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Bacteria Boost Vaccine Effectiveness | The Scientist Magazine®

Bacteria Boost Vaccine Effectiveness | The Scientist Magazine® | Virology News | Scoop.it
Researchers are looking to microbes to improve immune responses to a wide range of vaccines.
Ed Rybicki's insight:

Adjuvants rule, OK?!

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Virology News
Topical news snippets about viruses that affect people. And other things.
Curated by Ed Rybicki
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Rescooped by Ed Rybicki from Virology and Bioinformatics from Virology.ca
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40 Greatest Rock Documentaries

40 Greatest Rock Documentaries | Virology News | Scoop.it
From meeting the Beatles to Hendrix burning guitars, here are the 40 greatest rock documentaries of all time.

Via Chris Upton + helpers
Ed Rybicki's insight:

This is one of those "other things" that this site is for B-)

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Sierra Leone's 365 Ebola deaths traced back to one healer

Sierra Leone's 365 Ebola deaths traced back to one healer | Virology News | Scoop.it
It has laid waste to the tribal chiefdoms of Sierra Leone, leaving hundreds dead, but the Ebola crisis began with just one healer's claims to special powers.
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10 Deadly Diseases That Hopped Across Species

10 Deadly Diseases That Hopped Across Species | Virology News | Scoop.it
A host of infectious and deadly diseases have hopped from animals to humans, and the other way.
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From HIV to Ebola: How to protect health workers in West Africa

From HIV to Ebola: How to protect health workers in West Africa | Virology News | Scoop.it
Awoko
From HIV to Ebola: How to protect health workers in West Africa
Devex
EDITOR'S NOTE: What can we learn from the global response to HIV and AIDS that can be applied now to aid workers dealing with the Ebola outbreak in West Africa?
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Deadly 2010 polio outbreak in Congo linked to mutant virus

Deadly 2010 polio outbreak in Congo linked to mutant virus | Virology News | Scoop.it
Yahoo News Deadly 2010 polio outbreak in Congo linked to mutant virus Yahoo News Washington (AFP) - An unusually deadly outbreak of polio in 2010 in the Democratic Republic of Congo was linked Monday to a mutated form of the virus which common...
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Ebola: Uganda on High Alert for the Deadly Virus

Uganda is on high alert for Ebola, after the World Health Organization last Wednesday classified neighboring Kenya as a "high-risk" country, in the spread of Virus. Local authorities have begun...
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Human Clinical Trials Of Ebola Vaccine Accelerated

WASHINGTON — Researchers at the National Institutes of Health are accelerating human clinical trials for what scientists hope is a promising new vaccine to combat the deadly Ebola virus.

Phase 1 of the clinical trials, which were previously not expected to begin until the end of September, will start early next month in response to the Ebola outbreak in West Africa, said Dr. Anthony Fauci, director of the NIH’s National Institute of Allergy and Infectious Diseases. Fauci said researchers now hope to finish Phase 1 by the end of November rather than January 2015, as originally planned.

 

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Abalone discovery leads to herpes treatment hope

Abalone discovery leads to herpes treatment hope | Virology News | Scoop.it
Healed hand warts alert scientists to the herpes-fighting properties of the Tasmanian blacklip abalone.
Ed Rybicki's insight:

I love fortuitous discoveries - but I see no mention of the fact that warts are caused by papillomaviruses - so it may work for them too?

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Ill prepared for an influenza pandemic

Ill prepared for an influenza pandemic | Virology News | Scoop.it

Over the last 500 years, there have been, on average, three severe influenza pandemics in each century. The most recent pandemic was declared in 2009. Yet despite much investment in public health and many improvements in vaccine production techniques and know-how, the availability of influenza vaccines during this event was far from adequate. Six months into the pandemic, 534 million doses were available, and after one year that number had risen to 1.3 billion — enough for only 8%and 25%, respectively, of the world population. We were lucky that the pandemic declared in 2009 turned out later to be mild and that just one shot of vaccine was sufficient to protect most people. This is not usually the case during a severe influenza pandemic.

 
Ed Rybicki's insight:

"As countries continue to pre-book pandemic supply, it is more and more likely that the limited vaccines available during the first months of any pandemic during the next few years will be sold out almost completely"

And what does everyone think happened in South Africa during most of 2009 and 2010?

