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SciVerse ScienceDirect TOP25 Hottest Articles

SciVerse ScienceDirect TOP25 Hottest Articles | Virology News | Scoop.it

Note: number 1 is the article on "In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity" - that you read about here first.

 

ViroBlogy: serving the virology community...B-)  Thanks @MicrobeTweets!

 

Pandemic flu graphic courtesy of Russell Kightley Media

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Virology News
Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
Curated by Ed Rybicki
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Disease Detection Gets A Boost With Plans For A CDC In Africa

Disease Detection Gets A Boost With Plans For A CDC In Africa | Virology News | Scoop.it
African health officials are partnering with the U.S. to build a continentwide Centers for Disease Control and Prevention. The goal is a more rapid response to health emergencies, such as Ebola.

 

In 1946, a malaria outbreak across the Southern U.S. catalyzed the formation of what would eventually become the U.S. Centers for Disease Control and Prevention.

Then in 2002, China's CDC began its operations just as an outbreak of Severe Acute Respiratory Syndrome, or SARS, took hold.

 

Now, as the worst Ebola outbreak in history winds down, African health officials announced Monday they will partner with the U.S. to establish a continentwide African CDC.

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The Maps Within: Using Viruses in Forensic Biology

The Maps Within: Using Viruses in Forensic Biology | Virology News | Scoop.it
It is a romantic thought: we hold maps in our blood. Our DNA is a legacy that reaches back beyond our furthest forebears, and so too with our microbes. The place of our birth is reflected in the organisms that live, grow, and die within our bodies; how we live determines what presences we carry, telling own unique story of evolution, migration, and identity.
Ed Rybicki's insight:

Interesting...I wonder if the CIA knows about this B-)

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Health Officials Warn Ebola Survivors Against Having Sex After Virus Found in Fluid After 175 Days

Health Officials Warn Ebola Survivors Against Having Sex After Virus Found in Fluid After 175 Days | Virology News | Scoop.it
Health officials have warned that the Ebola virus can be transmitted through the fluids associated with sexual contact, but  they strengthened their warning after the virus was found longer than expected in a recovered Liberian man. According to the New York Times, the virus was found...
Ed Rybicki's insight:

You survive Ebola, then this?  Life's not fair sometimes....

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Virus hiding in our genome protects early human embryos

Virus hiding in our genome protects early human embryos | Virology News | Scoop.it

We may owe our survival and complexity to a stowaway virus that springs to life in the very first cells of human embryos. Not only does the virus seem to protect embryos from other viruses, but it also assists genes when the groundwork is under way for the body plan of a new human.

The finding backs the controversial idea that viruses which took up residence in our DNA millions of years ago may be playing the role of puppet master, quietly influencing our existence and evolution. 

Ed Rybicki's insight:

Old news, but nicely explained.

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Mysterious Childhood Paralysis Linked to a Common Cold Virus

Mysterious Childhood Paralysis Linked to a Common Cold Virus | Virology News | Scoop.it

Scientists have found evidence that a polio-like virus called EV-D68 is behind a mysterious outbreak of paralysis in children [in the USA] last year.

 

LAST YEAR, HUNDREDS of children across the country got sick with what looked like a common cold. Nothing to worry about: body aches, runny nose, coughing and sneezing. But then, mysteriously, a handful of those kids became paralyzed—first, just in an arm or a leg, and then spreading so far that some children needed a ventilator to breathe. The CDC reports that since August 2014, at least 115 children in 34 states have developed unexplained muscle weakness or paralysis, which they’re now calling acute flaccid myelitis. Doctors have urgently been hunting down the origin of this strange illness for over half a year, and now they think they’ve finally identified the culprit: enterovirus D68.

 
Ed Rybicki's insight:

And it's going to spread...vaccine time, people!

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Bio Restore 24's curator insight, April 19, 9:11 PM

Virus's and Bacteria keep changing their make up so that they can spread easier without being harmed by typical cleaning techniques.

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Virus Infects Winter Cereal Crops

Virus Infects Winter Cereal Crops | Virology News | Scoop.it
TWIN FALLS • A major disease threat to winter wheat and barley has appeared in fields across southern Idaho.

