Pathogenic Versus Commensal Tumor Viruses Another way to look at infectious carcinogens is whether or not a tumor virus is a rare or a common human infection. Commensal viruses are common, inapparent infections that do not usually cause symptoms or disease in the host.
Author summary Post-transcriptional gene silencing (PTGS) is an elaborately regulated process for defense against virus infection in plants. To achieve effective infection, a betasatellite molecule associated with geminivirus induced high levels of an endogenous RNA silencing suppressor, calmodulin-like protein (CaM), to counter host defenses. However, although CaM is one of the first identified cellular suppressors of RNA silencing, the mechanism of PTGS suppression is still poorly understood. This study demonstrates that CaM interacts with and degrades Suppressor of Gene Silencing 3 (SGS3) in Nicotiana benthamiana. We found that domains essential for the interaction between NbSGS3 and NbCaM are also required for the subcellular localization of NbSGS3 and for NbCaM suppressor activity. Moreover, NbCaM mediated NbSGS3 protein degradation can be blocked using the autophagy inhibitors 3-methyladenine and E64d, and by knock-down of key autophagy-related genes within the phosphatidylinositol 3-kinase (PI3K) complex. Silencing of the PI3K complex also inhibited geminivirus infection, which is consistent with autophagy playing an important role in RNA silencing suppression pathway and geminivirus infection.
A web page with a fake article from a fake publication, part of the marketing of the film “A Cure for Wellness.” Since the term fake news entered the national lexicon, the advertising world has grappled with its role in inadvertently fueling the spread online of made-up stories about controversial topics. Then came 20th…
MarketResearchReports.Biz has announced addition of new report “Global Influenza Vaccine Market: Industry Analysis & Outlook (2017-2021)” to its database. Influenza, also known as flu, is a contagious disease which spreads from person to person very rapidly. When an infected person sneezes or coughs the virus spreads to those close by, affecting immuno-compromised patients the most.
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