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Virology and Bioinformatics from Virology.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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Virology Weekly Newsletter 15.03.2013

Virology Weekly Newsletter 15.03.2013 | Virology and Bioinformatics from Virology.ca | Scoop.it
View the article's original source Author: AJ Cann Students taking my virology course at the University of Leicester get a weekly newsletter containing extra links relevant to the lectures. This we...
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This Protein Could Change Biotech Forever - Forbes

This Protein Could Change Biotech Forever - Forbes | Virology and Bioinformatics from Virology.ca | Scoop.it
It started with a quest to make better yogurt.

 

A tiny molecular machine used by bacteria to kill attacking viruses could change the way that scientists edit the DNA of plants, animals and fungi, revolutionizing genetic engineering.

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We hit 20,000 page views today!!!

getting more readers!!

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Thanks to all our curators!!!!

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The alternative "what it takes to be a bioinformatician"

Inspired by this beautifully written piece over at the NY Genome Centre Blog, I thought I'd quickly write down the alternative version, according to yours truly :) I mean, the NY genome piece has s...
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Fernan Aguero's curator insight, March 19, 2013 11:00 AM

The day-to-day truth of being a bioinformatician!

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A Cutting-Edge View on the Current State of Antiviral drugs - PubMed - NCBI

Prominent in the current stage of antiviral drug development.....

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Experimental infection with a Thai reassortant swine influenza virus of pandemic H1N1 origin induced disease

Following the emergence of the pandemic H1N1 influenza A virus in 2009 in humans, this novel virus spread into the swine population.
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Comparative analysis of the transduction efficiency of five adeno associated virus serotypes and VSV-G pseudotype lentiviral vector in lung cancer cells

Lung cancer is the leading cause of cancer-related deaths in the US. Recombinant vectors based on adeno-associated virus (AAV) and lentivirus are promising delivery tools for gene therapy due to low toxicity and long term expression.
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A Cutting-Edge View on the Current State of Anti... [Med Res Rev. 2013] - PubMed - NCBI

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Review on state of current and future antivirals for most clinically relevant viruses

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Marion Koopmans's curator insight, March 16, 2013 1:33 PM

Review on state of antiviral use and development for most clinically relevant viruses

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Immune Cells Cluster and Communicate Like Bees, Researcher Discovers - Infection Control Today

Immune Cells Cluster and Communicate Like Bees, Researcher Discovers - Infection Control Today | Virology and Bioinformatics from Virology.ca | Scoop.it
Immune Cells Cluster and Communicate Like Bees, Researcher Discovers Infection Control Today Krummel's lab team found that after individual T cells survey lymph nodes and sample foreign matter, such as vaccines, bacteria or viruses, they come...
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BMC Bioinformatics | Abstract | CGAP: a new comprehensive platform for the comparative analysis of chloroplast genomes

Chloroplast is an essential organelle in plants which contains independent genome. Chloroplast genomes have been widely used for plant phylogenetic inference recently.
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PLOS Pathogens: Intracellular Vesicle Acidification Promotes Maturation of Infectious Poliovirus Particles

PLOS Pathogens: Intracellular Vesicle Acidification Promotes Maturation of Infectious Poliovirus Particles | Virology and Bioinformatics from Virology.ca | Scoop.it
From molecules to physiology
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BMC Bioinformatics | Abstract | CGAP: a new comprehensive platform for the comparative analysis of chloroplast genomes

Chloroplast is an essential organelle in plants which contains independent genome. Chloroplast genomes have been widely used for plant phylogenetic inference recently.
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Predicting Hotspots for Influenza Virus Reassortment - Vol. 19 No. 4 - April 2013 - Emerging Infectious Disease journal - CDC

Predicting Hotspots for Influenza Virus Reassortment - Vol. 19 No. 4 - April 2013 - Emerging Infectious Disease journal - CDC | Virology and Bioinformatics from Virology.ca | Scoop.it
The 1957 and 1968 influenza pandemics, each of which killed ≈1 million persons, arose through reassortment events. Influenza virus in humans and domestic animals could reassort and cause another pandemic.
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Novel Virus Entry Portal Found | The Scientist Magazine®

Novel Virus Entry Portal Found | The Scientist Magazine® | Virology and Bioinformatics from Virology.ca | Scoop.it
Researchers identify the target protein of a recently discovered human coronavirus, shedding light on infection and possible interspecies spread.
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How proteins read meta DNA code

Scientists have accurately calculated the sliding mechanism for deciphering the second genetic code written within the DNA base pair sequence

 Three-quarters of the DNA in evolved organisms is wrapped around proteins, forming the basic unit of DNA packaging called nucleosomes, like a thread around a spool. The problem lies in understanding how DNA can then be read by such proteins. Now, Arman Fathizadeh, a physicist at Sharif University of Technology in Tehran, Iran, and colleagues have created a model showing how proteins move along DNA, in a paper just published in EPJ E.
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Rotavirus Roundup

