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PLOS Pathogens: Tubular Structure Induced by a Plant Virus Facilitates Viral Spread in Its Vector Insect

PLOS Pathogens: Tubular Structure Induced by a Plant Virus Facilitates Viral Spread in Its Vector Insect | Virology News | Scoop.it

"Numerous plant viruses that seriously damage agricultural crops are transmitted by insects. However, the mechanisms enabling virus transmission by vector insects have been poorly understood, in part, due to the lack of useful tools. A persistent-propagative plant virus replicates and encodes nonstructural proteins to form various cytopathological structures in their two types of hosts: plants and vector insects. Here, we took advantage of unique biological tools, including insect vector cell culture and RNA interference (RNAi) induced by synthesized dsRNA, to investigate the molecular mechanisms facilitating the efficient spread of Rice dwarf virus (RDV), a persistent-propagative plant virus, among cells and organs of leafhopper vector. Our experimental evidence shows that RDV exploited virus-containing tubules composed of nonstructural viral protein Pns10 to traffic along actin-based cellular machinery, allowing efficient cell-to-cell spread of the virus in leafhopper vector. Consistently, and in support of a function of Pns10 tubules as a determinant for viral spread in vector insect, the introduction of dsRNA from Pns10 gene into cultured insect vector cells or intact insect strongly inhibited such tubule formation, preventing efficient viral intercellular spread in the leafhopper in vitro and in vivo and subsequent transmission by the vector, without significant effect on viral multiplication in leafhopper cells."

 

This paper has some of what HAVE to be some of the nicest confocal pics I have ever seen illustrating structures to do with viruses in cells - and explains an old mystery, which is - why do many plant-infecting viruses induce the formation of tubular structures?  In this case, to spread the virus between cells of the vector.  Nice!

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Topical news snippets about viruses that affect people. And other things.
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Polio double vaccine gives better protection, study finds

Polio double vaccine gives better protection, study finds | Virology News | Scoop.it
Oral vaccine followed by injection could help fight disease in conflict-torn areas, according to WHO (RT @bsubram: #Polio double vaccine provides better protection. Study conducted with children in India.
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Vault nanoparticles show promise for cancer treatment and possible HIV cure

Vault nanoparticles show promise for cancer treatment and possible HIV cure | Virology News | Scoop.it

A multidisciplinary team of scientists from UCLA and Stanford University has used a naturally occurring nanoparticle called a vault to create a novel drug delivery system that could lead to advances in the treatment of cancer and HIV.The research team was led by Dr. Leonard Rome, associate director of UCLA’s California NanoSystems Institute, and Dr. Jerome Zack, co-director of the UCLA AIDS Institute, both of whom are also members of UCLA’s Jonsson Comprehensive Cancer Center. Co-first authors on the study were Daniel Buehler, a UCLA postdoctoral researcher and Matthew Marsden, adjunct assistant professor in the department of medicine and a member of the AIDS Institute.Their findings could lead to cancer treatments that are more effective with smaller doses and to therapies that could potentially eradicate the HIV virus.The paper is the cover story of the Aug. 26 print edition of the journal ACS Nano ("Bioengineered Vaults: Self-Assembling Protein Shell–Lipophilic Core Nanoparticles for Drug Delivery"), and it was recently published online.

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Liberian slums barricaded as ebola sets new record

Liberian slums barricaded as ebola sets new record | Virology News | Scoop.it
Riot police and soldiers acting on their president's orders used scrap wood and barbed wire to seal off 50,000 people inside their Liberian slum Wednesday, trying to contain the Ebola outbreak that has killed 1,350 people and counting across West...
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Successful siRNA Marburg Virus Treatment Offers Hope for Ebola Patients

Successful siRNA Marburg Virus Treatment Offers Hope for Ebola Patients | Virology News | Scoop.it
An experimental therapy showed success in monkeys with Marburg virus, offering hope for new treatments for related Ebola virus.
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Seals, not Spaniards, first brought TB to Americas

Seals, not Spaniards, first brought TB to Americas | Virology News | Scoop.it
Seals and sea lions may have brought a form of tuberculosis to the Americas, centuries before the Spanish did so (Blame the Spanish for #measles #malaria #influenza #smallpox but blame the seals for #tuberculosis via @newscientist
Ed Rybicki's insight:

ANOTHER species to be careful of...!

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A not-so-satirical take on Ebola reporting

Now that two people in America are being treated for it, the Ebola situation has now turned into a crisis. Visit us at Puppet Nation for more! http://puppet-...

Ed Rybicki's insight:

Priceless.  These guys are SO good.  Thanks to Steven Rybicki for pointing it out!

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Ebola No Threat To SA Tourism

Ebola No Threat To SA Tourism | Virology News | Scoop.it
The Minister of Communications, Faith Muthambi, said South Africa’s tourism industry is not under threat from the Ebola Virus Disease
Ed Rybicki's insight:

Because Africa's not a country, people: it's like saying "There's SARS in Canada - you can't visit Mexico!"