 

Barley yellow dwarf virus “is rampant from Parma to Ririe,” said Juliet Marshall, a University of Idaho Extension cereal pathologist in Idaho Falls. Some growers are killing infected fields and reseeding with other crops.

 
Ed Rybicki's insight:

Ah, BYDV...back to my roots of 31 years ago, when I published a paper and a thesis on BYDV in SOuth African small grains.  It's never gone away.

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A Virus In Your Mouth Helps Fight The Flu

A Virus In Your Mouth Helps Fight The Flu | Virology News | Scoop.it
It's related to herpes. And it infects most of the world — about half of Americans, nearly all the developing world. But don't go out and get infected. The virus has a dark side, too.
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HOW THE WORLD LOOKED AWAY WHILE WEST AFRICA BLED: 365 days of Ebola

HOW THE WORLD LOOKED AWAY WHILE WEST AFRICA BLED: 365 days of Ebola | Virology News | Scoop.it
How the world looked away while West Africa bled.

 

Sunday marked a year into the largest Ebola outbreak in history. It has been, and continues to be, a cruel lesson in bureaucratic ineptitude and “First World” disregard for Africans, yet it has also been a year when Africans and Westerners alike have shown fidelity by staring real horror in the face. As Medecins Sans Frontieres (Doctors Without Borders) international president, Dr Joanne Liu, said in an appeal to UN member states in September: ‘To put out this fire, we must run into the burning building.’

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Major neurosciences initiative launched at UCT and Groote Schuur

Major neurosciences initiative launched at UCT and Groote Schuur | Virology News | Scoop.it
Major neurosciences initiative launched at UCT and Groote Schuur
Ed Rybicki's insight:

Meanwhile. away from faeces-throwing and statues...

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2,000 died in UK through blood infected with HIV or Hep C 30 yrs ago

2,000 died in UK through blood infected with HIV or Hep C 30 yrs ago | Virology News | Scoop.it
The Government will apologise this week for the infection of thousands of patients with deadly diseases through contaminated blood products, three decades ago.
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Origins and evolution of viruses of eukaryotes: The ultimate modularity

Origins and evolution of viruses of eukaryotes: The ultimate modularity | Virology News | Scoop.it

Viruses and other selfish genetic elements are dominant entities in the biosphere, with respect to both physical abundance and genetic diversity. Various selfish elements parasitize on all cellular life forms. The relative abundances of different classes of viruses are dramatically different between prokaryotes and eukaryotes. In prokaryotes, the great majority of viruses possess double-stranded (ds) DNA genomes, with a substantial minority of single-stranded (ss) DNA viruses and only limited presence of RNA viruses. In contrast, in eukaryotes, RNA viruses account for the majority of the virome diversity although ssDNA and dsDNA viruses are common as well. Phylogenomic analysis yields tangible clues for the origins of major classes of eukaryotic viruses and in particular their likely roots in prokaryotes. Specifically, the ancestral genome of positive-strand RNA viruses of eukaryotes might have been assembled de novo from genes derived from prokaryotic retroelements and bacteria although a primordial origin of this class of viruses cannot be ruled out. Different groups of double-stranded RNA viruses derive either from dsRNA bacteriophages or from positive-strand RNA viruses. The eukaryotic ssDNA viruses apparently evolved via a fusion of genes from prokaryotic rolling circle-replicating plasmids and positive-strand RNA viruses. Different families of eukaryotic dsDNA viruses appear to have originated from specific groups of bacteriophages on at least two independent occasions. Polintons, the largest known eukaryotic transposons, predicted to also form virus particles, most likely, were the evolutionary intermediates between bacterial tectiviruses and several groups of eukaryotic dsDNA viruses including the proposed order “Megavirales” that unites diverse families of large and giant viruses. Strikingly, evolution of all classes of eukaryotic viruses appears to have involved fusion between structural and replicative gene modules derived from different sources along with additional acquisitions of diverse genes.

 

Graphic by Ed Rybicki

  

Ed Rybicki's insight:

Wow...!  A tour de force.  Quite simply, says it all.  REALLY nice piece of work!!  And of course, they back me up in my view of how ss(-)RNA viruses evolved. Again B-)

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Rabenstein, Frank's curator insight, March 23, 10:59 AM

Thank you Ed for this.

