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Major breakthrough in HIV prevention

Major breakthrough in HIV prevention | Virology News | Scoop.it
MELBOURNE researchers have developed cows' milk that can defend human cells against HIV.

Lead researcher, University of Melbourne's Marit Kramski said they vaccinated pregnant cows - which cannot contract human immunodeficiency virus - with an HIV protein [Env?] and studied the first milk produced by the cow after birth.

HIV cases in Australia on the rise

Dr Kramski said this first milk, called colostrum, produced milk high in antibodies to protect its newborn against disease.

The researchers were able to inhibit the virus from infecting cells when "combing the virus cells with milk" [sic - I think they mean combining the virus with milk containing antibodies].

 

I think this is very interesting, and has potential for trial in monkeys - not humans, because there is the little problem of the antibodies that would go into a virucidal cream being from cows - meaning they would elicit an immune response, unlike the humanised anti-HIV monoclonals being made in plants by the Fraunhofer Institute.

 

Still, using cow's milk is an inventive thing to do - and sounds like a very cheap source of antibodies.  Except that colostrum is ONLY produced immediately after birth of a calf, so it will nothing like as cheap as milk.

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Virology News
Topical news snippets about viruses that affect people.  And other things. Like Led Zeppelin. And zombies B-)
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Cann's Principles of Molecular Virology - 7th Edition

Cann's Principles of Molecular Virology - 7th Edition | Virology News | Scoop.it

Cann's Principles of Molecular Virology, - 7th Edition, revised by EP Rybicki. Print Book. ISBN 9780128227848. Now published!!


Instructor review copies: click on this link.

https://protect-za.mimecast.com/s/qU2qCNxKq0i0ZNRQxcmeDdo

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Harnessing the mechanisms of fungal bioluminescence to confer autonomous luminescence in plant and animal cells

Harnessing the mechanisms of fungal bioluminescence to confer autonomous luminescence in plant and animal cells | Virology News | Scoop.it
In a striking new study published in Science Advances, a team of synthetic biologists led by Karen Sarkisyan at the MRC Laboratory of Medical Sciences, have reported the discovery of multiple plant enzymes—hispidin synthases—that can perform the most complex reaction of the bioluminescence pathway.
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Structural Impact of the Interaction of the Influenza A Virus Nucleoprotein with Genomic RNA Segments

Structural Impact of the Interaction of the Influenza A Virus Nucleoprotein with Genomic RNA Segments | Virology News | Scoop.it
Influenza A viruses (IAVs) possess a segmented genome consisting of eight viral RNAs (vRNAs) associated with multiple copies of viral nucleoprotein (NP) and a viral polymerase complex. Despite the crucial role of RNA structure in IAV replication, the impact of NP binding on vRNA structure is not...
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Single-Dose Immunogenic DNA Vaccines Coding for Live-Attenuated Alpha- and Flaviviruses

Single-Dose Immunogenic DNA Vaccines Coding for Live-Attenuated Alpha- and Flaviviruses | Virology News | Scoop.it
Single-dose, immunogenic DNA (iDNA) vaccines coding for whole live-attenuated viruses are reviewed. This platform, sometimes called immunization DNA, has been used for vaccine development for flavi- and alphaviruses.
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The Effects of SARS-CoV-2 on the Angiopoietin/Tie Axis and the Vascular Endothelium

The Effects of SARS-CoV-2 on the Angiopoietin/Tie Axis and the Vascular Endothelium | Virology News | Scoop.it
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause potentially life-threatening coronavirus disease (COVID-19). COVID-19 is a multisystem disease and is associated with significant respiratory distress, systemic hyperinflammation, vasculitis, and multi-organ failure.
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Myocarditis after Covid-19 Vaccination in a Large Health Care Organization

Original Article from The New England Journal of Medicine — Myocarditis after Covid-19 Vaccination in a Large Health Care Organization...
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A simple and robust method to add functional molecules to peptides

A simple and robust method to add functional molecules to peptides | Virology News | Scoop.it
Peptides are short strands of amino acids that are increasingly used therapeutically, as biomaterials and as chemical and biological probes. The capacity to isolate, manipulate and label peptides and larger proteins is limited, however, by the ability to reliably attach functional molecules, such...
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Background for CDC's Updated Respiratory Virus Guidance | Respiratory Illnesses

Background for CDC's Updated Respiratory Virus Guidance | Respiratory Illnesses | Virology News | Scoop.it

 Executive summary The 2023-2024 fall and winter virus season, four years since the start of the COVID-19 pandemic, provided ongoing evidence of the changing face of respiratory diseases. COVID-19 remains an important public health threat, but it is no longer the emergency that it once was, and its health impacts increasingly resemble those of other respiratory viral illnesses, including influenza and RSV. This reality enables CDC to provide updated guidance proportionate to the current level of risk COVID-19 poses while balancing other critical health and societal needs. 

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Does COVID-19 Lead to Greater Relapse Risk, Deterioration in Multiple Sclerosis?

