Viruses and Bioinformatics from Virology.uvic.ca
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Viruses and Bioinformatics from Virology.uvic.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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It's a group effort - the curators:

It's a group effort - the curators: | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

get in touch if you want to help curate this topic

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Bwana Moses's comment, May 25, 2016 6:13 AM
Great work. Keep it going.
Bwana Moses's comment, March 7, 12:46 PM
Thank You.
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Epidemiology and genotype distribution of human papillomavirus (HPV) in Southwest China: a cross-sectional five years study in non-vaccinated women

Large-size data on type-specific HPV prevalence in Southwest China are required to estimate the cervical cancer burden in the country and to prepare for HPV-based cervical screening program and further HPV vaccination of China. This HPV study is a pooled analysis of data from five years in Chongqing of China, which is cross-sectional in design using data collecting. 


The type-specific prevalence rate of HPV 16 and HPV 18 were a little lower than the mean of international meta-analyses. Single HPV genotype infection was predominantly detected in different groups of cervical lesions in Chongqing, and HPV16, 52, 58 were the priority HPV types. The HPV genotyping study was found to be valuable for planning further preventive program for cervical cancer.

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Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases

Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

Highlights
• Crystal and cryo-EM structures of NSV polymerases influenza, La Crosse and VSV.
• Segmented and non-segmented NSV polymerases have a similar extended core architecture.
• Influenza and LACV structures show how the vRNA promoter is bound.
• The cap-snatching mechanism of influenza polymerase (sNSV) is explained.
• VSV (nsNSV) capping domains block product exit and thus need to rearrange.
• Separate exit channels for template and product allow replication within the RNP context.

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Fast and accurate phylogeny reconstruction using filtered spaced-word matches | Bioinformatics | Oxford Academic

Fast and accurate phylogeny reconstruction using filtered spaced-word matches | Bioinformatics | Oxford Academic | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
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Chikungunya Virus (CHIKV) in the Americas

Chikungunya Virus (CHIKV) in the Americas | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

22532 suspected cases (22532 in Central and South America, 0 in the Caribbean, 0 in North America), 7358 confirmed cases (14 North America, 5 Caribbean, 7336 Central and South America) (7350 autochthonous transmission and 8 travel related imported cases)


Via Ed Rybicki
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New antibody test can detect person’s risk for developing HPV-related cancer of the oropharynx

New antibody test can detect person’s risk for developing HPV-related cancer of the oropharynx | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Cancer of the oropharynx has become increasingly common: In the United States alone, the number of newly diagnosed cases has tripled over the past three decades. About 70 percent of these tumors are caused by infection with human papillomavirus (HPV) type 16.

Via Ed Rybicki
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An aspirin a day keeps the grim reaper away

An aspirin a day keeps the grim reaper away | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Low-dose aspirin is good for you. Any brand of aspirin  will do, Bayer or otherwise. Should you take an aspirin every day t
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The N50 misassembly problem

The N50 misassembly problem | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
This is the third in a series of posts where we explain the N50 (Nx) metric, discuss the problems surrounding it, give solutions to those problems, and suggest an alternative N50 metric for transcr…
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Needle free vaccine delivery on the horizon

Researchers are developing a new type of drug delivery system that could allow people to self administer vaccines without the use of needles. Ben Gruber ha

Via Ed Rybicki
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New antibody test can detect person’s risk for developing HPV-related cancer of the oropharynx

New antibody test can detect person’s risk for developing HPV-related cancer of the oropharynx | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Cancer of the oropharynx has become increasingly common: In the United States alone, the number of newly diagnosed cases has tripled over the past three decades. About 70 percent of these tumors are caused by infection with human papillomavirus (HPV) type 16.

Via Ed Rybicki
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Flu vaccine won't definitely stop you from getting the flu, but it's more important than you think

Flu vaccine won't definitely stop you from getting the flu, but it's more important than you think | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
As we head towards flu season, many people are wondering if it's worth getting vaccinated against influenza and if so, when. Here's what you need to know.

Via Ian M Mackay, PhD
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Emerging Microbes & Infections - Histo-blood group antigens as receptors for rotavirus, new understanding on rotavirus epidemiology and vaccine strategy

Emerging Microbes & Infections - Histo-blood group antigens as receptors for rotavirus, new understanding on rotavirus epidemiology and vaccine strategy | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

Emerging Microbes and Infections (EMI) is a new open access, fully peer-reviewed journal that will publish the best and most interesting research in emerging microbes and infectious disease.


