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Virology and Bioinformatics from Virology.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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BMC Bioinformatics | Abstract | MotifLab: a tools and data integration workbench for motif discovery and regulatory sequence analysis

Traditional methods for computational motif discovery often suffer from poor performance.
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An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis

Kenzibit's insight:

Herpesvirus entry functions of the conserved glycoproteins gB and gH–gL have been delineated, but their role in regulating cell–cell fusion is poorly understood. Varicella-zoster virus (VZV) infection provides a valuable model for investigating cell–cell fusion because of the importance of this process for pathogenesis in human skin and sensory ganglia.

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Kenzibit's curator insight, January 16, 2013 10:38 AM

Herpesvirus entry functions of the conserved glycoproteins gB and gH–gL have been delineated, but their role in regulating cell–cell fusion is poorly understood. Varicella-zoster virus (VZV) infection provides a valuable model for investigating cell–cell fusion because of the importance of this process for pathogenesis in human skin and sensory ganglia.

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Des Higgins: Visualizing Multiple Sequence Alignments

Des Higgins (http://bioinf.ucd.ie) gives a very entertaining introduction to the visualization of multiple sequence alignment, and to his widely-used Clustal tool.…
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F1000Research Article: ProfileGrids solve the large alignment visualization problem: influenza hemagglutinin example.

Read the latest article version by Alberto I Roca, Aaron C Abajian, David J Vigerust, at F1000Research.
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Distance learning in computational biology - The University of Manchester

Distance learning in computational biology - The University of Manchester | Virology and Bioinformatics from Virology.ca | Scoop.it
Distance learning courses for biologists and for computer scientists
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Oh, Go Get a Fucking Flu Shot Already!

Oh, Go Get a Fucking Flu Shot Already! | Virology and Bioinformatics from Virology.ca | Scoop.it
Hey, dum-dums! It's flu time again! Epidemic o'clock! Let's all get shots and not die and not kill the elderly and infect delicate babies with our germs, shall we?
Chris Upton + helpers's insight:

Sometimes, you've just got to say it....

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Ed Rybicki's comment, January 17, 2013 4:50 PM
Amen! Says he, who is in flu-infested North America without having been vaccinated. Idiot...!
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Science/AAAS | Special Issue: Inflammation

RT @stem_cells: This week, @ScienceMagazine brings you a special issue on inflammation and disease: http://t.co/Q5RZBGFL #immunology

Via Gilbert Faure au nom de l'ASSIM
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Bioinformatics analysis of large-scale viral sequences: From construction of data sets to annotation of a phylogenetic tree

 
burkesquires's insight:

Due to a significant decrease in the cost of DNA sequencing, the number of sequences submitted to the public databases has dramatically increased in recent years. Efficient analysis of these data sets may lead to a significant understanding of the nature of pathogens such as bacteria, viruses, parasites, etc. However, this has raised questions about the efficacy of currently available algorithms for the study of pathogen evolution and construction of phylogenetic trees. While the advanced algorithms and corresponding programs are being developed, it is crucial to optimize the available ones in order to cope with the current need. The protocol presented in this study is optimized using a number of strategies currently being proposed for handling large-scale DNA sequence data sets, and offers a highly efficacious and accurate method for computing phylogenetic trees with limited computer resources. The protocol may take up to 36 h for construction and annotation of a final tree of about 20,000 sequences.

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Get Into Google+: A Guide For Everyone

Get Into Google+: A Guide For Everyone | Virology and Bioinformatics from Virology.ca | Scoop.it
Curious about Google+, but don’t know where or why to start? Check out “Get Into Google+: A Guide For Everyone”, the latest free guide from MakeUseOf.
Chris Upton + helpers's insight:

Something I need....

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I'm a Scientist – the Film | A film by Stephen Curry

I'm a Scientist – the Film | A film by Stephen Curry | Virology and Bioinformatics from Virology.ca | Scoop.it
Kenzibit's insight:
When you think of scientists, what are the images that come to mind? If you have never met a scientist or visited a laboratory, it can be hard to get away from the stereotypes we see in films and on TV.
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Kenzibit's curator insight, January 14, 2013 4:07 AM

When you think of scientists, what are the images that come to mind? If you have never met a scientist or visited a laboratory, it can be hard to get away from the stereotypes we see in films and on TV.

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ViralFusionSeq: Accurately discover viral integration events and reconstruct fusion transcripts at single-base resolution

ViralFusionSeq: Accurately discover viral integration events and reconstruct fusion transcripts at single-base resolution | Virology and Bioinformatics from Virology.ca | Scoop.it
ViralFusionSeq (VFS) is described at Bioinformatics http://t.co/Tcj1jmrc and is deposited at SEQwiki http://t.co/EieBBJg6 #NGS #Genomics
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Tiny machine apes production line

Tiny machine apes production line | Virology and Bioinformatics from Virology.ca | Scoop.it
Manchester scientists develop a tiny molecular machine they hope one day could synthesize new drug molecules or new types of plastic.

Via ComplexInsight
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ComplexInsight's curator insight, January 12, 2013 8:30 PM

Manchester scientists have developed a tiny molecular machine that mirrors the function of the ribosome, which builds the proteins in our body's cells.

