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Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
Curated by Ed Rybicki
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Virophages, polintons, and transpovirons: a complex evolutionary network of diverse selfish genetic elements with different reproduction strategies

Virophages, polintons, and transpovirons: a complex evolutionary network of diverse selfish genetic elements with different reproduction strategies | Virology News | Scoop.it

The results of the phylogenomic analysis of the virophages and related genetic elements are compatible with the concept of network-like evolution of the virus world and emphasize multiple evolutionary connections between bona fide viruses and other classes of capsid-less mobile elements.

Altogether, virophages, polintons, a distinct Tetrahymena transposable element Tlr1, transpovirons, adenoviruses, and some bacteriophages form a network of evolutionary relationships that is held together by overlapping sets of shared genes and appears to represent a distinct module in the vast total network of viruses and mobile elements.


Via Chad Smithson
Ed Rybicki's insight:

Blow your MINDS, virologists...deep relationships between phages, human viruses, satellite viruses and big DNA viruses - as well as with diverse mobile elements within genomes.

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Ignacio López-Goñi's curator insight, May 25, 2013 3:50 AM

Apasionante: el tema se complica! 

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Ineffective – HIV Vaccine Trial Discontinued

Ineffective – HIV Vaccine Trial Discontinued | Virology News | Scoop.it

The National Institute of Allergy and Infectious Diseases (NIAID) has announced that it will halt its HVTN 505 HIV vaccine

trial due to a perceived lack of efficacy. A scheduled review by an independent data and safety monitoring board found that the vaccine regimen neither prevented HIV infection nor reduced viral load in vaccine recipients who became infected with HIV.

The announcement will come as a blow to those hoping the HVTN 505 would be an effective intervention to stem the HIV pandemic.

 

HIV particle graphic by Russell Kightley Media

Ed Rybicki's insight:

And another one bites the dust...not only not effective, but suspected of increasing infection rates.  VERY sad!

 

I am beginning to think that adenoviruses are simply useless when it comes to vectoring HIV genes for vaccine purposes.

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Billions of dollars later and still no Aids vaccine - Times LIVE

Billions of dollars later and still no Aids vaccine - Times LIVE | Virology News | Scoop.it
Latest news from South Africa, World, Politics, Entertainment and Lifestyle. The home of The Times and Sunday Times newspaper. (The hunt for an HIV vaccine has gobbled up $8-billion in the past decade with no real results.
Ed Rybicki's insight:

Beause of rampant band-wagon jumping and some ignoring of basic lessons from other lentiviruses...the Ad5 bandwagon was especially noticeable; it will be interesting to see what the new wagon will be, now that this has come to a grinding halt.  Poxviruses, anyone?

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