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Child critical in Brisbane hospital with bat virus

Child critical in Brisbane hospital with bat virus | Virology News | Scoop.it

An eight-year-old boy is critically ill in a Brisbane hospital with the Australian bat lyssavirus...The child was bitten or scratched by a bat two months ago prior to becoming ill in north Queensland, then three weeks ago the child became ill.


Rabies virus graphic courtesy of Russell Kightley Media

Ed Rybicki's insight:

Interesting how the virus is "closely related" to rabies, but is called something as innocuos as "Australian bat lyssavirus".  Because of course, Australia has no rabies.

 

 

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Virology News
Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
Curated by Ed Rybicki
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Rotavirus vaccine could save lives of almost 500,000 children a year

Rotavirus vaccine could save lives of almost 500,000 children a year | Virology News | Scoop.it
Positive outcome of trials in Niger fuels hope that vaccine can protect children in sub-Saharan Africa and beyond from infection that causes often fatal diarrhoea
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Genetic characterization of novel reassortant H5N6-subtype influenza viruses isolated from cats in eastern China

Cats are susceptible to influenza A viruses and therefore may act as transmission vectors within households, posing a potential public health concern. Two novel reassortant H5N6 influenza viruses were isolated from cats in Zhejiang Province, Eastern China, in 2016. Both viruses were characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis showed that these viruses received their genes from H5N6, H9N2, and H7N9 influenza viruses isolated from China. These H5N6 viruses were able to replicate in mice without prior adaptation. Our results show that continued circulation of these viruses could endanger humans.

Ed Rybicki's insight:
Great! First birds, then bats, now cats!
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Identification and genetic characterization of a novel circular single-stranded DNA virus in a human upper respiratory tract sample

Metagenomic analysis through high-throughput sequencing is a tool for detecting both known and novel viruses. Using this technique, a novel circular single-stranded DNA (ssDNA) virus genome was discovered in respiratory secretions from a febrile traveler. The virus, named human respiratory-associated PSCV-5-like virus (HRAPLV), has a genome comprising 3,018 bases, with two major putative ORFs inversely encoding capsid (Cap) and replicase (Rep) protein and separated by two intergenic regions. One stem-loop structure was predicted in the larger intergenic region (LIR). The predicted amino acid sequences of the Cap and Rep proteins of HRAPLV showed highest identity to those of porcine stool-associated circular virus 5 isolate CP3 (PoSCV 5) (53.0% and 48.9%, respectively). The host tropism of the virus is unknown, and further study is warranted to determine whether this novel virus is associated with human disease.

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Nigeria: Adewole - Three Cases of Monkey Pox Confirmed in Bayelsa, Lagos Free of Virus

Nigeria: Adewole - Three Cases of Monkey Pox Confirmed in Bayelsa, Lagos Free of Virus | Virology News | Scoop.it
Against palpable fear over the spread of monkey pox disease in Nigeria, the Minister of Health, Prof. Isaac Adewole, has declared Lagos State free from the virus while Bayelsa State has recorded about three confirmed cases after laboratory tests.
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Human papillomavirus vaccination of adult women and [lack of] risk of autoimmune and neurological diseases

Human papillomavirus vaccination of adult women and [lack of] risk of autoimmune and neurological diseases | Virology News | Scoop.it
Since 2006, human papillomavirus (HPV) vaccines have been introduced in many countries worldwide. Whilst safety studies have been reassuring, focus has been on the primary target group, the youn
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Flu Vaccine Fake News That Goes Viral During The Flu Season

Flu Vaccine Fake News That Goes Viral During The Flu Season | Virology News | Scoop.it

Winter is almost here, which means flu season is just around the corner. It also means that anti-flu vaccine misinformation will go viral again (pun inten
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Oral HPV Affects More Men Than Women

(Reuters Health) - Roughly one in nine U.S. men have oral infections of the cancer-causing human papillomavirus (HPV), more than triple the infection rat
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Findings add to evidence of association between Zika virus and Guillain-Barre syndrome

Findings add to evidence of association between Zika virus and Guillain-Barre syndrome | Virology News | Scoop.it
An examination of cases of Guillain-Barré syndrome in Puerto Rico identified Zika virus infection as a risk factor, according to a study published by JAMA.
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1 in 9 Men Have Oral HPV

1 in 9 Men Have Oral HPV | Virology News | Scoop.it
A new report reveals that about 1 in 9 men have an oral infection of human papillomavirus (HPV) in the United States.
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WATCH: Egg shortage looms as bird flu spreads 