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Ebola outbreak: the vaccine and 'secret serum' explained

Ebola outbreak: the vaccine and 'secret serum' explained | Virology News | Scoop.it
The Guardian
Ebola outbreak: the vaccine and 'secret serum' explained
The Guardian
Why hasn't an Ebola vaccine been developed so far?
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Soon, soluble tampons will prevent HIV spread

Soon, soluble tampons will prevent HIV spread | Virology News | Scoop.it
TheHealthSite
Soon, soluble tampons will prevent HIV spread
TheHealthSite
According to a research that appeared in the journal Antimicrobial Agents and Chemotherapy, a soluble tampon-like material could provide protection against HIV.
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HPV Vaccine Protects Against Infection 8 Years Out

Medscape
HPV Vaccine Protects Against Infection 8 Years Out: Study
Intelihealth.com
MONDAY, Aug.
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WHO Statement on travel in relation to Ebola outbreak

In order to support the global efforts to contain the spread of the disease and provide a coordinated international response for the travel and tourism sector, the heads of WHO, the International Civil Aviation Organization (ICAO), the World Tourism Organization (UNWTO), Airports Council International (ACI), International Air Transport Association (IATA) and the World Travel and Tourism Council (WTTC) decided to activate a Travel and Transport Task Force which will monitor the situation and provide timely information to the travel and tourism sector as well as to travellers.
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Ugandan President Signs Law Criminalizing HIV Transmission

Ugandan President Signs Law Criminalizing HIV Transmission | Virology News | Scoop.it
Ugandan President Signs Law Criminalizing HIV Transmission
BuzzFeed
The provisions that are most troubling to public health advocates are those that could result in the imprisonment of HIV-positive people.
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Flu Shot Recommended for All Pregnant Women

Flu Shot Recommended for All Pregnant Women | Virology News | Scoop.it
Medscape Flu Shot Recommended for All Pregnant Women Yahoo News Pregnant women should get the flu shot, regardless of how far along they are in their pregnancies, according to updated guidelines released by the American College of Obstetricians and...
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Ebola virus disease, a long terms perspective

David Heymann, professor of infectious disease epidemiology, and head and senior fellow, at the Chatham House Centre on Global Health Security was sent to investigate the first outbreaks of Ebola in 1 (RT @ChathamHouse: Podcast: David Heymann discusses...
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Ebola virus may not be contained in Nigeria as two more cases emerge

Ebola virus may not be contained in Nigeria as two more cases emerge | Virology News | Scoop.it
WorldStage Ebola virus may not be contained in Nigeria as two more cases emerge Al Jazeera America The two are spouses of a man and woman who had direct contact with Liberian-American Patrick Sawyer, who flew into Nigeria last month with the virus...
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Ebola virus outbreak: "This is why '75%' of victims are women"

Ebola virus outbreak: "This is why '75%' of victims are women" | Virology News | Scoop.it
The Independent Ebola virus outbreak: This is why '75%' of victims are women The Independent Maricel Seeger, a WHO spokeswoman in Monrovia, Liberia, said reaching women and educating them on the disease is crucial to tackling the virus' spread, as...
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No end in sight to Ebola outbreak, official says

No end in sight to Ebola outbreak, official says | Virology News | Scoop.it
There is no end in sight to the Ebola outbreak in West Africa, according to the head of the World Health Organization.
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"Scale up the supply of experimental Ebola drugs!"

"Scale up the supply of experimental Ebola drugs!" | Virology News | Scoop.it
Estimates of the probable impact of the outbreak show that existing stocks of potentially useful medicines are insufficient, says Oliver Brady.
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40 Greatest Rock Documentaries

40 Greatest Rock Documentaries | Virology News | Scoop.it
From meeting the Beatles to Hendrix burning guitars, here are the 40 greatest rock documentaries of all time.

Via Chris Upton + helpers
Ed Rybicki's insight:

This is one of those "other things" that this site is for B-)

 

Of course, they fail badly by not including "Mad Dogs and Englishmen", but I suppose they got it mostly right.

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Sierra Leone's 365 Ebola deaths traced back to one healer

Sierra Leone's 365 Ebola deaths traced back to one healer | Virology News | Scoop.it
It has laid waste to the tribal chiefdoms of Sierra Leone, leaving hundreds dead, but the Ebola crisis began with just one healer's claims to special powers.
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10 Deadly Diseases That Hopped Across Species

10 Deadly Diseases That Hopped Across Species | Virology News | Scoop.it
A host of infectious and deadly diseases have hopped from animals to humans, and the other way.
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From HIV to Ebola: How to protect health workers in West Africa

From HIV to Ebola: How to protect health workers in West Africa | Virology News | Scoop.it
Awoko
From HIV to Ebola: How to protect health workers in West Africa
Devex
EDITOR'S NOTE: What can we learn from the global response to HIV and AIDS that can be applied now to aid workers dealing with the Ebola outbreak in West Africa?
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Deadly 2010 polio outbreak in Congo linked to mutant virus

Deadly 2010 polio outbreak in Congo linked to mutant virus | Virology News | Scoop.it
Yahoo News Deadly 2010 polio outbreak in Congo linked to mutant virus Yahoo News Washington (AFP) - An unusually deadly outbreak of polio in 2010 in the Democratic Republic of Congo was linked Monday to a mutated form of the virus which common...
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Ebola: Uganda on High Alert for the Deadly Virus

Uganda is on high alert for Ebola, after the World Health Organization last Wednesday classified neighboring Kenya as a "high-risk" country, in the spread of Virus. Local authorities have begun...
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Human Clinical Trials Of Ebola Vaccine Accelerated

WASHINGTON — Researchers at the National Institutes of Health are accelerating human clinical trials for what scientists hope is a promising new vaccine to combat the deadly Ebola virus.

Phase 1 of the clinical trials, which were previously not expected to begin until the end of September, will start early next month in response to the Ebola outbreak in West Africa, said Dr. Anthony Fauci, director of the NIH’s National Institute of Allergy and Infectious Diseases. Fauci said researchers now hope to finish Phase 1 by the end of November rather than January 2015, as originally planned.

 

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