Well, they probably don't - because not that many of them got sick.  But THERE WAS NO VACCINE for the general population until LATE 2010 - when the chances of another round of H1N1pdm 2009 had dissipated due to summer coming on.

And the vaccine that HAD come into the the country in 2010 got used for medical personnel, and - for the 2010 World Cup staff.

Seriously, we need to do better than this - and responding QUICKLY to news of a pandemic would be the ticket.

Using plants B-)

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Nature Outlook : Vaccines. Free!

Nature Outlook : Vaccines.  Free! | Virology News | Scoop.it

Vaccination is a triumph of preventative healthcare. But the project to erect immunological shields against deadly pathogens is far from complete — some of the most lethal diseases still lack effective vaccines. Moreover, major inequities exist in the global distribution of vaccines. Despite substantial advances in vaccine production and development, global efforts to eradicate disease through inoculation still face scientific, technological and economic hurdles.

 
Ed Rybicki's insight:

Spread the word - educate the ignorant!

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FDA Enables Potential Use of Experimental Tekmira Vaccine on Ebola Patients

FDA Enables Potential Use of Experimental Tekmira Vaccine on Ebola Patients | Virology News | Scoop.it
FDA Enables Potential Use of Experimental Tekmira Vaccine on Ebola Patients
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US emergency labs ready to work on Ebola drugs

US emergency labs ready to work on Ebola drugs | Virology News | Scoop.it
All three US facilities established to quickly make vaccines and therapeutics in the event of a major public health threat say they are standing by to support any US government effort to scale up a treatment for Ebola.
Ed Rybicki's insight:

"We are prepared to make any kind of vaccine," Giroir said, from the traditional kind grown in chicken eggs to newer varieties grown in mammalian or bacterial cells. "The whole idea is to take a process that may exist only on sticky notes at a small biotech company and scale it up as fast as possible"


Well, not ANY vaccine, obviously: why don't they just engage Medicago, or Kentucky BioProcessing or Fraunhofer USA for the plant-made stuff??

 
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Ed Rybicki's curator insight, August 12, 2:32 AM

With plants as a distant afterthought.

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TEDx Speaker Interviews: Ed Rybicki on Ebola and vaccines

TEDx Speaker Interviews: Ed Rybicki on Ebola and vaccines | Virology News | Scoop.it
Ed and Fiona discuss everything viral (as in the small infectious agent not the spreading of information on the net) from Ebola to immunising children.
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Ebola No Threat To SA Tourism

Ebola No Threat To SA Tourism | Virology News | Scoop.it
The Minister of Communications, Faith Muthambi, said South Africa’s tourism industry is not under threat from the Ebola Virus Disease
Ed Rybicki's insight:

Because Africa's not a country, people: it's like saying "There's SARS in Canada - you can't visit Mexico!"

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Ebola outbreak: the vaccine and 'secret serum' explained

Ebola outbreak: the vaccine and 'secret serum' explained | Virology News | Scoop.it
The Guardian
Ebola outbreak: the vaccine and 'secret serum' explained
The Guardian
Why hasn't an Ebola vaccine been developed so far?
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Soon, soluble tampons will prevent HIV spread

Soon, soluble tampons will prevent HIV spread | Virology News | Scoop.it
TheHealthSite
Soon, soluble tampons will prevent HIV spread
TheHealthSite
According to a research that appeared in the journal Antimicrobial Agents and Chemotherapy, a soluble tampon-like material could provide protection against HIV.
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HPV Vaccine Protects Against Infection 8 Years Out

Medscape
HPV Vaccine Protects Against Infection 8 Years Out: Study
Intelihealth.com
MONDAY, Aug.
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WHO Statement on travel in relation to Ebola outbreak

In order to support the global efforts to contain the spread of the disease and provide a coordinated international response for the travel and tourism sector, the heads of WHO, the International Civil Aviation Organization (ICAO), the World Tourism Organization (UNWTO), Airports Council International (ACI), International Air Transport Association (IATA) and the World Travel and Tourism Council (WTTC) decided to activate a Travel and Transport Task Force which will monitor the situation and provide timely information to the travel and tourism sector as well as to travellers.
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Ugandan President Signs Law Criminalizing HIV Transmission

