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Aging cells lose their grip on DNA rogues | News | R&D Magazine

Aging cells lose their grip on DNA rogues | News | R&D Magazine | Virology News | Scoop.it
Transposable elements are mobile strands of DNA that insert themselves into chromosomes with mostly harmful consequences.

Cells have evolved ways to defend themselves, but in a new study, Brown University researchers describe how cells lose this ability as they age, possibly resulting in a decline in their function and health.

Ed Rybicki's insight:

Yet ANOTHER reason not to get old...B-(

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Virology News
Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
Curated by Ed Rybicki
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Lack of Marburg Virus Transmission From Experimentally Infected to Susceptible In-Contact Egyptian Fruit Bats

Lack of Marburg Virus Transmission From Experimentally Infected to Susceptible In-Contact Egyptian Fruit Bats | Virology News | Scoop.it

Egyptian fruit bats (Rousettus aegyptiacus) were inoculated subcutaneously (n = 22) with Marburg virus (MARV). No deaths, overt signs of morbidity, or gross lesions was identified, but microscopic pathological changes were seen in the liver of infected bats. The virus was detected in 15 different tissues and plasma but only sporadically in mucosal swab samples, urine, and fecal samples. Neither seroconversion nor viremia could be demonstrated in any of the in-contact susceptible bats (n = 14) up to 42 days after exposure to infected bats. In bats rechallenged (n = 4) on day 48 after infection, there was no viremia, and the virus could not be isolated from any of the tissues tested. This study confirmed that infection profiles are consistent with MARV replication in a reservoir host but failed to demonstrate MARV transmission through direct physical contact or indirectly via air. Bats develop strong protective immunity after infection with MARV.

 
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From our very own NICD!

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New, whole-virus vaccine for Ebola effective in primates

New, whole-virus vaccine for Ebola effective in primates | Virology News | Scoop.it
Novel whole virus vaccine offers promising protection against Ebola infection

 

A study published in Science demonstrates that vaccination with a mutated form of the Ebola virus provides some measure of protection to non-human primates. This finding places the vaccine one step closer to clinical trials in humans.

The researchers publishing this study have developed what’s called a “whole virus” vaccine for Ebola. Viruses have proteins on their exterior and genetic material on their interior. Whole virus vaccines present the host’s immune system with multiple viral proteins and the viral genetic material. These vaccines trigger broader immune system responses than vaccines that only present a single protein from the virus. Whole virus vaccines have had widespread success in offering protection against potentially deadly diseases such as smallpox, measles, and influenza.

Ed Rybicki's insight:

NOW everyone starts getting Ebola results...never mind, it'll be along again shortly - like flu.

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Researchers Use Polio Virus for Cancer Treatment

Researchers Use Polio Virus for Cancer Treatment | Virology News | Scoop.it
The cure to cancer could come from researchers at the Duke University Hospital Cancer Center.


Duke Medicine’s Dr. Matthias Gromeier has been working on a Glioblastoma treatment using a modified polio virus for more than 25-years.

Now, Duke researchers are testing the treatment and trials show it is working for some patients. 

After doctors told Clara Guy she had six to 18-months to live, she transferred to Duke Medicine’s Preston Robert Tisch Brain Tumor Center, where she became a stage four Glioblastoma research patient.  Glioblastoma is an aggressive and fast growing type of brain cancer.

"It's a big word...Glioblastoma is so much than a four letter word, and it really ought to be,” she said.

Guy was under the regulate vaccine trial.

"It turns your immune system onto high gear to teach it to fight the cancer cells,” she said. 

Neurooncologist Dr. Annick Desjardins is using the genetically modified polio virus as treatment for some patients during Phase One of the research. 

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Liberia: Ebola Vaccine Tests Show It Could 'Neutralise' Virus

Liberia: Ebola Vaccine Tests Show It Could 'Neutralise' Virus | Virology News | Scoop.it
An experimental Ebola vaccine tested on humans in Europe and Africa sparks the production of the antibodies needed to neutralize the deadly virus, a Geneva hospital said Wednesday.

Initial clinical trials of the VSV-ZEBOV candidate vaccine, manufactured by the Public Health Agency of Canada and developed by Merck, show that it "triggers the production of antibodies capable of neutralizing the Ebola virus," the Geneva University Hospitals (HUG) said in a statement.

 
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Ebola: it hasn't gone away.

Ebola: it hasn't gone away. | Virology News | Scoop.it

We've just got blase about it.  And we shouldn't be - because even as the epidemic declines, there are more cases per day than in ANY previous outbreak.  

 

Ebola replication graphic from Russell Kightley Media

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Avian influenza H7N9 human infection emerged 2 years ago...

