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Full genomic analysis of an influenza A (H1N2) virus identified during 2009 pandemic in Eastern India: evidence of reassortment event between co-circulating A(H1N1)pdm...

Full genomic analysis of an influenza A (H1N2) virus identified during 2009 pandemic in Eastern India: evidence of reassortment event between co-circulating A(H1N1)pdm... | Virology News | Scoop.it

"During the pandemic [Influenza A(H1N1)pdm09] period in 2009-2010, an influenza A (Inf-A) virus with H1N2 subtype (designated as A/Eastern India/N-1289/2009) was detected from a 25 years old male from Mizoram (North-eastern India).

The outcome of this full genome study revealed a unique reassortment event where the N-1289 virus acquired it's HA gene from a 2009 pandemic H1N1 virus with swine origin and the other genes from H3N2-like viruses of human origin.

Conclusions
This study provides information on possibility of occurrence of reassortment events during influenza season when infectivity is high and two different subtypes of Inf Aviruses co-circulate in same geographical location."

 

This is interesting, and sobering news: it shows how easily this sort of thing can happen; it is perhaps fortunate that both the NA of the new virus came from a circulating type, as otherwise the virus could have spread as far and been as serious as the new H1N1.

 

I thank Russell Kightley for the reassortant influenza virus graphic.

 

 

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Virology News
Topical news snippets about viruses that affect people. And other things.
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What we are NOT afraid to say about Ebola virus

What we are NOT afraid to say about Ebola virus | Virology News | Scoop.it
The message is clear: gain of function (airborne transmission) is accompanied by loss of function (virulence).
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The discussion is interesting.

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Ecology and evolution of viruses infecting uncultivated SUP05 bacteria

Ecology and evolution of viruses infecting uncultivated SUP05 bacteria | Virology News | Scoop.it

Viruses modulate microbial communities and alter ecosystem functions. However, due to cultivation bottlenecks specific virus-host interaction dynamics remain cryptic. Here we examined 127 single-cell amplified genomes (SAGs) from uncultivated SUP05 bacteria isolated from a marine oxygen minimum zone (OMZ) to identify 69 viral contigs representing five new genera within dsDNA Caudovirales and ssDNA Microviridae. Infection frequencies suggest that ~1/3 of SUP05 bacteria are viral-infected, with higher infection frequency where oxygen-deficiency was most severe. Observed Microviridae clonality suggests recovery of bloom-terminating viruses, while systematic co-infection between dsDNA and ssDNA viruses posits previously unrecognized cooperation modes. Analyses of 186 microbial and viral metagenomes revealed that SUP05 viruses persisted for years, but remained endemic to the OMZ. Finally, identification of virus-encoded dissimilatory sulfite reductase suggests SUP05 viruses reprogram their host's energy metabolism. Together these results demonstrate closely coupled SUP05 virus-host co-evolutionary dynamics with potential to modulate biogeochemical cycling in climate-critical and expanding OMZs - See more at: http://elifesciences.org/content/early/2014/08/29/eLife.03125#sthash.zHW4bHYA.IJrBl8h3.dpuf

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SA negating Ebola role: expert

SA negating Ebola role: expert | Virology News | Scoop.it

Pretoria - South Africa should have played the leading role in the fight against the spread of the Ebola virus in Africa, Frans Viljoen, director of the University of Pretoria's centre for human rights, said on Wednesday.

“As South Africans we should laud President Barack Obama,” he said during a University of Pretoria panel discussion on South Africa's preparedness for Ebola.

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Ebola: While Big Pharma Slept

Ebola: While Big Pharma Slept | Virology News | Scoop.it
The story of Ebola's most recent (and now deadliest) outbreak is a book worthy topic.
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Neal Stephenson: The sci-fi optimist in Nature

Neal Stephenson: The sci-fi optimist in Nature | Virology News | Scoop.it
Best-selling science-fiction writer Neal Stephenson's works cover everything from cryptography to Sumerian mythology. Ahead of next year's novel Seveneves, he talks about his influences, the stagnation in material technologies, and Hieroglyph, the forthcoming science-fiction anthology that he kick-started to stimulate the next generation of engineers.
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From Cedar and Peanut allergies to Cancer Vaccines and Immunotherapeutics: The future of DNA vaccines

From Cedar and Peanut allergies to Cancer Vaccines and Immunotherapeutics: The future of DNA vaccines | Virology News | Scoop.it
From Cedar and Peanut allergies to Cancer Vaccines and Immunotherapeutics: This is the future of DNA vaccine technology
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Anti-vaccine movement may have global repercussions

Anti-vaccine movement may have global repercussions | Virology News | Scoop.it
Opposition to vaccines threatens well-being of all children.
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People who refuse to vaccinate their children ought to be ostracised: not allowed to school their kids, not allowed to go to supermarkets....