Ugandan President Signs Law Criminalizing HIV Transmission | Virology News | Scoop.it
Ugandan President Signs Law Criminalizing HIV Transmission
BuzzFeed
The provisions that are most troubling to public health advocates are those that could result in the imprisonment of HIV-positive people.
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Flu Shot Recommended for All Pregnant Women

Flu Shot Recommended for All Pregnant Women | Virology News | Scoop.it
Medscape Flu Shot Recommended for All Pregnant Women Yahoo News Pregnant women should get the flu shot, regardless of how far along they are in their pregnancies, according to updated guidelines released by the American College of Obstetricians and...
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Is the trade in bush meat and apes responsible for spread of Ebola virus?

Is the trade in bush meat and apes responsible for spread of Ebola virus? | Virology News | Scoop.it
The vicious Ebola virus outbreak that has already killed more than 800 people this year, in addition to sowing panic, fear and confusion throughout West Africa, was not a strain endemic to the region as initially believed.
Ed Rybicki's insight:

REALLY nice article, with horrific images from bush meat markets - which illustrate just how likely the scenario is.

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Novel Vaccine for Chikungunya Virus?

Novel Vaccine for Chikungunya Virus? | Virology News | Scoop.it

While there is currently no FDA-approved vaccine to prevent the spread of the chikungunya virus, the head of viral immunity research at the Vaccine & Gene Therapy Institute of Florida (VGTI Florida®), a leading non-profit biomedical research institute, has developed a new platform vaccine technology that is expected to provide complete protection against chikungunya virus infection.

“We have developed a novel virus-like particle (VLP) vaccine that is a next-generation cell-culture technology, unique from traditional vaccines which are predominantly produced in chicken eggs,” stated Ted Ross, Ph.D., VGTI Florida’s Program Director of Vaccines & Viral Immunity. “Our VLP platform uses specific, proprietary proteins from the chikungunya virus capable of eliciting a potent, robust and enduring immune response, enabling the immune system to prevent replication of virus, and thus, prevent infection.”

 
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What Would Happen if You Got Ebola?

What Would Happen if You Got Ebola? | Virology News | Scoop.it
A secondary infection in the U.S. is highly unlikely. But here's how the healthcare system would respond if there was one.
Ed Rybicki's insight:

Goes without saying that this would happen in a lot of other places, too.  Including our very own South Africa - where it HAS happened, with Marburg, Ebola and Lujo viruses.  Written about right here on ViroBlogy.

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How can geminiviral Rep capture the cell cycle of differentiated plant cells?

How can geminiviral Rep capture the cell cycle of differentiated plant cells? | Virology News | Scoop.it

African cassava mosaic virus (ACMV) in the geminivirus family has being affected 500 million people worldwide by devastating cassava crops during the past decades. It has caused severe symptoms and reduced yield up to the complete loss of roots, the main starchy food source especially for subsistence farmers in Africa. How can a tiny virus with a small genome evoke such dramatic effects? The viral key component, the replication-initiator protein (Rep), forces differentiated plant cells in the phloem to reactivate DNA synthesis. Even more, it does the same in model cells of fission yeast. We have identified, now, a potential cyclin interaction motif, RXL, in the sequence of ACMV Rep, which may be important for cell cycle control. This motif is essential to induce rereplication in yeast and necessary for viral infection of plants.

 
Ed Rybicki's insight:

I am a sucker for geminiviruses and their replication - as can be seen in the pages published here and elsewhere over the years.  It is fascinating to me that a small protein like Rep - only ~30 kDa - can do so many things, and especially interfere in such a fundamental way with organised, differentiated cells.

What is even more interesting is that it can do it in such a wide variety of systems: it's been shown that ACMV can replicate in maize protoplasts as well as in the dicotyledonous cassava; it can evidently function well in yeast as well - and via a pathway that no-one suspected before now.

Truly, a protein of many parts!  Congratulations to Katharina Hipp and to my old friends Bruno and Holger.

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Tracing Ebola’s Breakout to an African 2-Year-Old

Tracing Ebola’s Breakout to an African 2-Year-Old | Virology News | Scoop.it
The current Ebola outbreak, the largest ever, seems likely to surpass all previous known Ebola outbreaks combined, and epidemiologists predict it will take months to control.
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