Virology and Bioinformatics from Virology.ca
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Virology and Bioinformatics from Virology.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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The interferon-inducible antiviral protein daxx is not essential for interferon-mediated protection against avian sarcoma virus

The antiviral protein Daxx acts as a restriction factor of avian sarcoma virus (ASV; Retroviridae) in mammalian cells by promoting epigenetic silencing of integrated proviral DNA. Although Daxx is encoded by a type I (alpha/beta) interferon-stimulated gene, the requirement for Daxx in the interferon anti-retroviral response has not been elucidated. In this report, we describe the results of experiments designed to investigate the role of Daxx in the type I interferon-induced anti-ASV response.
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PLoS Pathogens: The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold

PLoS Pathogens: The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold | Virology and Bioinformatics from Virology.ca | Scoop.it

Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are characterized by early suppression of the host innate immune system. One of the proteins likely responsible for this effect is VP24. VP24 is known to antagonize interferon signaling by binding host karyopherin α proteins, thereby preventing them from transporting the tyrosine-phosphorylated transcription factor STAT1 to the nucleus.

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Cytosolic DNA sensors regulating type I interferon induction 10.1016/j.it.2011.08.004 : Trends in Immunology | ScienceDirect.com

Cytosolic DNA sensors regulating type I interferon induction 10.1016/j.it.2011.08.004 : Trends in Immunology | ScienceDirect.com | Virology and Bioinformatics from Virology.ca | Scoop.it

Type I interferon (IFN) induction is a crucial anti-pathogen response mediated by innate immune stimulation.

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Ifitm3 Limits the Severity of Acute Influenza in Mice

Ifitm3 Limits the Severity of Acute Influenza in Mice | Virology and Bioinformatics from Virology.ca | Scoop.it

Interferon-induced transmembrane (IFITM) proteins are a family of viral restriction factors that inhibit the entry processes of several pathogenic viruses, including influenza A virus (IAV), in vitro. Here we report that IAV-infected knockout mice lacking the Ifitm locus on chromosome 7 exhibited accelerated disease progression, greater mortality, and higher pulmonary and systemic viral burdens as compared to wild type controls.

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Removal of Vaccinia Virus Genes That Block Interferon Type I and II Pathways Improves Adaptive and Memory Responses of the HIV/AIDS Vaccine Candidate NYVAC-C in Mice

Poxviruses encode multiple inhibitors of the interferon (IFN) system, acting at different levels and blocking the induction of host defense mechanisms. Two viral gene products, B19 and B8, have been shown to act as decoy receptors of type I and type II IFNs, blocking the binding of IFN to its receptor.

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