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Vaccines Face Same Mistrust That Fed Ebola

Vaccines Face Same Mistrust That Fed Ebola | Virology News | Scoop.it
The same mix of fear and distrust that helped the Ebola epidemic spread is hampering doctors conducting trials on new medicines.
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Human Papillomavirus (HPV): animated video

View more NUCLEUS medical animations at http://www.nucleuslibrary.com If you like this animation, LIKE us on Facebook: http://www.nucleusinc.com/facebook htt...
Ed Rybicki's insight:

Really useful little movie!

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Measles kills 6 in Margibi, Liberia

Measles kills 6 in Margibi, Liberia | Virology News | Scoop.it

As Margibi County observes the eradication of Ebola for more than 42 days without a new case, another disease has hit the county, killing at least six persons.

Speaking to reporters in Kakata, Margibi County on Friday, 10 April the County Mobilization Coordinator for UNICEF, Sophie Reeves, disclosed that there are about 77 measles cases with six deaths reported in the county.

Ed Rybicki's insight:

Poor folk can't catch a break...but that's why you vaccinate - and they couldn't, what with Ebola.

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HIV breakthrough 'imminent', says virus' discoverer

HIV breakthrough 'imminent', says virus' discoverer | Virology News | Scoop.it

Nobel laureate Francoise Barre-Sinoussi‚ who co-discovered the virus that causes Aids‚ believes it is possible that one day people will live with HIV‚ without taking medicine and yet remain healthy and un-infectious.

She was speaking at the Sci-Bono centre in Johannesburg on Friday.

Barre-Sinoussi believes a cure that will completely eliminate HIV from the body is "impossible". But she says sending the virus into remission is possible.

The scientist explained that clinical remission is when the virus is still in the body‚ but it is not replicating‚ not attacking the cells and the person cannot transmit HIV.

The virus would also not be activating the carrier's immune system and causing inflammation in the body‚ which is linked to lifestyle disease such as heart disease and cancer.

The reason she believes remission is possible is because up to three in 1000 HIV-positive people naturally send the virus into remission and never require medicine. They are called elite controllers. These are people whose bodies stop the virus replicating and remain healthy 20 years after infection without antiretroviral medication.

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Wild rabbits being poisoned by carrots laced with deadly virus

Wild rabbits being poisoned by carrots laced with deadly virus | Virology News | Scoop.it
Local councils in greater Sydney scattered the vegetables, which are laced with the haemorrhaging inducing calicivirus, in public areas to reduce the extensive damage rabbits cause.

 

Easter is over for the wild rabbits of greater Sydney as councils and parks prepare another attempt to kill them off with strategically placed carrots that have been laced with a deadly virus.

Public land managers are desperate to reduce the most recent 'significantly rampant population' of the pest, which causes millions of dollars of major agricultural and environmental damage each year.

 

Ed Rybicki's insight:

Deadly only to rabbits, we will note - and in Australia. Your kids are safe B-)

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Lack of Marburg Virus Transmission From Experimentally Infected to Susceptible In-Contact Egyptian Fruit Bats

Lack of Marburg Virus Transmission From Experimentally Infected to Susceptible In-Contact Egyptian Fruit Bats | Virology News | Scoop.it

Egyptian fruit bats (Rousettus aegyptiacus) were inoculated subcutaneously (n = 22) with Marburg virus (MARV). No deaths, overt signs of morbidity, or gross lesions was identified, but microscopic pathological changes were seen in the liver of infected bats. The virus was detected in 15 different tissues and plasma but only sporadically in mucosal swab samples, urine, and fecal samples. Neither seroconversion nor viremia could be demonstrated in any of the in-contact susceptible bats (n = 14) up to 42 days after exposure to infected bats. In bats rechallenged (n = 4) on day 48 after infection, there was no viremia, and the virus could not be isolated from any of the tissues tested. This study confirmed that infection profiles are consistent with MARV replication in a reservoir host but failed to demonstrate MARV transmission through direct physical contact or indirectly via air. Bats develop strong protective immunity after infection with MARV.

 
Ed Rybicki's insight:

From our very own NICD!

