Viruses and Bioinformatics from Virology.uvic.ca
89.7K views | +8 today
Follow
Viruses and Bioinformatics from Virology.uvic.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
Your new post is loading...
Your new post is loading...
Scooped by Chris Upton + helpers
Scoop.it!

Compound found to trigger innate immunity against viruses

Compound found to trigger innate immunity against viruses | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
A drug-like molecule can activate innate immunity and induce genes to control infection in a range of RNA viruses, including West Nile, dengue, hepatitis C, influenza A, respiratory syncytial, Nipah, Lassa and Ebola, according to new research.
more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

New coronavirus inhibitor exhibits antiviral activity by blocking viral hijacking of host

New coronavirus inhibitor exhibits antiviral activity by blocking viral hijacking of host | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Since the SARS epidemic in 2003, coronaviruses have been on the watch list for emerging pathogens, and the ongoing outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) confirmed that they represent a serious threat. No specific drugs exist against coronaviruses so far, but an article ...
more...
No comment yet.
Scooped by Hannah Davis
Scoop.it!

The Next Wave of Cancer Cures Could Come From Nasty Viruses - Smithsonian

The Next Wave of Cancer Cures Could Come From Nasty Viruses
Smithsonian
“The field has finally reached a stage … where many of the fundamental problems have been partially addressed,” Russell says.
more...
No comment yet.
Rescooped by Chris Upton + helpers from Virology News
Scoop.it!

H1N-What? Wading Through the Alphabet Soup of Flu Virus Names

H1N-What? Wading Through the Alphabet Soup of Flu Virus Names | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Muddled about all the new flu viruses?

It’s hard to keep up with the changing names in the news. H1Nwhat? Bird flu. Pig flu. MERS. SARS. Here ...

Via Ed Rybicki
Chris Upton + helpers's insight:

Bloody bats just would have to be different!!!

more...
Ed Rybicki's curator insight, February 4, 2014 10:22 AM

Great post on flu.

Scooped by Chris Upton + helpers
Scoop.it!

Dengue—an infectious disease of staggering proportions : The Lancet

About 50—100 million dengue infections occur every year, and the burden of disease not only falls heavily on southeast Asia, but also throughout Latin America. Today, about two-fifths of the world's population live in dengue-endemic countries. 

more...
No comment yet.
Scooped by Jeanmarie Verchot
Scoop.it!

Discovery may explain how prion diseases [eg: mad cow] spread between different types of animals | Virology News

Discovery may explain how prion diseases  [eg: mad cow] spread between different types of animals | Virology News | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Medical researchers have made a discovery that may explain how prion diseases, like chronic wasting disease and mad cow disease, adapt in order to spread between various types of animals.
more...
No comment yet.
Rescooped by Kenzibit from Virology News
Scoop.it!

Child born with HIV cured by US doctors

Child born with HIV cured by US doctors | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

Medical history made with first 'functional cure' of unnamed two-year-old born with the virus but now needing no medication.

Doctors began treating the baby 30 hours after birth. Unusually, they put the child on a course of three antiretroviral drugs, given as liquids through a syringe. The traditional treatment to try to prevent transmission after birth is a course of a single antiretroviral drug. The doctor opted for the more aggressive treatment because the mother had not received any during her pregnancy.

Several days later, blood drawn from the baby before treatment started showed the child was infected, probably shortly before birth. The doctors continued with the drugs and expected the child to take them for life.

However, within a month of starting therapy, the level of HIV in the baby's blood had fallen so low that routine lab tests failed to detect it.


Via Ed Rybicki
more...
Ed Rybicki's curator insight, March 4, 2013 3:01 AM

It would be SO good if this were generalisable to all children born to HIV+ mothers - but it's going to need a clinical trial to find out, and that is many millions of $$ and years down the track.

Chris Upton + helpers's comment, March 5, 2013 1:35 PM
Need to know the facts, remember cold fusion?
Scooped by Chris Upton + helpers
Scoop.it!

32nd Annual American Society for Virology July 20-24, 2013, Penn State University

more...
No comment yet.
Scooped by Kenzibit
Scoop.it!

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more severe disease. Cellular entry of both viruses is mediated by HBV envelope proteins. The pre-S1 domain of the large envelope protein is a key determinant for receptor(s) binding. However, the identity of the receptor(s) is unknown.

more...
No comment yet.
Scooped by Linda O'Reilly
Scoop.it!

