Virology and Bioinformatics from Virology.ca
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Virology and Bioinformatics from Virology.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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Genomics, Medicine, and Pseudoscience: Bad medicine infiltrates M.D. Anderson Cancer Center

Genomics, Medicine, and Pseudoscience: Bad medicine infiltrates M.D. Anderson Cancer Center | Virology and Bioinformatics from Virology.ca | Scoop.it
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BMC Bioinformatics | Abstract | Multiple consensus trees: a method to separate divergent genes

Background It is generally admitted that the species tree cannot be inferred from the genetic sequences of a single gene because the evolution of different genes, and thus the gene tree topologies, may vary substantially.
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Emerging Microbes & Infections - Pathogen-host-environment interplay and disease emergence

Emerging Microbes and Infections (EMI) is a new open access, fully peer-reviewed journal that will publish the best and most interesting research in emerging microbes and infectious disease.
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ComplexInsight's curator insight, February 12, 2013 11:57 AM

must add to reading list.

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An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity. Running title: ...

Lassa hemorrhagic fever (LHF) is a rodent-borne viral disease that can be fatal for human beings.
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PLOS Pathogens: Phylogeny and Origins of Hantaviruses Harbored by Bats, Insectivores, and Rodents

PLOS Pathogens: Phylogeny and Origins of Hantaviruses Harbored by Bats, Insectivores, and Rodents | Virology and Bioinformatics from Virology.ca | Scoop.it
From molecules to physiology
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ComplexInsight's curator insight, February 12, 2013 12:33 PM

Hantaviruses are among the most important zoonotic pathogens of humans and the subject of heightened global attention. Despite the importance of hantaviruses for public health, there is no consensus on their evolutionary history and especially the frequency of virus-host co-divergence versus cross-species virus transmission. Documenting the extent of hantavirus biodiversity, and particularly their range of mammalian hosts, is critical to resolving this issue and something this paper focuses on. Well worth reading in relation to public health planning and disease modeling and understanding how interconnected our health biome actually is.

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A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin

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Nature Structural & Molecular Biology (2013)

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Your Inner Lions: Get to Know Your Virome

Your Inner Lions: Get to Know Your Virome | Virology and Bioinformatics from Virology.ca | Scoop.it

I’ve been blogging a lot recently about dangerous viruses, like the flu and norovirus. But, truth be told, a lot of viruses we harbor don’t make us sick. They may even make us healthy. You’d think they’d be worth getting to know. But they’re mostly a mystery to us.

Ed Rybicki's insight:

Great article about the viruses that live in and on us - and STUNNING pictures!

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The Unsettling Beauty of Lethal Viruses

The Unsettling Beauty of Lethal Viruses | Virology and Bioinformatics from Virology.ca | Scoop.it
British artist Luke Jerram's handblown glass sculptures show the visual complexity and delicacy of E. coli, swine flu, malaria and other killing agents
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BMC Infectious Diseases | Abstract | A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18--26 years

Pre-vaccination information on HPV type-specific prevalence in target populations is essential for designing and monitoring immunization strategies for cervical cancer (CC) prevention.
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BMC Bioinformatics | Abstract | Seq2Ref: a web server to facilitate functional interpretation

The size of the protein sequence database has been exponentially increasing due to advances in genome sequencing.
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Can you predict how a disease will spread in a population?

Can you predict how a disease will spread in a population? | Virology and Bioinformatics from Virology.ca | Scoop.it
How, when and where a pathogen is transmitted between two individuals in a population is crucial in understanding and predicting how a disease will spread.
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JENNIFER LOPEZ FIGHTING PERTUSSIS. GET THE VACCINE FOR YOU AND YOUR BABY. Important, see the video - click HERE.

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Powerful ad for vaccines.

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Twitter / drflanders : Deaths from vaccine-preventable ...

