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Bacteria Boost Vaccine Effectiveness | The Scientist Magazine®

Bacteria Boost Vaccine Effectiveness | The Scientist Magazine® | Virology News | Scoop.it
Researchers are looking to microbes to improve immune responses to a wide range of vaccines.
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Adjuvants rule, OK?!

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Virology News
Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
Curated by Ed Rybicki
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A virus that made us sick that we don't even know about

A virus that made us sick that we don't even know about | Virology News | Scoop.it
Many infections are never diagnosed. We never know which virus or bacteria caused the illness - especially with colds and coughs. Thing is, until 2001, we didn't even know we all came down with Metapneumovirus.
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Another virus out there, MERS

Another virus out there, MERS | Virology News | Scoop.it
A virus in the Middle East has been worrying some doctors. This time it's from Camels. Yes, Camels.
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How Mutant Viral Swarms Spread Disease

How Mutant Viral Swarms Spread Disease | Virology News | Scoop.it
A new understanding of viral swarms is helping researchers predict how viruses will evolve and where disease is likely to spread.
Ed Rybicki's insight:

Gotta love those mutant viral swarms...aka quasispecies, unless I miss my guess?

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Seals Have Closest-Related Virus to Hepatitis A

Seals Have Closest-Related Virus to Hepatitis A | Virology News | Scoop.it
Columbia University researchers recently discovered a hepatitis A-like virus in seals off New England's coast.
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HPV infection of placentas linked to pregnancy complications

HPV infection of placentas linked to pregnancy complications | Virology News | Scoop.it
In a landmark study, University of Otago researchers have found that human papilloma virus (HPV) can infect the placenta and is linked to several pregnancy complications, including the potentially fatal disorder pre-eclampsia.
Ed Rybicki's insight:

Interesting...!  Yet another good reason to get vaccinated.

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Earlier is better for HIV treatment

Earlier is better for HIV treatment | Virology News | Scoop.it
People infected with HIV benefit from starting a drug regimen early, an international study finds.
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Sierra Leone begins 42-day countdown to be declared free of Ebola virus

Sierra Leone begins 42-day countdown to be declared free of Ebola virus | Virology News | Scoop.it
Sierra Leone today began its countdown to be declared by the World Health Organization as free of Ebola virus transmission as the West African nation’s President described the release of the last patient treated for the disease at a treatment centre...
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Universal flu vaccine comes closer, scientists say - BBC News

Universal flu vaccine comes closer, scientists say - BBC News | Virology News | Scoop.it
Researchers say they are closer to developing a universal ‘catch all’ flu jab after promising trials in animals.
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It's always closer...just like the Rand will improve.

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HPV/Cervical Dysplasia

As mentioned, this video was hard for me to make. It is something I never thought I would have to deal with ever. Last July 2014, when I got the dreaded call I just ...
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Ebola - 5 vaccine lessons

More than a year on from the start of the Ebola epidemic, the world has been hard at work trying to learn from the factors that have so far contributed to over 11,000 deaths.

Despite promising results from the recent Ebola vaccine trials, there are still signs that important lessons about research, health systems and vaccine preparedness have yet to be learned. Here, Dr Seth Berkley, CEO of Gavi, the Vaccine Alliance, draws them out in a TED talk delivered earlier this year in Vancouver.
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Effectiveness of less than three doses of Gardasil

Effectiveness of less than three doses of Gardasil | Virology News | Scoop.it
Background

Optimised two-dose human papillomavirus (HPV) vaccine schedules are now endorsed for young adolescents by the World Health Organization. Limited data are available about effectiveness of <3 doses using a standard dose schedule.

Methods

Deterministic data linkage was undertaken between the Victorian Cervical Cytology Registry and National HPV Vaccination Program Register to determine quadrivalent HPV vaccination status and incidence of cervical pathology among vaccine eligible women (aged 26 years or younger in 2007) screened in Victoria, Australia between April 2007 and December 2011. Proportional hazards regression was used to estimate hazard ratios (HR) adjusted for age, socioeconomic status and area of residence. Women were stratified into those vaccinated before or after first screen.

