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Microneedle vaccine patch boosts flu protection through robust skin cell immune response

Recent research found that microneedle vaccine patches are more effective at delivering protection against influenza virus in mice than subcutaneous or intramuscular inoculation.

 

Again, intelligent use of the largest organ of immunity of the human body - the skin

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Virology News
Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
Curated by Ed Rybicki
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Hep B vaccine should be given sooner: pediatricians group

Hep b vaccine should be given sooner: pediatricians group MONDAY, Aug. 28, 2017 HealthDay News The first dose of the hepatitis B vaccine should be given t
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Gavi CEO blames anti-vaccine mums for return of diseases

Mothers refusing to vaccinate children are helping to bring deadly diseases back to the West as hostility to science puts the developed world at risk
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Marijuana Exposure Associated With Improved Immunity in HIV Patients

Marijuana Exposure Associated With Improved Immunity in HIV Patients | NORML PETERSBURG, VA — Patients with HIV who test positive for pas
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Who knows? But it sounded good B-)
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Crack down on vaccine disinformation to prevent next Minnesota measles outbreak

Crack down on vaccine disinformation to prevent next Minnesota measles outbreak | Virology News | Scoop.it
Hearing needed this fall on the vaccine misinformation campaign that fueled measles outbreak.
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Bacteriophage therapy to combat bacterial infections in poultry

Infections in poultry are an economic and health problem in Europe and worldwide. The most common infections are associated with salmonellosis, colibacillosis, campylobacteriosis, and others. The prevalence of Campylobacter-positive poultry flocks in European countries varies from 18% to 90%. In the United States, the prevalence of infected flocks is nearly 90%. A similar percentage of infection has been noted for salmonellosis (about 75–90%) and E. coli (90–95%). The occurence of Clostridium perfringens is a major problem for the poultry industry, with some estimates suggesting colonization of as many as 95% of chickens, resulting in clinical or subclinical infections. In the US, annual economic losses due to Salmonella infections run from $1.188 billion to over $11.588 billion, based on an estimated 1.92 million cases. Similar costs are observed in the case of other types of infections. In 2005 economic losses in the the poultry industry due to mortalities reached 1,000,000 USD. Infections caused by these pathogens, often through poultry products, are also a serious public health issue. The progressive increase in the number of multi-drug resistant bacteria and the complete ban on the use of antibiotics in livestock feed in the EU, as well as the partial ban in the US, have led to the growth of research on the use of bacteriophages to combat bacterial infections in humans and animals. The high success rate and safety of phage therapy in comparison with antibiotics are partly due to their specificity for selected bacteria and the ability to infect only one species, serotype or strain. This mechanism does not cause the destruction of commensal bacterial flora. Phages are currently being used with success in humans and animals in targeted therapies for slow-healing infections. They have also found application in the US in eliminating pathogens from the surface of foods of animal and plant origin. At a time of growing antibiotic resistance in bacteria and the resulting restrictions on the use of antibiotics, bacteriophages can provide an alternative means of eliminating pathogens.
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Virus like particle-based vaccines against emerging infectious disease viruses

Virus like particle-based vaccines against emerging infectious disease viruses | Virology News | Scoop.it

Emerging infectious diseases are major threats to human health. Most severe viral disease outbreaks occur in developing regions where health conditions are poor. With increased international travel and business, the possibility of eventually transmitting infectious viruses between different countries is increasing. The most effective approach in preventing viral diseases is vaccination. However, vaccines are not currently available for numerous viral diseases. Virus-like particles (VLPs) are engineered vaccine candidates that have been studied for decades. VLPs are constructed by viral protein expression in various expression systems that promote the selfassembly of proteins into structures resembling virus particles. VLPs have antigenicity similar to that of the native virus, but are non-infectious as they lack key viral genetic material. VLP vaccines have attracted considerable research interest because they offer several advantages over traditional vaccines. Studies have shown that VLP vaccines can stimulate both humoral and cellular immune responses, which may offer effective antiviral protection. Here we review recent developments with VLP-based vaccines for several highly virulent emerging or re-emerging infectious diseases. The infectious agents discussed include RNA viruses from different virus families, such as the Arenaviridae, Bunyaviridae, Caliciviridae, Coronaviridae, Filoviridae, Flaviviridae, Orthomyxoviridae, Paramyxoviridae, and Togaviridae families.