WATCH: Egg shortage looms as bird flu spreads  | Virology News | Scoop.it
As poultry farms deal with the crippling consequences of the avian influenza outbreak, consumers are warned to prepare themselves for higher prices and … source
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Chris Upton + helpers's comment, October 11, 5:52 PM
Oh... and what do they grow the flu vaccine in? Eggs!
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Retrospective study of porcine circovirus type 2 infection reveals a novel genotype PCV2f

Transbound Emerg Dis. 2017 Sep 30. doi: 10.1111/tbed.12721. [Epub ahead of print]
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HPV-related Multiphenotypic Sinonasal Carcinoma

Am J Surg Pathol. 2017 Sep 4. doi: 10.1097/PAS.0000000000000944. [Epub ahead of print]
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A novel mechanism of antibody-mediated enhancement of flavivirus infection

A novel mechanism of antibody-mediated enhancement of flavivirus infection | Virology News | Scoop.it
Author summary Antibodies are an important component of antiviral host responses and their binding to the surface of virus particles usually leads to neutralization of viral infectivity. In some instances, however, antibodies at sub-neutralizing concentrations can enhance infection of certain cells, because they facilitate the uptake of infectious virus-antibody complexes through interactions with antibody-specific cellular receptors (Fcγ receptors). This mechanism is designated antibody-dependent enhancement of infection and implicated in the pathogenesis of dengue and possibly Zika virus infections, both mosquito-transmitted flaviviruses. Here we describe a novel mechanism of infection enhancement by antibodies that is independent of interactions with Fcγ receptors, using another important human-pathogenic flavivirus, tick-borne encephalitis virus. We demonstrate that binding of a specific antibody to the envelope protein E at the viral surface promotes the exposure of a structural element that interacts with the lipids of the cellular plasma membrane, thus increasing infection. Our study provides new insights into mechanisms that potentially modulate the antiviral effects of antibody populations present in post-infection sera.
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Discovery of two small circular ssDNA viruses associated with the whitefly Bemisia tabaci

The complete genome sequences of two novel small circular DNA viruses isolated from sweet-potato whiteflies collected in Central-West (AdDF) and Southeast (AdO) regions of Brazil were determined by Next Generation Sequencing (NGS), and confirmed by cloning and Sanger sequencing. The genomes are 2,199 and 2,211 nt-long, respectively, encoding a putative coat protein (CP) and a replication-associated protein (Rep) and showing a genomic organization typical of viruses from the family Genomoviridae. Phylogenetic analysis with deduced amino acid sequences of Rep indicates that the virus from AdO is closely related to other members of the genus Gemycircularvirus, while the virus from AdDF is related to those of the genus Gemyduguivirus. These new genomoviruses are tentatively named bemisia-associated genomovirus AdO and bemisia-associated genomovirus AdDF.

Ed Rybicki's insight:
I would be willing to bet some serious money that this is why my good friend Hanokh Czosnek and colelagues have persistently claimed that TYLCV replicates in whiteflies: the promiscuity of Rep-DNA interactions among ssDNA viruses could allow low-level replication of the geminiviral genome by the genomovirus Rep??
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Protective immune response of oral rabies vaccine in stray dogs, corsacs and steppe wolves after a single immunization

In this study the safety and protective immunity of an oral rabies vaccine, based on the live, modified rabies virus strain VRC-RZ2, was examined in stray dogs (Canis Sp.), corsacs (Vulpes corsac) and steppe wolves (Canis lupus campestris). In the safety group (dogs, n=6; corsacs, n=3; wolves, n=3) which was vaccinated with a 10-times field dose/animal, no animals showed any signs of disease or changes in behavior or appetite during the period of clinical observation, similar to the animals in the negative control group. Saliva samples taken from animals prior and post (5th and 10th days) vaccination failed to demonstrate rabies virus antigen. Observations of immunogenicity in vaccinated carnivores (dogs, corsacs and wolves) during a 180 day period showed the titers of virus neutralizing antibodies (VNA) in the blood sera of vaccinated dogs to be within 0.59-1.37 IU/mL. On 14 days post vaccination (dpv), all the wild carnivores had detectable levels of neutralizing antibodies, with mean titers ranging from 0.50 ± 0.07 IU/mL (for wolves) to 0.59 ± 0.10 IU/mL (for corsacs). Weeks after vaccination, all the vaccinated wolves and corsacs had higher levels of neutralizing antibodies: 0.70 ± 0.10 – 0.71 ± 0.08 IU/mL at 30 dpv, 1.06 ± 0.08 – 1.28 ± 0.21 IU/mL at 60 dpv and 0.41 ± 0.09 – 047 ± 0.06 at 180 dpv. The highest level of VNA (˃1.0 IU/ml) was detected at 60 dpv, in all vaccinated animals. After challenge all vaccinated dogs remained healthy for 180 days. Control animals (unvaccinated dogs) developed symptoms of rabies on day 6 post administration of a virulent virus and died of rabies on days 11-13. Of note, the VNA titers in all the wild carnivores (corsacs and wolves) immunized with VRC-RZ2 were higher than 0.5 IU/ml (0.59 ± 0.11 IU/ml), even as early as 14 days post vaccination. These, presumably protective, titers of antibodies to rabies virus were present in the dogs and wild carnivores examined in this study for at least 180 days.