Just a few millionths of a millimetre in size, the minute machine resembles a ring threaded on a rod. As this ring moves along the rod, it picks chemical units and assembles them into chains, just as ribosomes join up the building blocks of proteins. Its hard to overestimate how potentially important this is. ranging from drug production to synthetic materials the degree of promise is enormous. 

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Antibody Correlates and Predictors of Immunity to Naturally-occurring Influenza in Humans and the Importance of Antibody to the Neuraminidase.

Background. Serum antibody to the hemagglutinin (HA) of influenza viruses is a correlate and predictor of immunity to influenza in humans; the relative values of other correlates are uncertain.Methods. Serum and nasal secretions (NS) were collected fall and spring of 2009-11 from healthy adults who were monitored for acute respiratory illness (ARI). Sera were tested for hemagglutination-inhibition (HAI) antibody increase and secretions for virus if ill; enrollment sera were also tested for neuraminidase-inhibiting (NI) antibody and NS for neutralizing (neut), NI, IgA, and IgG anti-HA antibody.Results. Serum anti-HA and anti-neuraminidase (NA) antibody titers to 2009(H1N1) pandemic influenza virus (pH1N1) correlated with titers in NS (including IgA and IgG antibody). Increasing anti-HA and anti-NA titers in serum and NS tests all correlated with reducing infection and infection-associated illness. Multivariate analyses indicated serum HAI and NI each independently predicted immunity to infection and infection-associated illness. Only serum NI independently predicted reduced illness among infected subjects.Conclusions. Increasing anti-HA and NA antibody in serum and secretions correlated with reducing pH1N1 influenza virus infection and illness in healthy young adults. Both anti-HA and anti-NA antibody are independent predictors of immunity to influenza; ensuring induction of both by vaccination is desirable.

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Clustal Omega - fast, accurate, scalable multiple sequence alignment for proteins

Clustal Omega - fast, accurate, scalable multiple sequence alignment for proteins | Virology and Bioinformatics from Virology.ca | Scoop.it
Home of the Clustal Omega multiple sequence alignment program
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PhoScan

PhoScan | Virology and Bioinformatics from Virology.ca | Scoop.it

PhoScan is a software of prediction of kinase-specific phosphorylation sites with sequence features by a log-odds ratio approach.

 


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10 ways scientists can benefit from Twitter | AAAS MemberCentral

10 ways scientists can benefit from Twitter | AAAS MemberCentral | Virology and Bioinformatics from Virology.ca | Scoop.it
Scientists can use Twitter to engage with the public, get help with their experiments, and seek (and provide) career advice. We give lists of 10 reasons you should be on twitter, and some ideas on how to use the social media space effectively.
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The infelicities of quarantine | PLOS Blogs Network

The infelicities of quarantine | PLOS Blogs Network | Virology and Bioinformatics from Virology.ca | Scoop.it

In 2009, as panic struck global health systems confronted with the H1N1 flu epidemic, a familiar strategy was immediately invoked by health officials worldwide: quarantine. In Hong Kong, 300 hotel guests were quarantined in their hotel for at least a week after one guest came down with H1N1. Such measures are certainly extreme, but they do raise important questions about quarantine. How do we regulate quarantine in practice? How do we prevent this public health measure from squashing civil liberties?

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Genome Biology | Abstract | MetAMOS: a modular and open source metagenomic assembly and analysis pipeline

We describe MetAMOS, an open source and modular metagenomic assembly and analysis pipeline.
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Researchers identify genetic mutation for rare cancer

Researchers identify genetic mutation for rare cancer | Virology and Bioinformatics from Virology.ca | Scoop.it

By looking at the entire DNA from a fibrous tumor, University of Michigan Comprehensive CAncer Center researchers have found a genetic anomaly that provides an important clue to improving how this cancer is diagnosed and treated.


Via idtdna
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Connecting the Dots: Chicken Pox, Varicella Vaccine and Shingles | Vaccinews Blog

Connecting the Dots: Chicken Pox, Varicella Vaccine and Shingles | Vaccinews Blog | Virology and Bioinformatics from Virology.ca | Scoop.it
“How likely is it that my older 2 kids (who got wild pox and weren’t vaccinated) will get shingles later?”

Via anarchic_teapot
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anarchic_teapot's curator insight, January 13, 2013 2:38 PM

Important stuff. Needs to be read and passed on.

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The Tree of Life: Ten simple ways to share PDFs of your papers #PDFtribute

The Tree of Life: Ten simple ways to share PDFs of your papers #PDFtribute | Virology and Bioinformatics from Virology.ca | Scoop.it
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Immune Clearance of Attenuated Rabies Virus Results in Neuronal Survival with Altered Gene Expression

Immune Clearance of Attenuated Rabies Virus Results in Neuronal Survival with Altered Gene Expression | Virology and Bioinformatics from Virology.ca | Scoop.it
From molecules to physiology
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#overlyhonestmethods- a science communication wonder!

On Monday, @Dr_leigh tweeted- ‘incubation lasted three days because this is how long the undergrad forgot the experiment in the fridge #overlyhonestmethods’ and it didnt take long for the hash tag to start trending.
Naomi Osborne's insight:

On the hash tag that's gone viral amongst scientists this week. 

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Three Helpful Guides for Those Working on Genome Assembly « Homologus

Three Helpful Guides for Those Working on Genome Assembly « Homologus | Virology and Bioinformatics from Virology.ca | Scoop.it

Via Neelima Sinha
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