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BMC Genomics | Abstract | Genotyping 1000 yeast strains by next-generation sequencing

The throughput of next-generation sequencing machines has increased dramatically over the last few years; yet the cost and time for library preparation have not changed proportionally, thus representing the main bottleneck for sequencing large...
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BMC Bioinformatics | Abstract | MultiAlign: a multiple LC-MS analysis tool for targeted omics analysis

MultiAlign is a free software tool that aligns multiple liquid chromatography-mass spectrometry datasets to one another by clustering mass and chromatographic elution features across datasets.
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The expression of interleukin-32 is activated by human cytomegalovirus infection and down regulated by hcmv-miR-UL112-1

Interleukin-32 (IL-32) is an important factor in innate and adaptive immune responses, which activates the p38MAPK, NF-kappa B and AP-1 signaling pathways. Recent reports have highlighted that IL-32 is regulated during viral infection in humans.
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Do bacteria cause malnutrition?

Do bacteria cause malnutrition? | Virology and Bioinformatics from Virology.ca | Scoop.it
Last month I wrote a post on the link between obesity and our gut flora. Now there has been a study showing the opposite - that the gut flora also plays a role in malnutrition.
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PLOS ONE: Mixed Modeling of Meta-Analysis P-Values (MixMAP) Suggests Multiple Novel Gene Loci for Low Density Lipoprotein Cholesterol

PLOS ONE: Mixed Modeling of Meta-Analysis P-Values (MixMAP) Suggests Multiple Novel Gene Loci for Low Density Lipoprotein Cholesterol | Virology and Bioinformatics from Virology.ca | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Polio vaccinators killed in Nigeria

Polio vaccinators killed in Nigeria | Virology and Bioinformatics from Virology.ca | Scoop.it
Nine female polio vaccinators have been killed in two shootings at health centres in Nigeria's northern state of Kano, police tell the BBC.
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PLOS Pathogens: Identification and Manipulation of the Molecular Determinants Influencing Poliovirus Recombination

PLOS Pathogens: Identification and Manipulation of the Molecular Determinants Influencing Poliovirus Recombination | Virology and Bioinformatics from Virology.ca | Scoop.it

Viral recombination is critical to understanding the evolution of viral groups and impacts vaccine design, but is poorly understood. In the poliovirus vaccine, recombination is one potential mode of failure where vaccine strains recombine to produce a pathogenic product. We combine gene synthesis and deep sequencing to generate a high-resolution recombination map of poliovirus, both as a model RNA virus and a continuing threat that has yet to be eradicated. This map shows that recombination is concentrated into hotspots and suggests that predictable and alterable motifs in the RNA sequence are associated with recombination frequency. We demonstrate the utility of these observations by re-designing a poliovirus strain to recombine more frequently than normal, facilitating future studies on the role of viral recombination during infection. This result suggests that a large-scale redesign of the entire poliovirus genome to dampen recombination may be feasible, with implications for producing safer and more stable live vaccines.

 

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And people are worried about engineering H5N1 viruses??  I'm more scared of polio....

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Virology Journal Club 07.02.2013

Virology Journal Club 07.02.2013 | Virology and Bioinformatics from Virology.ca | Scoop.it
A journal club analysis of a research paper.
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Alan Cann shows you how to dissect a research paper.

Good advice for any student.

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Designing Tomorrow's Vaccines — NEJM

Designing Tomorrow's Vaccines — NEJM | Virology and Bioinformatics from Virology.ca | Scoop.it
Review Article from The New England Journal of Medicine — Designing Tomorrow's Vaccines
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BMC Bioinformatics | Abstract | HTQC: a fast quality control toolkit for Illumina sequencing data

Illumina sequencing platform is widely used in genome research. Sequence reads quality assessment and control are needed for downstream analysis.
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Natural Killer Cell Dependent Within-Host Competition Arises during Multiple MCMV Infection: Consequences for Viral Transmission and Evolution

Natural Killer Cell Dependent Within-Host Competition Arises during Multiple MCMV Infection: Consequences for Viral Transmission and Evolution | Virology and Bioinformatics from Virology.ca | Scoop.it
From molecules to physiology
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Women have stronger immune systems than men -- and it's all down to X-chromosome related microRNA

Women have stronger immune systems than men -- and it's all down to X-chromosome related microRNA | Virology and Bioinformatics from Virology.ca | Scoop.it
As anyone familiar with the phrase "man-flu" will know women consider themselves to be the more robust side of the species when it comes to health and illness. Now new research seems to support the idea.
Ed Rybicki's insight:

No, that's just sexist...except when it's true.  Like HSV2 vaccines not being as effective in men.

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