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Waterlogged: Six Tales of the Aquatic Undead

Waterlogged: Six Tales of the Aquatic Undead | Virology News | Scoop.it
Waterlogged: Six Tales of the Aquatic Undead: Horror Story Six-Packs, vol. 3 - Kindle edition by C. L. Hernandez, Walt McFee. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Waterlogged: Six Tales of the Aquatic Undead: Horror Story Six-Packs, vol. 3.
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I did say we do zombies too...B-)
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Deadly Bird Flu In China Evolves, Spreads To New Regions

Deadly Bird Flu In China Evolves, Spreads To New Regions | Virology News | Scoop.it
In the 2017 outbreak, the Chinese government reported 759 cases of the H7N9 avian flu, with 281 deaths. By comparison, in 2016 there were 123 cases.
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Anti-HPV vaccine myths have fatal consequences

After clean water, there is no health intervention that has saved more lives than vaccination – and none that has inspired more misguided opposition. This has been exemplified recently by the furore over the human papilloma virus (HPV) vaccine.
Ed Rybicki's insight:
Yes, all vaccines have risks associated with them; no, HPV vaccines are not so obviously life-saving as polio, MMR and hepatitis - but would you really want YOUR child to take the chance of being one of the >300 000 women who die every year of cervical cancer, when it is preventable?
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West Nile Virus Death In Los Angeles, Official Say

West Nile Virus Death In Los Angeles, Official Say | Virology News | Scoop.it
Los Angeles, CA - There have been three reported deaths from West Nile Virus in 2017, one of them, a Los Angeles resident.
Ed Rybicki's insight:
Just checking to see whether or not Dickson Despommier is reading these...see, Dickson, you get considerably more leeway to comment here than on Twitter, while at the same time being in a post that links to a Web page - and that can consierable text linked with it, not subject to being rendered as a JPG or other graphic!
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New CDC report says HPV vaccines are on the rise

New CDC report says HPV vaccines are on the rise | Virology News | Scoop.it
The CDC released a report last week saying 6 out of 10 parents are choosing to get their teenagers the HPV vaccine.
But health officials in Iowa are saying that's still not enough.
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HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis

HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis | Virology News | Scoop.it
A genomic survey of thousands of cases of HPV infection in women around the world
identifies a conserved sequence in the viral genome that is critical for carcinogenesis.
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The porcine virome and xenotransplantation

The porcine virome and xenotransplantation | Virology News | Scoop.it
The composition of the porcine virome includes viruses that infect pig cells, ancient virus-derived elements including endogenous retroviruses inserted in the pig chromosomes, and bacteriophages that infect a broad array of bacteria that inhabit pigs. Viruses infecting pigs, among them viruses also infecting human cells, as well as porcine endogenous retroviruses (PERVs) are of importance when evaluating the virus safety of xenotransplantation. Bacteriophages associated with bacteria mainly in the gut are not relevant in this context. Xenotransplantation using pig cells, tissues or organs is under development in order to alleviate the shortage of human transplants. Here for the first time published data describing the viromes in different pigs and their relevance for the virus safety of xenotransplantation is analysed. In conclusion, the analysis of the porcine virome has resulted in numerous new viruses being described, although their impact on xenotransplantation is unclear. Most importantly, viruses with known or suspected zoonotic potential were often not detected by next generation sequencing, but were revealed by more sensitive methods.
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There’s no vaccine yet for stupidity: anti-HPV vaccine campaigning in Ireland

