Virology and Bioinformatics from Virology.ca
81.9K views | +16 today
Follow
Virology and Bioinformatics from Virology.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
Your new post is loading...
Your new post is loading...
Scooped by Michael Wolfe
Scoop.it!

PLoS ONE: High Prevalence of Human Parvovirus 4 Infection in HBV and HCV Infected Individuals in Shanghai

Human parvovirus 4 (PARV4) has been detected in blood and diverse tissues samples from HIV/AIDS patients who are injecting drug users. Although B19 virus, the best characterized human parvovirus, has been shown to co-infect patients with hepatitis B or hepatitis C virus (HBV, HCV) infection, the association of PARV4 with HBV or HCV infections is still unknown.

...

more...
No comment yet.
Scooped by Michael Wolfe
Scoop.it!

PLoS ONE: Parvovirus B19 DNA CpG Dinucleotide Methylation and Epigenetic Regulation of Viral Expression

PLoS ONE: Parvovirus B19 DNA CpG Dinucleotide Methylation and Epigenetic Regulation of Viral Expression | Virology and Bioinformatics from Virology.ca | Scoop.it

CpG DNA methylation is one of the main epigenetic modifications playing a role in the control of gene expression. For DNA viruses whose genome has the ability to integrate in the host genome or to maintain as a latent episome, a correlation has been found between the extent of DNA methylation and viral quiescence. No information is available for Parvovirus B19, a human pathogenic virus, which is capable of both lytic and persistent infections. Within Parvovirus B19 genome, the inverted terminal regions display all the characteristic signatures of a genomic CpG island; therefore we hypothesised a role of CpG dinucleotide methylation in the regulation of viral genome expression.

more...
No comment yet.
Scooped by Michael Wolfe
Scoop.it!

Focal segmental glomerulosclerosis and parvovirus B19

Focal segmental glomerulosclerosis (FSGS) is a glomerular disease with a characteristic pathologic presentation that includes segmental scarring involving some but not all glomeruli. On immunofluorescence, deposits of immunoglobulin (Ig) M and C3 may be found in the areas of segmental scarring. Electron microscopy typically demonstrates diffuse epithelial cell foot process effacement and focal areas of retraction of glomerular basement membrane with collapse of the involved tuft (1)...

more...
No comment yet.
Scooped by Michael Wolfe
Scoop.it!

Occurrence of Chicken Parvovirus Infection in Poland

he aim of the foregoing study was the determination of the occurrence of parvovirus in chicken flocks from different regions of Poland during 2002-2011. The material used for this study originated from chickens showing clinical symptoms of stunting and emaciation. For the quick detection of genetic material of the viruses in field samples, real-time PCR was applied. The conducted study implied on the occurrence of parvoviral infections in Poland in approximately 18% of investigated chicken flocks. However, their exact role remains still unknown.

more...
No comment yet.