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New, whole-virus vaccine for Ebola effective in primates

New, whole-virus vaccine for Ebola effective in primates | Virology News | Scoop.it
Novel whole virus vaccine offers promising protection against Ebola infection

 

A study published in Science demonstrates that vaccination with a mutated form of the Ebola virus provides some measure of protection to non-human primates. This finding places the vaccine one step closer to clinical trials in humans.

The researchers publishing this study have developed what’s called a “whole virus” vaccine for Ebola. Viruses have proteins on their exterior and genetic material on their interior. Whole virus vaccines present the host’s immune system with multiple viral proteins and the viral genetic material. These vaccines trigger broader immune system responses than vaccines that only present a single protein from the virus. Whole virus vaccines have had widespread success in offering protection against potentially deadly diseases such as smallpox, measles, and influenza.

Ed Rybicki's insight:

NOW everyone starts getting Ebola results...never mind, it'll be along again shortly - like flu.

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Researchers Use Polio Virus for Cancer Treatment

Researchers Use Polio Virus for Cancer Treatment | Virology News | Scoop.it
The cure to cancer could come from researchers at the Duke University Hospital Cancer Center.


Duke Medicine’s Dr. Matthias Gromeier has been working on a Glioblastoma treatment using a modified polio virus for more than 25-years.

Now, Duke researchers are testing the treatment and trials show it is working for some patients. 

After doctors told Clara Guy she had six to 18-months to live, she transferred to Duke Medicine’s Preston Robert Tisch Brain Tumor Center, where she became a stage four Glioblastoma research patient.  Glioblastoma is an aggressive and fast growing type of brain cancer.

"It's a big word...Glioblastoma is so much than a four letter word, and it really ought to be,” she said.

Guy was under the regulate vaccine trial.

"It turns your immune system onto high gear to teach it to fight the cancer cells,” she said. 

Neurooncologist Dr. Annick Desjardins is using the genetically modified polio virus as treatment for some patients during Phase One of the research. 

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Liberia: Ebola Vaccine Tests Show It Could 'Neutralise' Virus

Liberia: Ebola Vaccine Tests Show It Could 'Neutralise' Virus | Virology News | Scoop.it
An experimental Ebola vaccine tested on humans in Europe and Africa sparks the production of the antibodies needed to neutralize the deadly virus, a Geneva hospital said Wednesday.

Initial clinical trials of the VSV-ZEBOV candidate vaccine, manufactured by the Public Health Agency of Canada and developed by Merck, show that it "triggers the production of antibodies capable of neutralizing the Ebola virus," the Geneva University Hospitals (HUG) said in a statement.

 
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Ebola: it hasn't gone away.

Ebola: it hasn't gone away. | Virology News | Scoop.it

We've just got blase about it.  And we shouldn't be - because even as the epidemic declines, there are more cases per day than in ANY previous outbreak.  

 

Ebola replication graphic from Russell Kightley Media

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Avian influenza H7N9 human infection emerged 2 years ago...

Seems like only 365 days ago I wrote about H7N9 being 1 year old.
Now - it's another year later.

Via Mel Melendrez-Vallard
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Measles Could Cause More Deaths Than Ebola In West Africa

Measles Could Cause More Deaths Than Ebola In West Africa | Virology News | Scoop.it
West Africa's Ebola outbreak could be stanched by mid-year – but in the epidemic's wake, another public health crisis looms. Disruption of the region's already feeble health care systems has derailed health campaigns targeting childhood diseases, leaving the door wide open for measles and other preventable illnesses.

Via Chris Upton + helpers
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Ever wondered how biotech seeds are made?

Ever wondered how biotech seeds are made? Their story begins with the world's first farmers 10,000 years ago…

Ed Rybicki's insight:

Really well done little infographic story

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The Gambian despot who 'cured HIV-AIDS' and his British homoeopath allies

The Gambian despot who 'cured HIV-AIDS' and his British homoeopath allies | Virology News | Scoop.it
President Yahyah Jammeh, the dictator who has defied medical opinion since 2007 by claiming to have found a cure for HIV-AIDS, has found allies in a British homoeopathic group sponsored by the official suppliers of homoeopathic medicine to the Royal...
Ed Rybicki's insight:

F*ckwits, all.

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