Virology and Bioi...
Follow
Find
57.4K views | +11 today
Virology and Bioinformatics from Virology.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
Your new post is loading...
Your new post is loading...
Scooped by Rebecca Kreston
Scoop.it!

PLOS ONE: Disruption of the Human Gut Microbiota following Norovirus Infection

The gut microbiota, the collection of all bacterial members in the intestinal tract, plays a key role in health. Disruption of the indigenous microbiota by a variety of stressors, including antibiotic therapy and intestinal infections, is associated with multiple health problems.

 

We sought to determine if infection with Norovirus disrupts the gut microbiota. Barcoded pyrosequencing of the 16S rRNA-encoding gene was used to characterize the stool microbiota in Norovirus-infected human patients (n = 38). While the microbiota in most infected patients (n = 31) resembled that seen in uninfected healthy controls, a minority of patients (n = 7) possessed a significantly altered microbiota characterized by reduced relative numbers of Bacteriodetes and a corresponding increase in Proteobacteria.

more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

A review of methods for detect human Papillomavirus infection

Human Papillomavirus (HPV) is the most common sexually transmitted virus. Worldwide, the most common high-risk (HR)-HPV are -16/18, and approximately 70% of cervical cancers (CC) are due to infection by these genotypes.
more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

Has cool #stencils for gene/cell components #OmniGraffle for Mac -

Has cool #stencils for gene/cell components #OmniGraffle for Mac - | Virology and Bioinformatics from Virology.ca | Scoop.it

Need a diagram, process chart, quick page-layout, website wireframe

more...
No comment yet.
Scooped by Rebecca Kreston
Scoop.it!

13K houses in Bangalore breeding dengue larvae

13K houses in Bangalore breeding dengue larvae | Virology and Bioinformatics from Virology.ca | Scoop.it

“The survey is currently in its first phase and is a door-to-door exercise. As of Monday, we surveyed 3,55,959 homes. Of them, 13,367 have been found to have larvae,” Dr Devaki told Express.

 

She added that every house that had dengue larvae was marked as D+. “We did this so that in the second phase of the survey we can concentrate only on D+ homes,” she said.

more...
No comment yet.
Rescooped by Chris Upton + helpers from DNA & RNA Research
Scoop.it!

NIH researchers discover gene alteration in rare #autoinflammatory #disease

NIH researchers discover gene alteration in rare #autoinflammatory #disease | Virology and Bioinformatics from Virology.ca | Scoop.it

Just 10 months after publishing a new disease discovery, researchers from the National Institutes of Health have repeated the achievement, bringing their attention back to the same gene. Both diseases cause ultra-rare autoinflammatory conditions, but because the gene is altered in different ways in each disorder, they present distinct symptoms. 


Via idtdna
more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

Biology Direct | Thousands of missed genes found in bacterial genomes and their analysis with COMBREX

The dramatic reduction in the cost of sequencing has allowed many researchers to join in the effort of sequencing and annotating prokaryotic genomes. Annotation methods vary considerably and may fail to identify some genes.
more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

BMC Research Notes | CooVar: Co-occurring variant analyzer

Evaluating the impact of genomic variations (GV) on protein-coding transcripts is an important step in identifying variants of functional significance.
more...
No comment yet.
Scooped by Ben Hetman
Scoop.it!

PLOS ONE: Protection of Rabbits and Immunodeficient Mice against Lethal Poxvirus Infections by Human Monoclonal Antibodies

PLOS ONE: Protection of Rabbits and Immunodeficient Mice against Lethal Poxvirus Infections by Human Monoclonal Antibodies | Virology and Bioinformatics from Virology.ca | Scoop.it

Smallpox (variola virus) is a bioweapon concern. Monkeypox is a growing zoonotic poxvirus threat. These problems have resulted in extensive efforts to develop potential therapeutics that can prevent or treat potentially lethal poxvirus infections in humans. Monoclonal antibodies (mAbs) against smallpox are a conservative approach to this problem, as the licensed human smallpox vaccine (vaccinia virus, VACV) primarily works on the basis of protective antibody responses against smallpox...

more...
No comment yet.
Scooped by Rebecca Kreston
Scoop.it!

