Virology and Bioinformatics from Virology.ca
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Virology and Bioinformatics from Virology.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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Rearrangement of influenza virus spliced segments for the development of live attenuated vaccines

IMPORTANCE Vaccination represents our best therapeutic option against influenza viral infections. However, the efficacy of current influenza vaccines is suboptimal, and novel approaches are necessary for the prevention of disease caused by this important human respiratory pathogen. In this work, we describe a novel approach to generate safer and more efficient live attenuated influenza vaccines (LAIV) based on recombinant viruses encoding non-overlapping and independent M1/M2 (Ms) or both M1/M2 and NS1/NEP (Ms/NSs) open reading frames. Viruses containing a modified M segment were highly attenuated in mice, but able to confer, upon a single intranasal immunization, complete protection against a lethal homologous challenge with wild-type virus. Notably, protection efficacy conferred by our split M viruses was better than that obtained with the current temperature sensitive influenza LAIV. Altogether, these results open a new avenue for the development of safer and more protective LAIV based on genome reorganization of spliced viral RNA segments.
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Damage wrought by measles on the immune system could 'last years'

Damage wrought by measles on the immune system could 'last years' | Virology and Bioinformatics from Virology.ca | Scoop.it
Scientists at the University of Princeton found the damage caused by the measles virus to a child's immune system can last up to three years, leaving them at risk of death from other serious diseases.
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The Measles Outbreak Is Twice As Big As You Thought

The Measles Outbreak Is Twice As Big As You Thought | Virology and Bioinformatics from Virology.ca | Scoop.it
The number of U.S. measles cases has continued climbing toward 200, with 173 cases noted in the CDC’s most recent report March 6 — but that’s only half the story. If you add in the cases multiplying north of the border, the outbreak nearly doubles in size. Canada is also facing [...]
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Queen’s instructor teaches that vaccines are harmful, students say

Queen’s instructor teaches that vaccines are harmful, students say | Virology and Bioinformatics from Virology.ca | Scoop.it
Controversy flares again amid the news about measles outbreaks and the role played by vaccination skeptics
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Vaccines Work. Here Are the Facts.

Vaccines Work. Here Are the Facts. - The Nib - Medium
The risks, the misinformation, and the science behind history’s greatest life saver
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We'll never find an Ebola vaccine without taking some risks

We'll never find an Ebola vaccine without taking some risks | Virology and Bioinformatics from Virology.ca | Scoop.it
The current West African ebolavirus outbreak, which has now reached more than 1,000 cases and resulted in more than 800 deaths, is a reminder of the often unpredictable nature of viruses and the difficulties…
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Parents urged to get children vaccinated following outbreak of rubella

Parents urged to get children vaccinated following outbreak of rubella | Virology and Bioinformatics from Virology.ca | Scoop.it

"HAMPSHIRE parents are being warned of the dangers of not getting their children vaccinated following an outbreak of rubella across the county.

Latest figures have revealed that there have been 14 confirmed cases of the potentially dangerous infection in Hampshire and the Isle of Wight between January and July this year – compared to none during the same period in 2011.

Although the infection can easily be prevented by youngsters receiving their measles, mumps and rubella (MMR) jabs, if caught it can be dangerous, particularly to pregnant women, causing rubella-associated miscarriages and birth defects.

Rubella is a viral infection that is spread in a similar way as a cold and will normally pass within seven to 10 days. But it becomes serious if a pregnant woman catches the infection during the first 16 weeks of pregnancy as it can disrupt the development of the baby, causing congenital rubella syndrome which could include cataracts, deafness, heart abnormalities and brain damage.

 

It is believed the outbreak has been caused by a dip in the number of children getting vaccinated, forcing health bosses to urge parents into action."

 

What IS it with these people??  They'd rather cause someone to have an abortion because of catching rubella from their child, than vaccinate the child??


Via Ed Rybicki
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Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor

IMPORTANCE The Junin virus is responsible for outbreaks of Argentine hemorrhagic fever in South America, where 5 million people are at risk. Limited options are currently available to treat infections by Junin virus or other viruses of the Arenaviridae, making the identification of additional tools, including small-molecule inhibitors, of great importance. How Junin virus enters cells is not yet fully understood. Here we describe new cell culture models in which the cells are susceptible to Junin virus infection and to which we applied CRISPR-Cas9 genome engineering strategies to help characterize early steps during virus entry. We also uncovered ZCL278 to be a new antiviral small molecule that potently inhibits the cellular entry of the Junin virus and other enveloped viruses. Moreover, we show that ZCL278 also functions in vivo, thereby preventing Junin virus replication in a mouse model, opening the possibility for the discovery of ZCL278 derivatives of therapeutic potential.
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Study of 95,000 children finds no link between MMR vaccines and autism

Study of 95,000 children finds no link between MMR vaccines and autism | Virology and Bioinformatics from Virology.ca | Scoop.it
A study of more than 95,000 children in the US has supported what almost two decades of scientific research has already been telling us - the measles-mumps-rubella vaccine (MMR) is safe and effective and is in no way associated with a heightened...
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This study is interesting because they show that even in children with autistic siblings (i.e. kids with a genetic predisposition to autism), vaccination with MMR has no effect on their risk of developing the condition.

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Once A Vaccine Skeptic, This Mom Changed Her Mind

Once A Vaccine Skeptic, This Mom Changed Her Mind | Virology and Bioinformatics from Virology.ca | Scoop.it
Juniper Russo wants what is best for her daughter, Vivian, and she sometimes questions mainstream medicine. But after three years of soul-searching, she decided vaccination was best.
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Two Infants Too Young For Vaccinations Contract Measles From Unvaccinated People At Disneyland

Two Infants Too Young For Vaccinations Contract Measles From Unvaccinated People At Disneyland | Virology and Bioinformatics from Virology.ca | Scoop.it
Nine cases of the highly contagious virus have been confirmed so far in people who recently visited the tourist destination -- most of whom haven't been vaccinated.
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Ebola vaccine trial 'interrupted'

Ebola vaccine trial 'interrupted' | Virology and Bioinformatics from Virology.ca | Scoop.it

The clinical trial of an Ebola vaccine in Switzerland has been interrupted after some patients complained of joint pains in their hands and feet.

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Vaccines and the Republican War on Science

Vaccines and the Republican War on Science | Virology and Bioinformatics from Virology.ca | Scoop.it
Ever since Chris Mooney’s Republican War on Science was published in 2005, folks have been looking for a way to argue that Democrats are just as bad.
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Measles Surge in Europe Raises Risks for Sports Fans

Measles Surge in Europe Raises Risks for Sports Fans | Virology and Bioinformatics from Virology.ca | Scoop.it

Sports fans at the London Olympics and European Championships for soccer later this year may face a
greater risk of contracting measles as vaccination rates drop across the continent, health authorities said.

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