Seems like only 365 days ago I wrote about H7N9 being 1 year old.
Now - it's another year later.

Via Mel Melendrez-Vallard
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Measles Could Cause More Deaths Than Ebola In West Africa

Measles Could Cause More Deaths Than Ebola In West Africa | Virology News | Scoop.it
West Africa's Ebola outbreak could be stanched by mid-year – but in the epidemic's wake, another public health crisis looms. Disruption of the region's already feeble health care systems has derailed health campaigns targeting childhood diseases, leaving the door wide open for measles and other preventable illnesses.

Via Chris Upton + helpers
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Ever wondered how biotech seeds are made?

Ever wondered how biotech seeds are made? Their story begins with the world's first farmers 10,000 years ago…

Ed Rybicki's insight:

Really well done little infographic story

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The Gambian despot who 'cured HIV-AIDS' and his British homoeopath allies

The Gambian despot who 'cured HIV-AIDS' and his British homoeopath allies | Virology News | Scoop.it
President Yahyah Jammeh, the dictator who has defied medical opinion since 2007 by claiming to have found a cure for HIV-AIDS, has found allies in a British homoeopathic group sponsored by the official suppliers of homoeopathic medicine to the Royal...
Ed Rybicki's insight:

F*ckwits, all.

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'Rich men fuel spread of HIV' - The Zimbabwe Standard

'Rich men fuel spread of HIV' - The Zimbabwe Standard | Virology News | Scoop.it
Minister of State for Manicaland Provincial Affairs Mandiitawepi Chimene has accused rich people of spreading HIV by using their money to entice vulnerable women into having unprotected sex.
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MERS kills 10 in Saudi after surge in virus deaths

MERS kills 10 in Saudi after surge in virus deaths | Virology News | Scoop.it
Ten more people have died in Saudi Arabia from the MERS virus since last week, health ministry data showed on Friday, adding to a surge in cases over the past month.
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WHO urges stepped-up battle against hepatitis B

WHO urges stepped-up battle against hepatitis B | Virology News | Scoop.it
The world can beat the liver-attacking hepatitis B virus, which results in some 650.000 deaths a year, the World Health Organization said Thursday, releasing its first treatment guidelines for the disease.
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Lack of Ebola Cases Shifts Vaccine Trials Away From Liberia

Lack of Ebola Cases Shifts Vaccine Trials Away From Liberia | Virology News | Scoop.it
Scientists are racing against the clock to create a vaccine before the outbreak is over
Ed Rybicki's insight:

So different to just a few weeks ago - but very welcome.

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Mysterious Childhood Paralysis Linked to a Common Cold Virus

Mysterious Childhood Paralysis Linked to a Common Cold Virus | Virology News | Scoop.it

Scientists have found evidence that a polio-like virus called EV-D68 is behind a mysterious outbreak of paralysis in children [in the USA] last year.

 

LAST YEAR, HUNDREDS of children across the country got sick with what looked like a common cold. Nothing to worry about: body aches, runny nose, coughing and sneezing. But then, mysteriously, a handful of those kids became paralyzed—first, just in an arm or a leg, and then spreading so far that some children needed a ventilator to breathe. The CDC reports that since August 2014, at least 115 children in 34 states have developed unexplained muscle weakness or paralysis, which they’re now calling acute flaccid myelitis. Doctors have urgently been hunting down the origin of this strange illness for over half a year, and now they think they’ve finally identified the culprit: enterovirus D68.

 
Ed Rybicki's insight:

And it's going to spread...vaccine time, people!

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Virus Infects Winter Cereal Crops

Virus Infects Winter Cereal Crops | Virology News | Scoop.it
TWIN FALLS • A major disease threat to winter wheat and barley has appeared in fields across southern Idaho.

 

Barley yellow dwarf virus “is rampant from Parma to Ririe,” said Juliet Marshall, a University of Idaho Extension cereal pathologist in Idaho Falls. Some growers are killing infected fields and reseeding with other crops.

 
Ed Rybicki's insight:

Ah, BYDV...back to my roots of 31 years ago, when I published a paper and a thesis on BYDV in SOuth African small grains.  It's never gone away.

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A Virus In Your Mouth Helps Fight The Flu

A Virus In Your Mouth Helps Fight The Flu | Virology News | Scoop.it
It's related to herpes. And it infects most of the world — about half of Americans, nearly all the developing world. But don't go out and get infected. The virus has a dark side, too.
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HOW THE WORLD LOOKED AWAY WHILE WEST AFRICA BLED: 365 days of Ebola

HOW THE WORLD LOOKED AWAY WHILE WEST AFRICA BLED: 365 days of Ebola | Virology News | Scoop.it
How the world looked away while West Africa bled.