PLOS ONE: Prevalence of Seropositivity to Pandemic Influenza A/H1N1 Virus in the United States following the 2009 Pandemic

PLOS ONE: Prevalence of Seropositivity to Pandemic Influenza A/H1N1 Virus in the United States following the 2009 Pandemic | Virology and Bioinformatics from Virology.ca | Scoop.it

2009 pandemic influenza A/H1N1 (A(H1N1)pdm09) was first detected in the United States in April 2009 and resulted in a global pandemic. We conducted a serologic survey to estimate the cumulative incidence of A(H1N1)pdm09 through the end of 2009 when pandemic activity had waned in the United States.

 

By December 2009, approximately one-fifth of the US population, or 61.9 million persons, may have been infected with A(H1N1)pdm09, including around half of school-aged children.

more...
No comment yet.
Scooped by Rebecca Kreston
Scoop.it!

Hendra Virus Outbreak Confirmed in Queensland

 

A horse euthanased on a far north Queensland property this week has been confirmed as having Hendra virus, authorities say.

Test results on Friday [2 Nov 2012] night confirmed the latest case, the 8th Hendra virus incident in Queensland this year [2012] and the 2nd in Ingham, north of Townsville.

 

Queensland Chief Veterinary Officer Dr Rick Symons today [3 Nov 2012] said the horse was 1st noticed to be sick by its owner on Wednesday [31 Oct 2012] afternoon.

 

Dr Symons said a private veterinarian treated the horse as a potential Hendra virus case due to the sudden onset of signs including neurological signs, lethargy and a lack of appetite.

 

By Thursday [1 Nov 2012] afternoon, the horse's condition had deteriorated, and a decision was made to euthanize the horse.

 

"Biosecurity Queensland officers were on-site this morning and have quarantined the property," Dr Symons said in a statement today [3 Nov 2012]. "They will also undertake tracing as a priority to assess whether any other animals were at risk of being exposed to the virus. Restrictions apply to moving horses and horse materials on and off the infected property, and the property will be quarantined for at least one month."

 

Queensland Health experts are determining whether anyone had contact with the infected horse.

 

more...
No comment yet.
Scooped by Rebecca Kreston
Scoop.it!

Missouri's Taney County issues warning on outbreak of fifth disease

The Taney County Health Department warns people to be aware of area cases of fifth disease, a contagious viral illness. Kim Foster, the Taney County Health Department epidemiologist, said there have been 32 cases. The disease has symptoms of the common cold: fever, runny nose and headache.

 

The disease, caused by the parvovirus B 19, gets its name because before vaccines, it was usually the “fifth disease” that a child would commonly develop.Measles was the first, and scarlet fever was the second.

People with fifth disease may also have a red rash on their faces and arms that makes them look as if they have been slapped.

more...
No comment yet.
Scooped by Rebecca Kreston
Scoop.it!

Ebola virus found in Kalimantan’s orangutan | The Jakarta Post

Ebola virus found in Kalimantan’s orangutan | The Jakarta Post | Virology and Bioinformatics from Virology.ca | Scoop.it

Researchers from Airlangga University’s Avian Influenza-zoonosis Research Center in Surabaya, East Java, report that they have detected evidence of Ebola virus in several orangutans in Kalimantan.

 

Researcher Chairil Anwar Nidom told The Jakarta Post on Friday that 65 serum samples collected from 353 healthy orangutans between December 2005 and December 2006 tested positive for Ebola virus.

more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

Oxford Nanopore to Unveil New DNA Sequencers This Week

Oxford Nanopore to Unveil New DNA Sequencers This Week | Virology and Bioinformatics from Virology.ca | Scoop.it
Oxford Nanopore Technologies Ltd.,
the closely held company developing a portable gene-sequencing
device that will sell for less than $1,000, plans to unveil two
instruments that use its novel technology today.
more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

BMC Genomics | Abstract | Whole genome sequencing of the fish pathogen Francisella noatunensis subsp. orientalis Toba04 gives novel insights into Francisella evolution and pathogenecity

Francisella is a genus of gram-negative bacterium highly virulent in fishes and human where F. tularensis is causing the serious disease tularaemia in human.
more...
No comment yet.
Scooped by Kenzibit
Scoop.it!

