Virology News
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Topical news snippets about viruses that affect people.  And other things. Like zombies B-)
Curated by Ed Rybicki
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Post-Ebola Syndrome, Sierra Leone

Post-Ebola Syndrome, Sierra Leone | Virology News | Scoop.it
Thousands of persons have survived Ebola virus disease. Almost all survivors describe symptoms that persist or develop after hospital discharge. A cross-sectional survey of the symptoms of all survivors from the Ebola treatment unit (ETU) at 34th Regimental Military Hospital, Freetown, Sierra Leone (MH34), was conducted after discharge at their initial follow-up appointment within 3 weeks after their second negative PCR result. From its opening on December 1, 2014, through March 31, 2015, the MH34 ETU treated 84 persons (8–70 years of age) with PCR-confirmed Ebola virus disease, of whom 44 survived. Survivors reported musculoskeletal pain (70%), headache (48%), and ocular problems (14%). Those who reported headache had had lower admission cycle threshold Ebola PCR than did those who did not (p<0.03). This complete survivor cohort from 1 ETU enables analysis of the proportion of symptoms of post-Ebola syndrome. The Ebola epidemic is waning, but the effects of the disease will remain.
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Ebola virus is unlikely to become endemic in West Africa

Concern over Ebola becoming endemic in West Africa has appeared in the medical and lay media. Routes of transmission, rates of viral evolution, suitability of humans as hosts and rarity of spillover events make this very unlikely. Without evidence that endemic Ebola is likely, ending epidemics should remain the focus.
Ed Rybicki's insight:
In humans: it may not become endemic in humans...what about other hosts??
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The Secret Life of Viral Entry Glycoproteins

The Secret Life of Viral Entry Glycoproteins | Virology News | Scoop.it

Survival of infection with Ebola virus (EBOV) depends on the ability of the host to mount early and strong immune responses [1], [2]. However, given that EBOV cases are associated with 40%–90% human mortality, EBOV has developed intricate solutions to human immunological defenses. Enveloped viruses, like EBOV, must deposit their genetic material within a cell to ensure their propagation. The roles of viral envelope glycoproteins in mediating virus attachment to host cells and catalyzing the subsequent fusion of the viral and host plasma membranes have been well described (reviewed in [3]). Given the limited number of genes in EBOV and other viruses, it stands to reason that these conformationally labile glycoproteins are also involved in more than just the initial steps of a productive infection. There is strong evidence that viral entry glycoproteins (GP) are modulators of host antiviral defenses (Table 1). In this article, we discuss our current structural understanding of the functions of envelope entry glycoproteins in immune evasion using EBOV as our example.

 
Ed Rybicki's insight:

Nice review on a very interesting and important topic - and highlights how viral entry proteins double as immune evasion agents.

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Chris Upton + helpers's comment, June 17, 2013 4:11 PM
"EBOV has developed intricate solutions to human immunological defenses." Since ebola didn't evolve in humans, this must be accidental. Similar activities may exist in the natural host but not with such high mortality consequences.
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Tracking Ebola in the Congo Jungle

Tracking Ebola in the Congo Jungle | Virology News | Scoop.it

NIAID scientists and their collaborators travel to a remote village in the Republic of the Congo to search for Ebola

and other emerging viruses.

Vaccination has been successful at controlling many of the world’s diseases. However, there are many emerging viral diseases for which no licensed (US or EU) vaccine exists. Here I’ve selected 10 emerging or re-emerging viruses which I think are especially important due to their incidence, prevalence, morbidity, mortality and suitability of current treatment...

 

Ebola virus graphic courtesy of Russell Kightely Media

Ed Rybicki's insight:

Nice video, on the sexy side of virology.  Interesting how well they can set up in the middle of the jungle.

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Ebola survivors feel long-term effects of virus

Ebola survivors feel long-term effects of virus | Virology News | Scoop.it
WASHINGTON, Feb. 26 (UPI) -- The Ebola virus remains in the bodies of survivors at low levels after recovery, causing symptoms and leaving open the possibility of spreading it, according to three recent studies of survivors in West Africa.

Post-Ebola syndrome continues to affect some of the approximately 17,000 people who survived the virus as many have eye, musculoskeletal or neurological symptoms, researchers have found in recent months.

Ebola has been found in the eyes, semen, spines and brains of survivors for six months or more after recovery. The World Health Organization suggests patients wait at least 90 days after recovery before having sex, or to practice safe sex, because doctors suspect the virus has been spread by sexual contact.
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Ebola Doctor Shortage Eases as Volunteers Step Forward

Ebola Doctor Shortage Eases as Volunteers Step Forward | Virology News | Scoop.it
Even with the volunteers, experts say, there will be a long gap before hospitals can be fully staffed to care for the growing numbers of Ebola patients.

Via Paul Kim
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New vaccines needed for pathogens infecting animals and humans: One Health – Dr. Thomas P. Monath

New vaccines needed for pathogens infecting animals and humans: One Health – Dr. Thomas P. Monath | Virology News | Scoop.it
World Vaccine Congress & Expo 2013 

Dr Thomas P. Monath, Adjunct Professor at Harvard School of Public Health gives his presentation on ‘New vaccines needed for pathogens infecting animals and humans: One Health’.

 

Ed Rybicki's insight:

This is a very interesting presentation for a number of reasons - prime among which is the fact that a number of very influential international organisations and funders are taking the notion of "One Health" very seriously.

 

That is, the development of reagents and vaccines that can be used for agents that cause both animal and human diseases, such as avian influenza, Nipah and Hendra and Rift Valley fever viruses, and so on.

 

Great idea - and one we are trying to address with making such things in plants!

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10 Emerging Viruses With No Licensed Vaccine

10 Emerging Viruses With No Licensed Vaccine | Virology News | Scoop.it

Vaccination has been successful at controlling many of the world’s diseases. However, there are many emerging viral diseases for which no licensed (US or EU) vaccine exists. Here I’ve selected 10 emerging or re-emerging viruses which I think are especially important due to their incidence, prevalence, morbidity, mortality and suitability of current treatment.

Ed Rybicki's insight:

Nice account, if brief!  I note Lassa, RFV, WNV and others have been covered in ViroBlogy (http://rybicki.wordpress.com) in recent years as well.

 

All candidates for Going Green...B-)

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