inoculation still face scientific, technological and economic hurdles.

 
Ed Rybicki's insight:

Spread the word - educate the ignorant!

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FDA Enables Potential Use of Experimental Tekmira Vaccine on Ebola Patients

FDA Enables Potential Use of Experimental Tekmira Vaccine on Ebola Patients | Virology News | Scoop.it
FDA Enables Potential Use of Experimental Tekmira Vaccine on Ebola Patients
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US emergency labs ready to work on Ebola drugs

US emergency labs ready to work on Ebola drugs | Virology News | Scoop.it
All three US facilities established to quickly make vaccines and therapeutics in the event of a major public health threat say they are standing by to support any US government effort to scale up a treatment for Ebola.
Ed Rybicki's insight:

"We are prepared to make any kind of vaccine," Giroir said, from the traditional kind grown in chicken eggs to newer varieties grown in mammalian or bacterial cells. "The whole idea is to take a process that may exist only on sticky notes at a small biotech company and scale it up as fast as possible"


Well, not ANY vaccine, obviously: why don't they just engage Medicago, or Kentucky BioProcessing or Fraunhofer USA for the plant-made stuff??

 
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Ed Rybicki's curator insight, August 12, 2:32 AM

With plants as a distant afterthought.

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TEDx Speaker Interviews: Ed Rybicki on Ebola and vaccines

TEDx Speaker Interviews: Ed Rybicki on Ebola and vaccines | Virology News | Scoop.it
Ed and Fiona discuss everything viral (as in the small infectious agent not the spreading of information on the net) from Ebola to immunising children.
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Poster: The Ebola Virus

Poster: The Ebola Virus | Virology News | Scoop.it
Poster «The Ebola Virus»

Absolutely the best detailed picture of an Ebola virus particle ever done.

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Ebola patients in west Africa to be denied experimental drugs used in US [because there are none left]

Ebola patients in west Africa to be denied experimental drugs used in US [because there are none left] | Virology News | Scoop.it
US tells Nigeria region would have to wait months for supplies because such small quantities exist, says health minister
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WHO to convene panel on use of experimental Ebola drugs

WHO to convene panel on use of experimental Ebola drugs | Virology News | Scoop.it
The organization is asking medical ethicists to advise it on the use of untested treatments during the Ebola crisis.
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Plant-made antibodies used as therapy for Ebola in humans: post-exposure prophylaxis goes green!

Plant-made antibodies used as therapy for Ebola in humans: post-exposure prophylaxis goes green! | Virology News | Scoop.it
Yes, I know you fans of ViroBlogy like Ebola - and just coincidentally, I was desperately trying to finish a review on "Plant-based vaccines against viruses" against a backdrop of an out-of-control...
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Nigerian doctor infected with Ebola as West Africa scrambles

Nigerian doctor infected with Ebola as West Africa scrambles | Virology News | Scoop.it
Doctor in Lagos treated man who died from virus after flying from Liberia, where officials are now ordering Ebola victim remains cremated
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Abundant, Widespread Virus Discovered in Human Faeces

Abundant, Widespread Virus Discovered in Human Faeces | Virology News | Scoop.it
Scientists identify a bacteriophage that is highly abundant in the gut bacteria of people around the world.
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Why Isn't There an AIDS Vaccine Yet?

Why Isn't There an AIDS Vaccine Yet? | Virology News | Scoop.it
Researchers have been working on an AIDS vaccine since the 1980s. So what's taking so long? (#30SecondsToKnow: Why isn't there an AIDS vaccine yet?
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