Methamphetamine Reduces Human Influenza A Virus Replication

Methamphetamine Reduces Human Influenza A Virus Replication | Virology and Bioinformatics from Virology.ca | Scoop.it

Methamphetamine (meth) is a highly addictive psychostimulant that is among the most widely abused illicit drugs, with an estimated over 35 million users in the world. Several lines of evidence suggest that chronic meth abuse is a major factor for increased risk of infections with human immunodeficiency virus and possibly other pathogens, due to its immunosuppressive property. Influenza A virus infections frequently cause epidemics and pandemics of respiratory diseases among human populations. However, little is known about whether meth has the ability to enhance influenza A virus replication, thus increasing severity of influenza illness in meth abusers. Herein, we investigated the effects of meth on influenza A virus replication in human lung epithelial A549 cells.

more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

Modulation of innate #immunity by #Toxoplasma gondii virulence effectors. (Nat Rev Microbiol. 2012]

Toxoplasma gondii is a common parasite of animals and humans and can cause serious opportunistic infections. However, the majority of infections are asymptomatic, possibly because the organism has co-evolved with its many vertebrate hosts and has developed multiple strategies to persist asymptomatically for the lifetime of the host. Over the past two decades, infection studies in the mouse, combined with forward-genetics approaches aimed at unravelling the molecular basis of infection, have revealed that T. gondii virulence is mediated, in part, by secretion of effector proteins into the host cell during invasion. Here, we review recent advances that illustrate how these virulence factors disarm innate immunity and promote survival of the parasite.

more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

InterPro: Protein sequence analysis & classifications

InterPro: Protein sequence analysis & classifications | Virology and Bioinformatics from Virology.ca | Scoop.it

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.

more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

The Genome Factory: Sorting FASTQ files by sequence length

The FASTQ file format is used to store short sequence reads, most commonly those from Illumina. The reads are typically between 36 and 250 bp long, and typical data sets contain between 1M to 1B reads.

more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

| Identifying structural domains of proteins using clustering

Protein structures are comprised of modular elements known as domains. These units are used and re-used over and over in nature, and usually serve some particular function in the structure.
more...
No comment yet.
Rescooped by Kenzibit from Host Cell & Pathogen Interactions
Scoop.it!

Innate Immune Sensing of HIV-1 by Dendritic Cells

HIV-1-specific antibodies and CD8+ cytotoxic T cells are detected in most HIV-1-infected people, yet HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus the inability to effectively prime naive, HIV-1-specific T cells.

more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

Marine microbes see a sea of gradients. [Science. 2012]

Marine bacteria influence Earth's environmental dynamics in fundamental ways by controlling the biogeochemistry and productivity of the oceans. These large-scale consequences result from the combined effect of countless interactions occurring at the level of the individual cells. At these small scales, the ocean is surprisingly heterogeneous, and microbes experience an environment of pervasive and dynamic chemical and physical gradients. Many species actively exploit this heterogeneity, while others rely on gradient-independent adaptations. This is an exciting time to explore this frontier of oceanography, but understanding microbial behavior and competition in the context of the water column's microarchitecture calls for new ecological frameworks, such as a microbial optimal foraging theory, to determine the relevant trade-offs and global consequences of microbial life in a sea of gradients.

more...
No comment yet.
Rescooped by Chris Upton + helpers from DNA & RNA Research
Scoop.it!

Will we ever… reveal all the secrets of life from DNA?

Will we ever… reveal all the secrets of life from DNA? | Virology and Bioinformatics from Virology.ca | Scoop.it

We may have sequenced the human and other species’ genomes, but we are still nowhere near predicting how this creates a living, breathing organism. Here’s why.


Via idtdna
more...
No comment yet.
Scooped by Rebecca Kreston
Scoop.it!

Mumbai terrorist Ajmal Kasab down with fever in prison, dengue suspected - The Times of India

Mumbai terrorist Ajmal Kasab down with fever in prison, dengue suspected - The Times of India | Virology and Bioinformatics from Virology.ca | Scoop.it

 

Mumbai terror attack convict Mohammed Ajmal Amir Kasab is suffering from fever and undergoing treatment in the high security Arthur Road jail.

 

"Kasab is being treated for fever for the past few days. Suspecting that the prisoner could be suffering from dengue, three tests were conducted on him by a team of doctors of JJ hospital but the results were negative," said a police official on condition of anonymity.

 

Kasab, the lone surviving terrorist of the 26/11 Mumbai attacks was involved in a grave crime and waging war against India that led to killing 166 people, including foreigners.

 

more...
No comment yet.
Scooped by Ed Rybicki
Scoop.it!

PLOS Pathogens: Circulating Virus Load Determines the Size of Bottlenecks in Viral Populations Progressing within a Host

PLOS Pathogens: Circulating Virus Load Determines the Size of Bottlenecks in Viral Populations Progressing within a Host | Virology and Bioinformatics from Virology.ca | Scoop.it
Coming to you live from Brisbane, Australia, it's your peripatetic correspondent.
more...
No comment yet.