Results

Any number of doses (1, 2 or 3) were associated with lower rates of high grade and low grade cytology diagnoses as long as doses were given before screening commencement (one dose HR high grade 0.44 (95% CI 0.32–0.59), one dose low grade 0.48 (95% CI 0.40–0.58); two doses HR high grade 0.63 (95% CI 0.50–0.80), HR low grade 0.52 (95% CI 0.44–0.61); three doses HR high grade 0.53 (95% CI 0.47–0.60), HR low grade 0.73 (95% CI 0.68–0.78)). Three doses of vaccine, but not fewer, were associated with reduced risk of high grade histologically confirmed abnormality in this cohort, regardless of whether vaccination occurred before or after screening (HR before 0.71 (95% CI 0.64–0.80), HR after 0.87 (95% CI 0.82–0.93)). Secondary analyses censoring end points occurring within 1, 6, 12, or 24 months of final vaccine dose suggested an increasing effect of partial vaccination courses over time.

Conclusion

Our data suggest that less than three doses of quadrivalent HPV vaccine provides some protection against cervical intraepithelial neoplasia, even when measured within 5 years in a population including those who were sexually active at the time of vaccination.

  
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New journal - and Open Access!

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Ebola epidemic : Nature News & Comment

Ebola epidemic : Nature News & Comment | Virology News | Scoop.it

Even if Ebola has faded from the headlines, the danger remains. As the largest and most deadly outbreak of Ebola winds down, scientists and public health officials are looking closely at what it will take to finish the job and to prepare better for the next big crisis. The apparent success of a nimble and creative clinical trial for a vaccine is a positive and instructive outcome. But many of the most important lessons come from failures in preparedness.

 
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Bio-Control of Salmonella Enteritidis in Foods Using Bacteriophages

Bio-Control of Salmonella Enteritidis in Foods Using Bacteriophages | Virology News | Scoop.it
Two lytic phages, vB_SenM-PA13076 (PA13076) and vB_SenM-PC2184 (PC2184), were isolated from chicken sewage and characterized with host strains Salmonella Enteritidis (SE) ATCC13076 and CVCC2184, respectively. Transmission electron microscopy revealed that they belonged to the family Myoviridae. The lytic abilities of these two phages in liquid culture showed 104 multiplicity of infection (MOI) was the best in inhibiting bacteria, with PC2184 exhibiting more activity than PA13076. The two phages
Ed Rybicki's insight:

Good current stuff - and something that I bet is going to get a lot more important as time goes on.

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How Methods Videos Are Making Science Smarter

How Methods Videos Are Making Science Smarter | Virology News | Scoop.it
For some researchers, the most significant obstacle to the successful replication of experiments is the outdated text format of traditional journals.

Via burkesquires
Ed Rybicki's insight:

Yup, something I've been thinking about quite a lot - now just to DO it!!

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Middle East respiratory syndrome: An emerging coronavirus infection tracked by the crowd

In 2012 in Jordan, infection by a novel coronavirus (CoV) caused the first known cases of Middle East respiratory syndrome (MERS). MERS-CoV sequences have since been found in a bat and the virus appears to be enzootic among dromedary camels across the Arabian Peninsula and in parts of Africa. The majority of human cases have occurred in the Kingdom of Saudi Arabia (KSA). In humans, the etiologic agent, MERS-CoV, has been detected in severe, mild and influenza-like illness and in those without any obvious signs or symptoms of disease. MERS is often a lower respiratory tract disease associated with fever, cough, breathing difficulties, pneumonia that can progress to acute respiratory distress syndrome, multiorgan failure and death among more than a third of those infected. Severe disease is usually found in older males and comorbidities are frequently present in cases of MERS. Compared to SARS, MERS progresses more rapidly to respiratory failure and acute kidney injury, is more often observed as severe disease in patients with underlying illnesses and is more often fatal. MERS-CoV has a broader tropism than SARS-CoV, rapidly triggers cellular damage, employs a different receptor and induces a delayed proinflammatory response in cells. Most human cases have been linked to lapses in infection prevention and control in healthcare settings, with a fifth of virus detections reported among healthcare workers. This review sets out what is currently known about MERS and the MERS-CoV, summarises the new phenomenon of crowd-sourced epidemiology and lists some of the many questions that remain unanswered, nearly three years after the first reported case.