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5 Diseases That Need Vaccines Even More Than Ebola

While the Ebola numbers seem staggering, infectious diseases like malaria and influenza kill hundreds of thousands of people every single year. (5 Diseases That Need Vaccines or Improvements: Malaria, dengue, tuberculosis, influenza, HIV.
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Ebola in the air? A nightmare that could happen

Ebola in the air? A nightmare that could happen | Virology News | Scoop.it
Every time the Ebola virus copies itself, it mutates. These mutations could change the way the virus behaves.
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Child respiratory virus rapidly sweeping across US

Eight states have confirmed cases of Enterovirus 68. Dr. William Schaffner, professor of preventative medicine at Vanderbilt University, discusses the spread of the virus with the "CBS This...
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Ebola Virus - YouTube

https://www.facebook.com/ArmandoHasudungan Source: http://www.who.int/mediacentre/factsheets/fs103/en/
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A virus hunter faces the big one: Ebola

A virus hunter faces the big one: Ebola | Virology News | Scoop.it
For years, Joseph Fair dreamed of fighting Ebola. Then he got his chance. It wasn’t what he expected.
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New analysis of old HIV vaccines finds potentially protective immune response

Applying the benefit of hindsight, researchers at Duke Medicine have reanalyzed the findings of two historic pediatric HIV vaccine trials with encouraging results. The vaccines had in fact triggered an antibody response -- now known to be associated with protection in adults -- that was previously unrecognized in the infants studied in the 1990s.
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Nepal in historic introduction of the injectable Inactivated Polio Vaccine (IPV)

Nepal in historic introduction of the injectable Inactivated Polio Vaccine (IPV) | Virology News | Scoop.it
The IPV will help secure a world free of all polio disease

KATHMANDU, 18 September 2014 – In a landmark step to accelerate the global eradication of polio and help prevent a resurgence of the disease, Nepal is today introducing the Inactivated Polio Vaccine (IPV) into its routine immunization programme. Nepal has the distinction of being the first country in South Asia region to launch IPV as part of the global roll-out of the vaccine.
Ed Rybicki's insight:

Indeed historic - because it marks the beginning of the global endgame in the battle against polio.  Using a killed vaccine means NO circulating live virus derived from vaccine strains.

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Ebola vaccine trial begins

Ebola vaccine trial begins | Virology News | Scoop.it

London - The first volunteer in a fast-tracked British safety trial of an experimental Ebola vaccine made by GlaxoSmithKline received the injection on Wednesday, trial organisers said.

The candidate Ebola vaccine, which GSK co-developed with the United States National Institutes of Health, has also been given to 10 volunteers taking part in a separate trial in the United States, and so far there were no signs of any serious adverse reactions, doctors said.

The vaccine is designed to specifically target the Zaire strain of Ebola, the one circulating in the West Africa epidemic, the worst Ebola outbreak recorded.

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Ebola crisis 'violently escalating'

Ebola crisis 'violently escalating' | Virology News | Scoop.it

World health officials say the number of people infected by the deadly Ebola virus has doubled in a matter of weeks. 
September 18 2014 at 10:54am

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"Forgotten" stores of ricin at NIH?

Ricin left behind A laboratory sweep at the US National Institutes of Health uncovered forgotten stores of the toxin ricin and four pathogens, according to an agency memo released on 5 September. The agency performed the search after finding improperly stored vials of the deadly smallpox virus in a refrigerator at its campus in Bethesda, Maryland, in July. See go.nature.com/eyyylw for more.

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Cuba to commit large health corps to Ebola fight

Cuba to commit large health corps to Ebola fight | Virology News | Scoop.it
Tiny island nation will send 165 doctors and nurses to Sierra Leone
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Engineering of inducible resistance in maize to Maize streak virus: a history, and a model for South-South collaboration

Engineering of inducible resistance in maize to Maize streak virus: a history, and a model for South-South collaboration | Virology News | Scoop.it
I blogged on this paper from our group over at Virology News, but then I decided to do it again here. Because, as I said there, "This is a big deal: seriously. It's the culmination of some 24 years...
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U.S. Military to Send 3,000 to Battle Ebola Virus

U.S. Military to Send 3,000 to Battle Ebola Virus | Virology News | Scoop.it
The U.S. military will deploy about 3,000 personnel to West Africa to coordinate international aid, build treatment centers and train health-care workers as part of President Barack Obama's offensive against a worsening Ebola outbreak, a senior...
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US Ebola Patient Gets Serum From Recovered Victim to Fight Virus

US Ebola Patient Gets Serum From Recovered Victim to Fight Virus | Virology News | Scoop.it
ABC News
US Ebola Patient Gets Serum From Recovered Victim to Fight Virus
ABC News
An American Ebola survivor has donated blood to help an infected U.S. doctor fight the deadly disease. Dr.
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The not so famous HIV prevention method

The not so famous HIV prevention method | Virology News | Scoop.it
The not so famous HIV prevention method
News24
The Centres for Disease Control and Prevention (CDC), recommends PrEP be considered for people who are HIV-negative and at substantial risk for HIV infection.
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Special Collection: Ebola

Special Collection: Ebola | Virology News | Scoop.it
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U.S. to announce major increase in aid to fight Ebola

U.S. to announce major increase in aid to fight Ebola | Virology News | Scoop.it
President Obama is expected to lay out details during visit to CDC on Tuesday.

President Obama plans to announce a significant boost in the U.S. response to the worst Ebola outbreak in history in West Africa, including more involvement of the U.S. military, according to an administration official.

Among the likely moves are setting up more field hospitals, sending more health-care personnel and training health workers in the hardest-hit countries of Liberia, Sierra Leone and Guinea. The Pentagon announced last week that it would send a 25-bed hospital to Liberia. The hospital is intended to treat health-care workers, including Liberians, and eventually will be turned over to the Liberian government. But it will be at least a month before the hospital is delivered. “There will be some additional facilities in the works,” the official said.

Obama is expected to lay out details during his visit to the Centers for Disease Control and Prevention in Atlanta on Tuesday, the official said.

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Mers: Saudis in push to keep Hajj free from deadly virus

Mers: Saudis in push to keep Hajj free from deadly virus | Virology News | Scoop.it
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