 

Sunday marked a year into the largest Ebola outbreak in history. It has been, and continues to be, a cruel lesson in bureaucratic ineptitude and “First World” disregard for Africans, yet it has also been a year when Africans and Westerners alike have shown fidelity by staring real horror in the face. As Medecins Sans Frontieres (Doctors Without Borders) international president, Dr Joanne Liu, said in an appeal to UN member states in September: ‘To put out this fire, we must run into the burning building.’

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Major neurosciences initiative launched at UCT and Groote Schuur

Major neurosciences initiative launched at UCT and Groote Schuur | Virology News | Scoop.it
Major neurosciences initiative launched at UCT and Groote Schuur
Ed Rybicki's insight:

Meanwhile. away from faeces-throwing and statues...

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2,000 died in UK through blood infected with HIV or Hep C 30 yrs ago

2,000 died in UK through blood infected with HIV or Hep C 30 yrs ago | Virology News | Scoop.it
The Government will apologise this week for the infection of thousands of patients with deadly diseases through contaminated blood products, three decades ago.
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Origins and evolution of viruses of eukaryotes: The ultimate modularity

Origins and evolution of viruses of eukaryotes: The ultimate modularity | Virology News | Scoop.it

Viruses and other selfish genetic elements are dominant entities in the biosphere, with respect to both physical abundance and genetic diversity. Various selfish elements parasitize on all cellular life forms. The relative abundances of different classes of viruses are dramatically different between prokaryotes and eukaryotes. In prokaryotes, the great majority of viruses possess double-stranded (ds) DNA genomes, with a substantial minority of single-stranded (ss) DNA viruses and only limited presence of RNA viruses. In contrast, in eukaryotes, RNA viruses account for the majority of the virome diversity although ssDNA and dsDNA viruses are common as well. Phylogenomic analysis yields tangible clues for the origins of major classes of eukaryotic viruses and in particular their likely roots in prokaryotes. Specifically, the ancestral genome of positive-strand RNA viruses of eukaryotes might have been assembled de novo from genes derived from prokaryotic retroelements and bacteria although a primordial origin of this class of viruses cannot be ruled out. Different groups of double-stranded RNA viruses derive either from dsRNA bacteriophages or from positive-strand RNA viruses. The eukaryotic ssDNA viruses apparently evolved via a fusion of genes from prokaryotic rolling circle-replicating plasmids and positive-strand RNA viruses. Different families of eukaryotic dsDNA viruses appear to have originated from specific groups of bacteriophages on at least two independent occasions. Polintons, the largest known eukaryotic transposons, predicted to also form virus particles, most likely, were the evolutionary intermediates between bacterial tectiviruses and several groups of eukaryotic dsDNA viruses including the proposed order “Megavirales” that unites diverse families of large and giant viruses. Strikingly, evolution of all classes of eukaryotic viruses appears to have involved fusion between structural and replicative gene modules derived from different sources along with additional acquisitions of diverse genes.

 

Graphic by Ed Rybicki

  

Ed Rybicki's insight:

Wow...!  A tour de force.  Quite simply, says it all.  REALLY nice piece of work!!  And of course, they back me up in my view of how ss(-)RNA viruses evolved. Again B-)

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Rabenstein, Frank's curator insight, March 23, 10:59 AM

Thank you Ed for this.

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Vaccines Face Same Mistrust That Fed Ebola

Vaccines Face Same Mistrust That Fed Ebola | Virology News | Scoop.it
The same mix of fear and distrust that helped the Ebola epidemic spread is hampering doctors conducting trials on new medicines.
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Human Papillomavirus (HPV): animated video

View more NUCLEUS medical animations at http://www.nucleuslibrary.com If you like this animation, LIKE us on Facebook: http://www.nucleusinc.com/facebook htt...
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Really useful little movie!

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Korean Rhinoceros Beetle Industry Threatened by Virus

Korean Rhinoceros Beetle Industry Threatened by Virus | Virology News | Scoop.it
By Josh Lancette In Korea, a rhinoceros beetle called Allomyrina dichotoma has traditionally been raised for medicinal uses. Some Koreans believe it to be effective against liver disease and diabet...
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There's an industry fr rhinoceros beetles??  Who knew?

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[US] Government Accused Of Letting Gay Men Die By Denying Boys HPV Vaccine

The virus causes an array of different cancers, as well as genital warts, yet only girls are vaccinated. Four doctors tell BuzzFeed News this is homophobic and sexist.
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Herpes Pill Might Control HIV

Herpes Pill Might Control HIV | Virology News | Scoop.it
A pill developed to fight herpes might help control the AIDS virus, researchers reported Friday.The drug's called valacyclovir and it's prescribed to people ...
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