Monkey fever confirmed - Deccan Herald

Monkey fever confirmed - Deccan Herald | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Monkey fever confirmedDeccan HeraldA medical report from the National Institute of Virology in Pune has confirmed that the recent death of monkeys in the Bandipur National Park limits was due to 'kyasanur forest disease' (KFD).
more...
No comment yet.
Scooped by Rebecca Kreston
Scoop.it!

Yellow fever mass vaccination campaign begins in Darfur | Outbreak News

Yellow fever mass vaccination campaign begins in Darfur | Outbreak News | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

The 10-day mass vaccination campaign, designed to target 2.2 million people in 12 localities in Darfur, began Nov. 20, according to a World Health Organization Global Alert and Response Nov. 22.

The yellow fever outbreak, which has affected 26 localities in Darfur, has seen a total of 459 suspected cases including 116 deaths as of last Saturday.

more...
No comment yet.
Scooped by Kenzibit
Scoop.it!

Uganda: Marburg outbreak comes just two weeks after Ebola outbreak declared over

Uganda: Marburg outbreak comes just two weeks after Ebola outbreak declared over | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
The Ugandan Ministry of Health is warning the public about another outbreak due to a deadly hemorrhagic fever in the Kibaale district, according to a report fro...
more...
No comment yet.
Scooped by Kenzibit
Scoop.it!

Cows with human chromosomes enlisted to fight hantavirus

Cows with human chromosomes enlisted to fight hantavirus | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Researchers have genetically engineered cows to produce human antibodies against the deadly hantavirus and possibly other diseases
more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

What Ecologists Can Tell Virologists - Annual Review of Microbiology, 68(1):

What Ecologists Can Tell Virologists - Annual Review of Microbiology, 68(1): | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

Ecology as a science evolved from natural history, the observational study of the interactions of plants and animals with each other and their environments. As natural history matured, it became increasingly quantitative, experimental, and taxonomically broad. Focus diversified beyond the Eukarya to include the hidden world of microbial life. Microbes, particularly viruses, were shown to exist in unfathomable numbers, affecting every living organism. Slowly viruses came to be viewed in an ecological context rather than as abstract, disease-causing agents.

more...
No comment yet.
Scooped by Hannah Davis
Scoop.it!

Ebola virus spread in west Africa not under control: WHO expert

Ebola virus spread in west Africa not under control: WHO expert | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Guinea's capital Conakry has recorded its first new Ebola cases in more than a month, while other previously unaffected areas have also reported infections in the past week, according to the World Health Organization.
more...
No comment yet.
Rescooped by Chris Upton + helpers from Virology News
Scoop.it!

Killer Pig Virus Wipes Out More Than 10 Percent Of [US] Hogs

Killer Pig Virus Wipes Out More Than 10 Percent Of [US] Hogs | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

The killer stalking U.S. hog farms is known as PEDv, a malady that in less than a year has wiped out more than 10 percent of the nation's pig population and helped send retail pork prices to record highs. The highly contagious Porcine Epidemic Diarrhea virus is puzzling scientists searching for its origins and its cure and leaving farmers devastated in ways that go beyond financial losses.


Via Ed Rybicki
more...
No comment yet.
Scooped by burkesquires
Scoop.it!

Virus assembly and maturation: auto-regulation through allosteric molecular switches J Mol Biol. 2013

We generalize the concept of allostery from the traditional non-active-site control of enzymes to virus maturation. Virtually, all animal viruses transition from a procapsid noninfectious state to a mature infectious state. The procapsid contains an encoded chemical program that is executed following an environmental cue. We developed an exceptionally accessible virus system for the study of the activators of maturation and the downstream consequences that result in particle stability and infectivity. Nudaurelia capensis omega virus (NωV) is a T=4 icosahedral virus that undergoes a dramatic maturation in which the 490-Å spherical procapsid condenses to a 400-Å icosahedral-shaped capsid with associated specific auto-proteolysis and stabilization. Employing X-ray crystallography, time-resolved electron cryo-microscopy and hydrogen/deuterium exchange as well as biochemistry, it was possible to define the mechanisms of allosteric communication among the four quasi-equivalent subunits in the icosahedral asymmetric unit. These gene products undergo proteolysis at different rates, dependent on quaternary structure environment, while particle stability is conferred globally following only a few local subunit transitions. We show that there is a close similarity between the concepts of tensegrity (associated with geodesic domes and mechanical engineering) and allostery (associated with biochemical control mechanisms).

more...
No comment yet.
Scooped by burkesquires
Scoop.it!