Rotavirus Roundup | Virology and Bioinformatics from Virology.ca | Scoop.it
Several interesting papers on responses to rotavirus infection have been published recently, so I thought I'd round them up in one place.
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Harpocrates Speaks: Demystifying Vaccine Ingredients - Formaldehyde

Harpocrates Speaks: Demystifying Vaccine Ingredients - Formaldehyde | Virology and Bioinformatics from Virology.ca | Scoop.it
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PLOS Pathogens: Influenza Virus Aerosols in Human Exhaled Breath: Particle Size, Culturability, and Effect of Surgical Masks

PLOS Pathogens: Influenza Virus Aerosols in Human Exhaled Breath: Particle Size, Culturability, and Effect of Surgical Masks | Virology and Bioinformatics from Virology.ca | Scoop.it

The CDC recommends that healthcare settings provide influenza patients with facemasks as a means of reducing transmission to staff and other patients, and a recent report suggested that surgical masks can capture influenza virus in large droplet spray. However, there is minimal data on influenza virus aerosol shedding, the infectiousness of exhaled aerosols, and none on the impact of facemasks on viral aerosol shedding from patients with seasonal influenza.

We collected samples of exhaled particles (one with and one without a facemask) in two size fractions (“coarse”>5 µm, “fine”≤5 µm) from 37 volunteers within 5 days of seasonal influenza onset, measured viral copy number using quantitative RT-PCR, and tested the fine-particle fraction for culturable virus.

Fine particles contained 8.8 (95% CI 4.1 to 19) fold more viral copies than did coarse particles. Surgical masks reduced viral copy numbers in the fine fraction by 2.8 fold (95% CI 1.5 to 5.2) and in the coarse fraction by 25 fold (95% CI 3.5 to 180). Overall, masks produced a 3.4 fold (95% CI 1.8 to 6.3) reduction in viral aerosol shedding. Correlations between nasopharyngeal swab and the aerosol fraction copy numbers were weak (r = 0.17, coarse; r = 0.29, fine fraction). Copy numbers in exhaled breath declined rapidly with day after onset of illness. Two subjects with the highest copy numbers gave culture positive fine particle samples.

Surgical masks worn by patients reduce aerosols shedding of virus. The abundance of viral copies in fine particle aerosols and evidence for their infectiousness suggests an important role in seasonal influenza transmission. Monitoring exhaled virus aerosols will be important for validation of experimental transmission studies in humans.

Ed Rybicki's insight:

Bottom line: masks work, to at least drastically reduce levels of aerosolised virus.  But the PATIENTS should wear them...B-)

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Do Cats With FIV Foretell HIV's Future? - PLoS Blogs (blog)

Do Cats With FIV Foretell HIV's Future? - PLoS Blogs (blog) | Virology and Bioinformatics from Virology.ca | Scoop.it
PLoS Blogs (blog)
Do Cats With FIV Foretell HIV's Future?
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Antibody and CD8+ T cell memory response to i... [J Appl Physiol. 2013] - PubMed - NCBI

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Working a tread mill can dampen respons to flu infection, leading to reduced morbidity but also lesser immmune response. 

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Wary of Attack With Smallpox, US Buys Up a Costly Drug - New York Times

Wary of Attack With Smallpox, US Buys Up a Costly Drug - New York Times | Virology and Bioinformatics from Virology.ca | Scoop.it
Wary of Attack With Smallpox, US Buys Up a Costly Drug
New York Times
Smallpox was eradicated by 1980, and the only known remaining virus is in government laboratories in the United States and Russia.
Marion Koopmans's insight:
Difficult decision: how usefull is this, in times of budget reduction? How do we weigh the potential benefits against these costs?Another way of looking at it: stockpiling this drug porbably does not cost more than a stretch of highway...
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Outbreak of viral hemorrhagic fever caused by dengue virus type 3 in Al-Mukalla, Yemen

Investigations were conducted by the authors to explore an outbreak of viral hemorrhagic fever (VHF) reported in 2010 from Al-Mukalla city, the capital of Hadramout in Yemen.
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PLOS Pathogens: Evolution of Virulence in Emerging Epidemics

PLOS Pathogens: Evolution of Virulence in Emerging Epidemics | Virology and Bioinformatics from Virology.ca | Scoop.it
From molecules to physiology
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Outbreak of viral hemorrhagic fever caused by dengue virus type 3 in Al-Mukalla, Yemen

Investigations were conducted by the authors to explore an outbreak of viral hemorrhagic fever (VHF) reported in 2010 from Al-Mukalla city, the capital of Hadramout in Yemen.
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U.S. stockpiling smallpox drug, first shipment of Arestvyr received -

U.S. stockpiling smallpox drug, first shipment of Arestvyr received - | Virology and Bioinformatics from Virology.ca | Scoop.it
Examiner.com
U.S. stockpiling smallpox drug, first shipment of Arestvyr received Examiner.com All known stocks of variola virus (smallpox) stocks are kept under security at two places: the Centers for Disease Control and Prevention (CDC) in Atlanta...
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