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Virology and Bioinformatics from Virology.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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Plant-produced virus-like particle vaccines

Virus-like particles (VLPs) are possibly the best candidates for safe, immunogenic, efficacious and inexpensive vaccines, for both animals and humans. Well-characterized human and animal viruses such as hepatitis B and C, HIV and papillomaviruses, rotaviruses, norovirus, foot-and-mouth disease viruses and even influenza A virus proteins have all been successfully investigated for VLP formation. Proteins have been produced in transgenic plants and via transient expression techniques; simple structures and structures depending on more than one protein, naked and enveloped particles, and peptides displayed on other viruses have all been made. There have been multiple proofs of concept, and more than a few proofs of efficacy. This chapter covers the history of VLP production in plants, and explores a few examples in detail to illustrate the potential of such a mode of production for human and animal medicine.


Via Ed Rybicki
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Ed Rybicki's curator insight, February 4, 5:12 AM

For those of you with brass in pocket...B-)

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Virology - Plant virus expression vectors set the stage as production platforms for biopharmaceutical proteins

Virology - Plant virus expression vectors set the stage as production platforms for biopharmaceutical proteins | Virology and Bioinformatics from Virology.ca | Scoop.it

Transgenic plants present enormous potential as a cost-effective and safe platform for large-scale production of vaccines and other therapeutic proteins. A number of different technologies are under development for the production of pharmaceutical proteins from plant tissues. One method used to express high levels of protein in plants involves the employment of plant virus expression vectors. Plant virus vectors have been designed to carry vaccine epitopes as well as full therapeutic proteins such as monoclonal antibodies in plant tissue both safely and effectively. Biopharmaceuticals such as these offer enormous potential on many levels, from providing relief to those who have little access to modern medicine, to playing an active role in the battle against cancer. This review describes the current design and status of plant virus expression vectors used as production platforms for biopharmaceutical proteins.

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