Viruses and Bioinformatics from Virology.uvic.ca
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Viruses and Bioinformatics from Virology.uvic.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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Engineering and expression of a human rotavirus candidate vaccine in Nicotiana benthamiana

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Virus-like particles produced in plants as potential vaccines

Virus-like particles produced in plants as potential vaccines | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

Virus-like particles (VLPs) have been produced as candidate vaccines in plants virtually since the introduction of biofarming. Even today, VLPs remain the best candidates for safe, immunogenic, efficacious and inexpensive vaccines. Well-characterized human animal viruses such as HBV, HCV, HIV and HPV, rotaviruses, norovirus, foot and mouth disease viruses and even influenza virus proteins have all been successfully investigated for VLP formation. Proteins have been produced in transgenic plants and via transient expression techniques; simple structures, structures depending on more than one protein, naked and enveloped particles have all been made. There have been multiple proofs of concept, more than a few proofs of efficacy, and several products moved into human trials. This review will cover the history of VLP production in plants, and will explore a few examples in detail to illustrate the potential of such a mode of production for human and animal medicine.

 Image of HIV-1 Pr55Gag VLPs produced in plants, courtesy of Ann Jaffray, UCT.  Bar = 100 nm


Via Ed Rybicki
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Ed Rybicki's curator insight, April 2, 2013 3:44 AM

OK, yes, blowing my own trumpet...but it will put the recent news of FMDV VLPs in perspective, AND point up the fact that these can be (and probably have been) produced in plants - as well as other even more complicated particles, like human rotavirus and bluetongue virus.

dayangyusof's curator insight, July 22, 2016 2:09 AM

OK, yes, blowing my own trumpet...but it will put the recent news of FMDV VLPs in perspective, AND point up the fact that these can be (and probably have been) produced in plants - as well as other even more complicated particles, like human rotavirus and bluetongue virus.

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ScienceDirect.com - Current Opinion in Virology - Rotavirus–host cell interactions: an arms race

ScienceDirect.com - Current Opinion in Virology - Rotavirus–host cell interactions: an arms race | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

► Rotavirus shuts off the translation of cellular transcripts by at least three different mechanisms.

► The formation of stress granules is prevented in rotavirus-infected cells.

► Rotavirus infection elicits and modulates the unfolded protein response of the cell.

► The innate immune response of the cells is controlled during rotavirus infection.

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U of A vice-president honoured for vaccine breakthroughs

Instead of gorging on Christmas leftovers, Lorne Babiuk spent the final week of 1978 inside his lab. The University of Saskatchewan virology professor was determined to reproduce rotavirus, the microscopic pathogen behind much of the world's most severe diarrhea in livestock and children.
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Medicago successfully produces plant-based Rotavirus VLP vaccine candidate

Medicago successfully produces plant-based Rotavirus VLP vaccine candidate | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

Medicago Inc., a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), today announced the successful production of a Rotavirus VLP vaccine candidate comprising all four structural antigens of rotavirus (VP2, VP4, VP6 and VP7) using Medicago's plant-based manufacturing platform.

Medicago also announced today that an international patent application under the Patent Cooperation Treaty (PCT) that broadly covers plant-produced Rotavirus VLPs has been filed.

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Ed Rybicki's curator insight, June 25, 2013 10:38 AM

Going green: how very sensible!

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Human rotavirus vaccine RotarixTM provides protection against diverse circulating rotavirus strains in African infants: a randomized controlled trial

Rotaviruses are the most important cause of severe acute gastroenteritis worldwide in...
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Launch in Rwanda of Africa's first national rotavirus vaccination ...

Merck (MSD outside the United States and Canada) said it welcomed the launch in Rwanda of Africa's first national rotavirus vaccination program with ROTATEQ (rotavirus vaccine, live, oral, pentavalent).

Via anarchic_teapot
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