Predicting Hotspots for Influenza Virus Reassortment - Vol. 19 No. 4 - April 2013 - Emerging Infectious Disease journal - CDC

Predicting Hotspots for Influenza Virus Reassortment - Vol. 19 No. 4 - April 2013 - Emerging Infectious Disease journal - CDC | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
The 1957 and 1968 influenza pandemics, each of which killed ≈1 million persons, arose through reassortment events. Influenza virus in humans and domestic animals could reassort and cause another pandemic.
more...
No comment yet.
Rescooped by Chris Upton + helpers from Virology News
Scoop.it!

Viruses and genes may increase risk of schizophrenia

Viruses and genes may increase risk of schizophrenia | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Viruses and genes interact in a way that may increase the risk of developing schizophrenia significantly. This happens already in the developing foetus.

 

Herpesvirus graphic by Russell Kightley Media


Via Ed Rybicki
more...
No comment yet.
Scooped by Naomi Osborne
Scoop.it!

MicroMicrobe • Winter Viruses and How to Beat Them BBC2 aired...

Winter Viruses and How to Beat Them


BBC2 aired another informative program on viruses last night; if you missed it due to a clash with Miranda, you can still catch up on ‘Winter Viruses and How to Beat Them’.
more...
No comment yet.
Scooped by Kenzibit
Scoop.it!

Immune cells engineered in lab to resist HIV infection, study shows

Immune cells engineered in lab to resist HIV infection, study shows | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Researchers have found a novel way to engineer key cells of the immune system so they remain resistant to infection with HIV, the virus that causes AIDS.
more...
No comment yet.
Scooped by Kenzibit
Scoop.it!

Virology Journal | Abstract | Inactivation of Chikungunya virus by 1,5 iodonapthyl azide

Chikungunya virus (CHIKV) is an arthropod borne alphavirus of the family Togaviridae. CHIKV is a reemerging virus for which there is no safe prophylactic vaccine.
more...
MPCIRHC.ORG's curator insight, July 22, 2014 11:25 PM

Money time...for Big Pharma.

Scooped by burkesquires
Scoop.it!

Zoonoses series

Zoonoses series | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

Zoonoses – pathogenic organisms such as bacteria or viruses which we share with animals – cause more than 60% of human infectious diseases, and have been responsible for some of the most devastating disease outbreaks in recent years, including HIV, Ebola, and SARS. However, despite their huge, and rising, impact on human health, there are still huge gaps in our understanding of how zoonoses spread and develop, which need to be urgently addressed if we are to be able to reduce the impact of the next zoonotic pandemic. In a new Lancet Series, leading experts discuss the ecology, drivers and dynamics of zoonoses, while also addressing how we might predict the next zoonotic pandemic, and reduce the potentially catastrophic human and economic cost of such an outbreak.

more...
No comment yet.
Rescooped by Chris Upton + helpers from Virology News
Scoop.it!

Virology: An Illustrated Colour Text

"This is a concise, highly accessible introduction to medical virology, incorporating essential basic principles as well as a systematic review of viruses and viral diseases. It pays particular attention to developments in anti-viral therapy that are becoming increasingly effective in modern medicine. It is an ideal textbook for the information-overloaded student and an invaluable everyday companion for the busy professional who needs a good understanding of the current state of medical virology.

In keeping with the highly successful format of other Illustrated Colour Texts, it presents the subject as a series of succinct 2 page ‘learning units’, using a superb collection of clear illustrations and clinical photographs, concise yet comprehensive text and key point boxes to aid quick access to information and examination preparation.

So whether you are a medical student, junior doctor, medical scientist, trainee in infectious diseases or student on another allied medical course, this book is here to make your life easier! It will also provide a very solid foundation for any who plan to delve deeper into this fascinating field."

 

It gives me great pleasure to be able to hype a book by colleagues from South Africa - and an eBook at that, given that it is available at a substantial discount for Kindle!  I shall be downloading it soonest.  Nice one, guys!


Via Ed Rybicki
more...
No comment yet.