Compared with patients with MS not infected with COVID-19, those who were did not have a greater risk for relapse or worse EDSS scores...
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Before and after COVID-19: Changes in symptoms and diagnoses in 13,033 adults

Before and after COVID-19: Changes in symptoms and diagnoses in 13,033 adults | Virology News | Scoop.it
Background Most patients with COVID-19 report experiencing one or more symptoms after acute infection subsides, known as post-acute sequelae of SARS-CoV-2 infection (PASC). Though research has examined PASC after acute COVID-19, few studies have examined PASC over a longer follow-up duration or...
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Early experiments show Ebola-fighting potential of engineered bacteria

Early experiments show Ebola-fighting potential of engineered bacteria | Virology News | Scoop.it
Since its 1976 emergence in Africa, the Ebola virus has proven an especially lethal contagion, killing roughly 50% of the people who contract it. The 2019 FDA approval of a vaccine, combined with the subsequent development of two antibody-based drugs, marked unprecedented progress against one...
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Optimizing boosters: How COVID mRNA vaccines reshape immune memory after each dose

COVID-19 vaccines elicit strong T-cell responses, but clonal-resolution analyses of these responses have not previously been performed. To address this gap, a team of researchers investigated the T- cell receptor sequence and tracked it using trammer analysis, uncovering key insights into the...
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Designing nanoparticles for pregnancy-safe treatments

Designing nanoparticles for pregnancy-safe treatments | Virology News | Scoop.it
Too often, the lack of clinical trials means that pregnant women suffer because available medications are prescribed off-label for them or not at all. A new study offers proof of concept for the important parameters to develop pregnancy-safe gene therapies.
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NASA unveils design for message heading to Jupiter's moon Europa

NASA unveils design for message heading to Jupiter's moon Europa | Virology News | Scoop.it
When it launches in October, the agency's Europa Clipper spacecraft will carry a richly layered dispatch that includes more than 2.6 million names submitted by the public.
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Quantitative Assessment of Energetic Contributions of Residues in a SARS-CoV-2 Viral Enzyme/Nanobody Interface

Quantitative Assessment of Energetic Contributions of Residues in a SARS-CoV-2 Viral Enzyme/Nanobody Interface | Virology News | Scoop.it
The highly conserved protease enzyme from SARS-CoV-2 (M<sup>Pro</sup>) is crucial for viral replication and is an attractive target for the design of novel inhibitory compounds.M<sup>Pro</sup> is known to be conformationally flexible and has been stabilized in an extended conformation in a complex...
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mRNA vaccines train T cells in waves, study shows

mRNA vaccines train T cells in waves, study shows | Virology News | Scoop.it
mRNA vaccines developed against the spike glycoprotein of severe acute respiratory syndrome type 2 coronavirus (SARS-CoV-2), displayed remarkable efficiency in combating coronavirus 19 (COVID-19).
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N6-methyladenosine modification is not a general trait of viral RNA genomes

N6-methyladenosine modification is not a general trait of viral RNA genomes | Virology News | Scoop.it
A comprehensive analysis found no evidence of m6A modifications in the genome of the cytoplasmic RNA viruses CHIKV and DENV, challenging the current notion that m6A modification is a general feature of cytoplasmic RNA viruses.
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Impact of Nonpharmaceutical Interventions during the COVID-19 Pandemic on the Prevalence of Respiratory Syncytial Virus in Hospitalized Children with Lower Respiratory Tr...

Impact of Nonpharmaceutical Interventions during the COVID-19 Pandemic on the Prevalence of Respiratory Syncytial Virus in Hospitalized Children with Lower Respiratory Tr... | Virology News | Scoop.it
During the COVID-19 pandemic, nonpharmaceutical interventions (NPIs) were implemented in order to control the transmission of SARS-CoV-2, potentially affecting the prevalence of respiratory syncytial virus (RSV).
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Breakthrough in COVID-19 Battle: New Antiviral Drugs Show Promise in Preclinical Trials

Breakthrough in COVID-19 Battle: New Antiviral Drugs Show Promise in Preclinical Trials | Virology News | Scoop.it
Groundbreaking antiviral drugs discovered by University of Alberta scientists offer new hope in the fight against COVID-19 and future pandemics.
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NIH to bolster RECOVER Long COVID research efforts 

NIH to bolster RECOVER Long COVID research efforts  | Virology News | Scoop.it
News & Events News Releases Leadership Q&A: NIH to bolster RECOVER Long COVID research efforts...
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Is COVID-19 Still a Pandemic?

Is COVID-19 Still a Pandemic? | Virology News | Scoop.it
The WHO declared COVID-19 a pandemic on March 11, 2020. Four years later, in 2024, is COVID-19 and SARS-CoV-2 still a pandemic?
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MIT Scientists Enhance Vaccines with Novel Nanoparticles

MIT Scientists Enhance Vaccines with Novel Nanoparticles | Virology News | Scoop.it
Numerous vaccines, such as those for whooping cough and hepatitis B, contain bits of bacterial or viral proteins.
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Expectations, experiences and challenges of nursing students using the virtual learning medium during the COVID-19 pandemic

Expectations, experiences and challenges of nursing students using the virtual learning medium during the COVID-19 pandemic | Virology News | Scoop.it
Background The COVID-19 pandemic caused several higher educational institutions to switch from traditional face-to-face to virtual learning medium. This abrupt shift came with new expectations, experiences and challenges to nursing/ midwifery students, particularly new users, and even more so when...
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How water guides the assembly of collagen, the building block of all humans

How water guides the assembly of collagen, the building block of all humans | Virology News | Scoop.it
Water determines life: humans are three-quarters water. An international research team led by the University of Amsterdam (UvA) has now discovered how water also determines the structure of the material that holds us together: collagen.
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Drones could help map the lunar surface with extreme precision

Drones could help map the lunar surface with extreme precision | Virology News | Scoop.it
Exploring the moon has become increasingly more of a focal point lately, especially with a series of landers recently launched with various degrees of success. One of the difficulties those landers and any future human missions face is understanding the terrain they are landing on and potentially...
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New study discovers how altered protein folding drives multicellular evolution

New study discovers how altered protein folding drives multicellular evolution | Virology News | Scoop.it
Researchers have discovered a mechanism steering the evolution of multicellular life. They identify how altered protein folding drives multicellular evolution.
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