Via Gilbert C FAURE
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The frenemies within: Viruses, retrotransposons, and plasmids that naturally infect Saccharomyces yeasts.

The frenemies within: Viruses, retrotransposons, and plasmids that naturally infect Saccharomyces yeasts. | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Viruses are a major focus of current research efforts because of their detrimental impact on humanity and their ubiquity within the environment. Bacteriophages have long been used to study host‐viru
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Peptide in frog slime can kill flu - Futurity

Peptide in frog slime can kill flu - Futurity | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
A component of a South Indian frog's skin mucus kills H1 influenza viruses. "I was almost knocked off my chair," says Joshy Jacob.

Via Ed Rybicki
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How CRISPR can fight antibiotic-resistant infections

How CRISPR can fight antibiotic-resistant infections | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Researchers are developing a probiotic to make disease-causing bacteria self-destruct.
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Scientists engineer human-germ hybrid molecules to attack drug-resistant bacteria

Scientists engineer human-germ hybrid molecules to attack drug-resistant bacteria | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Inspired by viruses that attack and kill bacteria, researchers at The Rockefeller University have created an entirely new weapon against disease-causing bacteria that shows great promis
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Comparative analysis estimates the relative frequencies of co-divergence and cross-species transmission within viral families

Comparative analysis estimates the relative frequencies of co-divergence and cross-species transmission within viral families | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Author summary Emerging infectious diseases are often characterized by host switching events, in which a pathogen jumps from its original host to infect a novel species. However, given the ecological and genetic barriers a virus must overcome to jump species and adapt to new hosts, it might be reasonable to assume that successful cross-species transmission is a relatively rare occurrence and that viruses are instead more likely to co-diverge with their hosts. Using a comparative co-phylogenetic analysis performed at the scale of virus family we have revealed that co-divergence is relatively infrequent among 19 diverse families of RNA and DNA viruses, such that cross-species transmission plays a central role in virus evolution. Host jumping was especially common in viruses with RNA genomes, and by drawing broad-scale comparisons our analysis reveals which virus families have a greater propensity to jump species barriers and hence successfully emerge in new hosts. Finally, our data suggest that sampling more viruses increases the likelihood of detecting host jumping events.
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GeoVax Awarded $658,000 NIH Grant for its HIV Vaccine Program

ATLANTA, GA - (NewMediaWire) - April 03, 2017 - GeoVax Labs, Inc. (OTCQB: GOVX), a biotechnology company developing human vaccines, announced today it ha

Via Ed Rybicki
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The N50 filtering problem

The N50 filtering problem | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
This is the second in a series of posts where we explain the N50 (Nx) metric, discuss the problems surrounding it, give solutions to those problems, and suggest an alternative N50 metric for transc…
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Zika virus

Zika virus | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Created using more than 10,000 images captured by a high-resolution technique, called cryo-electron microscopy, this illustration of the Zika virus reveals something like a topographic map of the infecting agent. This zoomed-in illustration shows not just the envelope that encircles the virus, but also the RNA (in yellow) that lives inside it and allows the virus to replicate.

Via Ed Rybicki
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NIH scientists advance understanding of herpesvirus infection

NIH scientists advance understanding of herpesvirus infection | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Herpes simplex virus (HSV) infections last a lifetime. Once a person has been infected, the virus can remain dormant (latent) for years before periodically reactivating to caus
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Chimpanzee Adenovirus Vector Ebola Vaccine — NEJM

Chimpanzee Adenovirus Vector Ebola Vaccine — NEJM | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Original Article from The New England Journal of Medicine — Chimpanzee Adenovirus Vector Ebola Vaccine
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Nucleic acid detection with CRISPR-Cas13a/C2c2

Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting CRISPR effector Cas13a (previously known as C2c2) exhibits a “collateral effect” of promiscuous RNAse activity upon target recognition. We combine the collateral effect of Cas13a with isothermal amplification to establish a CRISPR-based diagnostic (CRISPR-Dx), providing rapid DNA or RNA detection with attomolar sensitivity and single-base mismatch specificity. We use this Cas13a-based molecular detection platform, termed SHERLOCK (Specific High Sensitivity Enzymatic Reporter UnLOCKing), to detect specific strains of Zika and Dengue virus, distinguish pathogenic bacteria, genotype human DNA, and identify cell-free tumor DNA mutations. Furthermore, SHERLOCK reaction reagents can be lyophilized for cold-chain independence and long-term storage, and readily reconstituted on paper for field applications.


Via Gerd Moe-Behrens
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