Using the self-controlled case series design we examined 271,495 12 month vaccinations and 184,312 18 month vaccinations to examine the relative incidence of the composite endpoint of emergency room visits or hospital admissions in consecutive one day intervals following vaccination....
There are significantly elevated risks of primarily emergency room visits approximately one to two weeks following 12 and 18 month vaccination.
Given the effectiveness of the MMR vaccine in eliminating both measles and rubella, and the highly infectious nature of these diseases, high vaccination coverage is essential. The diseases that the vaccines are preventing are not benign and vaccination can eliminate many of the serious sequelae of these infections . Complications from measles include otitis media (7–9% of cases), pneumonia (1–6% of cases), encephalitis (1 per 1,000–2,000 cases), subacute sclerosing panecephalitis (1 per 100,000 cases), and death (1 per 3000 cases) , . Further studies attempting to predict which children develop post-vaccination reactions, as well as determining the effectiveness of prophylactic treatment with antipyrectics prior to the high risk period for symptom development are warranted.