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Immunological aspects of rabies: a literature review

Rabies is a lethal disease caused by the neurotropic virus rabies virus (RABV), and it remains an important public health problem globally. It is known that the host immune response is important for c
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Bacteria? Virus? Fungi? Diagnosing Common Cannabis Diseases

Bacteria? Virus? Fungi? Diagnosing Common Cannabis Diseases | Virology News | Scoop.it
Just like any other crop cultivated, cannabis is subject to a wide range of pests and diseases that can distress your plants.
Ed Rybicki's insight:
I'm still looking for a cannabis mild mosaic virus B-)
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UBC researchers pull paper linking vaccine component to autism

'There was a screw-up' UBC researchers pull paper linking vaccine component to autism. Researchers from the University of British Columbia are retractin
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Rabies vaccine cost bites as dogs run wild

This raises concern over the availability of the rabies vaccine and the cost. New Vision TV offers analyzed news content on trending stories in Uganda, b
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Full-Genome Sequence of Porcine Circovirus type 3 recovered from serum of sows with stillbirths in Brazil

Transbound Emerg Dis. 2017 Oct 12. doi: 10.1111/tbed.12735. [Epub ahead of print]
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WHO validates elimination of mother-to-child transmission of HIV and syphilis in Cuba

Cuba today became the first country in the world to receive validation from WHO that it has eliminated mother-to-child transmission of HIV and syphilis.
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HPV Vaccination of Adolescent Boys May Be Cost-Effective for Preventing Oropharyngeal Cancer

12:00 AM EDT April 13, 2015 HPV Vaccination of Adolescent Boys May Be Cost-Effective for Preventing Oropharyngeal Cancer A new study indicates that vaccinating 12-year-old boys against the humanpapilloma virus (HPV) may be a cost-effective strategy for preventing oropharyngeal squamous cell...
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Researchers make breakthrough in search for African Swine Fever vaccine

Researchers make breakthrough in search for African Swine Fever vaccine | Virology News | Scoop.it
Researchers in Australia and the US have uncovered genetic data they believe may contain the key to developing a vaccine for African Swine Fever
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Experiences of operational costs of HPV vaccine delivery strategies in Gavi-supported demonstration projects

Experiences of operational costs of HPV vaccine delivery strategies in Gavi-supported demonstration projects | Virology News | Scoop.it
From 2012 to 2016, Gavi, the Vaccine Alliance, provided support for countries to conduct small-scale demonstration projects for the introduction of the human papillomavirus vaccine, with the aim of determining which human papillomavirus vaccine delivery strategies might be effective and sustainable upon national scale-up. This study reports on the operational costs and cost determinants of different vaccination delivery strategies within these projects across twelve countries using a standardized micro-costing tool. The World Health Organization Cervical Cancer Prevention and Control Costing Tool was used to collect costing data, which were then aggregated and analyzed to assess the costs and cost determinants of vaccination. Across the one-year demonstration projects, the average economic and financial costs per dose amounted to US$19.98 (standard deviation ±12.5) and US$8.74 (standard deviation ±5.8), respectively. The greatest activities representing the greatest share of financial costs were social mobilization at approximately 30% (range, 6–67%) and service delivery at about 25% (range, 3–46%). Districts implemented varying combinations of school-based, facility-based, or outreach delivery strategies and experienced wide variation in vaccine coverage, drop-out rates, and service delivery costs, including transportation costs and per diems. Size of target population, number of students per school, and average length of time to reach an outreach post influenced cost per dose. Although the operational costs from demonstration projects are much higher than those of other routine vaccine immunization programs, findings from our analysis suggest that HPV vaccination operational costs will decrease substantially for national introduction. Vaccination costs may be decreased further by annual vaccination, high initial investment in social mobilization, or introducing/strengthening school health programs. Our analysis shows that drivers of cost are dependent on country and district characteristics. We therefore recommend that countries carry out detailed planning at the national and district levels to define a sustainable strategy for national HPV vaccine roll-out, in order to achieve the optimal balance between coverage and cost.
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Detection and genome sequencing of porcine circovirus 3 in neonatal pigs with congenital tremors in South China

Transbound Emerg Dis. 2017 Oct 3. doi: 10.1111/tbed.12702. [Epub ahead of print]
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