PLoS Neglected Tropical Diseases: Assessing the Potential of a Candidate Dengue Vaccine with Mathematical Modeling | Viruses and Bioinformatics from |

To date, most models of dengue transmission have been limited in scope and focused on specific questions in transmission dynamics. However, many aspects of the dynamics of dengue transmission are still not fully understood. In order for models to be accurate, realistic, and useful, there is an urgent need for improved understanding of dengue virology and immunology, as well as the entomological, social, and environmental factors that modulate dengue transmission. As these facets of dengue biology are further investigated, we will gain confidence that future mathematical models may come close to an accurate representation of true dengue epidemics.