There’s no vaccine yet for stupidity: anti-HPV vaccine campaigning in Ireland | Virology News | Scoop.it
The recent comments by Finian McGrath on the HPV vaccine made Dr Amy Morgan despair
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Melbourne girl, eight, dies as Australia's 'horror' flu season continues

Melbourne girl, eight, dies as Australia's 'horror' flu season continues | Virology News | Scoop.it
Victoria’s health minister urges people to get vaccinated as eastern seaboard sees slight decline in cases
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MIT creates microscopic cups to deliver vaccine doses to kids in one injection

MIT creates microscopic cups to deliver vaccine doses to kids in one injection | Virology News | Scoop.it
WASHINGTON, Sept. 18 (Xinhua) -- One single injection carrying several doses of vaccines has become true thanks to the research of the Massachusetts Institute of Technology (MIT). The MIT reported the technical breakthrough on its website of MIT news last week, telling the world their method of...
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Zika virus and Zika fever

Zika virus and Zika fever | Virology News | Scoop.it

An emerging mosquito-borne arbovirus named Zika virus (ZIKV), of the family Flaviviridae and genus Flavivirus, is becoming a global health threat. ZIKV infection was long neglected due to its sporadic nature and mild symptoms. However, recently, with its rapid spread from Asia to the Americas, affecting more than 30 countries, accumulating evidences have demonstrated a close association between infant microcephaly and Zika infection in pregnant women. Here, we reviewed the virological, epidemiological, and clinical essentials of ZIKV infection.

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Workers get paid for stopping bird flu spread in Pampanga

Workers get paid for stopping bird flu spread in Pampanga | Virology News | Scoop.it
Nameless and faceless, an army of 316 men came out en masse here on Wednesday to receive wages for spending days culling ailing chickens, ducks and quails to help control the avian flu outbreak.
Ed Rybicki's insight:
The generally unheard-from side of avian flu
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Potential Hepatitis Delta Virus Infection Treatment Gets Orphan Drug Designation

Potential Hepatitis Delta Virus Infection Treatment Gets Orphan Drug Designation | Virology News | Scoop.it
The FDA has granted orphan drug status to pegylated interferon lambda 1a (Lambda, Eiger Bio, Inc.) as a potential treatment for chronic hepatitis delta virus (HDV) infection.
Ed Rybicki's insight:
So: now we have vaccines to Hepatitis A and B, treatments for C and D...E, you're still lagging!
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SA Poultry Association: WC govt has bird flu outbreak under control

SA Poultry Association: WC govt has bird flu outbreak under control | Virology News | Scoop.it
The association's Charlotte Nkuna says they’re doing everything possible to minimise damage from the outbreak.
Ed Rybicki's insight:
Bugger: so they won't need my plant-made vaccine, mutter mutter...B-(
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You're sneezing wrong, and helping to spread the flu

You're sneezing wrong, and helping to spread the flu | Virology News | Scoop.it
THE way Australians are taught to sneeze may have fuelled the spread of deadly influenza across the country
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Bloody Australians. Always doing it wrong.
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Zika Virus May Persist in Semen Less Than 6 Months

Zika Virus May Persist in Semen Less Than 6 Months | Virology News | Scoop.it
A new study is disputing previous findings that the Zika virus persists in semen for up to 188 days.
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Latest H7N9 epidemic biggest yet, new vaccines sought

Latest H7N9 epidemic biggest yet, new vaccines sought | Virology News | Scoop.it
The latest H7N9 avian influenza epidemic to affect China is by far largest and most widespread, with 759 cases reported as of Aug. 7, according to researchers.
The epidemic included 281 deaths, and recent variations between viruses have prompted health care officials to develop several new vaccine candidates, researchers wrote in MMWR.
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More influenza-related deaths reported in Tasmanian care facilities

More influenza-related deaths reported in Tasmanian care facilities | Virology News | Scoop.it
The death toll from influenza-related illnesses in Tasmania stands at 14, the state's director of public health says.
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