  
Ed Rybicki's insight:

Great stuff!  Leveraging the power of people and of teh web.

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Why worries about a MERS virus outbreak at the Hajj are probably overblown

The virus has never spread outside of hospitals for a sustained period of time.
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Spain detects first ever case of mosquito-borne chikungunya virus

Spain detects first ever case of mosquito-borne chikungunya virus | Virology News | Scoop.it
Officials say Valencia man ‘most likely’ infected with painful viral disease in Gandia, a seaside Mediterranean resort
Ed Rybicki's insight:

Hey, ex Africa semper aliquid novi!  Or emerging, in this case.

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HPV DNA Detected in Mouthwash Predicts Oral Cancer Recurrence

HPV DNA Detected in Mouthwash Predicts Oral Cancer Recurrence | Virology News | Scoop.it
Patients who have HPV 16 DNA in their saliva following treatment of their oropharyngeal cancer are more likely to have their cancer recur, and a prospective cohort study has shown that a simple mouth rinse can be used to detect it.
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Data is helping Uganda eliminate mother-to-child HIV transmission

Data is helping Uganda eliminate mother-to-child HIV transmission | Virology News | Scoop.it
Today in Uganda, creative approaches are helping eliminate mother-to-child HIV transmission (MTCT) and leading to fewer and fewer babies being born HIV-infected.
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Jailing of Gay Men in Senegal Setback to HIV Fight in Africa

Jailing of Gay Men in Senegal Setback to HIV Fight in Africa | Virology News | Scoop.it
Activists say sentencing of 7 men to 6 months in prison, based on police discovery of condoms and lubricant, is hammer blow to groups promoting safe sex
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HPV vaccine making a difference in infection rates - Mayo Clinic

HPV vaccine making a difference in infection rates - Mayo Clinic | Virology News | Scoop.it
Researchers have found that since the introduction of the HPV vaccine, infection rates have dropped by almost 50 percent.
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Influenza vaccine also prevents heart attacks

Influenza vaccine also prevents heart attacks | Virology News | Scoop.it
Giving universal access to the flu vaccine to anybody aged over 50 is likely to save many more lives, a study has found.

 

It is like riding a bicycle to avoid the traffic and accidentally getting fit.

People who get the flu vaccine are less likely to have a heart attack.

A study by University of NSW researchers has found that people who have been vaccinated against influenza are 29 per cent less likely to have a heart attack - representing a greater protective effect than ceasing smoking and nearly as much as taking statins.

 

They are now advocating that the flu vaccine be provided free of charge to everybody aged over 50, extending the current scheme that makes it available to people over 65.

Ed Rybicki's insight:

Russell, this means you and me...B-)

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A Man Shed Live Polio Virus In His Stool For 28 Years

A Man Shed Live Polio Virus In His Stool For 28 Years | Virology News | Scoop.it
That's the longest span for one individual to excrete the live virus in history. It's not the norm, that's for certain. But how much of a concern is it in the war to wipe out polio?
Ed Rybicki's insight:

So - now for replacement of the live virus with killed and/or subunit - and preferably VLPs!!

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The growing global battle against blood-sucking ticks

The growing global battle against blood-sucking ticks | Virology News | Scoop.it
Scientists have no shortage of ideas about how to stop tick-borne illnesses. What is holding them back?
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The cannabis experiment

The cannabis experiment | Virology News | Scoop.it
As marijuana use becomes more acceptable, researchers are scrambling to answer key questions about the drug.
Ed Rybicki's insight:

Groovy, man...B-)

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